Citations for
1RNF43, ZNRF3
RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
Lu C, Lin X, Yamashita J, Xi R, Zhou M, Zhang YV, Wang H, Margolskee RF, Koo BK, Clevers H, Matsumoto I, Jiang P.
Stem Cell Reports. Feb 8;17(2):369-383. doi: 10.1016/j.stemcr.2021.12.002. Epub 2022 Jan 6. 2022
2RNF43, ZNRF3
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
Sun T, Annunziato S, Bergling S, Sheng C, Orsini V, Forcella P, Pikiolek M, Kancherla V, Holwerda S, Imanci D, Wu F, Meylan LC, Puehringer LF, Waldt A, Oertli M, Schuierer S, Terracciano LM, Reinker S, Ruffner H, Bouwmeester T, Sailer AW, George E, Roma G, de Weck A, Piscuoglio S, Lohmann F, Naumann U, Liberali P, Cong F, Tchorz JS.
Cell Stem Cell. Oct 7;28(10):1822-1837.e10. doi: 10.1016/j.stem.2021.05.013. Epub 2021 Jun 14. 2021
3RNF43
RNF43 is a Novel Tumor Suppressor and Prognostic Indicator in Clear Cell Renal Cell Carcinoma
Zhu D, Zhang L, Shi X, Gao S, Yue C, Zhang L, Bai Y, Wang Q, Okada A, Yasui T, Wang C, Cui X, Zuo L.
Oncol Res. Jul 2. doi: 10.3727/096504021X16252201000833. Epub ahead of print. 2021
4RNF43
Rnf43 is "lord of the ring" finger proteins in remyelination.
Sardar D, Deneen B.
Neuron. Oct 6;109(19):3069-3071. doi: 10.1016/j.neuron.2021.09.012. 2021
5RNF43
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response
Neumeyer V, Brutau-Abia A, Allgäuer M, Pfarr N, Weichert W, Falkeis-Veits C, Kremmer E, Vieth M, Gerhard M, Mejías-Luque R.
Cell Mol Gastroenterol Hepatol. 11(4):1071-1094. doi: 10.1016/j.jcmgh.2020.11.005. Epub 2020 Nov 11. 2021
6RNF43
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Tsukiyama T, Zou J, Kim J, Ogamino S, Shino Y, Masuda T, Merenda A, Matsumoto M, Fujioka Y, Hirose T, Terai S, Takahashi H, Ishitani T, Nakayama KI, Ohba Y, Koo BK, Hatakeyama S.
Nat Commun. Sep 15;11(1):4586. doi: 10.1038/s41467-020-18257-3. 2020
7RNF43
Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells
Neumeyer V, Grandl M, Dietl A, Brutau-Abia A, Allgäuer M, Kalali B, Zhang Y, Pan KF, Steiger K, Vieth M, Anton M, Mejías-Luque R, Gerhard M.
Carcinogenesis. Jun 10;40(4):551-559. doi: 10.1093/carcin/bgy152 2019
8RNF43
Rnf43.
Serra S, Chetty R.
J Clin Pathol. Jan;71(1):1-6. doi: 10.1136/jclinpath-2017-204763. Epub 2017 Oct 10 2018
9RNF43, RSPO2, ZNRF3
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B.
Nature. May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16. Erratum in: Nature. 2018 Sep;561(7722):E7. 2018
10DDB2, RNF43
DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P.
Cancer Res ancer Res. 2017 Oct 11. doi: 10.1158/0008-5472.CAN-17-1570. [Epub ahead of print] 2017
11RNF43
The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M.
Sci Signal 8(393):ra90. doi: 10.1126/scisignal.aac6757. 2015
12RNF43
Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers.
Jo YS, Kim MS, Lee JH, Lee SH, An CH, Yoo NJ.
Hum Pathol 46(11):1640-6. doi: 10.1016/j.humpath.2015.07.004. Epub 2015 Jul 15. 2015
13RNF43
The ubiquitin ligase RNF43 downregulation increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma.
Wang D, Tan J, Xu Y, Han M, Tu Y, Zhu Z, Dou C, Xin J, Tan X, Zeng JP, Zhao G, Liu Z.
Tumour Biol umour Biol. 2015 Aug 5. [Epub ahead of print] 2015
14RNF43
RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma.
Niu L, Qin HZ, Xi HQ, Wei B, Xia SY, Chen L.
Cell Physiol Biochem 36(5):1835-46. 2015
15RNF43, ZNRF3
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.
Koo BK, van Es JH, van den Born M, Clevers H.
Proc Natl Acad Sci U S A 112(24):7548-50. doi: 10.1073/pnas.1508113112. Epub 2015 May 28. 2015
16RNF43, ZNRF3
ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling.
Zebisch M, Jones EY.
Prog Biophys Mol Biol 118(3):112-8. doi: 10.1016/j.pbiomolbio.2015.04.006. Epub 2015 May 1. Review. 2015
17DVL1, RNF43, ZNRF3
Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.
Jiang X, Charlat O, Zamponi R, Yang Y, Cong F.
Mol Cell 58(3):522-33. doi: 10.1016/j.molcel.2015.03.015. Epub 2015 Apr 16. 2015
18RNF43
Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S.
Mol Cell Biol 35(11):2007-23. doi: 10.1128/MCB.00159-15. Epub 2015 Mar 30. 2015
19RNF43, SSPCS
A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.
Taupin D, Lam W, Rangiah D, McCallum L, Whittle B, Zhang Y, Andrews D, Field M, Goodnow CC, Cook MC.
Hum Genome Var. Apr 16;2:15013. doi: 10.1038/hgv.2015.13. 2015
20RNF43, SSPCS
Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas
Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC.
Gastroenterology. Feb;146(2):520-9. doi: 10.1053/j.gastro.2013.10.045. 2014
21LGR5, RNF43, RSPO1
The structural basis of R-spondin recognition by LGR5 and RNF43.
Chen PH, Chen X, Lin Z, Fang D, He X.
Genes Dev 27(12):1345-50. doi: 10.1101/gad.219915.113. Epub 2013 Jun 11. 2013
22RNF43
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F.
Proc Natl Acad Sci U S A Jul 30;110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11. 2013
23RNF43, ZNRF3
Oncogenic Wnt/â-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research.
Wang K, Li N, Yeung CH, Li JY, Wang HY, Cooper TG.
Mol Hum Reprod ol Hum Reprod. 2012 Nov 27. [Epub ahead of print] 2012
24RNF43, ZNRF3
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.
Nature 488(7413):665-9. doi: 10.1038/nature11308. 2012
25HECW1, RNF43
RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S.
Biochem Biophys Res Commun 404(1):143-7. Epub 2010 Nov 23. 2011
26AKAP8L, RNF43
A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.
Sugiura T, Yamaguchi A, Miyamoto K.
Exp Cell Res 314(7):1519-28. Epub 2008 Jan 26. 2008
27RNF43
Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.
Miyamoto K, Sakurai H, Sugiura T.
Proteomics 8(14):2907-10. 2008
28RNF43
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.
Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y.
Int J Oncol 25(5):1343-8. 2004
29RNF43
Ring finger protein 43 as a new target for cancer immunotherapy.
Uchida N, Tsunoda T, Wada S, Furukawa Y, Nakamura Y, Tahara H.
Clin Cancer Res 10(24):8577-86. 2004