| 1 | LGR6, RSPO1, RSPO2, RSPO3, RSPO4
|
| LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.2020
|
| Chai T, Shen Z, Zhang Z, Chen S, Gao L, Zhang P, Lin W, Kang M, Lin J.
|
| J Clin Lab Anal. Apr;34(4):e23121. doi: 10.1002/jcla.23121. Epub 2020 Jan 9 2021
|
| 2 | RSPO1
|
| R-spondin1 deficiency enhances β-Cell neogenesis in a murine model of diabetes.
|
| Chahal JK, Wong VS, Chaboissier MC, Brubaker PL.
|
| Pancreas 43(1):93-102. doi: 10.1097/MPA.0b013e3182a70bfb.
2014
|
| 3 | LGR4, RSPO1, RSPO3
|
| LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats
|
| Li JY, Chai B, Zhang W, Fritze DM, Zhang C, Mulholland MW.
|
| Endocrinology. Feb;155(2):429-40. doi: 10.1210/en.2013-1550. Epub 2013 Nov 26. P 2014
|
| 4 | CTNNB1, RSPO1
|
| Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
|
| Grigoryan T, Stein S, Qi J, Wende H, Garratt AN, Nave KA, Birchmeier C, Birchmeier W.
|
| Proc Natl Acad Sci U S A 110(45):18174-9. doi: 10.1073/pnas.1310490110. Epub 2013 Oct 22.
2013
|
| 5 | LGR5, RSPO1, ZNRF3
|
| Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
|
| Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P.
|
| PLoS One 8(12):e83110. doi: 10.1371/journal.pone.0083110. eCollection 2013.
2013
|
| 6 | LGR4, RSPO1, ZNRF3
|
| Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin.
|
| Xie Y, Zamponi R, Charlat O, Ramones M, Swalley S, Jiang X, Rivera D, Tschantz W, Lu B, Quinn L, Dimitri C, Parker J, Jeffery D, Wilcox SK, Watrobka M, LeMotte P, Granda B, Porter JA, Myer VE, Loew A, Cong F.
|
| EMBO Rep 14(12):1120-6. doi: 10.1038/embor.2013.167. Epub 2013 Oct 29.
2013
|
| 7 | LGR5, RNF43, RSPO1
|
| The structural basis of R-spondin recognition by LGR5 and RNF43.
|
| Chen PH, Chen X, Lin Z, Fang D, He X.
|
| Genes Dev 27(12):1345-50. doi: 10.1101/gad.219915.113. Epub 2013 Jun 11.
2013
|
| 8 | RSPO1, WNT4
|
| WNT4, RSPO1, and FOXL2 in sex development.
|
| Biason-Lauber A.
|
| Semin Reprod Med 30(5):387-95. doi: 10.1055/s-0032-1324722. Epub 2012 Oct 8.
2012
|
| 9 | RSPO1, WNT4
|
| WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.
|
| Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC.
|
| Development 139(23):4461-72. doi: 10.1242/dev.078972. Epub 2012 Oct 24.
2012
|
| 10 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
|
| R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
|
| Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.
|
| Proc Natl Acad Sci U S A 108(28):11452-7. Epub 2011 Jun 21.
2011
|
| 11 | LGR4, LGR5, LGR6, RSPO1, RSPO2, RSPO3, RSPO4
|
| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
|
| de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.
|
| Nature 476(7360):293-7. doi: 10.1038/nature10337.
2011
|
| 12 | RSPO1
|
| RSPO1/â-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.
|
| Chassot AA, Gregoire EP, Lavery R, Taketo MM, de Rooij DG, Adams IR, Chaboissier MC.
|
| PLoS One 6(10):e25641. doi: 10.1371/journal.pone.0025641. Epub 2011 Oct 3.
2011
|
| 13 | RSPO1
|
| Human RSPO1/R-spondin1 is expressed during early ovary development and augments â-catenin signaling.
|
| Tomaselli S, Megiorni F, Lin L, Mazzilli MC, Gerrelli D, Majore S, Grammatico P, Achermann JC.
|
| PLoS One 6(1):e16366. doi: 10.1371/journal.pone.0016366.
2011
|
| 14 | FLT4, RSPO1, VEGFC
|
| Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
|
| Gore AV, Swift MR, Cha YR, Lo B, McKinney MC, Li W, Castranova D, Davis A, Mukouyama YS, Weinstein BM.
|
| Development 138(22):4875-86. doi: 10.1242/dev.068460. Epub 2011 Oct 17.
2011
|
| 15 | RSPO1
|
| R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue.
|
| Wong VS, Yeung A, Schultz W, Brubaker PL.
|
| J Biol Chem 285(28):21292-302. doi: 10.1074/jbc.M110.129874. Epub 2010 May 4.
2010
|
| 16 | RSPO1, RSPO2, RSPO3, RSPO4
|
| Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.
|
| Li SJ, Yen TY, Endo Y, Klauzinska M, Baljinnyam B, Macher B, Callahan R, Rubin JS.
|
| Cell Signal ell Signal. 2009 Feb 6. [Epub ahead of print]
2009
|
| 17 | RSPO1
|
| R-spondin1 is required for normal epithelial morphogenesis during mammary gland development.
|
| Chadi S, Buscara L, Pechoux C, Costa J, Laubier J, Chaboissier MC, Pailhoux E, Vilotte JL, Chanat E, Le Provost F.
|
| Biochem Biophys Res Commun 390(3):1040-3. Epub 2009 Oct 24.PMID: 19857464 2009
|
| 18 | RSPO1, PPKSR
|
| Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation.
|
| Tomaselli S, Megiorni F, De Bernardo C, Felici A, Marrocco G, Maggiulli G, Grammatico B, Remotti D, Saccucci P, Valentini F, Mazzilli MC, Majore S, Grammatico P.
|
| Hum Mutat 29(2):220-6. 2008
|
| 19 | RSPO1
|
| Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
|
| Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC.
|
| Hum Mol Genet 17(9):1264-77. Epub 2008 Feb 4. 2008
|
| 20 | RSPO1, WNT4
|
| R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling.
|
| Tomizuka K, Horikoshi K, Kitada R, Sugawara Y, Iba Y, Kojima A, Yoshitome A, Yamawaki K, Amagai M, Inoue A, Oshima T, Kakitani M.
|
| Hum Mol Genet 17(9):1278-91. Epub 2008 Feb 4. 2008
|
| 21 | RSPO1, WNT3A
|
| R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.
|
| Lu W, Kim KA, Liu J, Abo A, Feng X, Cao X, Li Y.
|
| FEBS Lett 582(5):643-50. Epub 2008 Jan 31.
2008
|
| 22 | RSPO1, RSPO2, RSPO3, RSPO4
|
| R-Spondin family members regulate the Wnt pathway by a common mechanism.
|
| Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, Gros D, Korver W, Yonkovich S, Tomasevic N, Binnerts M, Abo A.
|
| Mol Biol Cell 19(6):2588-96. Epub 2008 Apr 9.
2008
|
| 23 | ADCY5, EFNA5, ERC2, GFPT2, GIPC2, GNA14, HSPA4L, MAGI1, MN1, MSX2, MYO5B, OCLN, RSPO1, SALL1, ZNF382
|
| Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.
|
| Kuang SQ, Tong WG, Yang H, Lin W, Lee MK, Fang ZH, Wei Y, Jelinek J, Issa JP, Garcia-Manero G.
|
| Leukemia 22(8):1529-38. Epub 2008 Jun 5.PMID: 18528427 2008
|
| 24 | DKK1, KREMEN1, LRP6, RSPO1
|
| R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
|
| Binnerts ME, Kim KA, Bright JM, Patel SM, Tran K, Zhou M, Leung JM, Liu Y, Lomas WE 3rd, Dixon M, Hazell SA, Wagle M, Nie WS, Tomasevic N, Williams J, Zhan X, Levy MD, Funk WD, Abo A.
|
| Proc Natl Acad Sci U S A 104(37):14700-5. Epub 2007 Sep 5. 2007
|
| 25 | RSPO1, PPKSR
|
| R-spondin1 is essential in sex determination, skin differentiation and malignancy.
|
| Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G.
|
| Nat Genet 38(11):1304-9. Epub 2006 Oct 15. 2006
|
| 26 | RSPO1, RSPO2, RSPO3, RSPO4
|
| R-Spondin proteins: a novel link to beta-catenin activation.
|
| Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD.
|
| Cell Cycle 5(1):23-6. Epub 2006 Jan 8.
2006
|
| 27 | RSPO1
|
| Mitogenic influence of human R-spondin1 on the intestinal epithelium.
|
| Kim KA, Kakitani M, Zhao J, Oshima T, Tang T, Binnerts M, Liu Y, Boyle B, Park E, Emtage P, Funk WD, Tomizuka K.
|
| Science 309(5738):1256-9. 2005
|
| 28 | RSPO1
|
| R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.
|
| Kamata T, Katsube K, Michikawa M, Yamada M, Takada S, Mizusawa H.
|
| Biochim Biophys Acta 1676(1):51-62. 2004
|