| 1 | HMGA1, PLAU, SERPINE1
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| HMGA1 regulates the Plasminogen activation system in the secretome of breast cancer cells
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| Resmini G, Rizzo S, Franchin C, Zanin R, Penzo C, Pegoraro S, Ciani Y, Piazza S, Arrigoni G, Sgarra R, Manfioletti G
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| Sci Rep. Sep 18;7(1):11768. doi: 10.1038/s41598-017-11409-4. 2017
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| 2 | SERPINE1, VTN
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| The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis.
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| Wheaton AK, Velikoff M, Agarwal M, Loo TT, Horowitz JC, Sisson TH, Kim KK.
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| Am J Physiol Lung Cell Mol Physiol 310(11):L1206-17. doi: 10.1152/ajplung.00424.2015.
2016
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| 3 | SERPINE1
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| Plasminogen activator inhibitor-1 promotes the proliferation and inhibits the apoptosis of pulmonary fibroblasts by Ca(2+) signaling.
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| Zhang YP, Wang WL, Liu J, Li WB, Bai LL, Yuan YD, Song SX.
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| Thromb Res 131(1):64-71. doi: 10.1016/j.thromres.2012.09.003. Epub 2012 Sep 25.
2013
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| 4 | DLC1, SERPINE1
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| Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
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| Shih YP, Takada Y, Lo SH.
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| Mol Cancer Res 10(1):34-9. doi: 10.1158/1541-7786.MCR-11-0450. Epub 2011 Nov 7.
2012
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| 5 | SERPINE1
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| Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity.
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| Jeon H, Kim JH, Kim JH, Lee WH, Lee MS, Suk K.
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| J Neuroinflammation 9:149. doi: 10.1186/1742-2094-9-149.
2012
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| 6 | SERPINE1
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| Estrogen regulates endothelial migration via plasminogen activator inhibitor (PAI-1).
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| Gopal S, Garibaldi S, Goglia L, Polak K, Palla G, Spina S, Genazzani AR, Genazzani AD, Simoncini T.
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| Mol Hum Reprod 18(8):410-6. doi: 10.1093/molehr/gas011. Epub 2012 Mar 2.
2012
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| 7 | SERPINE1
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| Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type β and epidermal growth factor.
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| Song X, Thalacker FW, Nilsen-Hamilton M.
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| J Biol Chem 287(15):12520-8. doi: 10.1074/jbc.M111.338079. Epub 2012 Feb 10.
2012
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| 8 | IGFBP3, PLAT, SERPINE1
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| Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.
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| Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.
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| Proc Natl Acad Sci U S A 109(30):12052-7. doi: 10.1073/pnas.1120437109. Epub 2012 Jul 9.
2012
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| 9 | SERPINE1
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| PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice.
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| Oishi K, Tomita T, Itoh N, Ohkura N.
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| Thromb Res 128(5):e81-5. doi: 10.1016/j.thromres.2011.06.020. Epub 2011 Jul 14.
2011
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| 10 | SERPINE1
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| Inhibition of neutrophil apoptosis by PAI-1.
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| Zmijewski JW, Bae HB, Deshane JS, Peterson CB, Chaplin DD, Abraham E.
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| Am J Physiol Lung Cell Mol Physiol 301(2):L247-54. doi: 10.1152/ajplung.00075.2011. Epub 2011 May 27.
2011
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| 11 | SERPINE1
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| The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles.
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| Jiang Q, Gingles NA, Olivier MA, Miles LA, Parmer RJ.
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| Blood 117(26):7155-63. doi: 10.1182/blood-2010-05-287672. Epub 2011 May 19.
2011
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| 12 | SERPINE1
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| Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis.
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| Beier JI, Kaiser JP, Guo L, Martínez-Maldonado M, Arteel GE.
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| Arch Biochem Biophys 510(1):19-26. doi: 10.1016/j.abb.2011.04.001. Epub 2011 Apr 9.
2011
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| 13 | FURIN, SERPINE1
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| Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase.
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| Bernot D, Stalin J, Stocker P, Bonardo B, Scroyen I, Alessi MC, Peiretti F.
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| J Cell Sci 124(Pt 8):1224-30. doi: 10.1242/jcs.079889. Epub 2011 Mar 15. 2011
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| 14 | SERPINE1
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| Transient reduction of placental angiogenesis in PAI-1-deficient mice.
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| Labied S, Blacher S, Carmeliet P, Noël A, Frankenne F, Foidart JM, Munaut C.
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| Physiol Genomics 43(4):188-98. doi: 10.1152/physiolgenomics.00147.2010. Epub 2010 Nov 30.
2011
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| 15 | PAI1, SERPINE1
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| Epigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa.
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| Gao S, Nielsen BS, Krogdahl A, Sřrensen JA, Tagesen J, Dabelsteen S, Dabelsteen E, Andreasen PA.
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| Genes Chromosomes Cancer 49(6):526-38.
2010
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| 16 | EGF, ELK1, SERPINE1
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| Epidermal growth factor regulates PAI-1 expression via activation of the transcription factor Elk-1.
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| Wyrzykowska P, Stalińska K, Wawro M, Kochan J, Kasza A.
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| Biochim Biophys Acta 1799(9):616-21. Epub 2010 Aug 19.
2010
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| 17 | PLAT, SERPINB2, SERPINE1
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| Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes.
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| Lee JA, Croucher DR, Ranson M.
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| Thromb Haemost 104(6):1133-42. doi: 10.1160/TH10-02-0121. Epub 2010 Sep 13.
2010
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| 18 | CETP, LPL, MTHFR, NOS3, OLR1, PAPPA, SERPINE1
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| Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes.
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| Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C.
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| Trends Mol Med rends Mol Med. 2008 Sep 9. [Epub ahead of print]
2008
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| 19 | SERPINE1, VTN
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| Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain.
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| Schar CR, Jensen JK, Christensen A, Blouse GE, Andreasen PA, Peterson CB.
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| J Biol Chem 283(42):28487-96. doi: 10.1074/jbc.M804257200.
2008
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| 20 | SERPINE1
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| Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality.
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| Min JK, Shaw LJ, Devereux RB, Okin PM, Weinsaft JW, Russo DJ, Lippolis NJ, Berman DS, Callister TQ.
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| J Am Coll Cardiol 50(12):1161-70. Epub 2007 Sep 4. 2007
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| 21 | ARNTL,ARNTL2,CLOCK,SERPINE1
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| Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.
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| Chong NW, Codd V, Chan D, Samani NJ.
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| FEBS Lett 580(18):4469-72. Epub 2006 Jul 14. 2006
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| 22 | FOXC2, SERPINE1
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| Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression.
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| Fujita H, Kang M, Eren M, Gleaves LA, Vaughan DE, Kume T.
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| Circ Res 98(5):626-34. Epub 2006 Feb 2. 2006
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| 23 | SERPINE1, ARNTL, ARNTL2
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| Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2.
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| Schoenhard JA, Smith LH, Painter CA, Eren M, Johnson CH, Vaughan DE.
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| J Mol Cell Cardiol 35(5):473-81. 2003
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| 24 | SERPINE1
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| PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs.
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| Balta G, Altay C, Gurgey A.
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| Am J Hematol 71(2):89-93. 2002
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| 25 | GRB10, MEST, NOS3, SERPINE1, UPD7M
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| Maternal and paternal chromosomes 7 show differential methylation of many genes in lymphoblast DNA.
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| Hannula K, Lipsanen-Nyman M, Scherer SW, Holmberg C, Hoglund P, Kere J.
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| Genomics 73(1):1-9. 2001
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| 26 | SERPINE1
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| PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects.
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| Segui R, Estelles A, Mira Y, Espana F, Villa P, Falco C, Vaya A, Grancha S, Ferrando F, Aznar J.
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| Br J Haematol 111(1):122-8. 2000
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| 27 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
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| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
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| Dang CV.
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| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
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| 28 | SERPINE1
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| 4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Research Group.
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| Hermans PW, et al.
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| Lancet 354(9178):556-60. 1999
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| 29 | SERPINE1
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| Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock.
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| Westendorp RG, et al.
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| Lancet 354(9178):561-3. 1999
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| 30 | PAI1, SERPINE1
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| Four cases of bleeding diathesis in children due to congenital plasminogen activator inhibitor-1 deficiency.
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| Minowa H, Takahashi Y, Tanaka T, Naganuma K, Ida S, Maki I, Yoshioka A.
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| Haemostasis 29(5):286-91. 1999
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| 31 | ITGB3, SERPINE1
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| Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.
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| Pastinen T, et al.
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| Hum Mol Genet 7 : 1453-1462. 1998
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| 32 | SERPINE1
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| Gene polymorphisms for plasminogen activator inhibitor-1/tissue plasminogen activator and development of allograft coronary artery disease.
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| Benza RL, et al.
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| Circulation 98 : 2248-2254. 1998
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| 33 | SERPINE1, TRBR, PAI1
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| Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene.
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| Fay WP, Parker AC, Condrey LR, Shapiro AD.
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| Blood 90(1):204-8. 1997
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| 34 | PAI1, SERPINE1
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| Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene.
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| Fay WP, Parker AC, Condrey LR, Shapiro AD.
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| Blood 90(1):204-8.
1997
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| 35 | SERPINE1, ST7
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| Allelic loss on chromosome 7q in ovarian adenocarcinomas : two critical regions and a rearrangement of the PLANH1 locus.
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| Kerr J, et al.
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| Oncogene 13 : 1815-1818. 1996
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| 36 | SERPINE1
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| Complete deficiency of plasminogen-activator inhibitor type 1 due to a frameshift mutation.
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| Fay WP, et al.
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| N Engl J Med 327 : 1729-1733. 1992
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| 37 | GUSB, SERPINE1
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| Deletion mapping of plasminogen activator inhibitor, type I (PLANH1) and beta-glucuronidase (GUSB) in 7q21-q22.
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| Schwartz CE, Stanislovitis P, Phelan MC, Klinger K, Taylor HA, Stevenson RE.
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| Cytogenet Cell Genet 56(3-4):152-3. 1991
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| 38 | SERPINE1
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| Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.
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| Cajot JF, et al.
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| Proc Natl Acad Sci U S A 87(18):6939-43. 1990
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| 39 | SERPINE1
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| Regional mapping of the plasminogen activator inhibitor type 1 gene to 7q21.3-q22 and assignment to the CF linkage group.
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| Klinger KW, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 640. 1987
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| 40 | SERPINE1
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| Abnormalities of chromosome 7 in cancer. Involvement of plasminogen activator inhibitor, type 1 gene?
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| Winqvist R, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 717. 1987
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| 41 | SERPINE1
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| Structure of the human plasminogen activator inhibitor 1 gene : nonrandom distribution of introns.
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| Loskutoff DJ, et al.
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| Biochemistry 26 : 3763-3768. 1987
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| 42 | SERPINE1
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| Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.
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| Klinger KW, et al.
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| Proc Natl Acad Sci U S A 84 : 8548-8552. 1987
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| 43 | SERPINE1
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| cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
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| Ginsburg D, et al.
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| J Clin Invest 78 : 1673-1680. 1986
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| 44 | SERPINE1
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| Two different mechanisms in patients with venous thrombosis and defective fibrinolysis : low concentration of plasmonigen activator of increased concentration of plasminogen activator inhibitor.
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| Nilsson IM, et al.
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| Br Med J 290 : 1453-1456. 1985
|