| 1 | MAPK9, RXRA
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| Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome.
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| Vernia S, Lee A, Kennedy NJ, Han MS, Isasa M, Cavanagh-Kyros J, Roy A, Syed A, Chaudhry S, Edwards YJK, Gygi SP, Gao G, Davis RJ.
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| Proc Natl Acad Sci U S A. Nov;119(44):e2210434119. doi: 10.1073/pnas.2210434119. Epub 2022 Oct 25. 2022
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| 2 | RXRA
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| Expression and clinical significance of retinoid X receptor α in esophageal carcinoma.
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| Ren HY, Guo YH, Yang LM, Dai TJ, Lin MZ, Yu L, Zhu QG, Meng JR.
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| Ann Diagn Pathol 34:110-115. doi: 10.1016/j.anndiagpath.2018.03.003. Epub 2018 Mar 28.
2018
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| 3 | NR4A1, RXRA
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| Effect of retinoid X receptor-α nuclear export inhibition on apoptosis of neurons in vivo and in vitro.
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| Liu Y, Tang J, Gao X, Wang M, Shen J, You X.
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| Mol Med Rep 16(2):2037-2044. doi: 10.3892/mmr.2017.6766. Epub 2017 Jun 14.
2017
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| 4 | RXRA
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| Protective effects of retinoid x receptors on retina pigment epithelium cells.
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| Ayala-Peña VB, Pilotti F, Volonté Y, Rotstein NP, Politi LE, German OL.
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| Biochim Biophys Acta 1863(6 Pt A):1134-45. doi: 10.1016/j.bbamcr.2016.02.010. Epub 2016 Feb 13.
2016
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| 5 | RXRA
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| Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis.
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| Grzegorzewska AE, Ostromecki G, Zielińska P, Mostowska A, Niemir Z, Polcyn-Adamczak M, Pawlik M, Sowińska A, Jagodziński PP.
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| Med Sci Monit 21:3671-81.
2015
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| 6 | RXRA
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| Distinct functional modes of SUMOylation for retinoid X receptor alpha.
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| Lee WP, Jena S, Rodriguez EP, O'Donovan SP, Wagner C, Jurutka PW, Thompson PD.
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| Biochem Biophys Res Commun 464(1):195-200. doi: 10.1016/j.bbrc.2015.06.115. Epub 2015 Jun 23.
2015
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| 7 | CYP3A4, RXRA
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| Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα.
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| Li J, Wan Y, Na S, Liu X, Dong G, Yang Z, Yang J, Yue J.
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| Biochem Pharmacol 93(1):92-103. doi: 10.1016/j.bcp.2014.10.010. Epub 2014 Oct 31. 2015
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| 8 | RXRA, RXRG, SREBF1
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| Regulation of retinoid X receptor gamma expression by fed state in mouse liver.
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| Park S, Lee YJ, Ko EH, Kim JW.
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| Biochem Biophys Res Commun 458(1):134-9. doi: 10.1016/j.bbrc.2015.01.082. Epub 2015 Jan 28.
2015
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| 9 | RXRA
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| Activation of RAS/ERK alone is insufficient to inhibit RXRα function and deplete retinoic acid in hepatocytes.
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| Wang AG, Song YN, Chen J, Li HL, Dong JY, Cui HP, Yao L, Li XF, Gao WT, Qiu ZW, Wang FJ, Wang JY.
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| Biochem Biophys Res Commun 452(3):801-7. doi: 10.1016/j.bbrc.2014.09.007. Epub 2014 Sep 12.
2014
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| 10 | RXRA, RXRB
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| Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
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| Coleman DJ, Garcia G, Hyter S, Jang HS, Chagani S, Liang X, Larue L, Ganguli-Indra G, Indra AK.
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| PLoS Genet 10(5):e1004321. doi: 10.1371/journal.pgen.1004321. eCollection 2014 May.
2014
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| 11 | PTGS2, RXRA
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| Elevated COX2 expression and PGE2 production by downregulation of RXRα in senescent macrophages.
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| Chen H, Ma F, Hu X, Jin T, Xiong C, Teng X.
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| Biochem Biophys Res Commun 440(1):157-62. doi: 10.1016/j.bbrc.2013.09.047. Epub 2013 Sep 16.
2013
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| 12 | CTBP2, RXRA
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| The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling.
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| Bajpe PK, Heynen GJ, Mittempergher L, Grernrum W, de Rink IA, Nijkamp W, Beijersbergen RL, Bernards R, Huang S.
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| Mol Cell Biol 33(16):3343-53. doi: 10.1128/MCB.01213-12. Epub 2013 Jun 17.
2013
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| 13 | NR1I2, RXRA
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| Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.
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| Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR.
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| J Mol Biol 425(14):2561-77. doi: 10.1016/j.jmb.2013.04.012. Epub 2013 Apr 16.
2013
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| 14 | NFE2L2, RXRA
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| RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
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| Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ, Tang X.
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| Cancer Res 73(10):3097-108. doi: 10.1158/0008-5472.CAN-12-3386. Epub 2013 Apr 23.
2013
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| 15 | PPARG, RXRA
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| Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.
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| Ruebner M, Langbein M, Strissel PL, Henke C, Schmidt D, Goecke TW, Faschingbauer F, Schild RL, Beckmann MW, Strick R.
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| J Cell Biochem 113(7):2383-96. doi: 10.1002/jcb.24110.
2012
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| 16 | RXRA, TGIF1
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| The TG-interacting factor TGIF1 regulates stress-induced proinflammatory phenotype of endothelial cells.
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| Hneino M, Blirando K, Buard V, Tarlet G, Benderitter M, Hoodless P, François A, Milliat F.
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| J Biol Chem 287(46):38913-21. doi: 10.1074/jbc.M112.388389. Epub 2012 Sep 20.
2012
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| 17 | HSPA9, RXRA
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| Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.
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| Shih YY, Lee H, Nakagawara A, Juan HF, Jeng YM, Tsay YG, Lin DT, Hsieh FJ, Pan CY, Hsu WM, Liao YF.
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| PLoS One 6(10):e26236. doi: 10.1371/journal.pone.0026236. Epub 2011 Oct 14.
2011
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| 18 | PLAC1, RXRA
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| RXRα and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1.
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| Chen Y, Moradin A, Schlessinger D, Nagaraja R.
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| Placenta 32(11):877-84. doi: 10.1016/j.placenta.2011.08.011. Epub 2011 Sep 19.
2011
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| 19 | RXRA
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| Tissue factor dependent liver injury causes release of retinoid receptors (RXR-α and RAR-α) as lipid droplets.
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| Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK.
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| Biochem Biophys Res Commun 410(1):146-51. doi: 10.1016/j.bbrc.2011.05.127. Epub 2011 May 30.
2011
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| 20 | NCOA1, NR1H3, RXRA
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| Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers.
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| Son YL, Lee YC.
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| FEBS Lett 584(18):3862-6. Epub 2010 Aug 1.
2010
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| 21 | RXRA
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| Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
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| Núñez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Boscá L, Glass CK, Arroyo AG, Ricote M.
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| Proc Natl Acad Sci U S A 107(23):10626-31. doi: 10.1073/pnas.0913545107. Epub 2010 May 24.
2010
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| 22 | IGFBP3, RXRA, TNF
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| IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription.
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| Zappalà G, Rechler MM.
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| Biochem Biophys Res Commun 382(4):785-9. Epub 2009 Mar 24.
2009
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| 23 | IGFBP3, RXRA
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| Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha.
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| Zappala G, Elbi C, Edwards J, Gorenstein J, Rechler MM, Bhattacharyya N.
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| Endocrinology 149(4):1802-12. Epub 2007 Dec 27.
2008
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| 24 | RXRA
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| Down-regulation of RXRalpha expression is essential for neutrophil development from granulocyte/monocyte progenitors.
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| Taschner S, Koesters C, Platzer B, Jörgl A, Ellmeier W, Benesch T, Strobl H.
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| Blood 109(3):971-9. Epub 2006 Oct 3.
2007
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| 25 | ABCC3, RARA, RXRA
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| Nuclear receptors RXRalpha:RARalpha are repressors for human MRP3 expression.
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| Chen W, Cai SY, Xu S, Denson LA, Soroka CJ, Boyer JL.
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| Am J Physiol Gastrointest Liver Physiol 292(5):G1221-7. Epub 2007 Feb 1.PMID: 17272513 2007
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| 26 | IGFBP3, RARA, RXRA
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| Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.
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| Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM, Baxter RC.
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| Arch Biochem Biophys 465(2):359-69. Epub 2007 Jun 26.PMID: 17644060 2007
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| 27 | RXRA
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| Identification and characterization of the human retinoid X receptor alpha gene promoter.
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| Li G, Yin W, Chamberlain R, Hewett-Emmett D, Roberts JN, Yang X, Lippman SM, Clifford JL.
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| Gene 372:118-27. Epub 2006 Mar 6. 2006
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| 28 | RXRA
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| Molecular cloning and characterization of two novel human RXR alpha splice variants.
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| Kojo H, Tajima K, Fukagawa M, Isogai T, Nishimura S.
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| J Steroid Biochem Mol Biol 92(1-2):19-28. 2004
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| 29 | RNF8, RXRA
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| The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.
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| Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y.
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| J Biol Chem 279(18):18926-34. Epub 2004 Feb 23. 2004
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| 30 | RXRA
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| Retinoid-X-receptor alpha (RXRalpha) expression during laryngeal carcinogenesis: detrimental or beneficial event?
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| Karamouzis MV, Sotiropoulou-Bonikou G, Vandoros G, Varakis I, Papavassiliou AG.
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| Cancer Lett 199(2):175-83. 2003
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| 31 | RXRA
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| Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.
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| Alfaro JM, Fraile B, Lobo MV, Royuela M, Paniagua R, Arenas MI.
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| J Androl 24(1):113-9. 2003
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| 32 | RARG, RXRA
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| The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers.
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| Gianni M, Tarrade A, Nigro EA, Garattini E, Rochette-Egly C.
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| J Biol Chem 278(36):34458-66. Epub 2003 Jun 24. 2003
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| 33 | NR1H3, RXRA
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| Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.
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| Zhang Y, Beyer T, Bramlett K, Yao S, Burris T, Schmidt R, Eacho P, Cao G.
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| Mol Genet Metab 77(1-2):150. 2002
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| 34 | RXRA
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| Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog.
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| Li G, Walch E, Yang X, Lippman SM, Clifford JL.
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| Biochem Biophys Res Commun 269(1):54-7. 2000
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| 35 | NOTCH1,NOTCH4,PBX1,PBX2,PBX3,RXRA,RXRB,RXRG
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| Paralogy mapping : identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci.
|
| Katsanis N, et al.
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| Genomics 35 : 101-108. 1996
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| 36 | RXRA
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| RXRalpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.
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| Gruber PJ, et al.
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| J Clin Invest 98 : 1332-1343. 1996
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| 37 | RXRB, RXRA, RXRG
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| Chromosomal localization of the human retinoid X receptors.
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| Almasan A, et al.
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| Genomics 20 : 397-403. 1994
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| 38 | RXRA
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| Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34.
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| Jones KA, et al.
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| Ann Hum Genet 57 : 195-201. 1993
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| 39 | RXRA
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| RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.
|
| Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG.
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| EMBO J 11(4):1409-18.
1992
|