| 1 | SDC2
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| A unique phenylalanine in the transmembrane domain strengthens homodimerization of the syndecan-2 transmembrane domain and functionally regulates syndecan-2.
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| Kwon MJ, Choi Y, Yun JH, Lee W, Han IO, Oh ES.
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| J Biol Chem 290(9):5772-82. doi: 10.1074/jbc.M114.599845. Epub 2015 Jan 8.
2015
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| 2 | GDF6, SDC2
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| Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.
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| Banka S, Cain SA, Carim S, Daly SB, Urquhart JE, Erdem G, Harris J, Bottomley M, Donnai D, Kerr B, Kingston H, Superti-Furga A, Unger S, Ennis H, Worthington J, Herrick AL, Merry CL, Yue WW, Kielty CM, Newman WG.
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| Ann Rheum Dis 74(6):1249-56. doi: 10.1136/annrheumdis-2013-204309. Epub 2014 Jan 17.
2015
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| 3 | SDC2
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| The PDZ-binding domain of syndecan-2 inhibits LFA-1 high-affinity conformation.
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| Rovira-Clavé X, Angulo-Ibáñez M, Reina M, Espel E.
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| Cell Signal 26(7):1489-99. doi: 10.1016/j.cellsig.2014.03.012. Epub 2014 Mar 21.
2014
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| 4 | IL1A, SDC2
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| Interleukin-1α promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression.
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| Kwon MJ, Hong E, Choi Y, Kang DH, Oh ES.
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| Biochem Biophys Res Commun 446(2):487-92. doi: 10.1016/j.bbrc.2014.02.142. Epub 2014 Mar 12.
2014
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| 5 | SDC2
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| Syndecan-2 regulates melanin synthesis via protein kinase C βII-mediated tyrosinase activation.
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| Jung H, Chung H, Chang SE, Choi S, Han IO, Kang DH, Oh ES.
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| Pigment Cell Melanoma Res 27(3):387-97. doi: 10.1111/pcmr.12223. Epub 2014 Feb 25.
2014
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| 6 | HMGA2, PEBP1, SDC2
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| RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
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| Sun M, Gomes S, Chen P, Frankenberger CA, Sankarasharma D, Chung CH, Chada KK, Rosner MR.
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| Oncogene 33(27):3528-37. doi: 10.1038/onc.2013.328. Epub 2013 Aug 26.
2014
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| 7 | SDC2
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| Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases.
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| Lim HC, Couchman JR.
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| Biochim Biophys Acta 1840(8):2482-90. doi: 10.1016/j.bbagen.2014.01.018. Epub 2014 Jan 18.
2014
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| 8 | SDC2, TGFB2
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| Syndecan-2 is a key regulator of transforming growth factor beta 2/Smad2-mediated adhesion in fibrosarcoma cells.
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| Mytilinaiou M, Bano A, Nikitovic D, Berdiaki A, Voudouri K, Kalogeraki A, Karamanos NK, Tzanakakis GN.
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| IUBMB Life 65(2):134-43. doi: 10.1002/iub.1112. Epub 2013 Jan 7.
2013
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| 9 | FGF2, SDC2
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| Sdc2 and Tbx16 regulate Fgf2-dependent epithelial cell morphogenesis in the ciliated organ of asymmetry.
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| Arrington CB, Peterson AG, Yost HJ.
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| Development 140(19):4102-9. doi: 10.1242/dev.096933.
2013
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| 10 | NOTCH2, NOTCH3, SDC2
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| Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells.
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| Zhao N, Liu H, Lilly B.
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| J Biol Chem 287(20):16111-20. doi: 10.1074/jbc.M111.322107. Epub 2012 Mar 21.
2012
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| 11 | SDC2
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| Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface.
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| Rovira-Clavé X, Angulo-Ibáñez M, Noguer O, Espel E, Reina M.
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| Immunology 137(3):214-25. doi: 10.1111/j.1365-2567.2012.03626.x.
2012
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| 12 | MC1R, SDC2
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| Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.
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| Chung H, Lee JH, Jeong D, Han IO, Oh ES.
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| J Biol Chem 287(23):19326-35. doi: 10.1074/jbc.M111.334730. Epub 2012 Apr 6.
2012
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| 13 | SDC2, SDCBP
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| Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1.
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| Lee H, Kim Y, Choi Y, Choi S, Hong E, Oh ES.
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| Biochem Biophys Res Commun 409(1):148-53. Epub 2011 May 5.
2011
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| 14 | SARM1, SDC2
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| Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology.
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| Chen CY, Lin CW, Chang CY, Jiang ST, Hsueh YP.
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| J Cell Biol 193(4):769-84. Epub 2011 May 9. 2011
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| 15 | PTPRJ, SDC2
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| Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.
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| Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR.
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| Mol Biol Cell 22(19):3609-24. Epub 2011 Aug 3. 2011
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| 16 | CASK, NF1, SDC2
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| Characterisation of the interaction between syndecan-2, neurofibromin and CASK: dependence of interaction on syndecan dimerization.
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| Volta M, Calza S, Roberts AM, Roberts RG.
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| Biochem Biophys Res Commun 391(2):1216-21. Epub 2009 Dec 16.PMID: 20006588 2010
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| 17 | SDC2, TRAPPC4
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| Solution structure of synbindin atypical PDZ domain and interaction with syndecan-2.
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| Fan S, Feng Y, Wei Z, Xia B, Gong W.
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| Protein Pept Lett 16(2):189-95.PMID: 19200043 2009
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| 18 | MMP7, SDC2
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| Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells.
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| Ryu HY, Lee J, Yang S, Park H, Choi S, Jung KC, Lee ST, Seong JK, Han IO, Oh ES.
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| J Biol Chem 284(51):35692-701. Epub .PMID: 19858218 2009
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| 19 | SDC2, SDC4
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| Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation.
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| Teixé T, Nieto-Blanco P, Vilella R, Engel P, Reina M, Espel E.
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| Mol Immunol 45(10):2905-19. Epub 2008 Mar 14.
2008
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| 20 | SDC2, MMP2
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| A novel function of syndecan-2, suppression of matrix metalloproteinase-2 activation, which causes suppression of metastasis.
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| Munesue S, Yoshitomi Y, Kusano Y, Koyama Y, Nishiyama A, Nakanishi H, Miyazaki K, Ishimaru T, Miyaura S, Okayama M, Oguri K.
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| J Biol Chem 282(38):28164-74. Epub 2007 Jul 10. 2007
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| 21 | PRKCD, SDC2
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| Dual involvement of protein kinase C delta in apoptosis induced by syndecan-2 in osteoblasts.
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| Orosco A, Fromigue O, Hay E, Marie PJ, Modrowski D.
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| J Cell Biochem 98(4):838-50. 2006
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| 22 | SDC2
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| Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling.
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| Modrowski D, Orosco A, Thevenard J, Fromigue O, Marie PJ.
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| Bone 37(2):180-9. 2005
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| 23 | SDC2
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| Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain.
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| Granes F, Berndt C, Roy C, Mangeat P, Reina M, Vilaro S.
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| FEBS Lett 547(1-3):212-6. 2003
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| 24 | SDC2
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| Syndecan-2 mediates adhesion and proliferation of colon carcinoma cells
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| Park H, Kim Y, Lim Y, Han I, Oh ES.
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| J Biol Chem 277(33):29730-6. 2002
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| 25 | GRPR, SDC2
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| Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene.
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| Ishikawa-Brush Y, Powell JF, Bolton P, Miller AP, Francis F, Willard HF, Lehrach H, Monaco AP.
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| Hum Mol Genet 6(8):1241-50. 1997
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| 26 | GEM, MYLL1, NDUFB9, RPL30, SDC2
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| Regional assignment of 64 human gene transcripts on chromosome 8.
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| Ugolini F, Chaffanet M, Houlgatte R, Patterson D, Wells D, Auffray C, Birnbaum D, Pebusque MJ.
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| Cytogenet Cell Genet 77(3-4):197-200. 1997
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| 27 | SDC2
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| The gene for 48kDa and the 90kDa core proteins of cell surface-associated heparan sulphate proteoglycan of human lung fibroblast maps to chromosome 8q2.
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| Marynen P, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1040. 1989
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