Citations for
1SERPINE1, VTN
The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis.
Wheaton AK, Velikoff M, Agarwal M, Loo TT, Horowitz JC, Sisson TH, Kim KK.
Am J Physiol Lung Cell Mol Physiol 310(11):L1206-17. doi: 10.1152/ajplung.00424.2015. 2016
2SERPINE1
Plasminogen activator inhibitor-1 promotes the proliferation and inhibits the apoptosis of pulmonary fibroblasts by Ca(2+) signaling.
Zhang YP, Wang WL, Liu J, Li WB, Bai LL, Yuan YD, Song SX.
Thromb Res 131(1):64-71. doi: 10.1016/j.thromres.2012.09.003. Epub 2012 Sep 25. 2013
3DLC1, SERPINE1
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
Shih YP, Takada Y, Lo SH.
Mol Cancer Res 10(1):34-9. doi: 10.1158/1541-7786.MCR-11-0450. Epub 2011 Nov 7. 2012
4SERPINE1
Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity.
Jeon H, Kim JH, Kim JH, Lee WH, Lee MS, Suk K.
J Neuroinflammation 9:149. doi: 10.1186/1742-2094-9-149. 2012
5SERPINE1
Estrogen regulates endothelial migration via plasminogen activator inhibitor (PAI-1).
Gopal S, Garibaldi S, Goglia L, Polak K, Palla G, Spina S, Genazzani AR, Genazzani AD, Simoncini T.
Mol Hum Reprod 18(8):410-6. doi: 10.1093/molehr/gas011. Epub 2012 Mar 2. 2012
6SERPINE1
Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type β and epidermal growth factor.
Song X, Thalacker FW, Nilsen-Hamilton M.
J Biol Chem 287(15):12520-8. doi: 10.1074/jbc.M111.338079. Epub 2012 Feb 10. 2012
7IGFBP3, PLAT, SERPINE1
Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.
Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.
Proc Natl Acad Sci U S A 109(30):12052-7. doi: 10.1073/pnas.1120437109. Epub 2012 Jul 9. 2012
8SERPINE1
PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice.
Oishi K, Tomita T, Itoh N, Ohkura N.
Thromb Res 128(5):e81-5. doi: 10.1016/j.thromres.2011.06.020. Epub 2011 Jul 14. 2011
9SERPINE1
Inhibition of neutrophil apoptosis by PAI-1.
Zmijewski JW, Bae HB, Deshane JS, Peterson CB, Chaplin DD, Abraham E.
Am J Physiol Lung Cell Mol Physiol 301(2):L247-54. doi: 10.1152/ajplung.00075.2011. Epub 2011 May 27. 2011
10SERPINE1
The anti-fibrinolytic SERPIN, plasminogen activator inhibitor 1 (PAI-1), is targeted to and released from catecholamine storage vesicles.
Jiang Q, Gingles NA, Olivier MA, Miles LA, Parmer RJ.
Blood 117(26):7155-63. doi: 10.1182/blood-2010-05-287672. Epub 2011 May 19. 2011
11SERPINE1
Plasminogen activator inhibitor-1 deficient mice are protected from angiotensin II-induced fibrosis.
Beier JI, Kaiser JP, Guo L, Martínez-Maldonado M, Arteel GE.
Arch Biochem Biophys 510(1):19-26. doi: 10.1016/j.abb.2011.04.001. Epub 2011 Apr 9. 2011
12FURIN, SERPINE1
Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase.
Bernot D, Stalin J, Stocker P, Bonardo B, Scroyen I, Alessi MC, Peiretti F.
J Cell Sci 124(Pt 8):1224-30. doi: 10.1242/jcs.079889. Epub 2011 Mar 15. 2011
13SERPINE1
Transient reduction of placental angiogenesis in PAI-1-deficient mice.
Labied S, Blacher S, Carmeliet P, Noël A, Frankenne F, Foidart JM, Munaut C.
Physiol Genomics 43(4):188-98. doi: 10.1152/physiolgenomics.00147.2010. Epub 2010 Nov 30. 2011
14PAI1, SERPINE1
Epigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa.
Gao S, Nielsen BS, Krogdahl A, Sřrensen JA, Tagesen J, Dabelsteen S, Dabelsteen E, Andreasen PA.
Genes Chromosomes Cancer 49(6):526-38. 2010
15EGF, ELK1, SERPINE1
Epidermal growth factor regulates PAI-1 expression via activation of the transcription factor Elk-1.
Wyrzykowska P, Stalińska K, Wawro M, Kochan J, Kasza A.
Biochim Biophys Acta 1799(9):616-21. Epub 2010 Aug 19. 2010
16PLAT, SERPINB2, SERPINE1
Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes.
Lee JA, Croucher DR, Ranson M.
Thromb Haemost 104(6):1133-42. doi: 10.1160/TH10-02-0121. Epub 2010 Sep 13. 2010
17CETP, LPL, MTHFR, NOS3, OLR1, PAPPA, SERPINE1
Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes.
Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C.
Trends Mol Med rends Mol Med. 2008 Sep 9. [Epub ahead of print] 2008
18SERPINE1, VTN
Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain.
Schar CR, Jensen JK, Christensen A, Blouse GE, Andreasen PA, Peterson CB.
J Biol Chem 283(42):28487-96. doi: 10.1074/jbc.M804257200. 2008
19SERPINE1
Prognostic value of multidetector coronary computed tomographic angiography for prediction of all-cause mortality.
Min JK, Shaw LJ, Devereux RB, Okin PM, Weinsaft JW, Russo DJ, Lippolis NJ, Berman DS, Callister TQ.
J Am Coll Cardiol 50(12):1161-70. Epub 2007 Sep 4. 2007
20ARNTL,ARNTL2,CLOCK,SERPINE1
Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.
Chong NW, Codd V, Chan D, Samani NJ.
FEBS Lett 580(18):4469-72. Epub 2006 Jul 14. 2006
21FOXC2, SERPINE1
Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression.
Fujita H, Kang M, Eren M, Gleaves LA, Vaughan DE, Kume T.
Circ Res 98(5):626-34. Epub 2006 Feb 2. 2006
22SERPINE1, ARNTL, ARNTL2
Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2.
Schoenhard JA, Smith LH, Painter CA, Eren M, Johnson CH, Vaughan DE.
J Mol Cell Cardiol 35(5):473-81. 2003
23SERPINE1
PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs.
Balta G, Altay C, Gurgey A.
Am J Hematol 71(2):89-93. 2002
24GRB10, MEST, NOS3, SERPINE1, UPD7M
Maternal and paternal chromosomes 7 show differential methylation of many genes in lymphoblast DNA.
Hannula K, Lipsanen-Nyman M, Scherer SW, Holmberg C, Hoglund P, Kere J.
Genomics 73(1):1-9. 2001
25SERPINE1
PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects.
Segui R, Estelles A, Mira Y, Espana F, Villa P, Falco C, Vaya A, Grancha S, Ferrando F, Aznar J.
Br J Haematol 111(1):122-8. 2000
26ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
Dang CV.
Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
27SERPINE1
4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Research Group.
Hermans PW, et al.
Lancet 354(9178):556-60. 1999
28SERPINE1
Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock.
Westendorp RG, et al.
Lancet 354(9178):561-3. 1999
29PAI1, SERPINE1
Four cases of bleeding diathesis in children due to congenital plasminogen activator inhibitor-1 deficiency.
Minowa H, Takahashi Y, Tanaka T, Naganuma K, Ida S, Maki I, Yoshioka A.
Haemostasis 29(5):286-91. 1999
30ITGB3, SERPINE1
Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.
Pastinen T, et al.
Hum Mol Genet 7 : 1453-1462. 1998
31SERPINE1
Gene polymorphisms for plasminogen activator inhibitor-1/tissue plasminogen activator and development of allograft coronary artery disease.
Benza RL, et al.
Circulation 98 : 2248-2254. 1998
32SERPINE1, TRBR, PAI1
Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene.
Fay WP, Parker AC, Condrey LR, Shapiro AD.
Blood 90(1):204-8. 1997
33PAI1, SERPINE1
Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene.
Fay WP, Parker AC, Condrey LR, Shapiro AD.
Blood 90(1):204-8. 1997
34SERPINE1, ST7
Allelic loss on chromosome 7q in ovarian adenocarcinomas : two critical regions and a rearrangement of the PLANH1 locus.
Kerr J, et al.
Oncogene 13 : 1815-1818. 1996
35SERPINE1
Complete deficiency of plasminogen-activator inhibitor type 1 due to a frameshift mutation.
Fay WP, et al.
N Engl J Med 327 : 1729-1733. 1992
36GUSB, SERPINE1
Deletion mapping of plasminogen activator inhibitor, type I (PLANH1) and beta-glucuronidase (GUSB) in 7q21-q22.
Schwartz CE, Stanislovitis P, Phelan MC, Klinger K, Taylor HA, Stevenson RE.
Cytogenet Cell Genet 56(3-4):152-3. 1991
37SERPINE1
Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.
Cajot JF, et al.
Proc Natl Acad Sci U S A 87(18):6939-43. 1990
38SERPINE1
Regional mapping of the plasminogen activator inhibitor type 1 gene to 7q21.3-q22 and assignment to the CF linkage group.
Klinger KW, et al.
(HGM9) Cytogenet Cell Genet 46 : 640. 1987
39SERPINE1
Abnormalities of chromosome 7 in cancer. Involvement of plasminogen activator inhibitor, type 1 gene?
Winqvist R, et al.
(HGM9) Cytogenet Cell Genet 46 : 717. 1987
40SERPINE1
Structure of the human plasminogen activator inhibitor 1 gene : nonrandom distribution of introns.
Loskutoff DJ, et al.
Biochemistry 26 : 3763-3768. 1987
41SERPINE1
Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.
Klinger KW, et al.
Proc Natl Acad Sci U S A 84 : 8548-8552. 1987
42SERPINE1
cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
Ginsburg D, et al.
J Clin Invest 78 : 1673-1680. 1986
43SERPINE1
Two different mechanisms in patients with venous thrombosis and defective fibrinolysis : low concentration of plasmonigen activator of increased concentration of plasminogen activator inhibitor.
Nilsson IM, et al.
Br Med J 290 : 1453-1456. 1985