Citations for
1POU3F3, ROCK1
Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho-associated protein kinase 1.
Wan X, Xiang J, Zhang Q, Bian C.
J Cell Biochem Cell Biochem. 2018 Nov 26. doi: 10.1002/jcb.28101. [Epub ahead of print] 2018
2OPHN1, ROCK1
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function.
Compagnucci C, Barresi S, Petrini S, Billuart P, Piccini G, Chiurazzi P, Alfieri P, Bertini E, Zanni G.
Stem Cells Transl Med 5(7):860-9. doi: 10.5966/sctm.2015-0303. Epub 2016 May 9. 2016
3LIMK1, LIMK2, ROCK1
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells.
Kapur R, Shi J, Ghosh J, Munugalavadla V, Sims E, Martin H, Wei L, Mali RS.
Oncotarget 7(13):16936-47. doi: 10.18632/oncotarget.7851. 2016
4ROCK1, ROCK2
Dissecting the roles of ROCK isoforms in stress-induced cell detachment.
Shi J, Surma M, Zhang L, Wei L.
Cell Cycle 12(10):1492-500. doi: 10.4161/cc.24699. Epub 2013 Apr 18. 2013
5CCND1, PCNA, ROCK1, ROCK2
Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA.
Zhao Y, Lv M, Lin H, Cui Y, Wei X, Qin Y, Kohama K, Gao Y.
Biochem Biophys Res Commun 432(3):488-93. doi: 10.1016/j.bbrc.2013.02.009. Epub 2013 Feb 10. 2013
6ROCK1, ROCK2
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, Kapur R, Wei L.
Cell Death Dis 4:e483. doi: 10.1038/cddis.2013.10. 2013
7NOTCH1, ROCK1
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.
Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T.
Mol Cell Biol 33(22):4434-47. doi: 10.1128/MCB.00577-13. Epub 2013 Sep 9. 2013
8CASP3, ROCK1
Active caspase-3 is removed from cells by release of caspase-3-enriched vesicles.
Böing AN, Stap J, Hau CM, Afink GB, Ris-Stalpers C, Reits EA, Sturk A, van Noorden CJ, Nieuwland R.
Biochim Biophys Acta 1833(8):1844-52. doi: 10.1016/j.bbamcr.2013.03.013. Epub 2013 Mar 24. 2013
9MARK2, ROCK1
ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.
Daley WP, Gervais EM, Centanni SW, Gulfo KM, Nelson DA, Larsen M.
Development 139(2):411-22. 2012
10CD1D, ROCK1, ROCK2
Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Gallo RM, Khan MA, Shi J, Kapur R, Wei L, Bailey JC, Liu J, Brutkiewicz RR.
J Immunol 189(4):1689-98. doi: 10.4049/jimmunol.1101484. Epub 2012 Jul 13. 2012
11ROCK1, ROCK2
ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.
Kalaji R, Wheeler AP, Erasmus JC, Lee SY, Endres RG, Cramer LP, Braga VM.
Biol Cell 104(8):435-51. doi: 10.1111/boc.201100093. Epub 2012 Jun 4. 2012
12ROCK1, ROCK2
Differential regulation of adhesion complex turnover by ROCK1 and ROCK2.
Lock FE, Ryan KR, Poulter NS, Parsons M, Hotchin NA.
PLoS One 7(2):e31423. doi: 10.1371/journal.pone.0031423. Epub 2012 Feb 13. 2012
13CTNND1, ROCK1
Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin.
Smith AL, Dohn MR, Brown MV, Reynolds AB.
Mol Biol Cell 23(1):99-110. doi: 10.1091/mbc.E11-06-0497. Epub 2011 Oct 26. 2012
14F11R, RHOA, ROCK1
Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.
Stamatovic SM, Sladojevic N, Keep RF, Andjelkovic AV.
Mol Cell Biol 32(17):3414-27. doi: 10.1128/MCB.06678-11. Epub 2012 Jun 25. 2012
15ROCK1, SHROOM2
Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
Mohan S, Rizaldy R, Das D, Bauer RJ, Heroux A, Trakselis MA, Hildebrand JD, VanDemark AP.
Mol Biol Cell 23(11):2131-42. doi: 10.1091/mbc.E11-11-0937. Epub 2012 Apr 4. 2012
16FRMD6, PARD3, PRKCI, ROCK1
Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
Ishiuchi T, Takeichi M.
Nat Cell Biol 13(7):860-6. doi: 10.1038/ncb2274. 2011
17MYBPH, NKX2-1, ROCK1
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
Hosono Y, Yamaguchi T, Mizutani E, Yanagisawa K, Arima C, Tomida S, Shimada Y, Hiraoka M, Kato S, Yokoi K, Suzuki M, Takahashi T.
EMBO J 31(2):481-93. doi: 10.1038/emboj.2011.416. 2011
18ACTG1, ROCK1
γ-Actin regulates cell migration and modulates the ROCK signaling pathway.
Shum MS, Pasquier E, Po'uha ST, O'Neill GM, Chaponnier C, Gunning PW, Kavallaris M.
FASEB J 25(12):4423-33. Epub 2011 Sep 9. 2011
19JAK1, ROCK1
ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.
Sanz-Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, Hooper S, Mitter R, Féral CC, Cook M, Larkin J, Marais R, Meneguzzi G, Sahai E, Marshall CJ.
Cancer Cell 20(2):229-45. 2011
20ROCK1
Functional role of Rho-kinase in ameloblast differentiation.
Otsu K, Kishigami R, Fujiwara N, Ishizeki K, Harada H.
J Cell Physiol 226(10):2527-34. doi: 10.1002/jcp.22597. 2011
21ROCK1
Crystal structure of a coiled-coil domain from human ROCK I.
Tu D, Li Y, Song HK, Toms AV, Gould CJ, Ficarro SB, Marto JA, Goode BL, Eck MJ.
PLoS One 6(3):e18080. 2011
22ROCK1
ROCK1 as a potential therapeutic target in osteosarcoma.
Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z.
J Orthop Res 29(8):1259-66. doi: 10.1002/jor.21403. Epub 2011 Mar 8. 2011
23PFN2, ROCK1, SMA, SMN1
The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.
Nölle A, Zeug A, van Bergeijk J, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, O'mer J, Srivastav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P.
Hum Mol Genet 20(24):4865-78. doi: 10.1093/hmg/ddr425. Epub 2011 Sep 14. 2011
24GNA12, MAPK8, ROCK1
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
Juneja J, Cushman I, Casey PJ.
PLoS One 6(11):e26085. doi: 10.1371/journal.pone.0026085. Epub 2011 Nov 7. 2011
25ROCK1
Activating ROCK1 somatic mutations in human cancer.
Lochhead PA, Wickman G, Mezna M, Olson MF.
Oncogene 29(17):2591-8. Epub 2010 Feb 8. 2010
26ROCK1
Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.
Chang TC, Chen YC, Yang MH, Chen CH, Hsing EW, Ko BS, Liou JY, Wu KK.
PLoS One 5(2):e9187. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/cf10edef-3ca9-413f-9c97-98b628c29a25. PLoS One. 2010;5(4). 2010
27ROCK1
Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation.
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kozawa O, Moriwaki H.
Int J Oncol 36(3):585-92. 2010
28CCM2, KRIT1, ROCK1
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Stockton RA, Shenkar R, Awad IA, Ginsberg MH.
J Exp Med 207(4):881-96. doi: 10.1084/jem.20091258. Epub 2010 Mar 22. 2010
29ROCK1
Targeted disruption of ROCK1 causes insulin resistance in vivo.
Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB.
J Biol Chem 284(18):11776-80. Epub 2009 Mar 10. 2009
30ROCK1, ROCK2
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.
Lock FE, Hotchin NA.
PLoS One 4(12):e8190. 2009
31FHOD1, ROCK1
The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.
Takeya R, Taniguchi K, Narumiya S, Sumimoto H.
EMBO J 27(4):618-28. Epub 2008 Jan 31. 2008
32FHOD1, ROCK1
The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.
Hannemann S, Madrid R, Stastna J, Kitzing T, Gasteier J, Schönichen A, Bouchet J, Jimenez A, Geyer M, Grosse R, Benichou S, Fackler OT.
J Biol Chem 283(41):27891-903. Epub 2008 Aug 11. 2008
33MAPK8IP3, ROCK1
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW.
Sci Signal 1(47):ra14. 2008
34ROCK1, ROCK2
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.
Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG.
Int J Oncol 33(3):585-93. 2008
35ROCK1
Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1.
Chen J, Ye L, Zhang L, Jiang WG.
J Cell Biochem 105(1):313-20. 2008
36RND3, ROCK1
N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization.
Garg R, Riento K, Keep N, Morris JD, Ridley AJ.
Biochem J 411(2):407-14.PMID: 18215121 2008
37ROCK1
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK.
J Clin Invest 118(5):1632-44.PMID: 18414683 2008
38ROCK1, SHROOM3
Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling.
Nishimura T, Takeichi M.
Development 135(8):1493-502. Epub 2008 Mar 13. 2008
39HTT, PFN1, PFN2, ROCK1
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
Shao J, Welch WJ, Diprospero NA, Diamond MI.
Mol Cell Biol 28(17):5196-208. doi: 10.1128/MCB.00079-08. Epub 2008 Jun 23. 2008
40CDC42BPA,NOTCH1,ROCK1,ROCK2
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP.
Genes Dev 21(5):562-77. 2007
41PDCD6IP, CEP55, TSG101, ROCK1, IQGAP1, CD2AP
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
EMBO J 26(19):4215-27. Epub 2007 Sep 13. 2007
42ROCK1, ROCK2
Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
Noma K, Goto C, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y.
J Am Coll Cardiol 49(6):698-705. Epub 2007 Jan 26. 2007
43ROCK1, CASP3
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.
Chang J, Xie M, Shah VR, Schneider MD, Entman ML, Wei L, Schwartz RJ.
Proc Natl Acad Sci U S A 103(39):14495-500. Epub 2006 Sep 18. 2006
44TAOK1, ROCK1
Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.
Zihni C, Mitsopoulos C, Tavares IA, Ridley AJ, Morris JD.
J Biol Chem 281(11):7317-23. Epub 2006 Jan 2. 2006
45ITGB1BP1, ROCK1
Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.
Stroeken PJ, Alvarez B, Van Rheenen J, Wijnands YM, Geerts D, Jalink K, Roos E.
J Cell Physiol 208(3):620-8.PMID: 16741948 2006
46LIMK1, ROCK1
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S.
Science 285(5429):895-8. 1999
47ROCK1
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
Fujisawa K, Fujita A, Ishizaki T, Saito Y, Narumiya S.
J Biol Chem 271(38):23022-8. 1996
48ROCK1
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S.
EMBO J 15(8):1885-93. 1996