| 1 | FRMD5, NEDEMA, ROCK1
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| De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement
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| Lu S, Ma M, Mao X, Bacino CA, Jankovic J, Sutton VR, Bartley JA, Wang X, Rosenfeld JA, Beleza-Meireles A, Chauhan J, Pan X, Li M, Liu P, Prescott K, Amin S, Davies G, Wangler MF, Dai Y, Bellen HJ.
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| Am J Hum Genet. Oct 6;109(10):1932-1943. doi: 10.1016/j.ajhg.2022.09.005. 2022
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| 2 | POU3F3, ROCK1
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| Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
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| Wan X, Xiang J, Zhang Q, Bian C.
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| J Cell Biochem Cell Biochem. 2018 Nov 26. doi: 10.1002/jcb.28101. [Epub ahead of print]
2018
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| 3 | OPHN1, ROCK1
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| Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
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| Compagnucci C, Barresi S, Petrini S, Billuart P, Piccini G, Chiurazzi P, Alfieri P, Bertini E, Zanni G.
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| Stem Cells Transl Med 5(7):860-9. doi: 10.5966/sctm.2015-0303. Epub 2016 May 9.
2016
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| 4 | LIMK1, LIMK2, ROCK1
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| ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
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| Kapur R, Shi J, Ghosh J, Munugalavadla V, Sims E, Martin H, Wei L, Mali RS.
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| Oncotarget 7(13):16936-47. doi: 10.18632/oncotarget.7851.
2016
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| 5 | FRMD5, ROCK1
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| FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1
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| Hu J, Niu M, Li X, Lu D, Cui J, Xu W, Li G, Zhan J, Zhang H.
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| FEBS Lett. Nov 28;588(23):4348-56. doi: 10.1016/j.febslet.2014.10.012. Epub 2014 Oct 18 2014
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| 6 | ROCK1, ROCK2
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| Dissecting the roles of ROCK isoforms in stress-induced cell detachment.
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| Shi J, Surma M, Zhang L, Wei L.
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| Cell Cycle 12(10):1492-500. doi: 10.4161/cc.24699. Epub 2013 Apr 18.
2013
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| 7 | CCND1, PCNA, ROCK1, ROCK2
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| Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA.
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| Zhao Y, Lv M, Lin H, Cui Y, Wei X, Qin Y, Kohama K, Gao Y.
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| Biochem Biophys Res Commun 432(3):488-93. doi: 10.1016/j.bbrc.2013.02.009. Epub 2013 Feb 10.
2013
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| 8 | ROCK1, ROCK2
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| Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
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| Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, Kapur R, Wei L.
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| Cell Death Dis 4:e483. doi: 10.1038/cddis.2013.10.
2013
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| 9 | NOTCH1, ROCK1
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| Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.
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| Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T.
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| Mol Cell Biol 33(22):4434-47. doi: 10.1128/MCB.00577-13. Epub 2013 Sep 9.
2013
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| 10 | CASP3, ROCK1
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| Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles.
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| Böing AN, Stap J, Hau CM, Afink GB, Ris-Stalpers C, Reits EA, Sturk A, van Noorden CJ, Nieuwland R.
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| Biochim Biophys Acta 1833(8):1844-52. doi: 10.1016/j.bbamcr.2013.03.013. Epub 2013 Mar 24.
2013
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| 11 | MARK2, ROCK1
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| ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
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| Daley WP, Gervais EM, Centanni SW, Gulfo KM, Nelson DA, Larsen M.
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| Development 139(2):411-22.
2012
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| 12 | CD1D, ROCK1, ROCK2
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| Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
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| Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, Brutkiewicz RR.
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| J Immunol 189(4):1689-98. doi: 10.4049/jimmunol.1101484. Epub 2012 Jul 13.
2012
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| 13 | ROCK1, ROCK2
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| ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.
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| Kalaji R, Wheeler AP, Erasmus JC, Lee SY, Endres RG, Cramer LP, Braga VM.
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| Biol Cell 104(8):435-51. doi: 10.1111/boc.201100093. Epub 2012 Jun 4.
2012
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| 14 | ROCK1, ROCK2
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| Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
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| Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA.
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| PLoS One 7(2):e31423. doi: 10.1371/journal.pone.0031423. Epub 2012 Feb 13.
2012
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| 15 | CTNND1, ROCK1
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| Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin.
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| Smith AL, Dohn MR, Brown MV, Reynolds AB.
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| Mol Biol Cell 23(1):99-110. doi: 10.1091/mbc.E11-06-0497. Epub 2011 Oct 26.
2012
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| 16 | F11R, RHOA, ROCK1
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| Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.
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| Stamatovic SM, Sladojevic N, Keep RF, Andjelkovic AV.
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| Mol Cell Biol 32(17):3414-27. doi: 10.1128/MCB.06678-11. Epub 2012 Jun 25.
2012
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| 17 | ROCK1, SHROOM2
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| Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
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| Mohan S, Rizaldy R, Das D, Bauer RJ, Heroux A, Trakselis MA, Hildebrand JD, VanDemark AP.
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| Mol Biol Cell 23(11):2131-42. doi: 10.1091/mbc.E11-11-0937. Epub 2012 Apr 4.
2012
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| 18 | FRMD6, PARD3, PRKCI, ROCK1
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| Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
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| Ishiuchi T, Takeichi M.
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| Nat Cell Biol 13(7):860-6. doi: 10.1038/ncb2274.
2011
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| 19 | MYBPH, NKX2-1, ROCK1
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| MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
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| Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T.
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| EMBO J 31(2):481-93. doi: 10.1038/emboj.2011.416.
2011
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| 20 | ACTG1, ROCK1
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| γ-Actin regulates cell migration and modulates the ROCK signaling pathway.
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| Shum MS, Pasquier E, Po'uha ST, O'Neill GM, Chaponnier C, Gunning PW, Kavallaris M.
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| FASEB J 25(12):4423-33. Epub 2011 Sep 9.
2011
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| 21 | JAK1, ROCK1
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| ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.
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| Sanz-Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, Hooper S, Mitter R, Féral CC, Cook M, Larkin J, Marais R, Meneguzzi G, Sahai E, Marshall CJ.
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| Cancer Cell 20(2):229-45.
2011
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| 22 | ROCK1
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| Functional role of Rho-kinase in ameloblast differentiation.
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| Otsu K, Kishigami R, Fujiwara N, Ishizeki K, Harada H.
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| J Cell Physiol 226(10):2527-34. doi: 10.1002/jcp.22597.
2011
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| 23 | ROCK1
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| Crystal structure of a coiled-coil domain from human ROCK I.
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| Tu D, Li Y, Song HK, Toms AV, Gould CJ, Ficarro SB, Marto JA, Goode BL, Eck MJ.
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| PLoS One 6(3):e18080.
2011
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| 24 | ROCK1
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| ROCK1 as a potential therapeutic target in osteosarcoma.
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| Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z.
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| J Orthop Res 29(8):1259-66. doi: 10.1002/jor.21403. Epub 2011 Mar 8.
2011
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| 25 | PFN2, ROCK1, SMA, SMN1
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| The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.
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| Nölle A, Zeug A, van Bergeijk J, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, O'mer J, Srivastav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P.
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| Hum Mol Genet 20(24):4865-78. doi: 10.1093/hmg/ddr425. Epub 2011 Sep 14.
2011
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| 26 | GNA12, MAPK8, ROCK1
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| G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
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| Juneja J, Cushman I, Casey PJ.
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| PLoS One 6(11):e26085. doi: 10.1371/journal.pone.0026085. Epub 2011 Nov 7.
2011
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| 27 | ROCK1
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| Activating ROCK1 somatic mutations in human cancer.
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| Lochhead PA, Wickman G, Mezna M, Olson MF.
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| Oncogene 29(17):2591-8. Epub 2010 Feb 8.
2010
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| 28 | ROCK1
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| Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.
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| Chang TC, Chen YC, Yang MH, Chen CH, Hsing EW, Ko BS, Liou JY, Wu KK.
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| PLoS One 5(2):e9187. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/cf10edef-3ca9-413f-9c97-98b628c29a25. PLoS One. 2010;5(4). 2010
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| 29 | ROCK1
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| Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation.
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| Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kozawa O, Moriwaki H.
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| Int J Oncol 36(3):585-92.
2010
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| 30 | CCM2, KRIT1, ROCK1
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| Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
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| Stockton RA, Shenkar R, Awad IA, Ginsberg MH.
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| J Exp Med 207(4):881-96. doi: 10.1084/jem.20091258. Epub 2010 Mar 22.
2010
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| 31 | ROCK1
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| Targeted disruption of ROCK1 causes insulin resistance in vivo.
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| Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB.
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| J Biol Chem 284(18):11776-80. Epub 2009 Mar 10.
2009
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| 32 | ROCK1, ROCK2
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| Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.
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| Lock FE, Hotchin NA.
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| PLoS One 4(12):e8190.
2009
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| 33 | FHOD1, ROCK1
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| The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
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| Takeya R, Taniguchi K, Narumiya S, Sumimoto H.
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| EMBO J 27(4):618-28. Epub 2008 Jan 31.
2008
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| 34 | FHOD1, ROCK1
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| The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
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| Hannemann S, Madrid R, Stastna J, Kitzing T, Gasteier J, Schönichen A, Bouchet J, Jimenez A, Geyer M, Grosse R, Benichou S, Fackler OT.
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| J Biol Chem 283(41):27891-903. Epub 2008 Aug 11. 2008
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| 35 | MAPK8IP3, ROCK1
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| Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
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| Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW.
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| Sci Signal 1(47):ra14.
2008
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| 36 | ROCK1, ROCK2
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| The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.
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| Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG.
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| Int J Oncol 33(3):585-93.
2008
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| 37 | ROCK1
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| Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1.
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| Chen J, Ye L, Zhang L, Jiang WG.
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| J Cell Biochem 105(1):313-20.
2008
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| 38 | RND3, ROCK1
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| N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization.
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| Garg R, Riento K, Keep N, Morris JD, Ridley AJ.
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| Biochem J 411(2):407-14.PMID: 18215121 2008
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| 39 | ROCK1
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| ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
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| Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK.
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| J Clin Invest 118(5):1632-44.PMID: 18414683 2008
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| 40 | ROCK1, SHROOM3
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| Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling.
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| Nishimura T, Takeichi M.
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| Development 135(8):1493-502. Epub 2008 Mar 13.
2008
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| 41 | HTT, PFN1, PFN2, ROCK1
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| Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
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| Shao J, Welch WJ, Diprospero NA, Diamond MI.
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| Mol Cell Biol 28(17):5196-208. doi: 10.1128/MCB.00079-08. Epub 2008 Jun 23. 2008
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| 42 | CDC42BPA,NOTCH1,ROCK1,ROCK2
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| Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
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| Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP.
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| Genes Dev 21(5):562-77. 2007
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| 43 | PDCD6IP, CEP55, TSG101, ROCK1, IQGAP1, CD2AP
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| Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
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| Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
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| EMBO J 26(19):4215-27. Epub 2007 Sep 13. 2007
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| 44 | ROCK1, ROCK2
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| Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
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| Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y.
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| J Am Coll Cardiol 49(6):698-705. Epub 2007 Jan 26.
2007
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| 45 | ROCK1, CASP3
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| Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.
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| Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.
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| Proc Natl Acad Sci U S A 103(39):14495-500. Epub 2006 Sep 18. 2006
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| 46 | TAOK1, ROCK1
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| Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.
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| Zihni C, Mitsopoulos C, Tavares IA, Ridley AJ, Morris JD.
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| J Biol Chem 281(11):7317-23. Epub 2006 Jan 2. 2006
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| 47 | ITGB1BP1, ROCK1
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| Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.
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| Stroeken PJ, Alvarez B, Van Rheenen J, Wijnands YM, Geerts D, Jalink K, Roos E.
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| J Cell Physiol 208(3):620-8.PMID: 16741948 2006
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| 48 | LIMK1, ROCK1
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| Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
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| Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S.
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| Science 285(5429):895-8. 1999
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| 49 | ROCK1
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| Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
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| Fujisawa K, Fujita A, Ishizaki T, Saito Y, Narumiya S.
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| J Biol Chem 271(38):23022-8. 1996
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| 50 | ROCK1
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| The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
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| Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S.
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| EMBO J 15(8):1885-93. 1996
|