Citations for
1MTOR, RRAGA, RRAGB, RRAGC, WDR35
RagA, an mTORC1 activator, interacts with a hedgehog signaling protein, WDR35/IFT121.
Sekiguchi T, Furuno N, Ishii T, Hirose E, Sekiguchi F, Wang Y, Kobayashi H.
Genes Cells. Feb;24(2):151-161. doi: 10.1111/gtc.12663. Epub 2019 Jan 15. 2019
2MTOR, RRAGA
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM.
Nature Jan 31;493(7434):679-83. doi: 10.1038/nature11745. Epub 2012 Dec 23 2013
3RRAGA, RRAGB, RRAGC, RRAGD, SH3BP4
dRAGging amino acid-mTORC1 signaling by SH3BP4.
Kim YM, Kim DH.
Mol Cells 35(1):1-6. doi: 10.1007/s10059-013-2249-1. Epub 2012 Dec 26. Review. 2013
4LAMTOR1, LAMTOR3, RRAGA, RRAGC
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y.
Genes Dev 25(16):1668-73. Epub 2011 Aug 4. 2011
5LAMTOR1, LAMTOR2, LAMTOR3, MTOR, RRAGA, RRAGB, RRAGC, RRAGD
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM.
Cell 141(2):290-303. Epub 2010 Apr 8. 2010
6RRAGA, RRAGB, RRAGC, RRAGD
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.
Science 320(5882):1496-501. Epub 2008 May 22. 2008
7RRAGA, RRAGC, RRAGD
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T.
J Biol Chem 279(9):8343-50. Epub 2003 Dec 4. 2004
8RRAGA
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T.
J Biol Chem 276(10):7246-57. Epub 2000 Nov 9. 2001
9RRAGA, RRAGB
RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.
Hirose E, Nakashima N, Sekiguchi T, Nishimoto T.
J Cell Sci 111 ( Pt 1):11-21. 1998
10RRAGA
Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.
Li Y, Kang J, Horwitz MS.
J Virol 71(2):1576-82. 1997
11RRAGA, RRAGB
Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.
Schurmann A, Brauers A, Massmann S, Becker W, Joost HG.
J Biol Chem 270(48):28982-8. 1995