| 1 | SCN10A
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| Sudden cardiac death in J wave syndrome with short QT associated to a novel mutation in Nav 1.8 coding gene SCN10A: First case report for a possible pharmacogenomic role.
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| Di Stolfo G, Palumbo P, Castellana S, Mastroianno S, Biagini T, Palumbo O, Leone MP, De Luca G, Potenza DR, Mazza T, Russo AA, Carella M.
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| J Electrocardiol 51(5):809-813. doi: 10.1016/j.jelectrocard.2018.06.005. Epub 2018 Jun 9.
2018
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| 2 | SCN10A
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| Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease.
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| Nettuwakul C, Praditsap O, Sawasdee N, Rungroj N, Ruamyod K, Watanapa WB, Junking M, Sangnual S, Sritippayawan S, Cheunsuchon B, Chuawattana D, Rojsatapong S, Chaowagul W, Dib-Hajj SD, Waxman SG, Yenchitsomanus PT.
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| Sci Rep 8(1):10453. doi: 10.1038/s41598-018-28623-3.
2018
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| 3 | SCN10A
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| Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.
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| Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani CM, Cupples LA, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van Wagoner DR, Chung MK, Vlahakes GJ, O'Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT.
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| Circ Genom Precis Med 11(5):e001663. doi: 10.1161/CIRCGEN.116.001663.
2018
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| 4 | SCN10A
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| Contribution of Nav1.8 sodium channels to retinal function.
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| Smith BJ, Côté PD, Tremblay F.
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| Neuroscience 340:279-290. doi: 10.1016/j.neuroscience.2016.10.054. Epub 2016 Oct 29.
2017
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| 5 | SCN10A
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| Association of common and rare variants of SCN10A gene with sudden unexplained nocturnal death syndrome in Chinese Han population.
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| Zhang L, Zhou F, Huang L, Wu Q, Zheng J, Wu Y, Yin K, Cheng J.
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| Int J Legal Med 131(1):53-60. doi: 10.1007/s00414-016-1397-1. Epub 2016 Jun 7.
2017
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| 6 | SCN10A
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| Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention.
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| Chen X, Yu L, Shi S, Jiang H, Huang C, Desai M, Li Y, Barajas-Martinez H, Hu D.
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| J Am Heart Assoc 5(11). pii: e004050.
2016
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| 7 | SCN10A
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| Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.
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| Roostaei T, Sadaghiani S, Park MT, Mashhadi R, Nazeri A, Noshad S, Salehi MJ, Naghibzadeh M, Moghadasi AN, Owji M, Doosti R, Taheri AP, Rad AS, Azimi A, Chakravarty MM, Voineskos AN, Nazeri A, Sahraian MA.
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| Neurology 86(5):410-7. doi: 10.1212/WNL.0000000000002326. Epub 2016 Jan 6.
2016
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| 8 | SCN10A
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| Association Between Genetic Variation in the SCN10A Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy.
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| Iio C, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Okayama H, Okura T, Shigematsu Y, Tabara Y, Kohara K, Miki T, Hamada M, Higaki J.
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| Int Heart J 56(4):421-7. doi: 10.1536/ihj.14-411. Epub 2015 Jun 24.
2015
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| 9 | SCN10A
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| Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.
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| Han C, Estacion M, Huang J, Vasylyev D, Zhao P, Dib-Hajj SD, Waxman SG.
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| J Neurophysiol 113(9):3172-85. doi: 10.1152/jn.00113.2015. Epub 2015 Mar 18.
2015
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| 10 | ASIC3, SCN10A, TRPV1
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| Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia.
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| Chen WN, Lee CH, Lin SH, Wong CW, Sun WH, Wood JN, Chen CC.
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| Mol Pain 10:40. doi: 10.1186/1744-8069-10-40.
2014
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| 11 | SCN10A
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| Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain.
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| Liu XD, Yang JJ, Fang D, Cai J, Wan Y, Xing GG.
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| PLoS One 9(12):e114623. doi: 10.1371/journal.pone.0114623. eCollection 2014.
2014
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| 12 | ANK3, SCN10A
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| Tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 constitutively interacts with ankyrin G.
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| Montersino A, Brachet A, Ferracci G, Fache MP, Angles d'Ortoli S, Liu W, Rueda-Boroni F, Castets F, Dargent B.
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| J Neurochem 131(1):33-41. doi: 10.1111/jnc.12785. Epub 2014 Jun 27.
2014
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| 13 | SCN10A
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| Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.
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| Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH.
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| Channels (Austin) 8(3):210-5.
2014
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| 14 | KIF5B, SCN10A
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| KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8.
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| Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y, Bao L.
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| J Neurosci 33(45):17884-96. doi: 10.1523/JNEUROSCI.0539-13.2013.
2013
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| 15 | HEY2, SCN10A, SCN5A
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| Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
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| Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R.
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| Nat Genet 45(9):1044-9. doi: 10.1038/ng.2712. Epub 2013 Jul 21. Erratum in: Nat Genet. 2013 Nov;45(11):1409. Borggrefe, Martin [added]; Sc 2013
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| 16 | FEPS2, SCN10A
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| Gain-of-function Nav1.8 mutations in painful neuropathy.
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| Faber CG, Lauria G, Merkies IS, Cheng X, Han C, Ahn HS, Persson AK, Hoeijmakers JG, Gerrits MM, Pierro T, Lombardi R, Kapetis D, Dib-Hajj SD, Waxman SG.
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| Proc Natl Acad Sci U S A 109(47):19444-9. doi: 10.1073/pnas.1216080109. Epub 2012 Oct 31.
2012
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| 17 | FEPS2, SCN10A
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| Gain-of-function Nav1.8 mutations in painful neuropathy.
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| Faber CG, Lauria G, Merkies IS, Cheng X, Han C, Ahn HS, Persson AK, Hoeijmakers JG, Gerrits MM, Pierro T, Lombardi R, Kapetis D, Dib-Hajj SD, Waxman SG.
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| Proc Natl Acad Sci U S A 109(47):19444-9. doi: 10.1073/pnas.1216080109. Epub 2012 Oct 31.
2012
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| 18 | SCN10A, SCN8A
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| Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits.
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| Zhao J, O'Leary ME, Chahine M.
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| J Neurophysiol 106(2):608-19. doi: 10.1152/jn.00107.2011. Epub 2011 May 11. 2011
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| 19 | SCN10A
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| Genetic variation in SCN10A influences cardiac conduction.
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| Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LR, de Jong JS, Sternberg MJ, McKenna W, Severs NJ, de Silva R, Wilde AA, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JS.
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| Nat Genet 42(2):149-52. Epub 2010 Jan 10.
2010
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| 20 | AQP1, SCN10A
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| Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons.
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| Zhang H, Verkman AS.
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| J Biol Chem 285(8):5896-906. Epub 2009 Dec 16.
2010
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| 21 | SCN10A
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| Altered expression of sodium channel distribution in the dorsal root ganglion after gradual elongation of rat sciatic nerves.
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| Ohno K, Yokota A, Hirofuji S, Kanbara K, Ohtsuka H, Kinoshita M.
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| J Orthop Res 28(4):481-6.
2010
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| 22 | SCN10A
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| A subtle alternative splicing event of the Na(V)1.8 voltage-gated sodium channel is conserved in human, rat, and mouse.
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| Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH.
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| J Mol Neurosci 41(2):310-4. Epub 2009 Dec 2.PMID: 19953341 2010
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| 23 | SCN10A, SCN11A
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| Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.
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| Leo S, D'Hooge R, Meert T.
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| Behav Brain Res 208(1):149-57. Epub 2009 Nov 30.PMID: 19931571 2010
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| 24 | SCN10A
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| Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8.
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| Puhl HL 3rd, Ikeda SR.
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| J Neurochem 106(3):1209-24. Epub 2008 May 7.PMID: 18466327 2008
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| 25 | SCN10A, SCN11A
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| Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina.
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| O'Brien BJ, Caldwell JH, Ehring GR, Bumsted O'Brien KM, Luo S, Levinson SR.
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| J Comp Neurol 508(6):940-51.PMID: 18399542 2008
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| 26 | ETHA, SCN10A, SCN11A, SCN9A
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| Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A.
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| Drenth JP, Te Morsche RH, Mansour S, Mortimer PS.
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| Arch Dermatol 144(3):320-4.PMID: 18347287 2008
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| 27 | SCN10A
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| Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons.
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| Choi JS, Hudmon A, Waxman SG, Dib-Hajj SD.
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| J Neurophysiol 96(1):97-108. Epub 2006 Apr 5.PMID: 16598065 2006
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| 28 | SCLT1, SCN10A
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| CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8.
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| Liu C, Cummins TR, Tyrrell L, Black JA, Waxman SG, Dib-Hajj SD.
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| Mol Cell Neurosci 28(4):636-49. 2005
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| 29 | SCN10A
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| A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.
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| Rabert DK, et al.
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| Pain 78(2):107-14. 1998
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| 30 | SCN10A
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| A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia.
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| Sangameswaran L, et al.
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| J Biol Chem 272(23):14805-9. 1997
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