| 1 | RNF4, TRIM28
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| RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
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| Kuo CY, Li X, Stark JM, Shih HM, Ann DK.
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| Cell Cycle 15(6):787-98. doi: 10.1080/15384101.2016.1138184.
2016
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| 2 | NR2C2, RNF4, TAB1, TAB2, TAB3
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| RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
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| Tan B, Mu R, Chang Y, Wang YB, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Zhang XM, Li AL, Li HY.
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| FEBS Lett 589(19 Pt B):2850-8. doi: 10.1016/j.febslet.2015.07.051. Epub 2015 Aug 20.
2015
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| 3 | RNF4, USP11
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| Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).
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| Hendriks IA, Schimmel J, Eifler K, Olsen JV, Vertegaal AC.
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| J Biol Chem 290(25):15526-37. doi: 10.1074/jbc.M114.618132. Epub 2015 May 12.
2015
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| 4 | CDK2, RNF4
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| CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.
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| Luo K, Deng M, Li Y, Wu C, Xu Z, Yuan J, Lou Z.
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| Nucleic Acids Res 43(11):5465-75. doi: 10.1093/nar/gkv434. Epub 2015 May 6.
2015
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| 5 | FANCA, RNF4
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| RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.
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| Xie J, Kim H, Moreau LA, Puhalla S, Garber J, Al Abo M, Takeda S, D'Andrea AD.
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| J Clin Invest 125(4):1523-32. doi: 10.1172/JCI79325. Epub 2015 Mar 9.
2015
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| 6 | MECP2, RNF4
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| RING finger protein 4 (RNF4) derepresses gene expression from DNA methylation.
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| Wang Y.
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| J Biol Chem 289(49):33808-13. doi: 10.1074/jbc.C114.611558. Epub 2014 Oct 29.
2014
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| 7 | RNF4
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| SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.
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| Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S.
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| Genes Cells 19(10):743-54. doi: 10.1111/gtc.12173. Epub 2014 Sep 10.
2014
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| 8 | RNF4
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| Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4.
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| Xu Y, Plechanovová A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJ.
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| Nat Commun 5:4217. doi: 10.1038/ncomms5217.
2014
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| 9 | RNF4
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| An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
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| Kuo CY, Li X, Kong XQ, Luo C, Chang CC, Chung Y, Shih HM, Li KK, Ann DK.
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| J Biol Chem 289(30):20757-72. doi: 10.1074/jbc.M114.555672. Epub 2014 Jun 6.
2014
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| 10 | RNF4, TERF2
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| RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response.
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| Groocock LM, Nie M, Prudden J, Moiani D, Wang T, Cheltsov A, Rambo RP, Arvai AS, Hitomi C, Tainer JA, Luger K, Perry JJ, Lazzerini-Denchi E, Boddy MN.
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| EMBO Rep 15(5):601-8. doi: 10.1002/embr.201338369. Epub 2014 Apr 8.
2014
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| 11 | RNF4
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| SUMO chain-induced dimerization activates RNF4.
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| Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT.
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| Mol Cell 53(6):880-92. doi: 10.1016/j.molcel.2014.02.031.
2014
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| 12 | KDM5B, RNF4
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| SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.
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| Bueno MT, Richard S.
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| Epigenetics 8(11):1162-75. doi: 10.4161/epi.26112. Epub 2013 Aug 22.
2013
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| 13 | RNF4
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| RNF4 is required for DNA double-strand break repair in vivo.
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| Vyas R, Kumar R, Clermont F, Helfricht A, Kalev P, Sotiropoulou P, Hendriks IA, Radaelli E, Hochepied T, Blanpain C, Sablina A, van Attikum H, Olsen JV, Jochemsen AG, Vertegaal AC, Marine JC.
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| Cell Death Differ 20(3):490-502. doi: 10.1038/cdd.2012.145. Epub 2012 Nov 30.
2013
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| 14 | RNF4, UIMC1
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| RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.
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| Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ.
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| Sci Signal 5(253):ra88. doi: 10.1126/scisignal.2003485.
2012
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| 15 | RNF4
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| SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.
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| Yin Y, Seifert A, Chua JS, Maure JF, Golebiowski F, Hay RT.
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| Genes Dev 26(11):1196-208. doi: 10.1101/gad.189274.112.
2012
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| 16 | RNF4
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| RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.
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| Galanty Y, Belotserkovskaya R, Coates J, Jackson SP.
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| Genes Dev 26(11):1179-95. doi: 10.1101/gad.188284.112.
2012
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| 17 | RNF4
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| Mechanism of ubiquitylation by dimeric RING ligase RNF4.
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| Plechanovová A, Jaffray EG, McMahon SA, Johnson KA, Navrátilová I, Naismith JH, Hay RT.
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| Nat Struct Mol Biol 18(9):1052-9. doi: 10.1038/nsmb.2108.
2011
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| 18 | EPAS1, RNF4, VHL
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| RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
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| van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC.
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| Nucleic Acids Res 38(6):1922-31. Epub 2009 Dec 21.
2010
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| 19 | RNF4
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| RING domain dimerization is essential for RNF4 function.
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| Liew CW, Sun H, Hunter T, Day CL.
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| Biochem J 431(1):23-9.PMID: 20681948 2010
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| 20 | RNF4
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| Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.
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| Hu XV, Rodrigues TM, Tao H, Baker RK, Miraglia L, Orth AP, Lyons GE, Schultz PG, Wu X.
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| Proc Natl Acad Sci U S A 107(34):15087-92. Epub 2010 Aug 9.PMID: 20696907 2010
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| 21 | RNF4, SENP6
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| The SUMO protease SENP6 is essential for inner kinetochore assembly.
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| Mukhopadhyay D, Arnaoutov A, Dasso M.
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| J Cell Biol 188(5):681-92.
2010
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| 22 | PARP1, RNF4
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| PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.
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| Martin N, Schwamborn K, Schreiber V, Werner A, Guillier C, Zhang XD, Bischof O, Seeler JS, Dejean A.
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| EMBO J 28(22):3534-48. Epub 2009 Sep 24.PMID: 19779455 2009
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| 23 | RNF4
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| RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
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| Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT.
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| Nat Cell Biol 10(5):538-46. Epub 2008 Apr 13.PMID: 18408734 2008
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| 24 | RNF4
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| SUMO-targeted ubiquitin ligases in genome stability.
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| Prudden J, Pebernard S, Raffa G, Slavin DA, Perry JJ, Tainer JA, McGowan CH, Boddy MN.
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| EMBO J 26(18):4089-101. Epub 2007 Aug 30.PMID: 17762865 2007
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| 25 | RNF4
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| Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.
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| Sun H, Leverson JD, Hunter T.
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| EMBO J 26(18):4102-12. Epub 2007 Aug 30.PMID: 17762864 2007
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| 26 | RNF4, SUMO1
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| SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies.
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| H�kli M, Karvonen U, J�nne OA, Palvimo JJ.
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| Exp Cell Res 304(1):224-33. Epub 2004 Nov 23.PMID: 15707587 2005
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| 27 | RNF4
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| Transcriptional coregulator SNURF (RNF4) possesses ubiquitin E3 ligase activity.
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| Häkli M, Lorick KL, Weissman AM, Jänne OA, Palvimo JJ.
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| FEBS Lett 560(1-3):56-62.PMID: 14987998 2004
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| 28 | GSC2, RNF4
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| Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region.
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| Galili N, Nayak S, Epstein JA, Buck CA.
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| Dev Dyn 218(1):102-11.
2000
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| 29 | RNF4
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| Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.
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| Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB.
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| Genomics 47(2):258-65. 1998
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| 30 | RNF4
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| Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription.
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| Moilanen AM, Poukka H, Karvonen U, Hakli M, Janne OA, Palvimo JJ.
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| Mol Cell Biol 18(9):5128-39. 1998
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| 31 | C4orf10, FAM193A, NOP14, RNF4, SH3BP2
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| The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3.
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| Hadano S, Ishida Y, Ikeda JE.
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| DNA Res 5(3):177-86. 1998
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| 32 | RNF4
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| The bromodomain : a conserved sequence found in human, Drosophila and yeast proteins.
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| Haynes SR, et al.
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| Nucleic Acids Res 20 : 2603. 1992
|