Citations for
1RSPO3
R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling.
Ter Steege EJ, Doornbos LW, Haughton PD, van Diest PJ, Hilkens J, Derksen PWB, Bakker ERM.
Cancer Lett. Aug 1;568:216301. doi: 10.1016/j.canlet.2023.216301. Epub 2023 Jul 3. 2023
2RSPO3
RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes
Takahashi T, Li Y, Chen W, Nyasha MR, Ogawa K, Suzuki K, Koide M, Hagiwara Y, Itoi E, Aizawa T, Tsuchiya M, Suzuki N, Aoki M, Kanzaki M.
Sci Rep. Aug 22;12(1):14291. doi: 10.1038/s41598-022-18190-z 2022
3LGR6, RSPO1, RSPO2, RSPO3, RSPO4
LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.2020
Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J.
J Clin Lab Anal. Apr;34(4):e23121. doi: 10.1002/jcla.23121. Epub 2020 Jan 9 2021
4RSPO3
RSPO3 is important for trabecular bone and fracture risk in mice and humans
Nilsson KH, Henning P, El Shahawy M, Nethander M, Andersen TL, Ejersted C, Wu J, Gustafsson KL, Koskela A, Tuukkanen J, Souza PPC, Tuckermann J, Lorentzon M, Ruud LE, Lehtimäki T, Tobias JH, Zhou S, Lerner UH, Richards JB, Movérare-Skrtic S, Ohlsson C
Nat Commun. Aug 13;12(1):4923. doi: 10.1038/s41467-021-25124-2. 2021
5RSPO3
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Loh NY, Minchin JEN, Pinnick KE, Verma M, Todorčević M, Denton N, Moustafa JE, Kemp JP, Gregson CL, Evans DM, Neville MJ, Small KS, McCarthy MI, Mahajan A, Rawls JF, Karpe F, Christodoulides C.
Nat Commun. Jun 3;11(1):2797. doi: 10.1038/s41467-020-16592-z. 2020
6IL1B, RSPO3
RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1
Skaria T, Bachli E, Schoedon G.
Mol Med. Aug 29;24(1):45. doi: 10.1186/s10020-018-0048-z. 2018
7RSPO3
RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.
Hilkens J, Timmer NC, Boer M, Ikink GJ, Schewe M, Sacchetti A, Koppens MAJ, Song JY, Bakker ERM.
Gut. Jun;66(6):1095-1105. doi: 10.1136/gutjnl-2016-311606. Epub 2016 Aug 10. 2017
8RSPO3
C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells.
Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N, Simizu S.
FEBS Lett. Aug;590(16):2639-49. doi: 10.1002/1873-3468.12274. Epub 2016 Jul 13. 2016
9RSPO3
The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H, Schedl A.
Cell Rep. Dec 1;13(9):1757-64. doi: 10.1016/j.celrep.2015.10.049. Epub 2015 Nov 19. 2015
10LGR4, RSPO1, RSPO3
LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats
Li JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland MW.
Endocrinology. Feb;155(2):429-40. doi: 10.1210/en.2013-1550. Epub 2013 Nov 26. P 2014
11LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.
Proc Natl Acad Sci U S A 108(28):11452-7. Epub 2011 Jun 21. 2011
12RSPO3, SDC4
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.
Ohkawara B, Glinka A, Niehrs C.
Dev Cell 20(3):303-14. 2011
13LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
Nature 476(7360):293-7. doi: 10.1038/nature10337. 2011
14RSPO1, RSPO2, RSPO3, RSPO4
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
Cell Signal ell Signal. 2009 Feb 6. [Epub ahead of print] 2009
15RSPO1, RSPO2, RSPO3, RSPO4
R-Spondin family members regulate the Wnt pathway by a common mechanism.
Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A.
Mol Biol Cell 19(6):2588-96. Epub 2008 Apr 9. 2008
16RSPO3
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C.
Development 135(22):3655-64. Epub 2008 Oct 8. 2008
17RSPO3
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.
Theodorou V, Kimm MA, Boer M, Wessels L, Theelen W, Jonkers J, Hilkens J.
Nat Genet 39(6):759-69. Epub 2007 Apr 29. 2007
18RSPO1, RSPO2, RSPO3, RSPO4
R-Spondin proteins: a novel link to beta-catenin activation.
Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
Cell Cycle 5(1):23-6. Epub 2006 Jan 8. 2006
19RSPO3, THBS1
A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats.
Hannah BL, Misenheimer TM, Annis DS, Mosher DF.
J Biol Chem 278(11):8929-34. 2003
20RSPO3
Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR.
Chen JZ, Wang S, Tang R, Yang QS, Zhao E, Chao Y, Ying K, Xie Y, Mao YM.
Mol Biol Rep 29(3):287-92. 2002
21RSPO3, ADAMTSL4
The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development.
Adams JC, Tucker RP.
Dev Dyn 218(2):280-99. Review. 2000