1 | RNF43, ZNRF3
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| RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
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| Lu C, Lin X, Yamashita J, Xi R, Zhou M, Zhang YV, Wang H, Margolskee RF, Koo BK, Clevers H, Matsumoto I, Jiang P.
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| Stem Cell Reports. Feb 8;17(2):369-383. doi: 10.1016/j.stemcr.2021.12.002. Epub 2022 Jan 6. 2022
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2 | RNF43, ZNRF3
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| ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
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| Sun T, Annunziato S, Bergling S, Sheng C, Orsini V, Forcella P, Pikiolek M, Kancherla V, Holwerda S, Imanci D, Wu F, Meylan LC, Puehringer LF, Waldt A, Oertli M, Schuierer S, Terracciano LM, Reinker S, Ruffner H, Bouwmeester T, Sailer AW, George E, Roma G, de Weck A, Piscuoglio S, Lohmann F, Naumann U, Liberali P, Cong F, Tchorz JS.
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| Cell Stem Cell. Oct 7;28(10):1822-1837.e10. doi: 10.1016/j.stem.2021.05.013. Epub 2021 Jun 14. 2021
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3 | RNF43
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| RNF43 is a Novel Tumor Suppressor and Prognostic Indicator in Clear Cell Renal Cell Carcinoma
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| Zhu D, Zhang L, Shi X, Gao S, Yue C, Zhang L, Bai Y, Wang Q, Okada A, Yasui T, Wang C, Cui X, Zuo L.
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| Oncol Res. Jul 2. doi: 10.3727/096504021X16252201000833. Epub ahead of print. 2021
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4 | RNF43
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| Rnf43 is "lord of the ring" finger proteins in remyelination.
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| Sardar D, Deneen B.
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| Neuron. Oct 6;109(19):3069-3071. doi: 10.1016/j.neuron.2021.09.012. 2021
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5 | RNF43
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| Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response
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| Neumeyer V, Brutau-Abia A, Allgäuer M, Pfarr N, Weichert W, Falkeis-Veits C, Kremmer E, Vieth M, Gerhard M, Mejías-Luque R.
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| Cell Mol Gastroenterol Hepatol. 11(4):1071-1094. doi: 10.1016/j.jcmgh.2020.11.005. Epub 2020 Nov 11. 2021
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6 | RNF43
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| A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
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| Tsukiyama T, Zou J, Kim J, Ogamino S, Shino Y, Masuda T, Merenda A, Matsumoto M, Fujioka Y, Hirose T, Terai S, Takahashi H, Ishitani T, Nakayama KI, Ohba Y, Koo BK, Hatakeyama S.
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| Nat Commun. Sep 15;11(1):4586. doi: 10.1038/s41467-020-18257-3. 2020
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7 | RNF43
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| Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells
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| Neumeyer V, Grandl M, Dietl A, Brutau-Abia A, Allgäuer M, Kalali B, Zhang Y, Pan KF, Steiger K, Vieth M, Anton M, Mejías-Luque R, Gerhard M.
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| Carcinogenesis. Jun 10;40(4):551-559. doi: 10.1093/carcin/bgy152 2019
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8 | RNF43
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| Rnf43.
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| Serra S, Chetty R.
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| J Clin Pathol. Jan;71(1):1-6. doi: 10.1136/jclinpath-2017-204763. Epub 2017 Oct 10 2018
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9 | RNF43, RSPO2, ZNRF3
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| RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
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| Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B.
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| Nature. May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16. Erratum in: Nature. 2018 Sep;561(7722):E7. 2018
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10 | DDB2, RNF43
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| DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
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| Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P.
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| Cancer Res ancer Res. 2017 Oct 11. doi: 10.1158/0008-5472.CAN-17-1570. [Epub ahead of print]
2017
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11 | RNF43
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| The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane.
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| Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M.
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| Sci Signal 8(393):ra90. doi: 10.1126/scisignal.aac6757.
2015
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12 | RNF43
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| Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers.
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| Jo YS, Kim MS, Lee JH, Lee SH, An CH, Yoo NJ.
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| Hum Pathol 46(11):1640-6. doi: 10.1016/j.humpath.2015.07.004. Epub 2015 Jul 15.
2015
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13 | RNF43
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| The ubiquitin ligase RNF43 downregulation increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma.
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| Wang D, Tan J, Xu Y, Han M, Tu Y, Zhu Z, Dou C, Xin J, Tan X, Zeng JP, Zhao G, Liu Z.
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| Tumour Biol umour Biol. 2015 Aug 5. [Epub ahead of print]
2015
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14 | RNF43
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| RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma.
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| Niu L, Qin HZ, Xi HQ, Wei B, Xia SY, Chen L.
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| Cell Physiol Biochem 36(5):1835-46.
2015
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15 | RNF43, ZNRF3
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| Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.
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| Koo BK, van Es JH, van den Born M, Clevers H.
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| Proc Natl Acad Sci U S A 112(24):7548-50. doi: 10.1073/pnas.1508113112. Epub 2015 May 28.
2015
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16 | RNF43, ZNRF3
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| ZNRF3/RNF43--A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling.
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| Zebisch M, Jones EY.
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| Prog Biophys Mol Biol 118(3):112-8. doi: 10.1016/j.pbiomolbio.2015.04.006. Epub 2015 May 1. Review.
2015
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17 | DVL1, RNF43, ZNRF3
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| Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.
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| Jiang X, Charlat O, Zamponi R, Yang Y, Cong F.
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| Mol Cell 58(3):522-33. doi: 10.1016/j.molcel.2015.03.015. Epub 2015 Apr 16.
2015
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18 | RNF43
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| Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
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| Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S.
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| Mol Cell Biol 35(11):2007-23. doi: 10.1128/MCB.00159-15. Epub 2015 Mar 30.
2015
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19 | RNF43, SSPCS
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| A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred.
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| Taupin D, Lam W, Rangiah D, McCallum L, Whittle B, Zhang Y, Andrews D, Field M, Goodnow CC, Cook MC.
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| Hum Genome Var. Apr 16;2:15013. doi: 10.1038/hgv.2015.13. 2015
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20 | RNF43, SSPCS
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| Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas
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| Gala MK, Mizukami Y, Le LP, Moriichi K, Austin T, Yamamoto M, Lauwers GY, Bardeesy N, Chung DC.
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| Gastroenterology. Feb;146(2):520-9. doi: 10.1053/j.gastro.2013.10.045. 2014
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21 | LGR5, RNF43, RSPO1
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| The structural basis of R-spondin recognition by LGR5 and RNF43.
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| Chen PH, Chen X, Lin Z, Fang D, He X.
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| Genes Dev 27(12):1345-50. doi: 10.1101/gad.219915.113. Epub 2013 Jun 11.
2013
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22 | RNF43
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| Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
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| Jiang X, Hao HX, Growney JD, Woolfenden S, Bottiglio C, Ng N, Lu B, Hsieh MH, Bagdasarian L, Meyer R, Smith TR, Avello M, Charlat O, Xie Y, Porter JA, Pan S, Liu J, McLaughlin ME, Cong F.
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| Proc Natl Acad Sci U S A Jul 30;110(31):12649-54. doi: 10.1073/pnas.1307218110. Epub 2013 Jul 11. 2013
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23 | RNF43, ZNRF3
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| Oncogenic Wnt/â-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research.
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| Wang K, Li N, Yeung CH, Li JY, Wang HY, Cooper TG.
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| Mol Hum Reprod ol Hum Reprod. 2012 Nov 27. [Epub ahead of print]
2012
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24 | RNF43, ZNRF3
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| Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
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| Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.
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| Nature 488(7413):665-9. doi: 10.1038/nature11308.
2012
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25 | HECW1, RNF43
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| RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
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| Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S.
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| Biochem Biophys Res Commun 404(1):143-7. Epub 2010 Nov 23.
2011
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26 | AKAP8L, RNF43
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| A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.
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| Sugiura T, Yamaguchi A, Miyamoto K.
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| Exp Cell Res 314(7):1519-28. Epub 2008 Jan 26. 2008
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27 | RNF43
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| Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins.
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| Miyamoto K, Sakurai H, Sugiura T.
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| Proteomics 8(14):2907-10.
2008
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28 | RNF43
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| A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.
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| Yagyu R, Furukawa Y, Lin YM, Shimokawa T, Yamamura T, Nakamura Y.
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| Int J Oncol 25(5):1343-8. 2004
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29 | RNF43
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| Ring finger protein 43 as a new target for cancer immunotherapy.
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| Uchida N, Tsunoda T, Wada S, Furukawa Y, Nakamura Y, Tahara H.
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| Clin Cancer Res 10(24):8577-86.
2004
|