1 | SDC4, VANGL2
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| Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.
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| Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M.
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| Development 143(23):4441-4451. Epub 2016 Oct 27.
2016
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2 | CYLD, DDX58, SDC4
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| Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.
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| Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L, Wang H, Chen D, Sun Q.
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| Nat Commun 7:11848. doi: 10.1038/ncomms11848.
2016
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3 | SDC4
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| Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus.
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| Li R, Xie J, Wu H, Li G, Chen J, Chen Q, Wang L, Xu B.
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| Biochem Biophys Res Commun 474(1):15-21. doi: 10.1016/j.bbrc.2016.03.112. Epub 2016 Mar 25.
2016
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4 | ADAMTS5, MMP3, SDC4
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| Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
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| Binch AL, Shapiro IM, Risbud MV.
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| Matrix Biol 52-54:355-62. doi: 10.1016/j.matbio.2016.01.005. Epub 2016 Jan 18. Review.
2016
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5 | SDC4, TRPC6
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| Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling.
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| Kim EY, Roshanravan H, Dryer SE.
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| Biochim Biophys Acta 1853(10 Pt A):2610-20. doi: 10.1016/j.bbamcr.2015.07.011. Epub 2015 Jul 17. Erratum in: Biochim Biophys Acta. 2015 Dec;1853(12): 2015
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6 | SDC4
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| The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc.
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| Beckett MC, Ralphs JR, Caterson B, Hayes AJ.
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| Eur Cell Mater 30:69-88; discussion 88.
2015
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7 | NUDT16L1, SDC4
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| Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan.
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| Kim H, Yoo J, Lee I, Kang YJ, Cho HS, Lee W.
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| Biochem Biophys Res Commun 463(4):762-7. doi: 10.1016/j.bbrc.2015.06.010. Epub 2015 Jun 19.
2015
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8 | SDC4, TGM2
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| Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells.
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| Nadella V, Wang Z, Johnson TS, Griffin M, Devitt A.
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| Biochim Biophys Acta 1853(1):201-12. doi: 10.1016/j.bbamcr.2014.09.020. Epub 2014 Oct 29.
2015
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9 | SDC4
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| Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells.
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| Carneiro BR, Pernambuco Filho PC, Mesquita AP, da Silva DS, Pinhal MA, Nader HB, Lopes CC.
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| PLoS One 9(12):e116001. doi: 10.1371/journal.pone.0116001. eCollection 2014.
2014
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10 | FGF10, SDC4
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| Expression and roles of syndecan-4 in dental epithelial cell differentiation.
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| Yan Z, Chen G, Yang Y, Sun L, Jiang Z, Feng L, Yu M, Guo W, Tian W.
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| Int J Mol Med 34(5):1301-8. doi: 10.3892/ijmm.2014.1910. Epub 2014 Aug 19.
2014
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11 | NFATC4, SDC4
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| Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.
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| Herum KM, Lunde IG, Skrbic B, Florholmen G, Behmen D, Sjaastad I, Carlson CR, Gomez MF, Christensen G.
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| J Mol Cell Cardiol 54:73-81. doi: 10.1016/j.yjmcc.2012.11.006. Epub 2012 Nov 22.
2013
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12 | SDC4, VANGL2
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| Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity.
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| Escobedo N, Contreras O, Muńoz R, Farías M, Carrasco H, Hill C, Tran U, Pryor SE, Wessely O, Copp AJ, Larraín J.
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| Development 140(14):3008-17. doi: 10.1242/dev.091173. Epub 2013 Jun 12.
2013
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13 | SDC4
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| Expression of syndecan-4 and correlation with metastatic potential in testicular germ cell tumours.
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| Labropoulou VT, Skandalis SS, Ravazoula P, Perimenis P, Karamanos NK, Kalofonos HP, Theocharis AD.
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| Biomed Res Int 2013:214864. doi: 10.1155/2013/214864. Epub 2013 Jun 15.
2013
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14 | SDC4
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| Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice.
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| Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'Accio F, Raschke MJ, Pap T, Dreier R.
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| Arthritis Rheum 65(3):743-52. doi: 10.1002/art.37817.
2013
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15 | AKT1, SDC4
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| Syndecan 4 regulation of PDK1-dependent Akt activation.
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| Ju R, Simons M.
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| Cell Signal 25(1):101-5. doi: 10.1016/j.cellsig.2012.09.007. Epub 2012 Sep 10.
2013
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16 | FGFR1, SDC4
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| Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.
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| Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M.
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| Sci Signal 5(223):ra36. doi: 10.1126/scisignal.2002495.
2012
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17 | SDC4
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| Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing.
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| Brooks R, Williamson R, Bass M.
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| Small GTPases 3(2):73-9. doi: 10.4161/sgtp.19301.
2012
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18 | SDC4
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| Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.
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| Tanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW.
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| Am J Respir Cell Mol Biol 47(2):196-202. doi: 10.1165/rcmb.2011-0294OC. Epub 2012 Mar 15.
2012
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19 | SDC4, TGM2
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| Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex.
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| Wang Z, Telci D, Griffin M.
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| Exp Cell Res 317(3):367-81. Epub 2010 Oct 28.
2011
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20 | RSPO3, SDC4
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| Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
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| Ohkawara B, Glinka A, Niehrs C.
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| Dev Cell 20(3):303-14.
2011
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21 | ADAM17, SDC1, SDC4
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| A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells.
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| Pruessmeyer J, Martin C, Hess FM, Schwarz N, Schmidt S, Kogel T, Hoettecke N, Schmidt B, Sechi A, Uhlig S, Ludwig A.
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| J Biol Chem 285(1):555-64. Epub 2009 Oct 29.PMID: 19875451 2010
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22 | SDC4
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| Syndecan-4 promotes the retention of phosphatidylinositol 4,5-bisphosphate in the plasma membrane.
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| Kwon S, Son H, Choi Y, Lee JH, Choi S, Lim Y, Han IO, Oh ES.
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| FEBS Lett 583(14):2395-400. Epub 2009 Jun 26.
2009
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23 | GPNMB, SDC4
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| The DC-HIL/syndecan-4 pathway inhibits human allogeneic T-cell responses.
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| Chung JS, Bonkobara M, Tomihari M, Cruz PD Jr, Ariizumi K.
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| Eur J Immunol 39(4):965-74.
2009
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24 | ADAMTS5, SDC4
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| Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
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| Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, Lee YJ, Song YW, Herzog C, Theilmeier G, Pap T.
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| Nat Med 15(9):1072-6. Epub 2009 Aug 16.
2009
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25 | SDC4
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| The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer.
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| Nagy N, Németh IB, Szabad G, Szolnoky G, Belső N, Bata-Csörgő Z, Dobozy A, Kemény L, Széll M.
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| Wound Repair Regen 16(4):495-502.
2008
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26 | SDC2, SDC4
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| Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation.
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| Teixé T, Nieto-Blanco P, Vilella R, Engel P, Reina M, Espel E.
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| Mol Immunol 45(10):2905-19. Epub 2008 Mar 14.
2008
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27 | SDC4, THBS1
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| Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1.
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| Nunes SS, Outeiro-Bernstein MA, Juliano L, Vardiero F, Nader HB, Woods A, Legrand C, Morandi V.
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| J Cell Physiol 214(3):828-37.
2008
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28 | SDC4, SPP1
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| Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin.
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| Kon S, Ikesue M, Kimura C, Aoki M, Nakayama Y, Saito Y, Kurotaki D, Diao H, Matsui Y, Segawa T, Maeda M, Kojima T, Uede T.
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| J Exp Med 205(1):25-33. Epub 2007 Dec 24.
2008
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29 | SDC1, SDC4
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| Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype.
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| Baba F, Swartz K, van Buren R, Eickhoff J, Zhang Y, Wolberg W, Friedl A.
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| Breast Cancer Res Treat 98(1):91-8. Epub 2006 Apr 25. 2006
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30 | SDC4
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| A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain.
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| Whiteford JR, Couchman JR.
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| J Biol Chem 281(43):32156-63. Epub 2006 Aug 25.
2006
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31 | SDC4, CXCL12, CXCR4
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| Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12.
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| Charnaux N, Brule S, Hamon M, Chaigneau T, Saffar L, Prost C, Lievre N, Gattegno L.
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| FEBS J 272(8):1937-51. 2005
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32 | SDC3, SDC4
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| Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.
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| Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB.
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| Genes Dev 18(18):2231-6.
2004
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33 | POU5F1, FOXD3, DNMT3B, FZD7, SDC4, GABRB3, GPC4, TERF1
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| Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.
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| Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA.
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| Proc Natl Acad Sci U S A 100(23):13350-5. Epub 2003 Oct 31. 2003
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34 | NUDT16L1, PXN, SDC4
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| Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.
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| Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, Neveu W, Goetinck PF.
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| J Biol Chem 277(14):12270-4. Epub 2002 Jan 22. 2002
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35 | SDC4
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| Syndecan-4 signals cooperatively with integrins in a Rho dependent manner in the assembly of focal adhesions and actin stress fibers.
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| Saoncella S, et al.
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| Proc Natl Acad Sci U S A 96(6):2805-2810. 1999
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36 | SDC4
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| Structural organization and promoter activity of the human ryudocan gene.
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| Takagi A, et al.
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| J Biochem 119 : 979-984. 1996
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37 | SDC4
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| Human ryudocan core protein : molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.
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| Kojima T, et al.
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| Biochem Biophys Res Commun 190 : 814-822. 1993
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