| 1 | RIPK3, USP22
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| USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination.
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| Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, van Wijk SJ.
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| EMBO Rep. Feb 3;22(2):e50163. doi: 10.15252/embr.202050163. Epub 2020 Dec 28. 2021
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| 2 | MAVS, RIPK3
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| RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection.
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| Downey J, Pernet E, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi M.
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| PLoS Pathog 13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr.
2017
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| 3 | IFNB1, RIPK1, RIPK3
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| Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.
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| Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A.
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| J Immunol 198(11):4435-4447. doi: 10.4049/jimmunol.1601717. Epub 2017 May 1.
2017
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| 4 | MLKL, RIPK1, RIPK3, ZBP1
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| RIPK1 inhibits ZBP1-driven necroptosis during development.
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| Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.
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| Nature 540(7631):129-133. doi: 10.1038/nature20559. Epub 2016 Nov 7.
2016
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| 5 | RIPK1, RIPK3
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| RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
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| Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.
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| Science 353(6299):603-8. doi: 10.1126/science.aaf6803.
2016
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| 6 | CDC37, HSP90AA1, RIPK3
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| A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
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| Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z.
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| Proc Natl Acad Sci U S A 112(16):5017-22. doi: 10.1073/pnas.1505244112. Epub 2015 Apr 7.
2015
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| 7 | RIPK1, RIPK3
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| The diverse role of RIP kinases in necroptosis and inflammation.
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| Silke J, Rickard JA, Gerlic M.
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| Nat Immunol 16(7):689-97. doi: 10.1038/ni.3206. Review. Erratum in: Nat Immunol. 2015 Aug;16(8):889.
2015
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| 8 | CASP8, RIPK3
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| A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing.
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| Moriwaki K, Bertin J, Gough PJ, Chan FK.
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| J Immunol 194(4):1938-44. doi: 10.4049/jimmunol.1402167. Epub 2015 Jan 7.
2015
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| 9 | RIPK1, RIPK3
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| Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.
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| Roderick JE, Hermance N, Zelic M, Simmons MJ, Polykratis A, Pasparakis M, Kelliher MA.
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| Proc Natl Acad Sci U S A 111(40):14436-41. doi: 10.1073/pnas.1409389111. Epub 2014 Sep 22.
2014
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| 10 | RIPK1, RIPK3
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| RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.
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| Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SW, Albert ML, Green DR, Oberst A.
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| Cell Death Differ 21(10):1511-21. doi: 10.1038/cdd.2014.76. Epub 2014 Jun 6.
2014
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| 11 | RIPK3, XIAP
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| XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
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| Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ.
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| Cell Rep 7(6):1796-808. doi: 10.1016/j.celrep.2014.05.008. Epub 2014 May 29.
2014
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| 12 | CASP8, RIPK1, RIPK3
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| RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
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| Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR.
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| Cell 157(5):1189-202. doi: 10.1016/j.cell.2014.04.018. Epub 2014 May 8.
2014
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| 13 | MLKL, RIPK3
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| The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
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| Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.
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| Immunity 39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5.
2013
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| 14 | RIPK3
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| RIP3: a molecular switch for necrosis and inflammation.
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| Moriwaki K, Chan FK.
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| Genes Dev 27(15):1640-9. doi: 10.1101/gad.223321.113. Review.
2013
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| 15 | RIPK3
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| RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition.
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| Dondelinger Y, Aguileta MA, Goossens V, Dubuisson C, Grootjans S, Dejardin E, Vandenabeele P, Bertrand MJ.
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| Cell Death Differ 20(10):1381-92. doi: 10.1038/cdd.2013.94. Epub 2013 Jul 26.
2013
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| 16 | CASP8, RIPK3, TLR3
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| Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
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| Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES.
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| J Biol Chem 288(43):31268-79. doi: 10.1074/jbc.M113.462341. Epub 2013 Sep 9.
2013
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| 17 | RIPK1, RIPK3
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| Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis.
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| McQuade T, Cho Y, Chan FK.
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| Biochem J 456(3):409-15. doi: 10.1042/BJ20130860.
2013
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| 18 | MLKL, RIPK3
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| Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
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| Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X.
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| Cell 148(1-2):213-27. doi: 10.1016/j.cell.2011.11.031.
2012
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| 19 | RIPK1, RIPK3
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| Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis.
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| Duprez L, Bertrand MJ, Vanden Berghe T, Dondelinger Y, Festjens N, Vandenabeele P.
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| J Biol Chem 287(18):14863-72. doi: 10.1074/jbc.M111.288670. Epub 2012 Feb 23.
2012
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| 20 | RIPK1, RIPK3
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| The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.
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| Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H.
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| Cell 150(2):339-50. doi: 10.1016/j.cell.2012.06.019.
2012
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| 21 | BIRC2, BIRC3, RIPK3, RIPK4
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| cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
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| Bertrand MJ, Lippens S, Staes A, Gilbert B, Roelandt R, De Medts J, Gevaert K, Declercq W, Vandenabeele P.
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| PLoS One 6(9):e22356. Epub 2011 Sep 12. 2011
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| 22 | FADD, RIPK3
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| FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
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| Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M.
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| Nature 477(7364):330-4. doi: 10.1038/nature10273.
2011
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| 23 | CASP8, RIPK3
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| Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
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| Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
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| Nature 471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.
2011
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| 24 | RIPK1, RIPK3
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| The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
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| Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T.
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| Sci Signal 3(115):re4. doi: 10.1126/scisignal.3115re4. Review.
2010
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| 25 | RIPK1, RIPK3
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| Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
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| Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK.
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| Cell 137(6):1112-23.
2009
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| 26 | RIPK1, RIPK3
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| RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
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| Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J.
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| Science 325(5938):332-6. Epub 2009 Jun 4.
2009
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| 27 | RIPK1, RIPK3, ZBP1
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| DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
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| Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J.
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| EMBO Rep 10(8):916-22. doi: 10.1038/embor.2009.109. Epub 2009 Jul 10.
2009
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| 28 | RIPK3
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| Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
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| He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X.
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| Cell 137(6):1100-11. doi: 10.1016/j.cell.2009.05.021.
2009
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| 29 | RIPK3
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| Cloning, overexpression, purification, and characterization of receptor-interacting protein 3 truncation in Escherichia coli.
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| Jeong MS, Park JS, Jang SB.
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| Appl Biochem Biotechnol 141(2-3):175-86.
2007
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| 30 | RIPK1, RIPK2, RIPK3, RIPK4
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| Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair.
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| Adams S, Pankow S, Werner S, Munz B.
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| J Invest Dermatol 127(3):538-44. Epub 2006 Oct 12.
2007
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| 31 | RIPK1, RIPK3
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| Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
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| Sun X, Yin J, Starovasnik MA, Fairbrother WJ, Dixit VM.
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| J Biol Chem 277(11):9505-11. Epub 2001 Dec 4.
2002
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| 32 | RIPK3
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| The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocationand localizes to mitochondria.
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| Kasof GM, Prosser JC, Liu D, Lorenzi MV, Gomes BC.
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| FEBS Lett 473(3):285-91. 2000
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| 33 | RIPK3
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| Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.
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| Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y.
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| Curr Biol 9(10):539-42. 1999
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| 34 | RIPK3
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| RIP3, a novel apoptosis-inducing kinase.
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| Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM.
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| J Biol Chem 274(24):16871-5. 1999
|