Citations for
1ACVR1, GDF11, MRPL53, RORA, SHH
Variant Analyses of Candidate Genes in Orofacial Clefts in Multi-Ethnic Populations.
Li M, Olotu J, Buxo-Martinez CJ, Mossey PA, Anand D, Busch T, Alade A, Gowans LJJ, Eshete M, Adeyemo WL, Naicker T, Awotoye WO, Gupta S, Adeleke C, Bravo V, Huang S, Adamson OO, Toraño AM, Bello CA, Soto M, Soto M, Ledesma R, Marquez M, Cordero JF, Lopez-Del Valle LM, Salcedo MI, Debs N, Petrin A, Malloy H, Elhadi K, James O, Ogunlewe MO, Abate F, Hailu A, Mohammed I, Gravem P, Deribew M, Gesses M, Hassan M, Pape J, Obiri-Yeboah S, Arthur FKN, Oti AA, Donkor P, Marazita ML, Lachke SA, Adeyemo AA, Murray JC, Butali A.
Oral Dis. Jun 1. doi: 10.1111/odi.13932. Epub ahead of print. 2021
2NDDCMB, RORA
Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia.
Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema L, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Guillen Sacoto MJ, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze JF, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali L, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S.
Am J Hum Genet 102(5):744-759. doi: 10.1016/j.ajhg.2018.02.021. Epub 2018 Apr 12. 2018
3RORA
Retinoic acid receptor-related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia.
Li H, Zhou L, Dai J.
J Cell Physiol 233(1):641-650. doi: 10.1002/jcp.25924. Epub 2017 May 19. 2018
4RORA, RORC
RORγt and RORα signature genes in human Th17 cells.
Castro G, Liu X, Ngo K, De Leon-Tabaldo A, Zhao S, Luna-Roman R, Yu J, Cao T, Kuhn R, Wilkinson P, Herman K, Nelen MI, Blevitt J, Xue X, Fourie A, Fung-Leung WP.
PLoS One 12(8):e0181868. doi: 10.1371/journal.pone.0181868. eCollection 2017. 2017
5RORA
RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network.
Kim K, Boo K, Yu YS, Oh SK, Kim H, Jeon Y, Bhin J, Hwang D, Kim KI, Lee JS, Im SS, Yoon SG, Kim IY, Seong JK, Lee H, Fang S, Baek SH.
Nat Commun 8(1):162. doi: 10.1038/s41467-017-00215-1. 2017
6RORA
Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.
Liu Y, Chen Y, Zhang J, Liu Y, Zhang Y, Su Z.
J Biol Chem 292(34):13959-13969. doi: 10.1074/jbc.M117.782391. Epub 2017 Jul 11. 2017
7RORA, SEMA3E
RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.
Sun Y, Liu CH, Wang Z, Meng SS, Burnim SB, SanGiovanni JP, Kamenecka TM, Solt LA, Chen J.
FASEB J 31(10):4492-4502. doi: 10.1096/fj.201700172R. Epub 2017 Jun 23. 2017
8CLDND1, RORA
The retinoic acid receptor-related orphan receptor α positively regulates tight junction protein claudin domain-containing 1 mRNA expression in human brain endothelial cells.
Matsuoka H, Shima A, Uda A, Ezaki H, Michihara A.
J Biochem 161(5):441-450. doi: 10.1093/jb/mvw092. 2017
9RORA
Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα.
Xiao L, Zhang Z, Luo X, Yang H, Li F, Wang N.
Mol Immunol 80:17-23. doi: 10.1016/j.molimm.2016.10.006. Epub 2016 Oct 24. 2016
10RORA
The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury.
He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J.
J Pineal Res 60(3):313-26. doi: 10.1111/jpi.12312. Epub 2016 Feb 16. 2016
11ALOX5, RORA
Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase.
Shajari S, Laliena A, Heegsma J, Tuñón MJ, Moshage H, Faber KN.
J Pineal Res 59(3):391-401. doi: 10.1111/jpi.12271. Epub 2015 Sep 15. 2015
12RORA
Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.
Sun Y, Liu CH, SanGiovanni JP, Evans LP, Tian KT, Zhang B, Stahl A, Pu WT, Kamenecka TM, Solt LA, Chen J.
Proc Natl Acad Sci U S A 112(33):10401-6. doi: 10.1073/pnas.1504387112. Epub 2015 Aug 4. 2015
13E2F1, RORA
RORα binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesis.
Xiong G, Xu R.
Mol Cell Biol 34(16):3066-75. doi: 10.1128/MCB.00279-14. Epub 2014 Jun 2. 2014
14RORA
Identification of insulin as a novel retinoic acid receptor-related orphan receptor α target gene.
Kuang J, Hou X, Zhang J, Chen Y, Su Z.
FEBS Lett 588(6):1071-9. doi: 10.1016/j.febslet.2014.02.029. Epub 2014 Feb 25. 2014
15FOXN1, RORA
The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1.
Dai J, Brooks Y, Lefort K, Getsios S, Dotto GP.
PLoS One 8(7):e70392. doi: 10.1371/journal.pone.0070392. Print 2013. 2013
16RORA
RORα, a potential tumor suppressor and therapeutic target of breast cancer.
Du J, Xu R.
Int J Mol Sci 13(12):15755-66. doi: 10.3390/ijms131215755. 2012
17RORA
Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα.
Hanyu O, Nakae H, Miida T, Higashi Y, Fuda H, Endo M, Kohjitani A, Sone H, Strott CA.
Biochem Biophys Res Commun 428(1):99-104. doi: 10.1016/j.bbrc.2012.10.013. Epub 2012 Oct 12. 2012
18CS, RORA
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley C, Wang Y, Banerjee S, Burris TP.
PLoS One 7(4):e33804. doi: 10.1371/journal.pone.0033804. Epub 2012 Apr 2. 2012
19RORA
RORalpha, a key to the development and functioning of the brain.
Jolly S, Journiac N, Vernet-der Garabedian B, Mariani J.
Cerebellum 11(2):451-2. doi: 10.1007/s12311-011-0339-1. Review. 2012
20RORA
Cell-autonomous and non-cell-autonomous neuroprotective functions of RORα in neurons and astrocytes during hypoxia.
Jolly S, Journiac N, Naudet F, Gautheron V, Mariani J, Vernet-der Garabedian B.
J Neurosci 31(40):14314-23. doi: 10.1523/JNEUROSCI.1443-11.2011. 2011
21RORA
Nuclear receptor retinoid-related orphan receptor α1 modulates the metabolic activity of human osteoblasts.
Benderdour M, Fahmi H, Beaudet F, Fernandes JC, Shi Q.
J Cell Biochem 112(8):2160-9. doi: 10.1002/jcb.23141. 2011
22MAGED1, RORA
Interaction of MAGED1 with nuclear receptors affects circadian clock function.
Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y.
EMBO J 29(8):1389-400. Epub 2010 Mar 18. 2010
23FGF21, RORA
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.
Wang Y, Solt LA, Burris TP.
J Biol Chem 285(21):15668-73. Epub 2010 Mar 23.PMID: 20332535 2010
24RORA
Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle.
Raichur S, Fitzsimmons RL, Myers SA, Pearen MA, Lau P, Eriksson N, Wang SM, Muscat GE.
Nucleic Acids Res 38(13):4296-312. Epub 2010 Mar 24. 2010
25BCL2, RORA
Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.
Nguyen A, Rauch TA, Pfeifer GP, Hu VW.
FASEB J 24(8):3036-51. Epub 2010 Apr 7.PMID: 20375269 2010
26NR1D1, RORA
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.
Crumbley C, Wang Y, Kojetin DJ, Burris TP.
J Biol Chem 285(46):35386-92. Epub 2010 Sep 3. 2010
27RORA
Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα.
Boukhtouche F, Brugg B, Wehrlé R, Bois-Joyeux B, Danan JL, Dusart I, Mariani J.
Neural Dev 5:18. doi: 10.1186/1749-8104-5-18. 2010
28RORA
Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-alpha signalling in endochondral bone growth.
Woods A, James CG, Wang G, Dupuis H, Beier F.
J Cell Mol Med 13(9B):3497-516.PMID: 20196782 2009
29RORA
The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes.
Journiac N, Jolly S, Jarvis C, Gautheron V, Rogard M, Trembleau A, Blondeau JP, Mariani J, Vernet-der Garabedian B.
Proc Natl Acad Sci U S A 106(50):21365-70. Epub 2009 Dec 1.PMID: 19955433 2009
30RORA
Control of Chondrocyte Gene Expression by Actin Dynamics: A Novel Role of Cholesterol/Roralpha Signaling in Endochondral Bone Growth.
Woods A, James CG, Wang G, Dupuis H, Beier F.
J Cell Mol Med Cell Mol Med. 2009 Jan 28. [Epub ahead of print]PMID: 19187119 2009
31RORA
SUMOylation of RORalpha potentiates transcriptional activation function.
Hwang EJ, Lee JM, Jeong J, Park JH, Yang Y, Lim JS, Kim JH, Baek SH, Kim KI.
Biochem Biophys Res Commun 378(3):513-7. Epub 2008 Nov 28.PMID: 19041634 2009
32OPN1MW, OPN1SW, RORA
Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development.
Fujieda H, Bremner R, Mears AJ, Sasaki H.
J Neurochem 108(1):91-101. Epub 2008 Nov 8. 2009
33FOXP3, RORA
Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3.
Du J, Huang C, Zhou B, Ziegler SF.
J Immunol 180(7):4785-92.PMID: 18354202 2008
34RORA
Expression of zebrafish ROR alpha gene in cerebellar-like structures.
Katsuyama Y, Oomiya Y, Dekimoto H, Motooka E, Takano A, Kikkawa S, Hibi M, Terashima T.
Dev Dyn 236(9):2694-701.PMID: 17685489 2007
35RORA
RORA, a large common fragile site gene, is involved in cellular stress response.
Zhu Y, McAvoy S, Kuhn R, Smith DI.
Oncogene 25(20):2901-8. 2006
36RORA, UNC5C
RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity.
Klar J, Asling B, Carlsson B, Ulvsback M, Dellsen A, Strom C, Rhedin M, Forslund A, Anneren G, Ludvigsson JF, Dahl N.
Eur J Hum Genet 13(8):928-34. 2005
37RORA
Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1.
Miki N, Ikuta M, Matsui T.
J Biol Chem 279(15):15025-31. Epub 2004 Jan 23. 2004
38RORA
RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.
Migita H, Satozawa N, Lin JH, Morser J, Kawai K.
FEBS Lett 557(1-3):269-74. 2004
39RORA, HIF1A, ARNT
The gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1.
Chauvet C, Bois-Joyeux B, Berra E, Pouyssegur J, Danan JL.
Biochem J 384(Pt 1):79-85. 2004
40RORA, NR1D1
Identification of Reverb(alpha) as a novel ROR(alpha) target gene.
Delerive P, Chin WW, Suen CS.
J Biol Chem 277(38):35013-8. Epub 2002 Jul 11. 2002
41RORA, RORB
Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1).
Gawlas K, Stunnenberg HG.
Biochim Biophys Acta 1494(3):236-41. 2000
42MYOD1, RORA
Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.
Lau P, et al.
Nucleic Acids Res 27(2):411-20. 1999
43RORA
The orphan nuclear receptor RORalpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.
Gigure V, et al.
Genomics 28 : 596-598. 1995
44RORA
The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions.
McBroom LD, et al.
Mol Cell Biol 15 : 796-808. 1995