Citations for
1MARCHF6, RNF139
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.
EMBO Rep 19(5). pii: e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8. 2018
2HMOX1, RNF139
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
Lin PH, Lan WM, Chau LY.
Oncogene 32(18):2325-34. doi: 10.1038/onc.2012.244. Epub 2012 Jun 11. 2013
3AMFR, AUP1, RNF139
Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.
Jo Y, Hartman IZ, DeBose-Boyd RA.
Mol Biol Cell 24(3):169-83. doi: 10.1091/mbc.E12-07-0564. Epub 2012 Dec 5. 2013
4AMFR, HMGCR, INSIG1, RNF139
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Mol Biol Cell 23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19. 2012
5AMFR, INSIG1, INSIG2, RNF139
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.
Proc Natl Acad Sci U S A 108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5. 2011
6RNF139
The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA, Gemmill RM.
Mol Cancer Res 8(1):93-106. doi: 10.1158/1541-7786.MCR-08-0491. Epub 2010 Jan 12. 2010
7RNF139
The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.
Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ.
J Cell Biol 186(5):685-92. doi: 10.1083/jcb.200906110. Epub 2009 Aug 31. 2009
8RNF139, SCAP, SREBF2
The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
Irisawa M, Inoue J, Ozawa N, Mori K, Sato R.
J Biol Chem 284(42):28995-9004. doi: 10.1074/jbc.M109.041376. Epub 2009 Aug 25. 2009
9RNF139, TSN
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma.
Gimelli S, Beri S, Drabkin HA, Gambini C, Gregorio A, Fiorio P, Zuffardi O, Gemmill RM, Giorda R, Gimelli G.
Mol Cancer 8:52. doi: 10.1186/1476-4598-8-52. 2009
10RNF139
A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin HA, Gemmill RM, Plon SE.
Genes Chromosomes Cancer 46(9):805-12. 2007
11RNF139
RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.
Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM.
Oncogene 26(16):2263-71. Epub 2006 Oct 2. 2007
12RCC3, RCC1, VHL, RNF139, CRCC
About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family.
Valle L, Cascon A, Melchor L, Otero I, Rodriguez-Perales S, Sanchez L, Cruz Cigudosa J, Robledo M, Weber B, Urioste M, Benitez J.
Eur J Hum Genet 13(5):570-8. 2005
13RNF139, COPS5
Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5.
Gemmill RM, Lee JP, Chamovitz DA, Segal D, Hooper JE, Drabkin HA.
Oncogene 24(21):3503-11. 2005
14RNF139, TSN
Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis.
Cho YS, Iguchi N, Yang J, Handel MA, Hecht NB.
Biol Reprod 73(4):840-7. Epub 2005 Jun 29. 2005
15BRCA1, MKRN1, MKRN2, MKRN3, MKRNP1, MKRNP2, MKRNP3, MKRNP4, MKRNP5, MKRNP6, RNF139, SIAH1, SIAH2
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.
Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM.
Proc Natl Acad Sci U S A 96(20):11364-9 1999
16CRCC, FHIT, RCC3, RNF139
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
Gemmill RM, et al.
Proc Natl Acad Sci U S A 95 : 9572-9577. 1998