| 1 | ARVD2, RYR2
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| CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.
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| Okuda S, Sufu-Shimizu Y, Kato T, Fukuda M, Nishimura S, Oda T, Kobayashi S, Yamamoto T, Morimoto S, Yano M.
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| Biochem Biophys Res Commun 496(4):1250-1256. doi: 10.1016/j.bbrc.2018.01.181. Epub 2018 Jan 31.
2018
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| 2 | RYR2
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| Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGFβ-1.
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| Ding Z, Yuan J, Liang Y, Wu J, Gong H, Ye Y, Jiang G, Yin P, Li Y, Zhang G, Yang C, Guo J, Chen Z, Wang X, Weng L, Zou Y.
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| Int Heart J 58(6):957-961. doi: 10.1536/ihj.16-572. Epub 2017 Nov 22.
2017
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| 3 | CMYA5, FSD2, RYR2
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| Ryanodine receptors are part of the myospryn complex in cardiac muscle
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| Benson MA, Tinsley CL, Waite AJ, Carlisle FA, Sweet SMM, Ehler E, George CH, Lai FA, Martin-Rendon E, Blake DJ.
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| Sci Rep. Jul 24;7(1):6312. doi: 10.1038/s41598-017-06395-6. 2017
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| 4 | ARVD2, RYR2
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| Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.
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| Xiao Z, Guo W, Sun B, Hunt DJ, Wei J, Liu Y, Wang Y, Wang R, Jones PP, Back TG, Chen SR.
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| J Biol Chem 291(47):24528-24537. Epub 2016 Oct 12.
2016
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| 5 | RYR2
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| Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.
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| Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SR, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD.
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| J Biol Chem 291(45):23490-23505. Epub 2016 Sep 12.
2016
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| 6 | CASQ2, RYR2
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| Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.
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| Handhle A, Ormonde CE, Thomas NL, Bralesford C, Williams AJ, Lai FA, Zissimopoulos S.
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| J Cell Sci 129(21):3983-3988. Epub 2016 Sep 8.
2016
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| 7 | CALM1, RYR1, RYR2, S100A1
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| S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.
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| Rebbeck RT, Nitu FR, Rohde D, Most P, Bers DM, Thomas DD, Cornea RL.
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| J Biol Chem 291(30):15896-907. doi: 10.1074/jbc.M115.713107. Epub 2016 May 19.
2016
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| 8 | CASQ2, HRC, RYR2, TRDN
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| Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
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| Rani S, Park CS, Sreenivasaiah PK, Kim DH.
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| Mol Cells 39(2):149-55. doi: 10.14348/molcells.2016.2284. Epub 2015 Dec 15.
2016
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| 9 | RYR1, RYR2, RYR3
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| The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening.
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| Bai XC, Yan Z, Wu J, Li Z, Yan N.
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| Cell Res 26(9):995-1006. doi: 10.1038/cr.2016.89. Epub 2016 Jul 29.
2016
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| 10 | CAV3, RYR2
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| The molecular interaction of heart LIM protein (HLP) with RyR2 and caveolin-3 is essential for Ca(2+)-induced Ca(2+) release in the heart.
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| Song DW, Lee KE, Ryu JY, Jeon H, Kim DH.
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| Biochem Biophys Res Commun 463(4):975-81. doi: 10.1016/j.bbrc.2015.06.045.
2015
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| 11 | RYR2, VTSIP1
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| Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.
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| Søndergaard MT, Tian X, Liu Y, Wang R, Chazin WJ, Chen SR, Overgaard MT.
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| J Biol Chem 290(43):26151-62. doi: 10.1074/jbc.M115.676627. Epub 2015 Aug 26.
2015
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| 12 | ITPR2, RYR2
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| Mitochondrial calcium overload is a key determinant in heart failure.
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| Santulli G, Xie W, Reiken SR, Marks AR.
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| Proc Natl Acad Sci U S A 112(36):11389-94. doi: 10.1073/pnas.1513047112. Epub 2015 Jul 27.
2015
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| 13 | RYR2
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| Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes.
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| Hiess F, Vallmitjana A, Wang R, Cheng H, ter Keurs HE, Chen J, Hove-Madsen L, Benitez R, Chen SR.
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| J Biol Chem 290(33):20477-87. doi: 10.1074/jbc.M115.650531. Epub 2015 Jun 24.
2015
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| 14 | RYR2
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| Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
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| Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D'Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR.
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| J Clin Invest 125(5):1968-78. doi: 10.1172/JCI79273. Epub 2015 Apr 6. Erratum in: J Clin Invest. 2015 Nov 2;125(11):4316.
2015
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| 15 | RYR2
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| Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination.
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| Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petegem F, Chen SR.
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| J Biol Chem 290(12):7736-46. doi: 10.1074/jbc.M114.618827. Epub 2015 Jan 27.
2015
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| 16 | RYR2
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| RyR2 modulates a Ca2+-activated K+ current in mouse cardiac myocytes.
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| Mu YH, Zhao WC, Duan P, Chen Y, Zhao WD, Wang Q, Tu HY, Zhang Q.
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| PLoS One 9(4):e94905. doi: 10.1371/journal.pone.0094905. eCollection 2014.
2014
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| 17 | CALM1, RYR2
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| Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.
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| Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM.
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| Circ Res 114(2):295-306. doi: 10.1161/CIRCRESAHA.114.302857. Epub 2013 Nov 1.
2014
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| 18 | RYR1, RYR2
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| Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation.
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| Gomez AC, Yamaguchi N.
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| Biochemistry 53(8):1373-9. doi: 10.1021/bi401586h. Epub 2014 Feb 21.
2014
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| 19 | RTN1, RYR2
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| Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.
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| Kaya L, Meissner B, Riedl MC, Muik M, Schwarzer C, Ferraguti F, Sarg B, Lindner H, Schweigreiter R, Knaus HG, Romanin C, Bandtlow CE.
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| Biochim Biophys Acta 1833(6):1421-33. doi: 10.1016/j.bbamcr.2013.02.012. Epub 2013 Feb 27.
2013
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| 20 | RYR2
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| Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.
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| Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, Arancio O, Marks AR.
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| Cell 150(5):1055-67. doi: 10.1016/j.cell.2012.06.052.
2012
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| 21 | RYR1, RYR2, RYR3
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| Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.
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| Thakur P, Dadsetan S, Fomina AF.
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| J Biol Chem 287(44):37233-44. doi: 10.1074/jbc.M112.398974. Epub 2012 Sep 4.
2012
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| 22 | RYR2, VTSIP1
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| A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium.
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| Meli AC, Refaat MM, Dura M, Reiken S, Wronska A, Wojciak J, Carroll J, Scheinman MM, Marks AR.
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| Circ Res 109(3):281-90. Epub 2011 Jun 9.
2011
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| 23 | ATP2A2, RYR1, RYR2, RYR3
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| Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle.
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| Clark JH, Kinnear NP, Kalujnaia S, Cramb G, Fleischer S, Jeyakumar LH, Wuytack F, Evans AM.
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| J Biol Chem 285(18):13542-9. Epub 2010 Feb 21.
2010
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| 24 | GSTM2, RYR2
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| The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor.2010 PMID:
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| Hewawasam R, Liu D, Casarotto MG, Dulhunty AF, Board PG.
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| Biochem Pharmacol. Aug 1;80(3):381-8. doi: 10.1016/j.bcp.2010.04.019. Epub 2010 Apr 22. 2010
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| 25 | RYR2
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| Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.
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| Jones PP, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, Liu Z, Chen SR.
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| Biochem J 410(2):261-70.
2008
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| 26 | RYR2, VTSIP1
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| Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features.
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| Bhuiyan ZA, van den Berg MP, van Tintelen JP, Bink-Boelkens MT, Wiesfeld AC, Alders M, Postma AV, van Langen I, Mannens MM, Wilde AA.
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| Circulation 116(14):1569-76. Epub 2007 Sep 17.
2007
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| 27 | RYR2, VTSIP1
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| Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model.
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| Liu N, Colombi B, Memmi M, Zissimopoulos S, Rizzi N, Negri S, Imbriani M, Napolitano C, Lai FA, Priori SG.
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| Circ Res 99(3):292-8. Epub 2006 Jul 6.
2006
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| 28 | FKBP1B, RYR1, RYR2
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| Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
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| Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR.
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| Proc Natl Acad Sci U S A 102(27):9607-12. Epub 2005 Jun 22. 2005
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| 29 | RYR2, VTSIP2
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| Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients.
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| Postma AV, Denjoy I, Kamblock J, Alders M, Lupoglazoff JM, Vaksmann G, Dubosq-Bidot L, Sebillon P, Mannens MM, Guicheney P, Wilde AA.
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| J Med Genet 42(11):863-70. 2005
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| 30 | RYR2, FKBP1B
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| Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.
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| Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR.
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| Science 304(5668):292-6. 2004
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| 31 | RYR2, VTSIP2
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| RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).
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| Jiang D, Xiao B, Yang D, Wang R, Choi P, Zhang L, Cheng H, Chen SR.
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| Proc Natl Acad Sci U S A 101(35):13062-7. Epub 2004 Aug 20. 2004
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| 32 | ARVD2, FKBP1B, RYR2
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| FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
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| Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR.
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| Cell 113(7):829-40. 2003
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| 33 | CALM1, RYR1, RYR2
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| Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor).
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| Yamaguchi N, Xu L, Pasek DA, Evans KE, Meissner G.
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| J Biol Chem 278(26):23480-6. Epub 2003 Apr 21. 2003
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| 34 | VTSIP2, ARVD2, FKBP1B, RYR2
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| The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations.
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| Tiso N, Salamon M, Bagattin A, Danieli GA, Argenton F, Bortolussi M.
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| Biochem Biophys Res Commun 299(4):594-8. 2002
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| 35 | RYR2, VTSIP1
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| Ryanodine receptors, FKBP12, and heart failure.
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| Marks AR.
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| Front Biosci 7:d970-7. Review.
2002
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| 36 | ARVD2, RYR2
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| Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).
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| Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli GA, Rampazzo A.
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| Hum Mol Genet 10(3):189-94. 2001
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| 37 | ARVT, RYR2, VTSIP2
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| Arrhythmic disorder mapped to chromosome 1q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts.
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| Swan H, Piippo K, Viitasalo M, Heikkila P, Paavonen T, Kainulainen K, Kere J, Keto P, Kontula K, Toivonen L.
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| J Am Coll Cardiol 34(7):2035-42. 1999
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| 38 | RYR1, RYR2, RYR3
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| The human cardiac muscle ryanodine receptor-calcium release channel : identification, primary structure and topological analysis.
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| Tunwell REA, et al.
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| Biochem J 318 : 477-487. 1996
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| 39 | RYR2
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| Cloning and characterization of the 5'-upstream regulatory region of the Ca2+-release channel gene of cardiac sarcoplasmic reticulum.
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| Nishida K, et al.
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| Eur J Biochem 240 : 408-415. 1996
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| 40 | ATP2A2, PLN, CASQ1, CASQ2, RYR2
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| Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.
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| Otsu K, et al.
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| Genomics 17 : 507-509. 1993
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| 41 | RYR2
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| Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
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| Otsu K, et al.
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| J Biol Chem 265 : 13472-13483. 1990
|