| 1 | RSPO2, TCF3
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| Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification.
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| Reis AH, Sokol SY.
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| Sci Rep. Jun 28;11(1):13433. doi: 10.1038/s41598-021-92824-6. 2021
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| 2 | LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.2020
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| Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J.
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| J Clin Lab Anal. Apr;34(4):e23121. doi: 10.1002/jcla.23121. Epub 2020 Jan 9 2021
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| 3 | FGF10, PAPPAS, PTLAH, RSPO2, TBX4
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| Homozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia.
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| Kariminejad A, Szenker-Ravi E, Lekszas C, Tajsharghi H, Moslemi AR, Naert T, Tran HT, Ahangari F, Rajaei M, Nasseri M, Haaf T, Azad A, Superti-Furga A, Maroofian R, Ghaderi-Sohi S, Najmabadi H, Abbaszadegan MR, Vleminckx K, Nikuei P, Reversade B.
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| Am J Hum Genet 105(6):1294-1301. doi: 10.1016/j.ajhg.2019.10.013. Epub 2019 Nov 21.
2019
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| 4 | RNF43, RSPO2, ZNRF3
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| RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
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| Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B.
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| Nature. May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16. Erratum in: Nature. 2018 Sep;561(7722):E7. 2018
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| 5 | RSPO2
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| Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.
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| Nakajima M, Kou I, Ohashi H; Genetic Study Group of the Investigation Committee on the Ossification of Spinal Ligaments, Ikegawa S.
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| Am J Hum Genet 99(1):202-7. doi: 10.1016/j.ajhg.2016.05.018. Epub 2016 Jun 30.
2016
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| 6 | LGR5, RSPO2
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| R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.
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| Nakashima H, Ohkawara B, Ishigaki S, Fukudome T, Ito K, Tsushima M, Konishi H, Okuno T, Yoshimura T, Ito M, Masuda A, Sobue G, Kiyama H, Ishiguro N, Ohno K.
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| Sci Rep 6:28512. doi: 10.1038/srep28512.
2016
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| 7 | LGR4, RSPO2
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| LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway.
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| Zhu C, Zheng XF, Yang YH, Li B, Wang YR, Jiang SD, Jiang LS.
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| Cell Signal 28(8):989-1000. doi: 10.1016/j.cellsig.2016.04.010. Epub 2016 Apr 29.
2016
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| 8 | RSPO2
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| R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.
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| Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K.
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| Biochem Biophys Res Commun 473(1):255-64. doi: 10.1016/j.bbrc.2016.03.089. Epub 2016 Mar 22. 2016
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| 9 | LGR5, RSPO2, ZNRF3
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| Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
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| Zebisch M, Jones EY.
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| J Struct Biol 191(2):149-55. doi: 10.1016/j.jsb.2015.05.008. Epub 2015 Jun 26.
2015
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| 10 | RSPO2
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| R-spondin2 activates hepatic stellate cells and promotes liver fibrosis.
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| Yin X, Yi H, Wu W, Shu J, Wu X, Yu L.
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| Dig Dis Sci 59(10):2452-61. doi: 10.1007/s10620-014-3208-1. Epub 2014 May 23.
2014
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| 11 | LGR5, RSPO2, ZNRF3
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| RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.
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| Wu C, Qiu S, Lu L, Zou J, Li WF, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X.
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| Nat Commun 5:3149. doi: 10.1038/ncomms4149.
2014
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| 12 | RSPO2
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| Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.
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| Mulvaney JF, Yatteau A, Sun WW, Jacques B, Takubo K, Suda T, Yamada W, Dabdoub A.
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| Dev Dyn 242(2):179-88. doi: 10.1002/dvdy.23908.
2013
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| 13 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
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| Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.
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| Proc Natl Acad Sci U S A 108(28):11452-7. Epub 2011 Jun 21.
2011
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| 14 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
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| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
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| de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
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| Nature 476(7360):293-7. doi: 10.1038/nature10337.
2011
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| 15 | RSPO2
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| The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction.
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| Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK.
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| Dev Biol 352(1):1-13. doi: 10.1016/j.ydbio.2011.01.004. Epub 2011 Jan 13.
2011
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| 16 | RSPO2
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| Craniofacial malformation in R-spondin2 knockout mice.
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| Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K.
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| Biochem Biophys Res Commun 381(3):453-8. Epub 2009 Feb 20.
2009
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| 17 | RSPO1, RSPO2, RSPO3, RSPO4
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| Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
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| Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
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| Cell Signal ell Signal. 2009 Feb 6. [Epub ahead of print]
2009
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| 18 | RSPO1, RSPO2, RSPO3, RSPO4
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| R-Spondin family members regulate the Wnt pathway by a common mechanism.
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| Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A.
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| Mol Biol Cell 19(6):2588-96. Epub 2008 Apr 9.
2008
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| 19 | RSPO2
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| R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis.
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| Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA.
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| Development 135(6):1049-58. Epub 2008 Feb 6.
2008
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| 20 | RSPO1, RSPO2, RSPO3, RSPO4
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| R-Spondin proteins: a novel link to beta-catenin activation.
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| Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
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| Cell Cycle 5(1):23-6. Epub 2006 Jan 8.
2006
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| 21 | RSPO2, RSPO4
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| R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.
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| Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W.
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| Dev Cell 7(4):525-34. 2004
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