Citations for
1SDC4, VANGL2
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M.
Development 143(23):4441-4451. Epub 2016 Oct 27. 2016
2CYLD, DDX58, SDC4
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.
Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L, Wang H, Chen D, Sun Q.
Nat Commun 7:11848. doi: 10.1038/ncomms11848. 2016
3SDC4
Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus.
Li R, Xie J, Wu H, Li G, Chen J, Chen Q, Wang L, Xu B.
Biochem Biophys Res Commun 474(1):15-21. doi: 10.1016/j.bbrc.2016.03.112. Epub 2016 Mar 25. 2016
4ADAMTS5, MMP3, SDC4
Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
Binch AL, Shapiro IM, Risbud MV.
Matrix Biol 52-54:355-62. doi: 10.1016/j.matbio.2016.01.005. Epub 2016 Jan 18. Review. 2016
5SDC4, TRPC6
Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling.
Kim EY, Roshanravan H, Dryer SE.
Biochim Biophys Acta 1853(10 Pt A):2610-20. doi: 10.1016/j.bbamcr.2015.07.011. Epub 2015 Jul 17. Erratum in: Biochim Biophys Acta. 2015 Dec;1853(12): 2015
6SDC4
The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc.
Beckett MC, Ralphs JR, Caterson B, Hayes AJ.
Eur Cell Mater 30:69-88; discussion 88. 2015
7NUDT16L1, SDC4
Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan.
Kim H, Yoo J, Lee I, Kang YJ, Cho HS, Lee W.
Biochem Biophys Res Commun 463(4):762-7. doi: 10.1016/j.bbrc.2015.06.010. Epub 2015 Jun 19. 2015
8SDC4, TGM2
Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells.
Nadella V, Wang Z, Johnson TS, Griffin M, Devitt A.
Biochim Biophys Acta 1853(1):201-12. doi: 10.1016/j.bbamcr.2014.09.020. Epub 2014 Oct 29. 2015
9SDC4
Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells.
Carneiro BR, Pernambuco Filho PC, Mesquita AP, da Silva DS, Pinhal MA, Nader HB, Lopes CC.
PLoS One 9(12):e116001. doi: 10.1371/journal.pone.0116001. eCollection 2014. 2014
10FGF10, SDC4
Expression and roles of syndecan-4 in dental epithelial cell differentiation.
Yan Z, Chen G, Yang Y, Sun L, Jiang Z, Feng L, Yu M, Guo W, Tian W.
Int J Mol Med 34(5):1301-8. doi: 10.3892/ijmm.2014.1910. Epub 2014 Aug 19. 2014
11NFATC4, SDC4
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.
Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G.
J Mol Cell Cardiol 54:73-81. doi: 10.1016/j.yjmcc.2012.11.006. Epub 2012 Nov 22. 2013
12SDC4, VANGL2
Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity.
Escobedo N, Contreras O, Muńoz R, Farías M, Carrasco H, Hill C, Tran U, Pryor SE, Wessely O, Copp AJ, Larraín J.
Development 140(14):3008-17. doi: 10.1242/dev.091173. Epub 2013 Jun 12. 2013
13SDC4
Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.
Labropoulou VT, Skandalis SS, Ravazoula P, Perimenis P, Karamanos NK, Kalofonos HP, Theocharis AD.
Biomed Res Int 2013:214864. doi: 10.1155/2013/214864. Epub 2013 Jun 15. 2013
14SDC4
Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice.
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'Accio F, Raschke MJ, Pap T, Dreier R.
Arthritis Rheum 65(3):743-52. doi: 10.1002/art.37817. 2013
15AKT1, SDC4
Syndecan 4 regulation of PDK1-dependent Akt activation.
Ju R, Simons M.
Cell Signal 25(1):101-5. doi: 10.1016/j.cellsig.2012.09.007. Epub 2012 Sep 10. 2013
16FGFR1, SDC4
Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.
Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M.
Sci Signal 5(223):ra36. doi: 10.1126/scisignal.2002495. 2012
17SDC4
Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing.
Brooks R, Williamson R, Bass M.
Small GTPases 3(2):73-9. doi: 10.4161/sgtp.19301. 2012
18SDC4
Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.
Tanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW.
Am J Respir Cell Mol Biol 47(2):196-202. doi: 10.1165/rcmb.2011-0294OC. Epub 2012 Mar 15. 2012
19SDC4, TGM2
Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex.
Wang Z, Telci D, Griffin M.
Exp Cell Res 317(3):367-81. Epub 2010 Oct 28. 2011
20RSPO3, SDC4
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
Ohkawara B, Glinka A, Niehrs C.
Dev Cell 20(3):303-14. 2011
21ADAM17, SDC1, SDC4
A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells.
Pruessmeyer J, Martin C, Hess FM, Schwarz N, Schmidt S, Kogel T, Hoettecke N, Schmidt B, Sechi A, Uhlig S, Ludwig A.
J Biol Chem 285(1):555-64. Epub 2009 Oct 29.PMID: 19875451 2010
22SDC4
Syndecan-4 promotes the retention of phosphatidylinositol 4,5-bisphosphate in the plasma membrane.
Kwon S, Son H, Choi Y, Lee JH, Choi S, Lim Y, Han IO, Oh ES.
FEBS Lett 583(14):2395-400. Epub 2009 Jun 26. 2009
23GPNMB, SDC4
The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses.
Chung JS, Bonkobara M, Tomihari M, Cruz PD Jr, Ariizumi K.
Eur J Immunol 39(4):965-74. 2009
24ADAMTS5, SDC4
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, Lee YJ, Song YW, Herzog C, Theilmeier G, Pap T.
Nat Med 15(9):1072-6. Epub 2009 Aug 16. 2009
25SDC4
The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer.
Nagy N, Németh IB, Szabad G, Szolnoky G, Belső N, Bata-Csörgő Z, Dobozy A, Kemény L, Széll M.
Wound Repair Regen 16(4):495-502. 2008
26SDC2, SDC4
Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation.
Teixé T, Nieto-Blanco P, Vilella R, Engel P, Reina M, Espel E.
Mol Immunol 45(10):2905-19. Epub 2008 Mar 14. 2008
27SDC4, THBS1
Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1.
Nunes SS, Outeiro-Bernstein MA, Juliano L, Vardiero F, Nader HB, Woods A, Legrand C, Morandi V.
J Cell Physiol 214(3):828-37. 2008
28SDC4, SPP1
Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin.
Kon S, Ikesue M, Kimura C, Aoki M, Nakayama Y, Saito Y, Kurotaki D, Diao H, Matsui Y, Segawa T, Maeda M, Kojima T, Uede T.
J Exp Med 205(1):25-33. Epub 2007 Dec 24. 2008
29SDC1, SDC4
Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype.
Baba F, Swartz K, van Buren R, Eickhoff J, Zhang Y, Wolberg W, Friedl A.
Breast Cancer Res Treat 98(1):91-8. Epub 2006 Apr 25. 2006
30SDC4
A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain.
Whiteford JR, Couchman JR.
J Biol Chem 281(43):32156-63. Epub 2006 Aug 25. 2006
31SDC4, CXCL12, CXCR4
Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12.
Charnaux N, Brule S, Hamon M, Chaigneau T, Saffar L, Prost C, Lievre N, Gattegno L.
FEBS J 272(8):1937-51. 2005
32SDC3, SDC4
Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.
Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB.
Genes Dev 18(18):2231-6. 2004
33POU5F1, FOXD3, DNMT3B, FZD7, SDC4, GABRB3, GPC4, TERF1
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.
Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA.
Proc Natl Acad Sci U S A 100(23):13350-5. Epub 2003 Oct 31. 2003
34NUDT16L1, PXN, SDC4
Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.
Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, Neveu W, Goetinck PF.
J Biol Chem 277(14):12270-4. Epub 2002 Jan 22. 2002
35SDC4
Syndecan-4 signals cooperatively with integrins in a Rho dependent manner in the assembly of focal adhesions and actin stress fibers.
Saoncella S, et al.
Proc Natl Acad Sci U S A 96(6):2805-2810. 1999
36SDC4
Structural organization and promoter activity of the human ryudocan gene.
Takagi A, et al.
J Biochem 119 : 979-984. 1996
37SDC4
Human ryudocan core protein : molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.
Kojima T, et al.
Biochem Biophys Res Commun 190 : 814-822. 1993