Citations for
1MAVS, RIPK3
RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection.
Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi M.
PLoS Pathog 13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr. 2017
2MLKL, RIPK1, RIPK3, ZBP1
RIPK1 inhibits ZBP1-driven necroptosis during development.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.
Nature 540(7631):129-133. doi: 10.1038/nature20559. Epub 2016 Nov 7. 2016
3RIPK1, RIPK3
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.
Science 353(6299):603-8. doi: 10.1126/science.aaf6803. 2016
4CDC37, HSP90AA1, RIPK3
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z.
Proc Natl Acad Sci U S A 112(16):5017-22. doi: 10.1073/pnas.1505244112. Epub 2015 Apr 7. 2015
5RIPK1, RIPK3
The diverse role of RIP kinases in necroptosis and inflammation.
Silke J, Rickard JA, Gerlic M.
Nat Immunol 16(7):689-97. doi: 10.1038/ni.3206. Review. Erratum in: Nat Immunol. 2015 Aug;16(8):889. 2015
6CASP8, RIPK3
A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing.
Moriwaki K, Bertin J, Gough PJ, Chan FK.
J Immunol 194(4):1938-44. doi: 10.4049/jimmunol.1402167. Epub 2015 Jan 7. 2015
7RIPK1, RIPK3
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.
Roderick JE, Hermance N, Zelic M, Simmons MJ, Polykratis A, Pasparakis M, Kelliher MA.
Proc Natl Acad Sci U S A 111(40):14436-41. doi: 10.1073/pnas.1409389111. Epub 2014 Sep 22. 2014
8RIPK1, RIPK3
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.
Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SW, Albert ML, Green DR, Oberst A.
Cell Death Differ 21(10):1511-21. doi: 10.1038/cdd.2014.76. Epub 2014 Jun 6. 2014
9RIPK3, XIAP
XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ.
Cell Rep 7(6):1796-808. doi: 10.1016/j.celrep.2014.05.008. Epub 2014 May 29. 2014
10CASP8, RIPK1, RIPK3
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR.
Cell 157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8. 2014
11MLKL, RIPK3
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.
Immunity 39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. 2013
12RIPK3
RIP3: a molecular switch for necrosis and inflammation.
Moriwaki K, Chan FK.
Genes Dev 27(15):1640-9. doi: 10.1101/gad.223321.113. Review. 2013
13RIPK3
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition.
Dondelinger Y, Aguileta MA, Goossens V, Dubuisson C, Grootjans S, Dejardin E, Vandenabeele P, Bertrand MJ.
Cell Death Differ 20(10):1381-92. doi: 10.1038/cdd.2013.94. Epub 2013 Jul 26. 2013
14CASP8, RIPK3, TLR3
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES.
J Biol Chem 288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9. 2013
15RIPK1, RIPK3
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis.
McQuade T, Cho Y, Chan FK.
Biochem J 456(3):409-15. doi: 10.1042/BJ20130860. 2013
16MLKL, RIPK3
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X.
Cell 148(1-2):213-27. doi: 10.1016/j.cell.2011.11.031. 2012
17RIPK1, RIPK3
Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.
Duprez L, Bertrand MJ, Vanden Berghe T, Dondelinger Y, Festjens N, Vandenabeele P.
J Biol Chem 287(18):14863-72. doi: 10.1074/jbc.M111.288670. Epub 2012 Feb 23. 2012
18RIPK1, RIPK3
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.
Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H.
Cell 150(2):339-50. doi: 10.1016/j.cell.2012.06.019. 2012
19BIRC2, BIRC3, RIPK3, RIPK4
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
Bertrand MJ, Lippens S, Staes A, Gilbert B, Roelandt R, De Medts J, Gevaert K, Declercq W, Vandenabeele P.
PLoS One 6(9):e22356. Epub 2011 Sep 12. 2011
20FADD, RIPK3
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M.
Nature 477(7364):330-4. doi: 10.1038/nature10273. 2011
21CASP8, RIPK3
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
Nature 471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2. 2011
22RIPK1, RIPK3
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T.
Sci Signal 3(115):re4. doi: 10.1126/scisignal.3115re4. Review. 2010
23RIPK1, RIPK3
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK.
Cell 137(6):1112-23. 2009
24RIPK1, RIPK3
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J.
Science 325(5938):332-6. Epub 2009 Jun 4. 2009
25RIPK1, RIPK3, ZBP1
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J.
EMBO Rep 10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10. 2009
26RIPK3
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X.
Cell 137(6):1100-11. doi: 10.1016/j.cell.2009.05.021. 2009
27RIPK3
Cloning, overexpression, purification, and characterization of receptor-interacting protein 3 truncation in Escherichia coli.
Jeong MS, Park JS, Jang SB.
Appl Biochem Biotechnol 141(2-3):175-86. 2007
28RIPK1, RIPK2, RIPK3, RIPK4
Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair.
Adams S, Pankow S, Werner S, Munz B.
J Invest Dermatol 127(3):538-44. Epub 2006 Oct 12. 2007
29RIPK1, RIPK3
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
Sun X, Yin J, Starovasnik MA, Fairbrother WJ, Dixit VM.
J Biol Chem 277(11):9505-11. Epub 2001 Dec 4. 2002
30RIPK3
The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocationand localizes to mitochondria.
Kasof GM, Prosser JC, Liu D, Lorenzi MV, Gomes BC.
FEBS Lett 473(3):285-91. 2000
31RIPK3
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.
Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y.
Curr Biol 9(10):539-42. 1999
32RIPK3
RIP3, a novel apoptosis-inducing kinase.
Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM.
J Biol Chem 274(24):16871-5. 1999