Citations for
1RRM2
Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-κB signaling pathway.
Zhong Z, Cao Y, Yang S, Zhang S.
Pharmazie 71(5):280-4. 2016
2RRM2
Targeting RRM2 and Mutant BRAF is a Novel Combinatorial Strategy for Melanoma.
Fatkhutdinov N, Sproesser K, Krepler C, Liu Q, Brafford PA, Herlyn M, Aird KM, Zhang R.
Mol Cancer Res ol Cancer Res. 2016 Jun 13. pii: molcanres.0099.2016. [Epub ahead of print] 2016
3E2F1, RRM2
E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.
Fang Z, Gong C, Liu H, Zhang X, Mei L, Song M, Qiu L, Luo S, Zhu Z, Zhang R, Gu H, Chen X.
Biochem Biophys Res Commun 464(2):407-15. doi: 10.1016/j.bbrc.2015.06.103. Epub 2015 Jun 18. 2015
4RRM2, RRM2B
Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
Tebbi A, Guittet O, Tuphile K, Cabriť A, Lepoivre M.
J Biol Chem 290(22):14077-90. doi: 10.1074/jbc.M115.649640. Epub 2015 Apr 15. 2015
5RRM2
Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer.
Wang N, Zhan T, Ke T, Huang X, Ke D, Wang Q, Li H.
Br J Cancer 110(4):1034-44. doi: 10.1038/bjc.2013.817. Epub 2014 Jan 14. 2014
6BCL2, RRM2
RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy.
Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica G, Deng X, Chen ZG, Shin DM.
Clin Cancer Res 19(13):3416-28. doi: 10.1158/1078-0432.CCR-13-0073. Epub 2013 May 29. 2013
7CCNF, RRM2
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
D'Angiolella V, Donato V, Forrester FM, Jeong YT, Pellacani C, Kudo Y, Saraf A, Florens L, Washburn MP, Pagano M.
Cell 149(5):1023-34. doi: 10.1016/j.cell.2012.03.043. 2012
8PLAU, RRM2
Regulation of urokinase expression at the posttranscription level by lung epithelial cells.
Shetty SK, Marudamuthu AS, Abernathy D, Shetty RS, Shetty P, Fu J, Idell S, Bhandary YP, Ji H, Liu MC, Shetty S.
Biochemistry 51(1):205-13. doi: 10.1021/bi201293x. Epub 2011 Dec 23. 2012
9RRM2
KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines.
Yoshida Y, Tsunoda T, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Takashima Y, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S.
Anticancer Res 31(7):2535-9. 2011
10RRM2
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Morikawa T, Hino R, Uozaki H, Maeda D, Ushiku T, Shinozaki A, Sakatani T, Fukayama M.
Hum Pathol 41(12):1742-8. doi: 10.1016/j.humpath.2010.06.001. Epub 2010 Sep 9. 2010
11RRM2, RRM2B
2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase
Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y.
Biochemistry 48(46):11134-41.PMID: 19728742 2009
12RRM2
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.
Zhang K, Hu S, Wu J, Chen L, Lu J, Wang X, Liu X, Zhou B, Yen Y.
Mol Cancer 8:11. doi: 10.1186/1476-4598-8-11. 2009
13RRM2
RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness.
Duxbury MS, Whang EE.
Biochem Biophys Res Commun 354(1):190-6. Epub 2006 Dec 29. 2007
14RRM1, RRM2B, RRM2
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
Qiu W, Zhou B, Darwish D, Shao J, Yen Y.
Biochem Biophys Res Commun 340(2):428-34. Epub 2005 Dec 15. 2006
15AP1S1, ATP6V1D, BM22, CASP8AP2, CDC16, CDC27, CENPE, CLDN16, CMTM4, CYTH3, DDX5, DHX8, EIF3A, EIF3H, EIF4A3, GALNT5, ITPR1, KIF11, KPNB1, LSM6, MFAP1, NCAPD3, NCAPG2, RBM19, RRM2, SART1, SNRPA1, SNRPB, SNW1, SPC25, VCP, ZDHHC5
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.
Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F.
Nature 432(7020):1036-40. 2004
16TP53, RRM1, RRM2, RRM2B
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y.
Cancer Res 63(5):980-6. 2003
17RRM2
Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses.
Zhou B, Yen Y.
Cytogenet Cell Genet 95(1-2):52-9. 2001
18RRM2
Characterization of the promoter of the human ribonucleotide reductase R2 gene.
Park JB, Levine M.
Biochem Biophys Res Commun 267(2):651-7. 2000
19RRM2, RRM2P1, RRM2P2, RRM2P3, RRM2P4, D2S18E
Genes for the M2 subunit of ribonucleotide reductase (RRM2) and for related and co-amplified sequences localized on human and mouse chromosomes.
Yang-Feng TL, et al.
(HGM9) Cytogenet Cell Genet 46 : 722. 1987