| 1 | RUNX1, RUNX1T1, STUB1
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| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1
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| Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S.
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| J Biol Chem. Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. 2017
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| 2 | JMJD1C, RUNX1, RUNX1T1
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| JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.
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| Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG.
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| Genes Dev 29(20):2123-39. doi: 10.1101/gad.267278.115.
2015
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| 3 | RUNX1, RUNX1T1
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| Decoding of exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene.
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| Grinev VV, Migas AA, Kirsanava AD, Mishkova OA, Siomava N, Ramanouskaya TV, Vaitsiankova AV, Ilyushonak IM, Nazarov PV, Vallar L, Aleinikova OV.
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| Int J Biochem Cell Biol 68:48-58. doi: 10.1016/j.biocel.2015.08.017. Epub 2015 Aug 29.
2015
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| 4 | RUNX1T1
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| Runx1t1 regulates the neuronal differentiation of radial glial cells from the rat hippocampus.
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| Linqing Z, Guohua J, Haoming L, Xuelei T, Jianbing Q, Meiling T.
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| Stem Cells Transl Med 4(1):110-6. doi: 10.5966/sctm.2014-0158. Epub 2014 Dec 3.
2015
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| 5 | RUNX1, RUNX1T1
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| RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinoma.
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| Xiong Z, Yu H, Ding Y, Feng C, Wei H, Tao S, Huang D, Zheng SL, Sun J, Xu J, Fang Z.
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| Biomed Res Int 2014:450621. doi: 10.1155/2014/450621. Epub 2014 Mar 25.
2014
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| 6 | CDK4, LAT2, RUNX1T1
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| Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia.
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| Baby N, Li Y, Ling EA, Lu J, Dheen ST.
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| PLoS One 9(2):e89326. doi: 10.1371/journal.pone.0089326. eCollection 2014.
2014
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| 7 | PRMT1, RUNX1, RUNX1T1
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| PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
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| Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR 3rd, Zhang DE.
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| Blood 119(21):4953-62. doi: 10.1182/blood-2011-04-347476. Epub 2012 Apr 12.
2012
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| 8 | RUNX1, RUNX1T1
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| RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
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| Lam K, Zhang DE.
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| Front Biosci (Landmark Ed) 17:1120-39. Review.
2012
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| 9 | EP300, RUNX1T1
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| The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
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| Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD.
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| Science 333(6043):765-9. Epub 2011 Jul 14.
2011
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| 10 | RUNX1, RUNX1T1
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| The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
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| Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD.
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| Science 333(6043):765-9. doi: 10.1126/science.1201662. Epub 2011 Jul 14.
2011
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| 11 | ASCL1, CBFA2T2, CBFA2T3, NEUROG2, RUNX1T1
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| Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.
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| Aaker JD, Patineau AL, Yang HJ, Ewart DT, Nakagawa Y, McLoon SC, Koyano-Nakagawa N.
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| Neurosci Lett 474(1):46-51. Epub 2010 Mar 7.
2010
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| 12 | GATA1, RUNX1T1
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| The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.
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| Ajore R, Dhanda RS, Gullberg U, Olsson I.
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| BMC Mol Biol 11:38. doi: 10.1186/1471-2199-11-38.
2010
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| 13 | RUNX1, RUNX1T1
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| RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress.
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| Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC.
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| Oncogene 28(27):2502-12. Epub 2009 May 18. 2009
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| 14 | RUNX1T1
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| Characterization of a t(5;8)(q31;q21) translocation in a patient with mental retardation and congenital heart disease: implications for involvement of RUNX1T1 in human brain and heart development.
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| Zhang L, Tümer Z, Møllgård K, Barbi G, Rossier E, Bendsen E, Møller RS, Ullmann R, He J, Papadopoulos N, Tommerup N, Larsen LA.
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| Eur J Hum Genet 17(8):1010-8. Epub 2009 Jan 28.
2009
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| 15 | RUNX1, RUNX1T1
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| Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery.
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| Guo C, Hu Q, Yan C, Zhang J.
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| Mol Cell Biol 29(10):2644-57. Epub 2009 Mar 16.PMID: 19289505 2009
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| 16 | RUNX1, RUNX1T1, TCF12
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| Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
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| Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck NA, Bushweller JH.
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| Blood 113(15):3558-67. Epub 2009 Feb 9.PMID: 19204326 2009
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| 17 | RBPJ, RUNX1, RUNX1T1, SPEN
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| ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
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| Salat D, Liefke R, Wiedenmann J, Borggrefe T, Oswald F.
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| Mol Cell Biol 28(10):3502-12. Epub 2008 Mar 10.
2008
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| 18 | RUNX1, RUNX1T1, TCF12
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| AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.
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| Gardini A, Cesaroni M, Luzi L, Okumura AJ, Biggs JR, Minardi SP, Venturini E, Zhang DE, Pelicci PG, Alcalay M.
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| PLoS Genet 4(11):e1000275. Epub 2008 Nov 28.PMID: 19043539 2008
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| 19 | RUNX1, RUNX1T1
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| AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain.
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| Wei H, Liu X, Xiong X, Wang Y, Rao Q, Wang M, Wang J.
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| FEBS Lett 582(15):2167-72. Epub 2008 Jun 2.PMID: 18519037 2008
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| 20 | CBFA2T3, RUNX1T1
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| Novel RNA-binding properties of the MTG chromatin regulatory proteins.
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| Rossetti S, van Unen L, Sacchi N, Hoogeveen AT.
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| BMC Mol Biol 9:93.
2008
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| 21 | RUNX1, RUNX1T1
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| A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.
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| Yan M, Kanbe E, Peterson LF, Boyapati A, Miao Y, Wang Y, Chen IM, Chen Z, Rowley JD, Willman CL, Zhang DE.
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| Nat Med 12(8):945-9. Epub 2006 Jul 30. 2006
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| 22 | NTRK1, RUNX1T1, RUNX1
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| AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.
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| Mulloy JC, Jankovic V, Wunderlich M, Delwel R, Cammenga J, Krejci O, Zhao H, Valk PJ, Lowenberg B, Nimer SD.
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| Proc Natl Acad Sci U S A 102(11):4016-21. Epub 2005 Feb 24. 2005
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| 23 | RUNX1, RUNX1T1
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| MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).
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| Kozu T, Fukuyama T, Yamami T, Akagi K, Kaneko Y.
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| Genes Chromosomes Cancer 43(1):45-53. 2005
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| 24 | CBFA2T2, RUNX1T1, CBFA2T3
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| The MTG proteins: chromatin repression players with a passion for networking.
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| Rossetti S, Hoogeveen AT, Sacchi N.
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| Genomics 84(1):1-9. 2004
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| 25 | LAT2, RUNX1, RUNX1T1
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| Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.
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| Fliegauf M, Stock M, Berg T, Lübbert M.
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| Oncogene 23(56):9070-81.
2004
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| 26 | RUNX1, RUNX1T1
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| t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia.
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| Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, Yamauchi K, Kitano K, Kiyosawa K.
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| Cancer Genet Cytogenet 132(2):133-5. 2002
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| 27 | RUNX1T1, RUNX1
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| Molecular characterization of genomic AML1-ETO fusions in childhood leukemia.
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| Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL.
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| Leukemia 15(12):1906-13. 2001
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| 28 | RUNX1T1
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| Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8).
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| Odaka Y, Mally A, Elliott LT, Meyers S.
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| Oncogene 19(32):3584-97. 2000
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| 29 | RUNX1T1, NCOR1
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| Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
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| Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C, Pelicci PG.
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| Mol Cell 5(5):811-20. 2000
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| 30 | RARA, RUNX1T1
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| Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17).
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| Varella-Garcia M, et al.
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| Leuk Lymphoma 33(3-4):403-6. 1999
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| 31 | AML1, RUNX1, RUNX1T1
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| Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia.
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| Le XF, et al.
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| Eur J Haematol 60 : 217-225. 1998
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| 32 | RUNX1T1, CBFA2T2, CBFA2T3
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| The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.
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| Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M.
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| Blood 91 : 4028-4037. 1998
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| 33 | RUNX1T1, CBFA2T2, CBFA2T3
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| CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.
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| Calabi F, Cilli V.
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| Genomics 52 : 332-341. 1998
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| 34 | RUNX1T1, CBFA2T2, CBFA2T3
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| The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.
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| Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M.
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| Mol Cell Biol 18 : 846-858. 1998
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| 35 | RUNX1T1
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| ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors.
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| Lutterbach B, et al.
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| Mol Cell Biol 18 : 7176-7184. 1998
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| 36 | RUNX1T1, HDAC1, NCOR1
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| ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.
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| Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM.
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| Proc Natl Acad Sci U S A 95(18):10860-5. 1998
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| 37 | AML1, RUNX1, RUNX1T1
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| Structure and expression of the human MTG8/ETO gene.
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| Wolford JK, Prochazka M.
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| Gene 212(1):103-9. 1998
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| 38 | RUNX1T1
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| Transformation properties of the ETO gene, fusion partner in t(8:21) leukemias.
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| Wang J, Wang M, Liu JM.
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| Cancer Res 57(14):2951-5. 1997
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| 39 | RUNX1T1
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| t(8;20)(q22;p13): a novel variant translocation of t(8;21) in acute myeloblastic leukaemia.
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| Xue Y, Yu F, Xin Y, Lu D, Zou Z, Guo Y, Xie X.
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| Br J Haematol 98(3):733-5. 1997
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| 40 | BCL2, RUNX1, RUNX1T1
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| The AML1/ETO fusion protein activates transcription of BCL-2.
|
| Klampfer L, et al.
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| Proc Natl Acad Sci U S A 93 : 14059-14064. 1996
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| 41 | RUNX1T1
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| Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia.
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| Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M.
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| Genomics 29(3):755-9. 1995
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| 42 | AML1, RUNX1, RUNX1T1
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| Functional domains of the t(8;21) fusion protein, AML-1/ETO.
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| Lenny N, Meyers S, Hiebert SW.
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| Oncogene 11 : 1761-1769. 1995
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| 43 | AML1, RUNX1, RUNX1T1
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| The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.
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| Frank R, et al.
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| Oncogene 11 : 2667-2674. 1995
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| 44 | AML1, RUNX1, RUNX1T1
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| Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia.
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| Nucifora G, et al.
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| Blood 81 : 883-888. 1993
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| 45 | RUNX1T1
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| Expression of AML1-ETO fusion transcripts and detection of minimal residual disease in t(8;21)-positive acute myeloid leukemia.
|
| Chang KS, et al.
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| Oncogene 8 : 983-988. 1993
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| 46 | AML1, RUNX1, RUNX1T1
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| The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
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| Miyoshi H, et al.
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| EMBO J 12 : 2715-2721. 1993
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| 47 | AML1, RUNX1, RUNX1T1
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| An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation.
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| Downing JR, et al.
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| Blood 11 : 2860-2865. 1993
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| 48 | AML1, RUNX1, RUNX1T1
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| Translocation breakpoints are clustered on both chromosome 8 and chromosome21 in the t(8;21) of acute myeloid leukemia.
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| Tighe JE, et al.
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| Blood 81 : 592-596. 1993
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| 49 | AML1, RUNX1, RUNX1T1
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| Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.
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| Kozu T, et al.
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| Blood 82 : 1270-1276. 1993
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| 50 | AML1, RUNX1, RUNX1T1
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| Molecular analysis of 12 patients with the t(8;21) translocation and M2 acute myelogenous leukemia.
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| Yaspo ML, et al.
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| Genes Chromosomes Cancer 5 : 166-177. 1992
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| 51 | AML1, RUNX1, RUNX1T1
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| Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
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| Erickson P, et al.
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| Blood 80 : 1825-1831. 1992
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| 52 | AML1, RUNX1, RUNX1T1
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| Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.
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| Shimizu K, et al.
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| Cancer Res 52 : 6945-6948. 1992
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| 53 | AML1, RUNX1, RUNX1T1
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| Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in the t(8;21) leukemic cells.
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| Nisson PE, et al.
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| Cancer Genet Cytogenet 63 : 81-88. 1992
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| 54 | AML1, CD19, RUNX1, RUNX1T1
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| Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality : frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34.
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| Kita K, et al.
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| Blood 80 : 470-477. 1992
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| 55 | AML1, RUNX1, RUNX1T1
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| t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
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| Miyoshi H, et al.
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| Proc Natl Acad Sci U S A 88 : 10431-10434. 1991
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| 56 | AML1, RUNX1, RUNX1T1
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| Molecular assignment of a translocation breakpoint in acute myeloid leukemia with t(8;21).
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| Shimizu K, et al.
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| Genes Chromosomes Cancer 3 : 163-167. 1991
|