Citations for
1DDB2, RNF43
DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P.
Cancer Res ancer Res. 2017 Oct 11. doi: 10.1158/0008-5472.CAN-17-1570. [Epub ahead of print] 2017
The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M.
Sci Signal 8(393):ra90. doi: 10.1126/scisignal.aac6757. 2015
Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers.
Jo YS, Kim MS, Lee JH, Lee SH, An CH, Yoo NJ.
Hum Pathol 46(11):1640-6. doi: 10.1016/j.humpath.2015.07.004. Epub 2015 Jul 15. 2015
The ubiquitin ligase RNF43 downregulation increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma.
Wang D, Tan J, Xu Y, Han M, Tu Y, Zhu Z, Dou C, Xin J, Tan X, Zeng JP, Zhao G, Liu Z.
Tumour Biol umour Biol. 2015 Aug 5. [Epub ahead of print] 2015
RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma.
Niu L, Qin HZ, Xi HQ, Wei B, Xia SY, Chen L.
Cell Physiol Biochem 36(5):1835-46. 2015
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.
Koo BK, van Es JH, van den Born M, Clevers H.
Proc Natl Acad Sci U S A 112(24):7548-50. doi: 10.1073/pnas.1508113112. Epub 2015 May 28. 2015
ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling.
Zebisch M, Jones EY.
Prog Biophys Mol Biol 118(3):112-8. doi: 10.1016/j.pbiomolbio.2015.04.006. Epub 2015 May 1. Review. 2015
Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.
Jiang X, Charlat O, Zamponi R, Yang Y, Cong F.
Mol Cell 58(3):522-33. doi: 10.1016/j.molcel.2015.03.015. Epub 2015 Apr 16. 2015
Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S.
Mol Cell Biol 35(11):2007-23. doi: 10.1128/MCB.00159-15. Epub 2015 Mar 30. 2015
10LGR5, RNF43, RSPO1
The structural basis of R-spondin recognition by LGR5 and RNF43.
Chen PH, Chen X, Lin Z, Fang D, He X.
Genes Dev 27(12):1345-50. doi: 10.1101/gad.219915.113. Epub 2013 Jun 11. 2013
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F.
Proc Natl Acad Sci U S A 110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11. 2013
12RNF43, ZNRF3
Oncogenic Wnt/â-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research.
Wang K, Li N, Yeung CH, Li JY, Wang HY, Cooper TG.
Mol Hum Reprod ol Hum Reprod. 2012 Nov 27. [Epub ahead of print] 2012
13RNF43, ZNRF3
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.
Nature 488(7413):665-9. doi: 10.1038/nature11308. 2012
14HECW1, RNF43
RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S.
Biochem Biophys Res Commun 404(1):143-7. Epub 2010 Nov 23. 2011
A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.
Sugiura T, Yamaguchi A, Miyamoto K.
Exp Cell Res 314(7):1519-28. Epub 2008 Jan 26. 2008
Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.
Miyamoto K, Sakurai H, Sugiura T.
Proteomics 8(14):2907-10. 2008
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.
Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y.
Int J Oncol 25(5):1343-8. 2004
Ring finger protein 43 as a new target for cancer immunotherapy.
Uchida N, Tsunoda T, Wada S, Furukawa Y, Nakamura Y, Tahara H.
Clin Cancer Res 10(24):8577-86. 2004