| 1 | SETD8, STRA8
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| Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis
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| Niu C, Guo J, Shen X, Ma S, Xia M, Xia J, Zheng Y.
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| J Cell Mol Med. Apr;24(7):4194-4211. doi: 10.1111/jcmm.15080. Epub 2020 Feb 24 2020
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| 2 | GATA2, SETD8
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| Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation.
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| Malik J, Getman M, Steiner LA.
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| Mol Cell Biol 35(12):2059-72. doi: 10.1128/MCB.01413-14.
2015
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| 3 | SETD8
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| The role of PR-Set7 in replication licensing depends on Suv4-20h.
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| Beck DB, Burton A, Oda H, Ziegler-Birling C, Torres-Padilla ME, Reinberg D.
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| Genes Dev 26(23):2580-9. doi: 10.1101/gad.195636.112. Epub 2012 Nov 14.
2012
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| 4 | SETD8
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| The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues.
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| Kudithipudi S, Dhayalan A, Kebede AF, Jeltsch A.
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| Biochimie 94(11):2212-8. doi: 10.1016/j.biochi.2012.04.024. Epub 2012 May 11.
2012
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| 5 | PCNA, SETD8
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| Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
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| Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Maejima K, Ueda K, Masuda A, Dohmae N, Field HI, Tsunoda T, Kobayashi T, Akasu T, Sugiyama M, Ohnuma S, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R.
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| Cancer Res 72(13):3217-27. doi: 10.1158/0008-5472.CAN-11-3701. Epub 2012 May 3.
2012
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| 6 | SETD8, TWIST1
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| SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities.
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| Yang F, Sun L, Li Q, Han X, Lei L, Zhang H, Shang Y.
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| EMBO J 31(1):110-23. doi: 10.1038/emboj.2011.364. Epub 2011 Oct 7.
2012
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| 7 | DTL, SETD8
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| SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.
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| Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.
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| J Cell Biol 192(1):43-54. doi: 10.1083/jcb.201009076.
2011
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| 8 | SETD8
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| The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin.
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| Driskell I, Oda H, Blanco S, Nascimento E, Humphreys P, Frye M.
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| EMBO J 31(3):616-29. doi: 10.1038/emboj.2011.421.
2011
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| 9 | SETD8, UBE2I
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| The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression.
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| Spektor TM, Congdon LM, Veerappan CS, Rice JC.
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| PLoS One 6(7):e22785. doi: 10.1371/journal.pone.0022785. Epub 2011 Jul 29.
2011
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| 10 | L3MBTL1, SETD8
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| The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.
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| West LE, Roy S, Lachmi-Weiner K, Hayashi R, Shi X, Appella E, Kutateladze TG, Gozani O.
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| J Biol Chem 285(48):37725-32. Epub 2010 Sep 24. 2010
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| 11 | DTL, PCNA, SETD8
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| Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
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| Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.
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| Mol Cell 40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.
2010
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| 12 | DTL, SETD8
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| CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.
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| Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.
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| Mol Cell 40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.
2010
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| 13 | DTL, SETD8
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| CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.
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| Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A.
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| Mol Cell 40(1):9-21. doi: 10.1016/j.molcel.2010.09.014.
2010
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| 14 | SETD8
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| The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.
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| Wakabayashi K, Okamura M, Tsutsumi S, Nishikawa NS, Tanaka T, Sakakibara I, Kitakami J, Ihara S, Hashimoto Y, Hamakubo T, Kodama T, Aburatani H, Sakai J.
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| Mol Cell Biol 29(13):3544-55. doi: 10.1128/MCB.01856-08. Epub 2009 May 4.
2009
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| 15 | SETD8
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| Structural origins for the product specificity of SET domain protein methyltransferases.
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| Couture JF, Dirk LM, Brunzelle JS, Houtz RL, Trievel RC.
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| Proc Natl Acad Sci U S A 105(52):20659-64. Epub 2008 Dec 16.
2008
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| 16 | SETD8
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| SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail.
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| Yin Y, Yu VC, Zhu G, Chang DC.
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| Cell Cycle 7(10):1423-32. Epub 2008 Mar 3.
2008
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| 17 | SETD8
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| Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication.
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| Huen MS, Sy SM, van Deursen JM, Chen J.
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| J Biol Chem 283(17):11073-7. Epub 2008 Mar 3.
2008
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| 18 | HIST4H4, L3MBTL1, SETD8
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| Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.
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| Kalakonda N, Fischle W, Boccuni P, Gurvich N, Hoya-Arias R, Zhao X, Miyata Y, Macgrogan D, Zhang J, Sims JK, Rice JC, Nimer SD.
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| Oncogene 27(31):4293-304. Epub 2008 Apr 14. 2008
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| 19 | SETD8
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| The histone methyltransferase SET8 is required for S-phase progression.
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| Jørgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sørensen CS.
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| J Cell Biol 179(7):1337-45.
2007
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| 20 | SETD8
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| Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.
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| Couture JF, Collazo E, Brunzelle JS, Trievel RC.
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| Genes Dev 19(12):1455-65. Epub 2005 Jun 2.
2005
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| 21 | SETD8, SETD8P1
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| PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
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| Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y,Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D.
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| Mol Cell 9(6):1201-13. 2002
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| 22 | SETD8
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| Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
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| Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H,Tempst P, Simon JA, Zhang Y.
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| Curr Biol 12(13):1086-99. 2002
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