| 1 | FOXL2, RUNX1
|
| RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
|
| Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH.
|
| Nat Commun. Nov 11;10(1):5116. doi: 10.1038/s41467-019-13060-1. 2019
|
| 2 | NOTCH4, RUNX1
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| Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation.
|
| Li Y, Jin C, Bai H, Gao Y, Sun S, Chen L, Qin L, Liu PP, Cheng L, Wang QF.
|
| Blood Jan 11;131(2):191-201. doi: 10.1182/blood-2017-04-780379. Epub 2017 Nov 3 2018
|
| 3 | RUNX1, ZFP36L2
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| ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation.
|
| Liu J, Lu W, Liu S, Wang Y, Li S, Xu Y, Xing H, Tang K, Tian Z, Rao Q, Wang M, Wang J.
|
| Leuk Res. May;68:15-21. doi: 10.1016/j.leukres.2018.02.017. Epub 2018 Feb 27 2018
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| 4 | FUBP1, KIT, RUNX1
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| Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation
|
| Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB
|
| Nucleic Acids Res. Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. 2018
|
| 5 | FANCD2, RUNX1, RUNX3
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| A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity.
|
| Krishnan V, Ito Y.
|
| Adv Exp Med Biol 962:491-510. doi: 10.1007/978-981-10-3233-2_29.
2017
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| 6 | CKMT1A, CKMT1B, MECOM, RUNX1
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| The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
|
| Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K.
|
| Nat Med 23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13. 2017
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| 7 | BLOC1S6, RUNX1
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| Dysregulation of PLDN (pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency.
|
| Mao GF, Goldfinger LE, Fan DC, Lambert MP, Jalagadugula G, Freishtat R, Rao AK.
|
| J Thromb Haemost 15(4):792-801. doi: 10.1111/jth.13619. Epub 2017 Feb 23.
2017
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| 8 | GATA1, PRKACB, RUNX1, TAL1
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| Hematopoietic transcription factors and differential cofactor binding regulate PRKACB isoform expression.
|
| Kuvardina ON, Herkt S, Meyer A, Schneider L, Yillah J, Kohrs N, Bonig H, Seifried E, Müller-Tidow C, Lausen J.
|
| Oncotarget Apr 24;8(42):71685-71698. doi: 10.18632/oncotarget.17386. eCollection 2017 Sep 22. 2017
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| 9 | RUNX1, RUNX1T1, STUB1
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| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1
|
| Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S.
|
| J Biol Chem. Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. 2017
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| 10 | FLI1, GATA1, GFI1B, RUNX1
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| Inherited platelet dysfunction and hematopoietic transcription factor mutations.
|
| Songdej N, Rao AK.
|
| Platelets latelets. 2016 Jul 27:1-7. [Epub ahead of print]
2016
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| 11 | LIFR, RUNX1
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| The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1.
|
| Qadi AA, Taberlay PC, Phillips JL, Young A, West AC, Brettingham-Moore KH, Dickinson JL, Holloway AF.
|
| J Cell Biochem. Jan;117(1):49-58. doi: 10.1002/jcb.25246 2016
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| 12 | JMJD1C, RUNX1, RUNX1T1
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| JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.
|
| Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG.
|
| Genes Dev 29(20):2123-39. doi: 10.1101/gad.267278.115.
2015
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| 13 | RUNX1, RUNX1T1
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| Decoding of exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene.
|
| Grinev VV, Migas AA, Kirsanava AD, Mishkova OA, Siomava N, Ramanouskaya TV, Vaitsiankova AV, Ilyushonak IM, Nazarov PV, Vallar L, Aleinikova OV.
|
| Int J Biochem Cell Biol 68:48-58. doi: 10.1016/j.biocel.2015.08.017. Epub 2015 Aug 29.
2015
|
| 14 | ETS1, RUNX1
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| Structural basis of Ets1 activation by Runx1.
|
| Shrivastava T, Mino K, Babayeva ND, Baranovskaya OI, Rizzino A, Tahirov TH.
|
| Leukemia 28(10):2040-8. doi: 10.1038/leu.2014.111. Epub 2014 Mar 20.
2014
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| 15 | RUNX1, RUNX1T1
|
| RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinoma.
|
| Xiong Z, Yu H, Ding Y, Feng C, Wei H, Tao S, Huang D, Zheng SL, Sun J, Xu J, Fang Z.
|
| Biomed Res Int 2014:450621. doi: 10.1155/2014/450621. Epub 2014 Mar 25.
2014
|
| 16 | CHRND, CHRNG, NCAM1, RUNX1
|
| Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice.
|
| Barns M, Gondro C, Tellam RL, Radley-Crabb HG, Grounds MD, Shavlakadze T.
|
| Int J Biochem Cell Biol 53:174-85. doi: 10.1016/j.biocel.2014.04.025. Epub 2014 May 13.
2014
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| 17 | CBFB, FLT3, RUNX1
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| Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder.
|
| Satpathy AT, Briseńo CG, Cai X, Michael DG, Chou C, Hsiung S, Bhattacharya D, Speck NA, Egawa T.
|
| Blood 123(19):2968-77. doi: 10.1182/blood-2013-11-539643. Epub 2014 Mar 27.
2014
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| 18 | NFE2, RUNX1
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| RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.
|
| Kapralova K, Lanikova L, Lorenzo F, Song J, Horvathova M, Divoky V, Prchal JT.
|
| Blood 123(3):391-4. doi: 10.1182/blood-2013-10-534222. Epub 2013 Dec 2.
2014
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| 19 | PCGF1, RUNX1
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| Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
|
| Junco SE, Wang R, Gaipa JC, Taylor AB, Schirf V, Gearhart MD, Bardwell VJ, Demeler B, Hart PJ, Kim CA.
|
| Structure 21(4):665-71. doi: 10.1016/j.str.2013.02.013. Epub 2013 Mar 21.
2013
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| 20 | GATA2, GFI1, MYSM1, RUNX1
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| The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation.
|
| Wang T, Nandakumar V, Jiang XX, Jones L, Yang AG, Huang XF, Chen SY.
|
| Blood 122(16):2812-22. doi: 10.1182/blood-2013-03-489641. Epub 2013 Sep 6.
2013
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| 21 | RUNX1, RUNX3, TP53
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| Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation.
|
| Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A.
|
| J Biol Chem 288(2):1353-64. doi: 10.1074/jbc.M112.402594. Epub 2012 Nov 12.
2013
|
| 22 | ELK1, MECOM, RUNX1
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| Functional characterization of the promoter region of the human EVI1 gene in acute myeloid leukemia: RUNX1 and ELK1 directly regulate its transcription.
|
| Maicas M, Vázquez I, Vicente C, García-Sánchez MA, Marcotegui N, Urquiza L, Calasanz MJ, Odero MD.
|
| Oncogene 32(16):2069-78. doi: 10.1038/onc.2012.222. Epub 2012 Jun 11.
2013
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| 23 | RUNX1, TAL1
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| Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
|
| Tornack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M.
|
| PLoS One 8(7):e70116. doi: 10.1371/journal.pone.0070116. Print 2013.
2013
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| 24 | PF4, RUNX1
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| RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins.
|
| Okada Y, Watanabe M, Nakai T, Kamikawa Y, Shimizu M, Fukuhara Y, Yonekura M, Matsuura E, Hoshika Y, Nagai R, Aird WC, Doi T.
|
| J Thromb Haemost 11(9):1742-50. doi: 10.1111/jth.12355.
2013
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| 25 | RUNX1, RUNX3
|
| Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons.
|
| Yoshikawa M, Murakami Y, Senzaki K, Masuda T, Ozaki S, Ito Y, Shiga T.
|
| Dev Neurobiol 73(6):469-79. doi: 10.1002/dneu.22073.
2013
|
| 26 | GFI1, GFI1B, RUNX1
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| GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.
|
| Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, Vargel O, Wilson NK, Möröy T, Bonifer C, Göttgens B, Kouskoff V, Lacaud G.
|
| Blood 120(2):314-22. doi: 10.1182/blood-2011-10-386094. Epub 2012 Jun 5.
2012
|
| 27 | RUNX1, RUNX3
|
| Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells.
|
| Li L, Patsoukis N, Petkova V, Boussiotis VA.
|
| PLoS One 7(9):e45115. doi: 10.1371/journal.pone.0045115. Epub 2012 Sep 12.
2012
|
| 28 | CEBPB, P2RX3, RUNX1
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| Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription.
|
| Ugarte GD, Opazo T, Leisewitz F, van Zundert B, Montecino M.
|
| J Cell Physiol 227(4):1645-52. doi: 10.1002/jcp.22882.
2012
|
| 29 | PCGF1, RUNX1
|
| Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
|
| Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T, Behrens K, Hubner N, Mann M, Waskow C, Stocking C, Buchholz F.
|
| Blood 119(18):4152-61. doi: 10.1182/blood-2011-09-382390. Epub 2012 Mar 12.
2012
|
| 30 | PRMT1, RUNX1, RUNX1T1
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| PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
|
| Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR 3rd, Zhang DE.
|
| Blood 119(21):4953-62. doi: 10.1182/blood-2011-04-347476. Epub 2012 Apr 12.
2012
|
| 31 | RUNX1, RUNX1T1
|
| RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.
|
| Lam K, Zhang DE.
|
| Front Biosci (Landmark Ed) 17:1120-39. Review.
2012
|
| 32 | KDM1A, MYEF2, RUNX1
|
| A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
|
| van Riel B, Pakozdi T, Brouwer R, Monteiro R, Tuladhar K, Franke V, Bryne JC, Jorna R, Rijkers EJ, van Ijcken W, Andrieu-Soler C, Demmers J, Patient R, Soler E, Lenhard B, Grosveld F.
|
| Mol Cell Biol 32(19):3814-22. doi: 10.1128/MCB.05938-11. Epub 2012 Jul 16.
2012
|
| 33 | DEL21Q22, RUNX1
|
| De Novo 21q22.1q22.2 deletion including RUNX1 mimicking a congenital infection.
|
| Thevenon J, Callier P, Thauvin-Robinet C, Mejean N, Falcon-Eicher S, Maynadie M, de Maistre E, Bidot S, Huet F, Beri-Dexheimer M, Jonveaux P, Mugneret F, Faivre L.
|
| Am J Med Genet A 155(1):126-9. doi: 10.1002/ajmg.a.33809. No abstract available. PMID: 21204219 2011
|
| 34 | DEL21Q22, RUNX1
|
| Monosomy 21q22.11-q22.13 presenting as a Fanconi anemia phenotype.
|
| Byrd RS, Zwerdling T, Moghaddam B, Pinter JD, Steinfeld MB.
|
| Am J Med Genet A 155(1):120-5. doi: 10.1002/ajmg.a.33801.PMID: 21204218 2011
|
| 35 | ETS1, RUNX1, TAL1
|
| Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.
|
| Palii CG, Perez-Iratxeta C, Yao Z, Cao Y, Dai F, Davison J, Atkins H, Allan D, Dilworth FJ, Gentleman R, Tapscott SJ, Brand M.
|
| EMBO J 30(3):494-509. Epub 2010 Dec 21.
2011
|
| 36 | RUNX1
|
| RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis.
|
| Schnittger S, Dicker F, Kern W, Wendland N, Sundermann J, Alpermann T, Haferlach C, Haferlach T.
|
| Blood 117(8):2348-57. Epub 2010 Dec 9.
2011
|
| 37 | RUNX1
|
| Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments.
|
| Osorio KM, Lilja KC, Tumbar T.
|
| J Cell Biol 193(1):235-50.
2011
|
| 38 | RUNX1, SPI1
|
| RUNX1 regulates corepressor interactions of PU.1.
|
| Hu Z, Gu X, Baraoidan K, Ibanez V, Sharma A, Kadkol S, Munker R, Ackerman S, Nucifora G, Saunthararajah Y.
|
| Blood 117(24):6498-508. Epub 2011 Apr 25.
2011
|
| 39 | RUNX1, SMAD6
|
| A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
|
| Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich N, Groner Y, de Bruijn M, Göttgens B, Pimanda JE.
|
| Mol Cell Biol 31(14):2817-26. Epub 2011 May 16.
2011
|
| 40 | CCNA1, RUNX1, SERPINB13
|
| SERPINB13 is a novel RUNX1 target gene.
|
| Boyapati A, Ren B, Zhang DE.
|
| Biochem Biophys Res Commun 411(1):115-20. Epub 2011 Jun 23.
2011
|
| 41 | C16orf54, RUNX1
|
| Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development.
|
| Ferreras C, Lancrin C, Lie-A-Ling M, Kouskoff V, Lacaud G.
|
| Blood 118(3):594-7. Epub 2011 Apr 15.
2011
|
| 42 | RUNX1
|
| Transcriptional regulation and spatial organisation of the human AML1/RUNX1 gene.
|
| Markova EN, Kantidze OL, Razin SV.
|
| J Cell Biochem 112(8):1997-2005. doi: 10.1002/jcb.23117.
2011
|
| 43 | CD34, RUNX1
|
| RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
|
| Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG.
|
| EMBO J 30(19):4059-70. doi: 10.1038/emboj.2011.285.
2011
|
| 44 | RUNX1, RUNX3
|
| Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein.
|
| Inoue K, Ito Y.
|
| Gene 487(2):151-5. doi: 10.1016/j.gene.2011.05.016. Epub 2011 May 27.
2011
|
| 45 | ETV6, RUNX1
|
| The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression.
|
| Fuka G, Kauer M, Kofler R, Haas OA, Panzer-Grümayer R.
|
| PLoS One 6(10):e26348. doi: 10.1371/journal.pone.0026348. Epub 2011 Oct 20.
2011
|
| 46 | RUNX1, RUNX1T1
|
| The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
|
| Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD.
|
| Science 333(6043):765-9. doi: 10.1126/science.1201662. Epub 2011 Jul 14.
2011
|
| 47 | ALOX12, RUNX1
|
| RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency.
|
| Kaur G, Jalagadugula G, Mao G, Rao AK.
|
| Blood 115(15):3128-35. Epub 2010 Feb 24.PMID: 20181616 2010
|
| 48 | RUNX1
|
| Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.
|
| Challen GA, Goodell MA.
|
| Exp Hematol 38(5):403-16. Epub 2010 Mar 3.PMID: 20206228 2010
|
| 49 | DEL21Q22, RUNX1
|
| Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: Report of three patients.
|
| Katzaki E, Morin G, Pollazzon M, Papa FT, Buoni S, Hayek J, Andrieux J, Lecerf L, Popovici C, Receveur A, Mathieu-Dramard M, Renieri A, Mari F, Philip N.
|
| Am J Med Genet A 152A(7):1711-1717. [Epub ahead of print]PMID: 20578134 2010
|
| 50 | CLCA2, RUNX1
|
| CLCA2, a novel RUNX1 partner gene in a therapy-related leukemia with t(1;21)(p22;q22).
|
| Gigučre A, Hébert J.
|
| Cancer Genet Cytogenet 202(2):94-100. doi: 10.1016/j.cancergencyto.2010.07.116.
2010
|
| 51 | RUNX1
|
| Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.
|
| Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA.
|
| Nature 457(7231):887-91. Epub 2009 Jan 7.
2009
|
| 52 | RUNX1, RUNX1T1
|
| RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress.
|
| Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC.
|
| Oncogene 28(27):2502-12. Epub 2009 May 18. 2009
|
| 53 | RUNX1, RUNX3
|
| RUNX3-mediated repression of RUNX1 in B cells.
|
| Brady G, Farrell PJ.
|
| J Cell Physiol 221(2):283-7. Review.
2009
|
| 54 | RUNX1, RUNX1T1
|
| Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery.
|
| Guo C, Hu Q, Yan C, Zhang J.
|
| Mol Cell Biol 29(10):2644-57. Epub 2009 Mar 16.PMID: 19289505 2009
|
| 55 | RUNX1, RUNX1T1, TCF12
|
| Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
|
| Park S, Chen W, Cierpicki T, Tonelli M, Cai X, Speck NA, Bushweller JH.
|
| Blood 113(15):3558-67. Epub 2009 Feb 9.PMID: 19204326 2009
|
| 56 | LPXN, RUNX1
|
| LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.
|
| Dai HP, Xue YQ, Zhou JW, Li AP, Wu YF, Pan JL, Wang Y, Zhang J.
|
| Genes Chromosomes Cancer 48(12):1027-36.PMID: 19760607 2009
|
| 57 | DEL21Q22, RUNX1
|
| Clinical phenotype of germline RUNX1 haploinsufficiency: from point mutations to large genomic deletions.
|
| Béri-Dexheimer M, Latger-Cannard V, Philippe C, Bonnet C, Chambon P, Roth V, Grégoire MJ, Bordigoni P, Lecompte T, Leheup B, Jonveaux P.
|
| Eur J Hum Genet 16(8):1014-8. Epub 2008 May 14. 2008
|
| 58 | FPDAML, RUNX1
|
| Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy (FPD/AML).
|
| Owen CJ, Toze CL, Koochin A, Forrest DL, Smith CA, Stevens JM, Jackson SC, Poon MC, Sinclair GD, Leber B, Johnson PR, Macheta A, Yin JA, Barnett MJ, Lister TA, Fitzgibbon J.
|
| Blood lood. 2008 Aug 21. [Epub ahead of print]
2008
|
| 59 | CLIC6, DEL21Q22, DSCR, FPDAML, KCNE1, RUNX1
|
| Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q.
|
| Shinawi M, Erez A, Shardy DL, Lee B, Naeem R, Weissenberger G, Chinault AC, Cheung SW, Plon SE.
|
| Blood 112(4):1042-7. Epub 2008 May 16. 2008
|
| 60 | AML1, FPDAML, RUNX1
|
| Integrative analysis of RUNX1 downstream pathways and target genes.
|
| Michaud J, Simpson KM, Escher R, Buchet-Poyau K, Beissbarth T, Carmichael C, Ritchie ME, Schütz F, Cannon P, Liu M, Shen X, Ito Y, Raskind WH, Horwitz MS, Osato M, Turner DR, Speed TP, Kavallaris M, Smyth GK, Scott HS.
|
| BMC Genomics 9:363. 2008
|
| 61 | MPL, RUNX1
|
| AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells.
|
| Satoh Y, Matsumura I, Tanaka H, Ezoe S, Fukushima K, Tokunaga M, Yasumi M, Shibayama H, Mizuki M, Era T, Okuda T, Kanakura Y.
|
| J Biol Chem 283(44):30045-56. Epub 2008 Aug 7.
2008
|
| 62 | ETV6, RUNX1, TBLX1R1
|
| The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1.
|
| Parker H, An Q, Barber K, Case M, Davies T, Konn Z, Stewart A, Wright S, Griffiths M, Ross FM, Moorman AV, Hall AG, Irving JA, Harrison CJ, Strefford JC.
|
| Genes Chromosomes Cancer 47(12):1118-25.
2008
|
| 63 | PRMT1, RUNX1, SIN3A
|
| Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.
|
| Zhao X, Jankovic V, Gural A, Huang G, Pardanani A, Menendez S, Zhang J, Dunne R, Xiao A, Erdjument-Bromage H, Allis CD, Tempst P, Nimer SD.
|
| Genes Dev 22(5):640-53.
2008
|
| 64 | RBPJ, RUNX1, RUNX1T1, SPEN
|
| ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
|
| Salat D, Liefke R, Wiedenmann J, Borggrefe T, Oswald F.
|
| Mol Cell Biol 28(10):3502-12. Epub 2008 Mar 10.
2008
|
| 65 | RUNX1, RUNX1T1, TCF12
|
| AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.
|
| Gardini A, Cesaroni M, Luzi L, Okumura AJ, Biggs JR, Minardi SP, Venturini E, Zhang DE, Pelicci PG, Alcalay M.
|
| PLoS Genet 4(11):e1000275. Epub 2008 Nov 28.PMID: 19043539 2008
|
| 66 | RUNX1, RUNX1T1
|
| AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain.
|
| Wei H, Liu X, Xiong X, Wang Y, Rao Q, Wang M, Wang J.
|
| FEBS Lett 582(15):2167-72. Epub 2008 Jun 2.PMID: 18519037 2008
|
| 67 | FPDAML, RUNX1
|
| A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies.
|
| Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N.
|
| Haematologica 93(1):155-6.PMID: 18166807 2008
|
| 68 | AFF3, RUNX1
|
| Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA.
|
| Chinen Y, Taki T, Nishida K, Shimizu D, Okuda T, Yoshida N, Kobayashi C, Koike K, Tsuchida M, Hayashi Y, Taniwaki M.
|
| Oncogene 27(15):2249-56. Epub 2007 Oct 29.PMID: 17968322 2008
|
| 69 | RUNX1, USP16
|
| Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.
|
| Gelsi-Boyer V, Trouplin V, Adélaďde J, Aceto N, Remy V, Pinson S, Houdayer C, Arnoulet C, Sainty D, Bentires-Alj M, Olschwang S, Vey N, Mozziconacci MJ, Birnbaum D, Chaffanet M.
|
| BMC Cancer 8:299.PMID: 18925961 2008
|
| 70 | RUNX1, RUNX2, RUNX3, STAT5B
|
| Physical and functional interactions between STAT5 and Runx transcription factors.
|
| Ogawa S, Satake M, Ikuta K.
|
| J Biochem 143(5):695-709. Epub 2008 Feb 22.PMID: 18296717 2008
|
| 71 | MECOM, RUNX1
|
| Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
|
| Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
|
| Cell Stem Cell 3(2):207-20.
2008
|
| 72 | RUNX1, RUNX2, CCD, FPDAML
|
| Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.
|
| Matheny CJ, Speck ME, Cushing PR, Zhou Y, Corpora T, Regan M, Newman M, Roudaia L, Speck CL, Gu TL, Griffey SM, Bushweller JH, Speck NA.
|
| EMBO J 26(4):1163-75. Epub 2007 Feb 8. 2007
|
| 73 | RUNX1
|
| Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome.
|
| Agerstam H, Lilljebjrn H, Lassen C, Swedin A, Richter J, Vandenberghe P, Johansson B, Fioretos T.
|
| Genes Chromosomes Cancer 46(7):635-43. 2007
|
| 74 | RUNX1, THOC4
|
| ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.
|
| Mertz JA, Kobayashi R, Dudley JP.
|
| J Virol 81(7):3503-13. Epub 2007 Jan 17.
2007
|
| 75 | RUNX1
|
| Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions.
|
| Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, Mills GB.
|
| Oncogene 26(18):2574-84. Epub 2006 Oct 30.
2007
|
| 76 | MECOM, RUNX1
|
| Repression of RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis.
|
| Senyuk V, Sinha KK, Li D, Rinaldi CR, Yanamandra S, Nucifora G.
|
| Cancer Res 67(12):5658-66. 2007
|
| 77 | MACROD1, RUNX1
|
| LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).
|
| Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.
|
| Eur J Haematol 79(1):25-31. Epub 2007 May 28.
2007
|
| 78 | RUNX1, RUNX2, RUNX3
|
| Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.
|
| Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.
|
| J Bone Miner Res 22(8):1260-70.
2007
|
| 79 | PRDM16, RUNX1
|
| Identification of truncated RUNX1 and RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive therapy-related AML.
|
| Stevens-Kroef MJ, Schoenmakers EF, van Kraaij M, Huys E, Vermeulen S, van der Reijden B, van Kessel AG.
|
| Leukemia 20(6):1187-9. No abstract available.
2006
|
| 80 | RPTOR, RUNX1
|
| Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage.
|
| Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, Elder JT.
|
| J Med Genet 43(1):12-7. Epub 2005 May 27. 2006
|
| 81 | GATA1, BACH1, SON, GABPA, C21orf66, RUNX1
|
| Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
|
| Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cave H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, Zwaan CM, Golub TR, Orkin SH.
|
| Proc Natl Acad Sci U S A 103(9):3339-44. Epub 2006 Feb 21. 2006
|
| 82 | RUNX1, RUNX1T1
|
| A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis.
|
| Yan M, Kanbe E, Peterson LF, Boyapati A, Miao Y, Wang Y, Chen IM, Chen Z, Rowley JD, Willman CL, Zhang DE.
|
| Nat Med 12(8):945-9. Epub 2006 Jul 30. 2006
|
| 83 | RUNX1, YTHDF2, ZNF687, SH3D19
|
| Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia.
|
| Nguyen TT, Ma LN, Slovak ML, Bangs CD, Cherry AM, Arber DA.
|
| Genes Chromosomes Cancer 45(10):918-32. 2006
|
| 84 | RUNX1, PRDM16
|
| Overexpression of PRDM16 in the presence and absence of the RUNX1/PRDM16 fusion gene in myeloid leukemias.
|
| Hazourli S, Chagnon P, Sauvageau M, Fetni R, Busque L, Hebert J.
|
| Genes Chromosomes Cancer 45(11):1072-6. No abstract available. 2006
|
| 85 | NTRK1, RUNX1T1, RUNX1
|
| AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.
|
| Mulloy JC, Jankovic V, Wunderlich M, Delwel R, Cammenga J, Krejci O, Zhao H, Valk PJ, Lowenberg B, Nimer SD.
|
| Proc Natl Acad Sci U S A 102(11):4016-21. Epub 2005 Feb 24. 2005
|
| 86 | RUNX1, RUNX1T1
|
| MYND-less splice variants of AML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21).
|
| Kozu T, Fukuyama T, Yamami T, Akagi K, Kaneko Y.
|
| Genes Chromosomes Cancer 43(1):45-53. 2005
|
| 87 | RUNX1, PRDM16
|
| Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22).
|
| Sakai I, Tamura T, Narumi H, Uchida N, Yakushijin Y, Hato T, Fujita S, Yasukawa M.
|
| Genes Chromosomes Cancer 44(3):265-70. 2005
|
| 88 | RUNX1
|
| Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia.
|
| Steensma DP, Gibbons RJ, Mesa RA, Tefferi A, Higgs DR.
|
| Eur J Haematol 74(1):47-53. 2005
|
| 89 | ZFPM2, CTBP1, RUNX1
|
| AML1-FOG2 fusion protein in myelodysplasia.
|
| Chan EM, Comer EM, Brown FC, Richkind KE, Holmes ML, Chong BH, Shiffman R, Zhang DE, Slovak ML, Willman CL, Noguchi CT, Li Y, Heiber DJ, Kwan L, Chan RJ, Vance GH, Ramsey HC, Hromas RA.
|
| Blood 105(11):4523-6. Epub 2005 Feb 10. 2005
|
| 90 | AML1, RUNX1
|
| Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.
|
| Osato M.
|
| Oncogene 23(24):4284-96. Review.
2004
|
| 91 | AML1, FPDAML, RUNX1
|
| Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia.
|
| Ganly P, Walker LC, Morris CM.
|
| Leuk Lymphoma 45(1):1-10. Review. 2004
|
| 92 | RUNX1
|
| AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.
|
| Ichikawa M, Asai T, Saito T, Yamamoto G, Seo S, Yamazaki I, Yamagata T, Mitani K, Chiba S, Hirai H, Ogawa S, Kurokawa M.
|
| Nat Med 10(3):299-304. Epub 2004 Feb 15. 2004
|
| 93 | RUNX1
|
| AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.
|
| Theriault FM, Roy P, Stifani S.
|
| Proc Natl Acad Sci U S A 101(28):10343-8. Epub 2004 Jul 06. 2004
|
| 94 | PRDX4, RUNX1
|
| PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22).
|
| Zhang Y, Emmanuel N, Kamboj G, Chen J, Shurafa M, Van Dyke DL, Wiktor A, Rowley JD.
|
| Genes Chromosomes Cancer 40(4):365-70. 2004
|
| 95 | CEBPA, MDS1, MECOM, RUNX1
|
| The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin.
|
| Helbling D, Mueller BU, Timchenko NA, Hagemeijer A, Jotterand M, Meyer-Monard S, Lister A, Rowley JD, Huegli B, Fey MF, Pabst T.
|
| Proc Natl Acad Sci U S A 101(36):13312-7. Epub 2004 Aug 23. 2004
|
| 96 | BRCA1H, FGA7, RUNX1
|
| A novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acute lymphoblastic leukemia.
|
| Mikhail FM, Coignet L, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Farahat N, Ncifora G.
|
| Genes Chromosomes Cancer 39(2):110-8. 2004
|
| 97 | LAT2, RUNX1, RUNX1T1
|
| Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.
|
| Fliegauf M, Stock M, Berg T, Lübbert M.
|
| Oncogene 23(56):9070-81.
2004
|
| 98 | SLC22A4, RUNX1
|
| An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
|
| Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K.
|
| Nat Genet 35(4):341-8. Epub 2003 Nov 09. 2003
|
| 99 | SLC9A3R1, RUNX1, NAT9
|
| A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis.
|
| Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM.
|
| Nat Genet 35(4):349-56. Epub 2003 Nov 09. 2003
|
| 100 | RUNX1
|
| Identification of RUNX1/AML1 as a classical tumor suppressor gene.
|
| Silva FP, Morolli B, Storlazzi CT, Anelli L, Wessels H, Bezrookove V, Kluin-Nelemans HC, Giphart-Gassler M.
|
| Oncogene 22(4):538-47. 2003
|
| 101 | LGALS3, RUNX1, RUNX2, RUNX3
|
| Expression of galectin-3 in skeletal tissues is controlled by Runx2.
|
| Stock M, Schafer H, Stricker S, Gross G, Mundlos S, Otto F.
|
| J Biol Chem 278(19):17360-7. Epub 2003 Feb 25. 2003
|
| 102 | ETV6, RUNX1
|
| A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001).
|
| Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Le Calvez G, Marion V, Abgrall JF, Berthou C, De Braekeleer M.
|
| Cancer Genet Cytogenet 144(2):143-7. 2003
|
| 103 | RUNX1
|
| Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.
|
| Langabeer SE, Gale RE, Rollinson SJ, Morgan GJ, Linch DC.
|
| Genes Chromosomes Cancer 34(1):24-32. 2002
|
| 104 | RUNX1, RUNX3
|
| Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development.
|
| Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR.
|
| Cell 111(5):621-33. 2002
|
| 105 | RUNX1, RUNX1T1
|
| t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia.
|
| Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, Yamauchi K, Kitano K, Kiyosawa K.
|
| Cancer Genet Cytogenet 132(2):133-5. 2002
|
| 106 | RUNX1
|
| Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 gene mutation.
|
| Penther D, Preudhomme C, Talmant P, Roumier C, Godon A, Mechinaud F, Milpied N, Bataille R, Avet-Loiseau H.
|
| Leukemia 16(6):1131-4. 2002
|
| 107 | RUNX1, FPDAML
|
| A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia.
|
| Walker LC, Stevens J, Campbell H, Corbett R, Spearing R, Heaton D, Macdonald DH, Morris CM, Ganly P.
|
| Br J Haematol 117(4):878-81. 2002
|
| 108 | RUNX1
|
| A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia.
|
| Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G.
|
| Cancer Genet Cytogenet 135(1):96-100. 2002
|
| 109 | RUNX1, TWIST1
|
| TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts.
|
| Yousfi M, Lasmoles F, Marie PJ.
|
| Biochem Biophys Res Commun 297(3):641-4. Erratum in: Biochem Biophys Res Commun. 2003 May 23;305(1):209. 2002
|
| 110 | RUNX1
|
| Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.
|
| Tahirov TH, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K.
|
| Cell 104(5):755-67. 2001
|
| 111 | RUNX1
|
| Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21.
|
| Streubel B, Valent P, Lechner K, Fonatsch C.
|
| Cancer Genet Cytogenet 124(1):42-6. 2001
|
| 112 | KAT6A, RUNX1
|
| Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.
|
| Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A, Ohki M.
|
| EMBO J 20(24):7184-96. 2001
|
| 113 | RUNX1
|
| Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1.
|
| Levanon D, Glusman G, Bangsow T, Ben-Asher E, Male DA, Avidan N, Bangsow C, Hattori M, Taylor TD, Taudien S, Blechschmidt K, Shimizu N, Rosenthal A, Sakaki Y, Lancet D, Groner Y.
|
| Gene 262(1-2):23-33. 2001
|
| 114 | RUNX1T1, RUNX1
|
| Molecular characterization of genomic AML1-ETO fusions in childhood leukemia.
|
| Xiao Z, Greaves MF, Buffler P, Smith MT, Segal MR, Dicks BM, Wiencke JK, Wiemels JL.
|
| Leukemia 15(12):1906-13. 2001
|
| 115 | KMT2A, RUNX1
|
| Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
|
| Mathew S, Head D, Rubnitz JE, Raimondi SC.
|
| Genes Chromosomes Cancer 28(2):227-32. 2000
|
| 116 | ETV6, RUNX1
|
| Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia.
|
| Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M.
|
| Genes Chromosomes Cancer 29(3):219-28. 2000
|
| 117 | RUNX1
|
| Low BCL-2 expression in acute leukemia with t(8;21) chromosomal abnormality.
|
| Shikami M, et al.
|
| Leukemia 13(3):358-68. 1999
|
| 118 | RUNX1
|
| Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.
|
| Osato M, et al.
|
| Blood 93(6):1817-24. 1999
|
| 119 | RUNX1
|
| Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.
|
| Mao S, et al.
|
| Mol Cell Biol 19(5):3635-44. 1999
|
| 120 | RUNX1, FPDAML
|
| Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
|
| Song WJ, et al.
|
| Nat Genet 23(2):166-75 1999
|
| 121 | RUNX1, RUNX2, RUNX3
|
| Runt domains take the lead in hematopoiesis and osteogenesis.
|
| Werner MH, Shigesada K, Ito Y.
|
| Nat Med 5(12):1356-7. No abstract available 1999
|
| 122 | CBFA2T3, CORO1A, EVI14, EVI15, EVI18, EVI21, HMGCR, IL17RB, RARG, RASGRP2, RUNX1, SETD1B, SOX4, ZFP36
|
| Leukaemia disease genes: large-scale cloning and pathway predictions.
|
| Li J, Shen H, Himmel KL, Dupuy AJ, Largaespada DA, Nakamura T, Shaughnessy JD Jr, Jenkins NA, Copeland NG.
|
| Nat Genet 23(3):348-53 1999
|
| 123 | RUNX1
|
| Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase.
|
| Kojima K, Yasukawa M, Ishimaru F, Dansako H, Matsuo Y, Kimura Y, Nawa Y, Hara M, Harada M.
|
| Br J Haematol 106(3):720-2 1999
|
| 124 | CR1, RUNX1
|
| AML1, the target of chromosomal rearrangements in human leukemia, regulates the expression of human complement receptor type 1 (CR1) gene.
|
| Kim JH, Lee S, Rho JK, Choe SY.
|
| Int J Biochem Cell Biol 31(9):933-40. 1999
|
| 125 | RUNX1
|
| Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains.
|
| Zeng C, et al.
|
| Proc Natl Acad Sci U S A 95 : 1585-1589. 1998
|
| 126 | ETV6, RUNX1
|
| Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.
|
| Ford AM, et al.
|
| Proc Natl Acad Sci U S A 95 : 4584-4588. 1998
|
| 127 | AML1, RUNX1, RUNX1T1
|
| Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia.
|
| Le XF, et al.
|
| Eur J Haematol 60 : 217-225. 1998
|
| 128 | RUNX1
|
| CBFA2 (AML1) translocations with novel partner chromosomes in myeloid leukemias : association with prior therapy.
|
| Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD.
|
| Blood 92 : 2879-2885. 1998
|
| 129 | RUNX1, TLE1
|
| TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation.
|
| Imai Y, et al.
|
| Biochem Biophys Res Commun 252 : 582-589. 1998
|
| 130 | AML1, RUNX1, RUNX1T1
|
| Structure and expression of the human MTG8/ETO gene.
|
| Wolford JK, Prochazka M.
|
| Gene 212(1):103-9. 1998
|
| 131 | RUNX1
|
| Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors.
|
| Zeng C, et al.
|
| Proc Natl Acad Sci U S A 94 : 6746-6751. 1997
|
| 132 | AML1, RUNX1
|
| The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.
|
| Zent CS, et al.
|
| Proc Natl Acad Sci U S A 93 : 1044-1048. 1996
|
| 133 | ETV6, RUNX1, TSG12B
|
| The 12;21 translocation involving TEL and deletion of the other TEL allele : two frequently associated alterations found in childhood acute lymphoblastic leukemia.
|
| Raynaud S, et al.
|
| Blood 87 : 2891-2899. 1996
|
| 134 | AML1, RUNX1, ETV6
|
| TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
|
| Kim DH, et al.
|
| Blood 88 : 785-794. 1996
|
| 135 | AML1, RUNX1, ETV6
|
| Correlation between the ETV6/CBFA2 (TEL/AMLI) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia.
|
| Fears S, et al.
|
| Genes Chromosomes Cancer 17 : 127-135. 1996
|
| 136 | BCL2, RUNX1, RUNX1T1
|
| The AML1/ETO fusion protein activates transcription of BCL-2.
|
| Klampfer L, et al.
|
| Proc Natl Acad Sci U S A 93 : 14059-14064. 1996
|
| 137 | ETV6, RUNX1
|
| TEL-AML1 fusion in acute lymphoblastic leukaemia of adults.
|
| Aguiar RCT, et al.
|
| Br J Haematol 95 : 673-677. 1996
|
| 138 | ETV6, RUNX1
|
| TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia.
|
| McLean TW, et al.
|
| Blood 88 : 4252-4258. 1996
|
| 139 | EVI1, MDS1, MECOM, RUNX1
|
| Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.
|
| Fears S, et al.
|
| Proc Natl Acad Sci U S A 93 : 1642-1647. 1996
|
| 140 | AML1, RUNX1, RUNX1T1
|
| Functional domains of the t(8;21) fusion protein, AML-1/ETO.
|
| Lenny N, Meyers S, Hiebert SW.
|
| Oncogene 11 : 1761-1769. 1995
|
| 141 | AML1, RUNX1, RUNX1T1
|
| The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B.
|
| Frank R, et al.
|
| Oncogene 11 : 2667-2674. 1995
|
| 142 | CBFB, RUNX1
|
| Structure of the leukemia-associated human CBFB gene.
|
| Hajra A, et al.
|
| Genomics 26 : 571-579. 1995
|
| 143 | AML1, RUNX1, ETV6
|
| Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
|
| Golub TR, et al.
|
| Proc Natl Acad Sci U S A 92 : 4917-4921. 1995
|
| 144 | ETV6, RUNX1
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| High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
|
| Romana SP, et al.
|
| Blood 86 : 4263-4269. 1995
|
| 145 | RUNX1, AML1
|
| Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.
|
| Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T, Yokoyama K, Soeda E, Ohki M.
|
| Nucleic Acids Res 23(14):2762-9. 1995
|
| 146 | EVI1, MECOM, RUNX1
|
| Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.
|
| Mitani K, et al.
|
| EMBO J 13 : 504-510. 1994
|
| 147 | EVI1, MDS1, MECOM, RPL22P1, RUNX1
|
| Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.
|
| Nucifora G, et al.
|
| Proc Natl Acad Sci U S A 91 : 4004-4008. 1994
|
| 148 | AML1, AMLT2, AMLT3, RUNX2, RUNX1, RUNX3
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| AML1, AML2, and AML3, the human members of the runt domain gene-family : cDNA structure, expression, and chromosomal localization.
|
| Levanon D, et al.
|
| Genomics 23 : 425-432. 1994
|
| 149 | RUNX1
|
| AML1 fusion transcripts in t(3;21) positive leukemia : evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.
|
| Sacchi N, et al.
|
| Genes Chromosomes Cancer 11 : 226-236. 1994
|
| 150 | AML1, RUNX1, RUNX1T1
|
| Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia.
|
| Nucifora G, et al.
|
| Blood 81 : 883-888. 1993
|
| 151 | CBFB, RUNX1
|
| PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.
|
| Ogawa E, et al.
|
| Proc Natl Acad Sci U S A 90 : 6859-6863. 1993
|
| 152 | AML1, RUNX1, RUNX1T1
|
| The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
|
| Miyoshi H, et al.
|
| EMBO J 12 : 2715-2721. 1993
|
| 153 | RUNX1
|
| An EcoRI polymorphism in the AML1 gene.
|
| Birn DJ, et al.
|
| Hum Mol Genet 2 : 1084. 1993
|
| 154 | AML1, RUNX1, RUNX1T1
|
| An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation.
|
| Downing JR, et al.
|
| Blood 11 : 2860-2865. 1993
|
| 155 | AML1, RUNX1, RUNX1T1
|
| Translocation breakpoints are clustered on both chromosome 8 and chromosome21 in the t(8;21) of acute myeloid leukemia.
|
| Tighe JE, et al.
|
| Blood 81 : 592-596. 1993
|
| 156 | AML1, RPL22P1, RUNX1
|
| The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER1.
|
| Nucifora G, et al.
|
| Proc Natl Acad Sci U S A 90 : 7784-7788. 1993
|
| 157 | AML1, RUNX1, RUNX1T1
|
| Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.
|
| Kozu T, et al.
|
| Blood 82 : 1270-1276. 1993
|
| 158 | AML1, RUNX1, RUNX1T1
|
| Molecular analysis of 12 patients with the t(8;21) translocation and M2 acute myelogenous leukemia.
|
| Yaspo ML, et al.
|
| Genes Chromosomes Cancer 5 : 166-177. 1992
|
| 159 | RUNX1
|
| Linkage mapping of the AML1 gene on human chromosome 21 using a DNA polymorphism in the 3' untranslated region.
|
| Avramopoulos D, et al.
|
| Genomics 14 : 506-507. 1992
|
| 160 | AML1, RUNX1, RUNX1T1
|
| Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
|
| Erickson P, et al.
|
| Blood 80 : 1825-1831. 1992
|
| 161 | AML1, RUNX1, RUNX1T1
|
| Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.
|
| Shimizu K, et al.
|
| Cancer Res 52 : 6945-6948. 1992
|
| 162 | AML1, RUNX1, RUNX1T1
|
| Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in the t(8;21) leukemic cells.
|
| Nisson PE, et al.
|
| Cancer Genet Cytogenet 63 : 81-88. 1992
|
| 163 | AML1, CD19, RUNX1, RUNX1T1
|
| Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality : frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34.
|
| Kita K, et al.
|
| Blood 80 : 470-477. 1992
|
| 164 | AML1, RUNX1, RUNX1T1
|
| t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
|
| Miyoshi H, et al.
|
| Proc Natl Acad Sci U S A 88 : 10431-10434. 1991
|
| 165 | AML1, RUNX1, RUNX1T1
|
| Molecular assignment of a translocation breakpoint in acute myeloid leukemia with t(8;21).
|
| Shimizu K, et al.
|
| Genes Chromosomes Cancer 3 : 163-167. 1991
|