1 | HUWE1, RNF168, RNF8
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| DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.
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| Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.
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| Sci Rep 7(1):15353. doi: 10.1038/s41598-017-15194-y.
2017
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2 | RNF168, RNF8, USP11
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| USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168.
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| Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W.
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| J Biol Chem 291(2):959-67. doi: 10.1074/jbc.M114.624478. Epub 2015 Oct 27.
2016
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3 | RNF168
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| RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage.
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| Gatti M, Pinato S, Maiolica A, Rocchio F, Prato MG, Aebersold R, Penengo L.
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| Cell Rep ell Rep. 2015 Jan 7. pii: S2211-1247(14)01050-X. doi: 10.1016/j.celrep.2014.12.021. [Epub ahead of print]
2015
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4 | KDM1A, RNF168, TP53BP1
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| Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage.
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| Peng B, Wang J, Hu Y, Zhao H, Hou W, Zhao H, Wang H, Liao J, Xu X.
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| Nucleic Acids Res 43(12):5936-47. doi: 10.1093/nar/gkv528. Epub 2015 May 20.
2015
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5 | RNF168, RNF8, TP53BP1
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| Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair.
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| Hu Y, Wang C, Huang K, Xia F, Parvin JD, Mondal N.
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| PLoS One 9(10):e110522. doi: 10.1371/journal.pone.0110522. eCollection 2014.
2014
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6 | RNF168, RNF8
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| The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells.
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| Mok MT, Cheng AS, Henderson BR.
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| Int J Biochem Cell Biol 57:27-34. doi: 10.1016/j.biocel.2014.09.027. Epub 2014 Oct 7.
2014
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7 | BCL10, RNF168, RNF8, UBE2N
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| BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.
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| Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X.
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| Cell Cycle 13(11):1777-87. doi: 10.4161/cc.28707. Epub 2014 Apr 14.
2014
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8 | RNF168
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| The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.
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| Mattiroli F, Uckelmann M, Sahtoe DD, van Dijk WJ, Sixma TK.
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| Nat Commun 5:3291. doi: 10.1038/ncomms4291. Erratum in: Nat Commun. 2014;5:3692.
2014
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9 | RNF168, RNF8, UBE2N
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| Structural basis for role of ring finger protein RNF168 RING domain.
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| Zhang X, Chen J, Wu M, Wu H, Arokiaraj AW, Wang C, Zhang W, Tao Y, Huen MS, Zang J.
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| Cell Cycle 12(2):312-21. doi: 10.4161/cc.23104. Epub 2012 Jan 15.
2013
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10 | RNF168, TP53BP1
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| RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
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| Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.
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| Proc Natl Acad Sci U S A 110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.
2013
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11 | RNF168, RNF8, USP44
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| The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.
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| Mosbech A, Lukas C, Bekker-Jensen S, Mailand N.
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| J Biol Chem 288(23):16579-87. doi: 10.1074/jbc.M113.459917. Epub 2013 Apr 24.
2013
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12 | RNF168, UBE2A, UBE2B
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| RNF168 forms a functional complex with RAD6 during the DNA damage response.
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| Liu C, Wang D, Wu J, Keller J, Ma T, Yu X.
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| J Cell Sci 126(Pt 9):2042-51. doi: 10.1242/jcs.122945. Epub 2013 Mar 22.
2013
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13 | HERC2, RNF168
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| DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.
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| Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikström M, Bekker-Jensen S, Mailand N.
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| J Cell Biol 197(2):179-87. doi: 10.1083/jcb.201106152.
2012
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14 | RNF168, RNF169
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| Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage.
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| Chen J, Feng W, Jiang J, Deng Y, Huen MS.
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| J Biol Chem 287(33):27715-22. doi: 10.1074/jbc.M112.373530. Epub 2012 Jun 25.
2012
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15 | RNF168, RNF8, STUB1, TRAF6, UBE2N
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| Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
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| Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.
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| J Biol Chem 287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15.
2012
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16 | RNF168, TRIP12, UBR5
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| TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
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| Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.
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| Cell 150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug 9. Erratum in: Cell. 2014 Dec 4;159(6):1476-7.
2012
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17 | RNF168, RNF8
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| RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.
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| Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK.
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| Cell 150(6):1182-95. doi: 10.1016/j.cell.2012.08.005.
2012
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18 | BRCA1, RNF168, TP53BP1
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| RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.
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| Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.
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| J Biol Chem 287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.
2012
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19 | RNF168
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| UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway.
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| Pinato S, Gatti M, Scandiuzzi C, Confalonieri S, Penengo L.
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| Mol Cell Biol 31(1):118-26. Epub 2010 Nov 1.
2011
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20 | RNF168, RNF8
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| Critical roles of ring finger protein RNF8 in replication stress responses.
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| Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS.
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| J Biol Chem 286(25):22355-61. Epub 2011 May 10.
2011
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21 | AKT1, ATM, MRE11A, RNF168
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| MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
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| Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
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| Cell Cycle 10(13):2218-32. Epub 2011 Jul 1.
2011
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22 | RIDIS, RNF168
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| Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia.
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| Devgan SS, Sanal O, Doil C, Nakamura K, Nahas SA, Pettijohn K, Bartek J, Lukas C, Lukas J, Gatti RA.
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| Cell Death Differ 18(9):1500-6. doi: 10.1038/cdd.2011.18. Epub 2011 Mar 11.
2011
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23 | L3MBTL1, RNF168, RNF8
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| The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.
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| Acs K, Luijsterburg MS, Ackermann L, Salomons FA, Hoppe T, Dantuma NP.
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| Nat Struct Mol Biol 18(12):1345-50. doi: 10.1038/nsmb.2188.
2011
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24 | RNF168, RNF8, TP53BP1
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| The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
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| Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.
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| Proc Natl Acad Sci U S A 107(2):809-14. Epub 2009 Dec 22.PMID: 20080757 2010
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25 | MDC1, RNF168, RNF8, TP53BP1, TRIM28
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| 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
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| Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.
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| Nat Cell Biol 12(2):177-84. Epub 2010 Jan 17.PMID: 20081839 2010
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26 | ATM, RNF168, RNF8, USP16
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| ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.
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| Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA.
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| Cell 141(6):970-81.
2010
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27 | OTUB1, RNF168, UBE2N
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| Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
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| Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
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| Nature 466(7309):941-6. doi: 10.1038/nature09297.
2010
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28 | RIDIS, RNF168
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| The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
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| Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
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| Cell 136(3):420-34.
2009
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29 | RNF168, RNF8
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| RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
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| Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
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| Cell 136(3):435-46. 2009
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30 | HIST2H2AC, RNF168
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| RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
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| Pinato S, Scandiuzzi C, Arnaudo N, Citterio E, Gaudino G, Penengo L.
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| BMC Mol Biol 10:55.PMID: 19500350 2009
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31 | FANCD2, RIDIS, RNF168, TEX15
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| Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.
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| Mantere T, Tervasmäki A, Nurmi A, Rapakko K, Kauppila S, Tang J, Schleutker J, Kallioniemi A, Hartikainen JM, Mannermaa A, Nieminen P, Hanhisalo R, Lehto S, Suvanto M, Grip M, Jukkola-Vuorinen A, Tengström M, Auvinen P, Kvist A, Borg Å, Blomqvist C, Aittomäki K, Greenberg RA, Winqvist R, Nevanlinna H, Pylkäs K.
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