| 1 | FANCD2, RUNX1, RUNX3
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| A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity.
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| Krishnan V, Ito Y.
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| Adv Exp Med Biol 962:491-510. doi: 10.1007/978-981-10-3233-2_29.
2017
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| 2 | KEAP1, NTRK2, RUNX3
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| TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression.
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| Kim MS, Lee WS, Jin W.
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| Mol Cells 39(3):258-65. doi: 10.14348/molcells.2016.2310.
2016
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| 3 | NTRK3, RUNX3
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| Runx3-regulated expression of two Ntrk3 transcript variants in dorsal root ganglion neurons.
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| Ogihara Y, Masuda T, Ozaki S, Yoshikawa M, Shiga T.
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| Dev Neurobiol 76(3):313-22. doi: 10.1002/dneu.22316.
2016
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| 4 | RUNX3
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| Runx3 specifies lineage commitment of innate lymphoid cells.
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| Ebihara T, Song C, Ryu SH, Plougastel-Douglas B, Yang L, Levanon D, Groner Y, Bern MD, Stappenbeck TS, Colonna M, Egawa T, Yokoyama WM.
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| Nat Immunol 16(11):1124-33. doi: 10.1038/ni.3272.
2015
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| 5 | RUNX3, TBX21
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| Aberrant expression of RUNX3 in patients with immune thrombocytopenia.
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| Qiao J, Liu Y, Wu Y, Li X, Zhu F, Xia Y, Yao H, Chu P, Li H, Ma P, Li D, Li Z, Xu K, Zeng L.
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| Int Immunopharmacol 28(1):252-6. doi: 10.1016/j.intimp.2015.06.008.
2015
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| 6 | RUNX3
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| Runx3 at the interface of immunity, inflammation and cancer.
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| Lotem J, Levanon D, Negreanu V, Bauer O, Hantisteanu S, Dicken J, Groner Y.
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| Biochim Biophys Acta 1855(2):131-43. doi: 10.1016/j.bbcan.2015.01.004. Review.
2015
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| 7 | RUNX3
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| Loss of osteoblast Runx3 produces severe congenital osteopenia.
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| Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y.
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| Mol Cell Biol 35(7):1097-109. doi: 10.1128/MCB.01106-14.
2015
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| 8 | NR4A1, RUNX3
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| The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.
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| Nowyhed HN, Huynh TR, Blatchley A, Wu R, Thomas GD, Hedrick CC.
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| Sci Rep 5:9059. doi: 10.1038/srep09059.
2015
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| 9 | IL23A, RUNX3
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| A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.
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| Hor YT, Voon DC, Koo JK, Wang H, Lau WM, Ashktorab H, Chan SL, Ito Y.
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| Cell Rep 8(1):50-8. doi: 10.1016/j.celrep.2014.06.003. Epub 2014 Jul 5.
2014
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| 10 | RUNX3, TBX21
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| Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.
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| Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D.
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| Immunity 41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.
2014
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| 11 | RUNX3
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| Requirement of Runx3 in pulmonary vasculogenesis.
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| Lee JM, Kwon HJ, Lai WF, Jung HS.
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| Cell Tissue Res 356(2):445-9. doi: 10.1007/s00441-014-1816-x.
2014
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| 12 | PIN1, RUNX3
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| Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer.
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| Nicole Tsang YH, Wu XW, Lim JS, Wee Ong C, Salto-Tellez M, Ito K, Ito Y, Chen LF.
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| Oncogene 32(12):1488-96. doi: 10.1038/onc.2012.178. Epub 2012 May 14.
2013
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| 13 | RUNX1, RUNX3, TP53
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| Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation.
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| Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A.
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| J Biol Chem 288(2):1353-64. doi: 10.1074/jbc.M112.402594. Epub 2012 Nov 12.
2013
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| 14 | RUNX3
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| Runx3-mediated transcriptional program in cytotoxic lymphocytes.
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| Lotem J, Levanon D, Negreanu V, Leshkowitz D, Friedlander G, Groner Y.
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| PLoS One 8(11):e80467. doi: 10.1371/journal.pone.0080467.
2013
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| 15 | RUNX2, RUNX3
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| Functional role of Runx3 in the regulation of aggrecan expression during cartilage development.
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| Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC.
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| J Cell Physiol 228(11):2232-42. doi: 10.1002/jcp.24396.
2013
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| 16 | RUNX1, RUNX3
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| Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons.
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| Yoshikawa M, Murakami Y, Senzaki K, Masuda T, Ozaki S, Ito Y, Shiga T.
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| Dev Neurobiol 73(6):469-79. doi: 10.1002/dneu.22073.
2013
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| 17 | RUNX1, RUNX3
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| Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.
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| Li L, Patsoukis N, Petkova V, Boussiotis VA.
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| PLoS One 7(9):e45115. doi: 10.1371/journal.pone.0045115. Epub 2012 Sep 12.
2012
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| 18 | RUNX3
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| Positional differences of axon growth rates between sensory neurons encoded by Runx3.
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| Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P.
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| EMBO J 31(18):3718-29. doi: 10.1038/emboj.2012.228. Epub 2012 Aug 17.
2012
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| 19 | RUNX3
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| Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.
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| Voon DC, Wang H, Koo JK, Nguyen TA, Hor YT, Chu YS, Ito K, Fukamachi H, Chan SL, Thiery JP, Ito Y.
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| Stem Cells 30(10):2088-99. doi: 10.1002/stem.1183.
2012
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| 20 | IFNG, RUNX3, TWIST1
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| Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
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| Pham D, Vincentz JW, Firulli AB, Kaplan MH.
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| J Immunol 189(2):832-40. doi: 10.4049/jimmunol.1200854. Epub 2012 Jun 8.
2012
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| 21 | RUNX3
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| Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma.
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| Tanaka S, Shiraha H, Nakanishi Y, Nishina S, Matsubara M, Horiguchi S, Takaoka N, Iwamuro M, Kataoka J, Kuwaki K, Hagihara H, Toshimori J, Ohnishi H, Takaki A, Nakamura S, Nouso K, Yagi T, Yamamoto K.
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| Int J Cancer 131(11):2537-46. doi: 10.1002/ijc.27575. Epub 2012 Apr 24.
2012
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| 22 | ICAM3, RUNX3
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| RUNX3 regulates intercellular adhesion molecule 3 (ICAM-3) expression during macrophage differentiation and monocyte extravasation.
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| Estecha A, Aguilera-Montilla N, Sánchez-Mateos P, Puig-Kröger A.
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| PLoS One 7(3):e33313. doi: 10.1371/journal.pone.0033313. Epub 2012 Mar 29.
2012
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| 23 | RUNX3
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| The role of the tumor suppressor RUNX3 in giant cell tumor of the bone.
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| Han YX, Liang DY.
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| Int J Oncol 40(3):673-8. doi: 10.3892/ijo.2011.1249. Epub 2011 Nov 4.
2012
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| 24 | ESR1, RUNX3
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| RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α.
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| Huang B, Qu Z, Ong CW, Tsang YH, Xiao G, Shapiro D, Salto-Tellez M, Ito K, Ito Y, Chen LF.
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| Oncogene 31(4):527-34. doi: 10.1038/onc.2011.252. Epub 2011 Jun 27.
2012
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| 25 | AKT1, RUNX3
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| RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells.
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| Lin FC, Liu YP, Lai CH, Shan YS, Cheng HC, Hsu PI, Lee CH, Lee YC, Wang HY, Wang CH, Cheng JQ, Hsiao M, Lu PJ.
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| Oncogene 31(39):4302-16. doi: 10.1038/onc.2011.596.
2012
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| 26 | CXCL12, RUNX3
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| The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression.
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| Sánchez-Martín L, Estecha A, Samaniego R, Sánchez-Ramón S, Vega MÁ, Sánchez-Mateos P.
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| Blood 117(1):88-97. Epub 2010 Oct 7.
2011
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| 27 | RUNX3
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| Oncogenic role of RUNX3 in head and neck cancer.
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| Kudo Y, Tsunematsu T, Takata T.
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| J Cell Biochem 112(2):387-93. doi: 10.1002/jcb.22967. Review.
2011
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| 28 | RUNX3
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| Control of RUNX3 by histone methyltransferases.
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| Lee YM.
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| J Cell Biochem 112(2):394-400. doi: 10.1002/jcb.22969. Review.
2011
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| 29 | NOTCH1, RUNX3
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| RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal.
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| Fu Y, Chang AC, Fournier M, Chang L, Niessen K, Karsan A.
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| J Biol Chem 286(13):11803-13. Epub 2011 Feb 2.
2011
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| 30 | RUNX1, RUNX3
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| Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein.
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| Inoue K, Ito Y.
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| Gene 487(2):151-5. doi: 10.1016/j.gene.2011.05.016. Epub 2011 May 27.
2011
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| 31 | RUNX3, SRC
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| Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
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| Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC.
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| J Biol Chem 285(13):10122-9. Epub 2010 Jan 25. 2010
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| 32 | RUNX3
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| Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
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| Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC.
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| Oncogene 29(23):3349-61. Epub 2010 Mar 15.PMID: 20228843 2010
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| 33 | RUNX3, TP53
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| RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.
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| Yamada C, Ozaki T, Ando K, Suenaga Y, Inoue K, Ito Y, Okoshi R, Kageyama H, Kimura H, Miyazaki M, Nakagawara A.
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| J Biol Chem 285(22):16693-703. Epub 2010 Mar 30.
2010
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| 34 | CCND1, RUNX3
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| Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction.
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| Iwatani K, Fujimoto T, Ito T.
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| Biochem Biophys Res Commun 400(3):426-31. Epub 2010 Aug 27.
2010
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| 35 | RUNX3, ZFHX3
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| Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
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| Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T.
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| Biochem Biophys Res Commun 398(2):321-5. doi: 10.1016/j.bbrc.2010.06.090. Epub 2010 Jun 25.
2010
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| 36 | RUNX3
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| Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells.
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| Lee SH, Kim J, Kim WH, Lee YM.
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| Oncogene 28(2):184-94. Epub 2008 Oct 13.
2009
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| 37 | RUNX1, RUNX3
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| RUNX3-mediated repression of RUNX1 in B cells.
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| Brady G, Farrell PJ.
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| J Cell Physiol 221(2):283-7. Review.
2009
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| 38 | RUNX3
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| RUNX3 inhibits cell proliferation and induces apoptosis by TGF-beta-dependent and -independent mechanisms in human colon carcinoma cells.
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| Tong DD, Jiang Y, Li M, Kong D, Meng XN, Zhao YZ, Jin Y, Bai J, Fu SB, Geng JS.
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| Pathobiology 76(4):163-9. Epub 2009 Jun 29.
2009
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| 39 | RUNX3, ZBTB7B
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| Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment.
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| Egawa T.
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| J Cell Biochem 107(6):1037-45. doi: 10.1002/jcb.22212. Review.
2009
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| 40 | RUNX3, ZBTB7B
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| Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes.
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| Egawa T, Taniuchi I.
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| Blood Cells Mol Dis 43(1):27-9. doi: 10.1016/j.bcmd.2009.03.004. Epub 2009 Apr 16.
2009
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| 41 | EZH2, RUNX3
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| Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.
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| Fujii S, Ito K, Ito Y, Ochiai A.
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| J Biol Chem 283(25):17324-32. Epub 2008 Apr 22.
2008
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| 42 | RUNX1, RUNX2, RUNX3, STAT5B
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| Physical and functional interactions between STAT5 and Runx transcription factors.
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| Ogawa S, Satake M, Ikuta K.
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| J Biochem 143(5):695-709. Epub 2008 Feb 22.PMID: 18296717 2008
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| 43 | RUNX3, SP7
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| Runx3 negatively regulates Osterix expression in dental pulp cells.
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| Zheng L, Iohara K, Ishikawa M, Into T, Takano-Yamamoto T, Matsushita K, Nakashima M.
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| Biochem J 405(1):69-75. 2007
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| 44 | RUNX1, RUNX2, RUNX3
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| Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.
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| Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.
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| J Bone Miner Res 22(8):1260-70.
2007
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| 45 | GSDMA, LMO1, RUNX3
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| GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling.
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| Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H.
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| Oncogene 26(45):6488-98. Epub 2007 Apr 30.PMID: 17471240 2007
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| 46 | RUNX3
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| Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma.
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| Long C, Yin B, Lu Q, Zhou X, Hu J, Yang Y, Yu F, Yuan Y.
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| Cancer Invest 25(8):685-90.PMID: 18058463 2007
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| 47 | RUNX3
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| RUNX3 protein is overexpressed in human basal cell carcinomas.
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| Salto-Tellez M, Peh BK, Ito K, Tan SH, Chong PY, Han HC, Tada K, Ong WY, Soong R, Voon DC, Ito Y.
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| Oncogene 25(58):7646-9. Epub 2006 Jun 12.
2006
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| 48 | RUNX3
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| Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma.
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| Mori T, Nomoto S, Koshikawa K, Fujii T, Sakai M, Nishikawa Y, Inoue S, Takeda S, Kaneko T, Nakao A.
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| Liver Int 25(2):380-8. 2005
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| 49 | RUNX3
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| RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.
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| Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, Hiong KC, Peh BK, Han HC, Ito T, Teh M, Yeoh KG, Ito Y.
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| Cancer Res. 65(17):7743-50. 2005
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| 50 | RUNX3, CDKN1A
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| RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.
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| Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC.
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| Mol Cell Biol 25(18):8097-107. 2005
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| 51 | RUNX3
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| RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors.
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| Kim WJ, Kim EJ, Jeong P, Quan C, Kim J, Li QL, Yang JO, Ito Y, Bae SC.
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| Cancer Res 65(20):9347-54. 2005
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| 52 | RUNX3
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| Exclusion of RUNX3 as a tumour-suppressor gene in early-onset gastric carcinomas.
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| Carvalho R, Milne AN, Polak M, Corver WE, Offerhaus GJ, Weterman MA.
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| Oncogene 24(56):8252-8. 2005
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| 53 | RUNX3
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| RUNX3 expression in primary and metastatic pancreatic cancer.
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| Li J, Kleeff J, Guweidhi A, Esposito I, Berberat PO, Giese T, Buchler MW, Friess H.
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| J Clin Pathol 57(3):294-9. 2004
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| 54 | RUNX3
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| Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines.
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| Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, Chiba T.
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| Oncogene 23(13):2401-7. 2004
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| 55 | RUNX3
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| Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines.
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| Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG.
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| Oncogene 23(40):6736-42. 2004
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| 56 | LGALS3, RUNX1, RUNX2, RUNX3
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| Expression of galectin-3 in skeletal tissues is controlled by Runx2.
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| Stock M, Schafer H, Stricker S, Gross G, Mundlos S, Otto F.
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| J Biol Chem 278(19):17360-7. Epub 2003 Feb 25. 2003
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| 57 | RUNX3
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| Causal relationship between the loss of RUNX3 expression and gastric cancer.
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| Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y.
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| Cell 109(1):113-24. 2002
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| 58 | RUNX1, RUNX3
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| Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development.
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| Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR.
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| Cell 111(5):621-33. 2002
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| 59 | RUNX3
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| The RUNX3 gene--sequence, structure and regulated expression.
|
| Bangsow C, Rubins N, Glusman G, Bernstein Y, Negreanu V, Goldenberg D, Lotem J, Ben-Asher E, Lancet D, Levanon D, Groner Y.
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| Gene 279(2):221-32. 2001
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| 60 | RUNX1, RUNX2, RUNX3
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| Runt domains take the lead in hematopoiesis and osteogenesis.
|
| Werner MH, Shigesada K, Ito Y.
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| Nat Med 5(12):1356-7. No abstract available 1999
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| 61 | RUNX3
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| Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.
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| Wijmenga C, et al.
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| Genomics 26 : 611-614. 1995
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| 62 | RUNX3
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| Cloning, mapping and expression of PEBP2alphaC, a third gene encoding the mammalian runt domain.
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| Bae SC, et al.
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| Gene 159 : 245-248. 1995
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| 63 | AML1, AMLT2, AMLT3, RUNX2, RUNX1, RUNX3
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| AML1, AML2, and AML3, the human members of the runt domain gene-family : cDNA structure, expression, and chromosomal localization.
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| Levanon D, et al.
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| Genomics 23 : 425-432. 1994
|