Citations for
1LGR6, RSPO1, RSPO2, RSPO3, RSPO4
LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.2020
Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J.
J Clin Lab Anal. Apr;34(4):e23121. doi: 10.1002/jcla.23121. Epub 2020 Jan 9 2021
2LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.
Proc Natl Acad Sci U S A 108(28):11452-7. Epub 2011 Jun 21. 2011
3LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
Nature 476(7360):293-7. doi: 10.1038/nature10337. 2011
4RSPO1, RSPO2, RSPO3, RSPO4
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
Cell Signal ell Signal. 2009 Feb 6. [Epub ahead of print] 2009
5RSPO1, RSPO2, RSPO3, RSPO4
R-Spondin family members regulate the Wnt pathway by a common mechanism.
Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A.
Mol Biol Cell 19(6):2588-96. Epub 2008 Apr 9. 2008
6ANYC, RSPO4
A novel missense mutation in RSPO4 gene underlies autosomal recessive congenital anonychia in a consanguineous Pakistani family.
Chishti MS, Kausar N, Rafiq MA, Amin M, Ahmad W.
Br J Dermatol 158(3):621-3. Epub 2007 Dec 6. No abstract available. 2008
7ANYC, RSPO4
Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia.
Ishii Y, Wajid M, Bazzi H, Fantauzzo KA, Barber AG, Blaydon DC, Nam JS, Yoon JK, Kelsell DP, Christiano AM.
J Invest Dermatol 128(4):867-70. Epub 2007 Sep 6. 2008
8ANYC, RSPO4
RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4.
Brüchle NO, Frank J, Frank V, Senderek J, Akar A, Koc E, Rigopoulos D, van Steensel M, Zerres K, Bergmann C.
J Invest Dermatol 128(4):791-6. Epub 2007 Oct 4.PMID: 17914448 [ 2008
9RSPO4, ANYC
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh MT, Ruschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, Watson R, de Berker D, Wajid M, Christiano AM, Kelsell DP.
Nat Genet 38(11):1245-7. Epub 2006 Oct 15. 2006
10RSPO4, ANYC, DBA3, RPS24
Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia.
Gazda HT, Grabowska A, Merida-Long LB, Latawiec E, Schneider HE, Lipton JM, Vlachos A, Atsidaftos E, Ball SE, Orfali KA, Niewiadomska E, Da Costa L, Tchernia G, Niemeyer C, Meerpohl JJ, Stahl J, Schratt G, Glader B, Backer K, Wong C, Nathan DG, Beggs AH, Sieff CA.
Am J Hum Genet 79(6):1110-8. Epub 2006 Nov 2. 2006
11RSPO1, RSPO2, RSPO3, RSPO4
R-Spondin proteins: a novel link to beta-catenin activation.
Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
Cell Cycle 5(1):23-6. Epub 2006 Jan 8. 2006
12ANYC, RSPO4
Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia.
Bergmann C, Senderek J, Anhuf D, Thiel CT, Ekici AB, Poblete-Gutierrez P, van Steensel M, Seelow D, Nürnberg G, Schild HH, Nürnberg P, Reis A, Frank J, Zerres K.
Am J Hum Genet 79(6):1105-9. Epub 2006 Oct 17. 2006
13RSPO2, RSPO4
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W.
Dev Cell 7(4):525-34. 2004