| 1 | PLK2, PLK4, ROCK2
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| Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification.
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| Ling H, Hanashiro K, Luong TH, Benavides L, Fukasawa K.
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| Cell Cycle 14(4):544-53. doi: 10.4161/15384101.2014.989121.
2015
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| 2 | CDKN3, ROCK2
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| KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
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| Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD.
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| Oncogene ncogene. 2014 Apr 7. doi: 10.1038/onc.2014.49. [Epub ahead of print]
2014
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| 3 | PTK7, ROCK2
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| PTK7-Src Signaling at Epithelial Cell Contacts Mediates Spatial Organization of Actomyosin and Planar Cell Polarity.
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| Andreeva A, Lee J, Lohia M, Wu X, Macara IG, Lu X.
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| Dev Cell ev Cell. 2014 Apr 2. pii: S1534-5807(14)00101-4. doi: 10.1016/j.devcel.2014.02.008. [Epub ahead of print]
2014
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| 4 | MEF2D, RBFOX2, ROCK2
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| Rbfox2-Coordinated Alternative Splicing of Mef2d and Rock2 Controls Myoblast Fusion during Myogenesis.
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| Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA.
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| Mol Cell 55(4):592-603. doi: 10.1016/j.molcel.2014.06.035. Epub 2014 Jul 31.
2014
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| 5 | ROCK2
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| Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice.
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| Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Ikeda S, Shimokawa H.
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| Arterioscler Thromb Vasc Biol 33(12):2780-91. doi: 10.1161/ATVBAHA.113.301357. Epub 2013 Oct 17.
2013
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| 6 | ROCK1, ROCK2
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| Dissecting the roles of ROCK isoforms in stress-induced cell detachment.
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| Shi J, Surma M, Zhang L, Wei L.
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| Cell Cycle 12(10):1492-500. doi: 10.4161/cc.24699. Epub 2013 Apr 18.
2013
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| 7 | CCND1, PCNA, ROCK1, ROCK2
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| Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA.
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| Zhao Y, Lv M, Lin H, Cui Y, Wei X, Qin Y, Kohama K, Gao Y.
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| Biochem Biophys Res Commun 432(3):488-93. doi: 10.1016/j.bbrc.2013.02.009. Epub 2013 Feb 10.
2013
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| 8 | ROCK1, ROCK2
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| Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
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| Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, Kapur R, Wei L.
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| Cell Death Dis 4:e483. doi: 10.1038/cddis.2013.10.
2013
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| 9 | FHL2, ROCK2
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| FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
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| Okamoto R, Li Y, Noma K, Hiroi Y, Liu PY, Taniguchi M, Ito M, Liao JK.
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| FASEB J 27(4):1439-49. doi: 10.1096/fj.12-217018. Epub 2012 Dec 27.
2013
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| 10 | ROCK2
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| Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
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| Saito T, Hirano M, Ide T, Ichiki T, Koibuchi N, Sunagawa K, Hirano K.
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| Circulation 127(1):104-14. doi: 10.1161/CIRCULATIONAHA.112.135608. Epub 2012 Nov 21.
2013
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| 11 | ARHGEF18, RHOA, ROCK2
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| ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.
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| Herder C, Swiercz JM, Müller C, Peravali R, Quiring R, Offermanns S, Wittbrodt J, Loosli F.
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| Development 140(13):2787-97. doi: 10.1242/dev.096487.
2013
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| 12 | ARHGEF18, RHOA, ROCK2
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| ArhGEF18 regulated Rho signaling in vertebrate retina development.
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| Loosli F.
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| Small GTPases 4(4):242-6. doi: 10.4161/sgtp.27061. Review.
2013
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| 13 | PTPN11, ROCK2
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| SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
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| Langdon Y, Tandon P, Paden E, Duddy J, Taylor JM, Conlon FL.
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| Development 139(5):948-57. doi: 10.1242/dev.067579. Epub 2012 Jan 25.
2012
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| 14 | CD1D, ROCK1, ROCK2
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| Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
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| Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, Brutkiewicz RR.
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| J Immunol 189(4):1689-98. doi: 10.4049/jimmunol.1101484. Epub 2012 Jul 13.
2012
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| 15 | ROCK1, ROCK2
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| ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.
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| Kalaji R, Wheeler AP, Erasmus JC, Lee SY, Endres RG, Cramer LP, Braga VM.
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| Biol Cell 104(8):435-51. doi: 10.1111/boc.201100093. Epub 2012 Jun 4.
2012
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| 16 | ROCK1, ROCK2
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| Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
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| Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA.
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| PLoS One 7(2):e31423. doi: 10.1371/journal.pone.0031423. Epub 2012 Feb 13.
2012
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| 17 | BRCA2, NPM1, ROCK2
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| BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.
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| Wang HF, Takenaka K, Nakanishi A, Miki Y.
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| Cancer Res 71(1):68-77. Epub 2010 Nov 16.
2011
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| 18 | ROCK2, SORL1
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| Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.
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| Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ.
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| J Biol Chem 286(8):6117-27. Epub 2010 Dec 8.
2011
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| 19 | ROCK2
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| Regulation of ROCKII membrane localization through its C-terminus.
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| Kher SS, Worthylake RA.
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| Exp Cell Res 317(20):2845-52. doi: 10.1016/j.yexcr.2011.09.009. Epub 2011 Oct 1.
2011
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| 20 | RHOA, RHOC, ROCK2
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| RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.
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| Kanai M, Crowe MS, Zheng Y, Vande Woude GF, Fukasawa K.
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| Oncogene 29(45):6040-50. doi: 10.1038/onc.2010.328. Epub 2010 Aug 9.
2010
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| 21 | OLR1, ROCK2
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| ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
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| Mattaliano MD, Wooters J, Shih HH, Paulsen JE.
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| Am J Physiol Cell Physiol 298(5):C1180-7. doi: 10.1152/ajpcell.00483.2009. Epub 2010 Feb 24.
2010
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| 22 | ROCK2
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| The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity.
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| Couzens AL, Saridakis V, Scheid MP.
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| Biochem J 419(1):141-8.
2009
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| 23 | ROCK1, ROCK2
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| Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.
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| Lock FE, Hotchin NA.
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| PLoS One 4(12):e8190.
2009
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| 24 | ROCK1, ROCK2
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| The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.
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| Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG.
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| Int J Oncol 33(3):585-93.
2008
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| 25 | ARHGEF11, PTK2, ROCK2
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| FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
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| Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.
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| J Cell Sci 121(Pt 6):895-905. Epub 2008 Feb 26.PMID: 18303050 2008
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| 26 | PTPN11, ROCK2
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| Regulation of RhoA-dependent ROCKII activation by Shp2.
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| Lee HH, Chang ZF.
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| J Cell Biol 181(6):999-1012.PMID: 18559669 2008
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| 27 | CDC42BPA,NOTCH1,ROCK1,ROCK2
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| Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
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| Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP.
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| Genes Dev 21(5):562-77. 2007
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| 28 | ROCK1, ROCK2
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| Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
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| Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y.
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| J Am Coll Cardiol 49(6):698-705. Epub 2007 Jan 26.
2007
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| 29 | ROCK2
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| Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions.
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| Samarin SN, Ivanov AI, Flatau G, Parkos CA, Nusrat A.
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| Mol Biol Cell 18(9):3429-39. Epub 2007 Jun 27.
2007
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| 30 | ROCK2
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| Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
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| Takahashi N, et al.
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| Genomics 55(2):235-7. 1999
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| 31 | AATK, ACIN1, ACOT11, ACSBG1, ADAMTS4, ADGRV1, AKAP11, ANKLE2, ARHGAP26, ARHGEF2, ASTN2, ATP2C2, ATP9A, BICD2, BZRAP1, C12orf51, CAND2, CEP135, CLASP1, CLASP2, CLUAP1, CLUH, CNOT3, COBL, CPNE3, CRTC1, CRY2, CSTF2T, CUL3, CUL4B, DAAM1, DAGLA, DEPDC5, DNAJC13, DOCK10, DZIP3, FBXW11, FKBP15, G3BP2, HEPH, HIP1R, HIPK1, ICOSLG, KIAA0649, KIAA0652, KIF13B, KIF1C, KIF21A, L3MBTL1, LDB3, MAGI2, MAP4K4, MFAP3L, MGEA5, MRC2, MTMR4, N4BP1, NPHP4, OBSL1, PAN2, PHACTR2, PHF2, PHLDB1, PLXND1, PPFIA3, PTCD1, RAB11FIP3, RBM19, RICH2, RNF40, RNF8, ROCK2, RRP12, SAPS2, SETX, SIN3B, SLC24A1, SMCHD1, SNAP91, SOCS5, SS18L1, SWAP70, TBC1D9B, TELO2, TNRC15, TSC22D2, UBE4B, UHRF1BP1L, ULK2, ZBED4, ZC3H11A, ZNF623
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| Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N,Ohara O.
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| DNA Res 5(3):169-76. 1998
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| 32 | ROCK2
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| Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
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| Matsui T, et al.
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| EMBO J 15(9):2208-16. 1996
|