| 1 | RSPO3
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| R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
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| Ter Steege EJ, Doornbos LW, Haughton PD, van Diest PJ, Hilkens J, Derksen PWB, Bakker ERM.
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| Cancer Lett. Aug 1;568:216301. doi: 10.1016/j.canlet.2023.216301. Epub 2023 Jul 3. 2023
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| 2 | RSPO3
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| RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes
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| Takahashi T, Li Y, Chen W, Nyasha MR, Ogawa K, Suzuki K, Koide M, Hagiwara Y, Itoi E, Aizawa T, Tsuchiya M, Suzuki N, Aoki M, Kanzaki M.
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| Sci Rep. Aug 22;12(1):14291. doi: 10.1038/s41598-022-18190-z 2022
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| 3 | LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.2020
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| Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J.
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| J Clin Lab Anal. Apr;34(4):e23121. doi: 10.1002/jcla.23121. Epub 2020 Jan 9 2021
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| 4 | RSPO3
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| RSPO3 is important for trabecular bone and fracture risk in mice and humans
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| Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C
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| Nat Commun. Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. 2021
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| 5 | RSPO3
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| RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
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| Loh NY, Minchin JEN, Pinnick KE, Verma M, Todorčević M, Denton N, Moustafa JE, Kemp JP, Gregson CL, Evans DM, Neville MJ, Small KS, McCarthy MI, Mahajan A, Rawls JF, Karpe F, Christodoulides C.
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| Nat Commun. Jun 3;11(1):2797. doi: 10.1038/s41467-020-16592-z. 2020
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| 6 | IL1B, RSPO3
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| RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
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| Skaria T, Bachli E, Schoedon G.
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| Mol Med. Aug 29;24(1):45. doi: 10.1186/s10020-018-0048-z. 2018
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| 7 | RSPO3
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| RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.
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| Hilkens J, Timmer NC, Boer M, Ikink GJ, Schewe M, Sacchetti A, Koppens MAJ, Song JY, Bakker ERM.
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| Gut. Jun;66(6):1095-1105. doi: 10.1136/gutjnl-2016-311606. Epub 2016 Aug 10. 2017
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| 8 | RSPO3
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| C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells.
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| Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N, Simizu S.
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| FEBS Lett. Aug;590(16):2639-49. doi: 10.1002/1873-3468.12274. Epub 2016 Jul 13. 2016
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| 9 | RSPO3
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| The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation
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| Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A.
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| Cell Rep. Dec 1;13(9):1757-64. doi: 10.1016/j.celrep.2015.10.049. Epub 2015 Nov 19. 2015
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| 10 | LGR4, RSPO1, RSPO3
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| LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats
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| Li JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland MW.
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| Endocrinology. Feb;155(2):429-40. doi: 10.1210/en.2013-1550. Epub 2013 Nov 26. P 2014
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| 11 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
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| Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.
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| Proc Natl Acad Sci U S A 108(28):11452-7. Epub 2011 Jun 21.
2011
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| 12 | RSPO3, SDC4
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| Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
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| Ohkawara B, Glinka A, Niehrs C.
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| Dev Cell 20(3):303-14.
2011
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| 13 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
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| de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
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| Nature 476(7360):293-7. doi: 10.1038/nature10337.
2011
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| 14 | RSPO1, RSPO2, RSPO3, RSPO4
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| Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
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| Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
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| Cell Signal ell Signal. 2009 Feb 6. [Epub ahead of print]
2009
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| 15 | RSPO1, RSPO2, RSPO3, RSPO4
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| R-Spondin family members regulate the Wnt pathway by a common mechanism.
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| Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A.
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| Mol Biol Cell 19(6):2588-96. Epub 2008 Apr 9.
2008
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| 16 | RSPO3
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| The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
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| Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C.
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| Development 135(22):3655-64. Epub 2008 Oct 8.
2008
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| 17 | RSPO3
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| MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.
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| Theodorou V, Kimm MA, Boer M, Wessels L, Theelen W, Jonkers J, Hilkens J.
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| Nat Genet 39(6):759-69. Epub 2007 Apr 29. 2007
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| 18 | RSPO1, RSPO2, RSPO3, RSPO4
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| R-Spondin proteins: a novel link to beta-catenin activation.
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| Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
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| Cell Cycle 5(1):23-6. Epub 2006 Jan 8.
2006
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| 19 | RSPO3, THBS1
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| A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats.
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| Hannah BL, Misenheimer TM, Annis DS, Mosher DF.
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| J Biol Chem 278(11):8929-34. 2003
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| 20 | RSPO3
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| Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR.
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| Chen JZ, Wang S, Tang R, Yang QS, Zhao E, Chao Y, Ying K, Xie Y, Mao YM.
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| Mol Biol Rep 29(3):287-92. 2002
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| 21 | RSPO3, ADAMTSL4
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| The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development.
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| Adams JC, Tucker RP.
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| Dev Dyn 218(2):280-99. Review. 2000
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