| 1 | RORB, RORC
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| RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells.
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| Taneera J, Mohammed AK, Dhaiban S, Hamad M, Prasad RB, Sulaiman N, Salehi A.
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| Islets ;11(1):10-20. doi: 10.1080/19382014.2019.1566684. Epub 2019 Feb 14. 2019
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| 2 | RORC
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| Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.
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| Li X, Anderson M, Collin D, Muegge I, Wan J, Brennan D, Kugler S, Terenzio D, Kennedy C, Lin S, Labadia ME, Cook B, Hughes R, Farrow NA.
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| J Biol Chem 292(28):11618-11630. doi: 10.1074/jbc.M117.789024. Epub 2017 May 25.
2017
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| 3 | RORA, RORC
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| RORγt and RORα signature genes in human Th17 cells.
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| Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, Yu J, Cao T, Kuhn R, Wilkinson P, Herman K, Nelen MI, Blevitt J, Xue X, Fourie A, Fung-Leung WP.
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| PLoS One 12(8):e0181868. doi: 10.1371/journal.pone.0181868. eCollection 2017.
2017
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| 4 | RORC, USP15
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| Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment.
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| He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z.
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| J Immunol 197(4):1148-58. doi: 10.4049/jimmunol.1600548. Epub 2016 Jul 18.
2016
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| 5 | IL17A, RORC
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| Inhibition of the Nuclear Receptor RORγ and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia.
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| Talia DM, Deliyanti D, Agrotis A, Wilkinson-Berka JL.
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| Arterioscler Thromb Vasc Biol 36(6):1186-96. doi: 10.1161/ATVBAHA.115.307080. Epub 2016 Apr 7.
2016
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| 6 | RORC
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| Down-regulation of expression of retinoid acid-related orphan receptor C (RORC) in systemic lupus erythematosus.
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| El-Karaksy SM, Raafat HA, Abadir MN, Hanna MO.
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| J Recept Signal Transduct Res 36(2):207-12. doi: 10.3109/10799893.2015.1075042. Epub 2015 Oct 26. Erratum in: J Recept Signal Transduct Res. 2016;36(2):i.
2016
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| 7 | IMD42, RORC
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| IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.
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| Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CSL, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL.
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| Science 349(6248):606-613. doi: 10.1126/science.aaa4282. Epub 2015 Jul 9.
2015
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| 8 | RORC
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| Identification of an allosteric binding site for RORγt inhibition.
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| Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S, Soisson SM, Kornienko M, Wiley K, Elsen N, Sharma S, Correll CC, Trotter BW, van der Stelt M, Oubrie A, Ottmann C, Parthasarathy G, Brunsveld L.
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| Nat Commun 6:8833. doi: 10.1038/ncomms9833.
2015
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| 9 | EP300, RORC
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| Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.
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| Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J, Li B.
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| Sci Rep 5:16355. doi: 10.1038/srep16355.
2015
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| 10 | RORC, TRAF5
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| TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
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| Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B.
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| J Biol Chem 290(48):29086-94. doi: 10.1074/jbc.M115.664573. Epub 2015 Oct 9.
2015
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| 11 | RORC, SIRT1
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| SIRT1 deacetylates RORγt and enhances Th17 cell generation.
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| Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.
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| J Exp Med 212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. Erratum in: J Exp Med. 2015 Jun 1;212(6):973.
2015
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| 12 | RORC
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| A crucial role of RORγt in the development of spontaneous Sialadenitis-like Sjögren's syndrome.
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| Iizuka M, Tsuboi H, Matsuo N, Asashima H, Hirota T, Kondo Y, Iwakura Y, Takahashi S, Matsumoto I, Sumida T.
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| J Immunol 194(1):56-67. doi: 10.4049/jimmunol.1401118. Epub 2014 Nov 19.
2015
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| 13 | MAF, RORC, SOX5, STAT3
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| Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
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| Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H.
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| J Exp Med 211(9):1857-74. doi: 10.1084/jem.20130791. Epub 2014 Jul 29.
2014
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| 14 | RORC
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| Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.
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| Takeda Y, Kang HS, Lih FB, Jiang H, Blaner WS, Jetten AM.
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| Nucleic Acids Res 42(16):10448-59. doi: 10.1093/nar/gku766. Epub 2014 Aug 20.
2014
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| 15 | RORC
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| The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells.
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| Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B.
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| J Biol Chem 289(37):25546-55. doi: 10.1074/jbc.M114.565291. Epub 2014 Jul 28.
2014
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| 16 | NFIL3, RORC
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| TH17 cell differentiation is regulated by the circadian clock.
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| Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.
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| Science 342(6159):727-30. doi: 10.1126/science.1243884.
2013
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| 17 | RORC
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| Cutting edge: Leptin-induced RORγt expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus.
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| Yu Y, Liu Y, Shi FD, Zou H, Matarese G, La Cava A.
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| J Immunol 190(7):3054-8. doi: 10.4049/jimmunol.1203275. Epub 2013 Feb 27.
2013
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| 18 | ID2, NOTCH1, RORC
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| Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
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| Cherrier M, Sawa S, Eberl G.
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| J Exp Med 209(4):729-40. doi: 10.1084/jem.20111594. Epub 2012 Mar 19.
2012
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| 19 | RORC
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| A novel isoform of the orphan receptor RORγt suppresses IL-17 production in human T cells.
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| Rauen T, Juang YT, Hedrich CM, Kis-Toth K, Tsokos GC.
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| Genes Immun 13(4):346-50. doi: 10.1038/gene.2011.85. Epub 2012 Jan 12.
2012
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| 20 | IL17A, LY9, RORC, SLAMF6
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| CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.
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| Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC.
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| J Biol Chem 287(45):38168-77. doi: 10.1074/jbc.M112.415067. Epub 2012 Sep 18.
2012
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| 21 | RORC
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| RORC and Foxp3 axis in cerebrospinal fluid of patients with Neuro-Behçet's Disease.
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| Hamzaoui K, Borhani Haghighi A, Ghorbel IB, Houman H.
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| J Neuroimmunol 233(1-2):249-53. Epub 2011 Mar 1.
2011
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| 22 | RORC
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| T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
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| Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, Sun Z.
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| J Immunol 187(11):5964-73. doi: 10.4049/jimmunol.1101205. Epub 2011 Oct 28.
2011
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| 23 | KLRB1, RORC
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| CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.
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| Maggi L, Santarlasci V, Capone M, Peired A, Frosali F, Crome SQ, Querci V, Fambrini M, Liotta F, Levings MK, Maggi E, Cosmi L, Romagnani S, Annunziato F.
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| Eur J Immunol 40(8):2174-81.
2010
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| 24 | EBI3, RORC
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| Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t.
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| Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H.
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| Eur J Immunol 38(5):1204-14.
2008
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| 25 | RORC
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| Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes.
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| Wang H, Chu W, Das SK, Zheng Z, Hasstedt SJ, Elbein SC.
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| Mol Genet Metab 79(3):176-82. 2003
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| 26 | RORC
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| Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene.
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| Medvedev A, Chistokhina A, Hirose T, Jetten AM.
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| Genomics 46(1):93-102. 1997
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| 27 | RORC
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| ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.
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| Hirose T, et al.
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| Biochem Biophys Res Commun 205(3):1976-83 1994
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