| 1 | CDKL3, RRM2
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| Identification of CDKL3 as a critical regulator in development of glioma through regulating RRM2 and the JNK signaling pathway
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| Cui Y, Yang Z, Wang H, Yan Y, Huang Q, Gong Z, Hong F, Zhang X, Li W, Chen J, Xu T.
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| Cancer Sci. Aug;112(8):3150-3162. doi: 10.1111/cas.15010. Epub 2021 Jun 28. 2021
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| 2 | RRM2
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| Overexpression of RRM2 in gastric cancer cell promotes their invasiveness via AKT/NF-κB signaling pathway.
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| Zhong Z, Cao Y, Yang S, Zhang S.
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| Pharmazie 71(5):280-4. 2016
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| 3 | RRM2
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| Targeting RRM2 and Mutant BRAF is a Novel Combinatorial Strategy for Melanoma.
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| Fatkhutdinov N, Sproesser K, Krepler C, Liu Q, Brafford PA, Herlyn M, Aird KM, Zhang R.
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| Mol Cancer Res ol Cancer Res. 2016 Jun 13. pii: molcanres.0099.2016. [Epub ahead of print]
2016
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| 4 | E2F1, RRM2
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| E2F1 promote the aggressiveness of human colorectal cancer by activating the ribonucleotide reductase small subunit M2.
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| Fang Z, Gong C, Liu H, Zhang X, Mei L, Song M, Qiu L, Luo S, Zhu Z, Zhang R, Gu H, Chen X.
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| Biochem Biophys Res Commun 464(2):407-15. doi: 10.1016/j.bbrc.2015.06.103. Epub 2015 Jun 18.
2015
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| 5 | RRM2, RRM2B
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| Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
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| Tebbi A, Guittet O, Tuphile K, Cabrié A, Lepoivre M.
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| J Biol Chem 290(22):14077-90. doi: 10.1074/jbc.M115.649640. Epub 2015 Apr 15.
2015
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| 6 | RRM2
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| Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer.
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| Wang N, Zhan T, Ke T, Huang X, Ke D, Wang Q, Li H.
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| Br J Cancer 110(4):1034-44. doi: 10.1038/bjc.2013.817. Epub 2014 Jan 14.
2014
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| 7 | BCL2, RRM2
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| RRM2 regulates Bcl-2 in head and neck and lung cancers: a potential target for cancer therapy.
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| Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica G, Deng X, Chen ZG, Shin DM.
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| Clin Cancer Res 19(13):3416-28. doi: 10.1158/1078-0432.CCR-13-0073. Epub 2013 May 29.
2013
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| 8 | CCNF, RRM2
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| Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
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| D'Angiolella V, Donato V, Forrester FM, Jeong YT, Pellacani C, Kudo Y, Saraf A, Florens L, Washburn MP, Pagano M.
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| Cell 149(5):1023-34. doi: 10.1016/j.cell.2012.03.043.
2012
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| 9 | PLAU, RRM2
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| Regulation of urokinase expression at the posttranscription level by lung epithelial cells.
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| Shetty SK, Marudamuthu AS, Abernathy D, Shetty RS, Shetty P, Fu J, Idell S, Bhandary YP, Ji H, Liu MC, Shetty S.
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| Biochemistry 51(1):205-13. doi: 10.1021/bi201293x. Epub 2011 Dec 23.
2012
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| 10 | RRM2
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| KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines.
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| Yoshida Y, Tsunoda T, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Takashima Y, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S.
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| Anticancer Res 31(7):2535-9.
2011
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| 11 | RRM2
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| Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
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| Morikawa T, Hino R, Uozaki H, Maeda D, Ushiku T, Shinozaki A, Sakatani T, Fukayama M.
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| Hum Pathol 41(12):1742-8. doi: 10.1016/j.humpath.2010.06.001. Epub 2010 Sep 9.
2010
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| 12 | RRM2, RRM2B
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| 2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase
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| Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y.
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| Biochemistry 48(46):11134-41.PMID: 19728742 2009
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| 13 | RRM2
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| Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.
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| Zhang K, Hu S, Wu J, Chen L, Lu J, Wang X, Liu X, Zhou B, Yen Y.
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| Mol Cancer 8:11. doi: 10.1186/1476-4598-8-11.
2009
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| 14 | RRM2
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| RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness.
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| Duxbury MS, Whang EE.
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| Biochem Biophys Res Commun 354(1):190-6. Epub 2006 Dec 29.
2007
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| 15 | RRM1, RRM2B, RRM2
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| Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
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| Qiu W, Zhou B, Darwish D, Shao J, Yen Y.
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| Biochem Biophys Res Commun 340(2):428-34. Epub 2005 Dec 15. 2006
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| 16 | AP1S1, ATP6V1D, BM22, CASP8AP2, CDC16, CDC27, CENPE, CLDN16, CMTM4, CYTH3, DDX5, DHX8, EIF3A, EIF3H, EIF4A3, GALNT5, ITPR1, KIF11, KPNB1, LSM6, MFAP1, NCAPD3, NCAPG2, RBM19, RRM2, SART1, SNRPA1, SNRPB, SNW1, SPC25, VCP, ZDHHC5
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| An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.
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| Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F.
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| Nature 432(7020):1036-40. 2004
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| 17 | TP53, RRM1, RRM2, RRM2B
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| Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
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| Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y.
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| Cancer Res 63(5):980-6. 2003
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| 18 | RRM2
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| Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses.
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| Zhou B, Yen Y.
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| Cytogenet Cell Genet 95(1-2):52-9. 2001
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| 19 | RRM2
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| Characterization of the promoter of the human ribonucleotide reductase R2 gene.
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| Park JB, Levine M.
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| Biochem Biophys Res Commun 267(2):651-7. 2000
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| 20 | RRM2, RRM2P1, RRM2P2, RRM2P3, RRM2P4, D2S18E
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| Genes for the M2 subunit of ribonucleotide reductase (RRM2) and for related and co-amplified sequences localized on human and mouse chromosomes.
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| Yang-Feng TL, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 722. 1987
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