| 1 | KDM2A, SFRP2
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| Demethylation of SFRP2 by histone demethylase KDM2A regulated osteo-/dentinogenic differentiation of stem cells of the apical papilla.
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| Yu G, Wang J, Lin X, Diao S, Cao Y, Dong R, Wang L, Wang S, Fan Z.
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| Cell Prolif 49(3):330-40. doi: 10.1111/cpr.12256. Epub 2016 Apr 13.
2016
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| 2 | SFRP2, SREBF1
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| Sfrp2 is a transcriptional target of SREBP-1 in mouse chondrogenic cells.
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| Kim MJ, Kim JE, Lee W, Park SY.
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| Mol Cell Biochem. Aug;406(1-2):163-71. doi: 10.1007/s11010-015-2434-y. Epub 2015 May 14 2015
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| 3 | SFRP1, SFRP2
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| Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.
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| Xavier CP, Melikova M, Chuman Y, Üren A, Baljinnyam B, Rubin JS.
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| Cell Signal 26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.
2014
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| 4 | SFRP1, SFRP2
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| Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells.
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| Sugiyama Y, Shelley EJ, Wen L, Stump RJ, Shimono A, Lovicu FJ, McAvoy JW.
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| Dev Biol 384(2):181-93. doi: 10.1016/j.ydbio.2013.10.008. Epub 2013 Oct 16.
2013
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| 5 | DKKL1, DLX3, HR, SFRP1, SFRP2, SOSTDC1
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| Hairless plays a role in formation of inner root sheath via regulation of Dlx3 gene.
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| Kim BK, Lee HY, Choi JH, Kim JK, Yoon JB, Yoon SK.
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| J Biol Chem 287(20):16681-8. doi: 10.1074/jbc.M111.320770. Epub 2012 Mar 22.
2012
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| 6 | ADAM10, SFRP1, SFRP2
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| SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
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| Esteve P, Sandonìs A, Cardozo M, Malapeira J, Ibañez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P.
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| Nat Neurosci 14(5):562-9. Epub 2011 Apr 10.
2011
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| 7 | SFRP2
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| Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling.
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| von Marschall Z, Fisher LW.
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| Biochem Biophys Res Commun 400(3):299-304. Epub 2010 Aug 17.
2010
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| 8 | SFRP1, SFRP2
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| SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway.
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| Chung MT, Lai HC, Sytwu HK, Yan MD, Shih YL, Chang CC, Yu MH, Liu HS, Chu DW, Lin YW.
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| Gynecol Oncol 112(3):646-53. Epub 2008 Dec 18. 2009
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| 9 | SFRP1, SFRP2
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| Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells.
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| Nakajima H, Ito M, Morikawa Y, Komori T, Fukuchi Y, Shibata F, Okamoto S, Kitamura T.
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| Biochem Biophys Res Commun 390(1):65-70. Epub 2009 Sep 22.
2009
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| 10 | SFRP2, SFRP5
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| Silencing of secreted frizzled-related protein genes in MSI colorectal carcinogenesis.
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| Tanaka J, Watanabe T, Kanazawa T, Tada T, Kazama Y, Tanaka T, Nagawa H.
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| Hepatogastroenterology 55(85):1265-8. 2008
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| 11 | SFRP1, SFRP2, SFRP5
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| Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.
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| Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y.
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| J Gastroenterol 43(5):378-89. Epub 2008 Jul 1. 2008
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| 12 | SFRP2
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| Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer.
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| Veeck J, Noetzel E, Bektas N, Jost E, Hartmann A, Knüchel R, Dahl E.
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| Mol Cancer 7:83.
2008
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| 13 | SFRP1, SFRP2, SFRP5
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| Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.
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| Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y.
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| Oncogene 26(32):4699-713. Epub 2007 Feb 5.
2007
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| 14 | SFRP1, SFRP2, SFRP3, SFRP5
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| SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway.
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| Shih YL, Hsieh CB, Lai HC, Yan MD, Hsieh TY, Chao YC, Lin YW.
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| Int J Cancer 121(5):1028-35.
2007
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| 15 | SFRP2, TMEFF2
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| Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.
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| Huang ZH, Li LH, Yang F, Wang JF.
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| World J Gastroenterol 13(6):950-4.
2007
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| 16 | SFRP2
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| Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
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| Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Dong Chen W, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB.
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| Nat Genet 36(4):417-22. Epub 2004 Mar 14. 2004
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| 17 | SFRP2
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| Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas.
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| Jones SE, Jomary C, Grist J, Stewart HJ, Neal MJ.
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| Invest Ophthalmol Vis Sci 41(6):1297-301. 2000
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| 18 | SFRP2, SFRP5
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| Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.
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| Chang JT, et al.
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| Hum Mol Genet 8(4):575-83. 1999
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| 19 | SFRP1, SFRP2, FRZB, SFRP4
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| A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.
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| Rattner A, et al.
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| Proc Natl Acad Sci U S A 94 : 2859-2863. 1997
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| 20 | SFRP1, SFRP2, SFRP5
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| SARPs : a family of secreted apoptosis-related proteins.
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| Melkonyan HS, et al.
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| Proc Natl Acad Sci U S A 94 : 13636-13641. 1997
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| 21 | FZD2, FZD9, SFRP1, SFRP2, FZD8
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| A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
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| Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.
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| J Biol Chem 271(8):4468-76. 1996
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