Citations for
1RHOA, TET2
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.
Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Yang Y, Zhou Y, Rao A, You MJ, Sun D, Huang Y.
J Clin Invest 127(8):2998-3012. doi: 10.1172/JCI92026. Epub 2017 Jul 10. 2017
2PKHD1, RHOA, SMURF1, SMURF2
NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology
Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG
Sci Rep. Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4. 2017
3FMN1, RHOA
RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells.
Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB.
J Cell Sci. Jan 15;130(2):420-428. doi: 10.1242/jcs.194704. Erratum in: J Cell Sci. 2017 Mar 1;130(5):1017. 2017
4ARHGEF40, KRT18, KRT8, RHOA
Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement.
Fujiwara S, Ohashi K, Mashiko T, Kondo H, Mizuno K.
Mol Biol Cell 27(6):954-66. doi: 10.1091/mbc.E15-06-0417. Epub 2016 Jan 28. 2016
5ARHGEF2, CGN, RHOA
Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.
Tian Y, Gawlak G, Tian X, Shah AS, Sarich N, Citi S, Birukova AA.
J Biol Chem 291(45):23681-23692. Epub 2016 Sep 2. 2016
6MYLPF, RHOA
RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis.
Duan X, Liu J, Zhu CC, Wang QC, Cui XS, Kim NH, Xiong B, Sun SC.
Cell Cycle. 15(3):471-7. doi: 10.1080/15384101.2015.1128590. Epub 2015 Dec 23 2016
7ADGRG1, GNA12, GNA13, RHOA
The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
Ackerman SD, Garcia C, Piao X, Gutmann DH, Monk KR.
Nat Commun 6:6122. doi: 10.1038/ncomms7122. 2015
8PTK2, PXN, RACGAP1, RHOA
RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088. 2015
9DLC1, RHOA, TNS1
Tensin1 positively regulates RhoA activity through its interaction with DLC1.
Shih YP, Sun P, Wang A, Lo SH.
Biochim Biophys Acta 1853(12):3258-65. doi: 10.1016/j.bbamcr.2015.09.028. Epub 2015 Sep 28. 2015
10ADD1, RHOA
Adducin is required for desmosomal cohesion in keratinocytes.
Rötzer V, Breit A, Waschke J, Spindler V.
J Biol Chem 289(21):14925-40. doi: 10.1074/jbc.M113.527127. Epub 2014 Apr 7. 2014
11GEM, GEMIP, RHOA
Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.
Andrieu G, Quaranta M, Leprince C, Cuvillier O, Hatzoglou A.
Carcinogenesis 35(11):2503-11. doi: 10.1093/carcin/bgu185. Epub 2014 Aug 30. 2014
12CDC42, RHOA, STARD13
StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion.
Hanna S, Khalil B, Nasrallah A, Saykali BA, Sobh R, Nasser S, El-Sibai M.
Int J Oncol 44(5):1499-511. doi: 10.3892/ijo.2014.2330. Epub 2014 Mar 7. 2014
13RAC1, RHOA, TRIO
Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis.
Cannet A, Schmidt S, Delaval B, Debant A.
Mol Biol Cell 25(25):4063-71. doi: 10.1091/mbc.E14-06-1153. Epub 2014 Oct 29. 2014
14BIRC2, RHOA, XIAP
A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.
Hornburger MC, Mayer BA, Leonhardt S, Willer EA, Zahler S, Beyerle A, Rajalingam K, Vollmar AM, Fürst R.
FASEB J 28(4):1938-46. doi: 10.1096/fj.13-235754. Epub 2013 Dec 26. 2014
15CGN, CGNL1, RHOA
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
Guillemot L, Guerrera D, Spadaro D, Tapia R, Jond L, Citi S.
Mol Biol Cell 25(13):1995-2005. doi: 10.1091/mbc.E13-11-0680. Epub 2014 May 7. 2014
16RHOA, RHOB, RHOC
RhoA, RhoB and RhoC have different roles in cancer cell migration.
Ridley AJ.
J Microsc 251(3):242-9. doi: 10.1111/jmi.12025. Epub 2013 Mar 12. 2013
17FN1, NFATC1, RHOA
Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes.
Zhu L, Qi XY, Aoudjit L, Mouawad F, Baldwin C, Nattel S, Takano T.
Am J Physiol Renal Physiol 304(7):F849-62. doi: 10.1152/ajprenal.00495.2012. Epub 2013 Feb 6. 2013
18DIAPH1, PLECKHG5, RHOA
The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.
Dachsel JC, Ngok SP, Lewis-Tuffin LJ, Kourtidis A, Geyer R, Johnston L, Feathers R, Anastasiadis PZ.
Mol Cell Biol 33(24):4909-18. doi: 10.1128/MCB.00565-13. Epub 2013 Oct 14. 2013
19ARHGAP21, RHOA, RHOC
ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.
Lazarini M, Traina F, Machado-Neto JA, Barcellos KS, Moreira YB, Brandão MM, Verjovski-Almeida S, Ridley AJ, Saad ST.
Biochim Biophys Acta 1832(2):365-74. doi: 10.1016/j.bbadis.2012.11.010. Epub 2012 Nov 28. 2013
20RHOA, SLC3A2
CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.
Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, Féral CC.
J Exp Med 210(1):173-90. doi: 10.1084/jem.20121651. Epub 2013 Jan 7. 2013
21ARHGEF18, RHOA, ROCK2
ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation.
Herder C, Swiercz JM, Müller C, Peravali R, Quiring R, Offermanns S, Wittbrodt J, Loosli F.
Development 140(13):2787-97. doi: 10.1242/dev.096487. 2013
22ARHGEF18, RHOA, ROCK2
ArhGEF18 regulated Rho signaling in vertebrate retina development.
Loosli F.
Small GTPases 4(4):242-6. doi: 10.4161/sgtp.27061. Review. 2013
23CES1, RHOA
Control of RhoA methylation by carboxylesterase I.
Cushman I, Cushman SM, Potter PM, Casey PJ.
J Biol Chem 288(26):19177-83. doi: 10.1074/jbc.M113.467407. Epub 2013 May 8. 2013
24FOXO1, RHOA, RIPOR2
Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration
Rougerie P, Largeteau Q, Megrelis L, Carrette F, Lejeune T, Toffali L, Rossi B, Zeghouf M, Cherfils J, Constantin G, Laudanna C, Bismuth G, Mangeney M, Delon J
J Immunol. Jan 15;190(2):748-55. doi: 10.4049/jimmunol.1201174. Epub 2012 Dec 14. 2013
25INPPL1, RHOA
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
Kato K, Yazawa T, Taki K, Mori K, Wang S, Nishioka T, Hamaguchi T, Itoh T, Takenawa T, Kataoka C, Matsuura Y, Amano M, Murohara T, Kaibuchi K.
Mol Biol Cell 23(13):2593-604. doi: 10.1091/mbc.E11-11-0958. Epub 2012 May 16. 2012
26ARHGEF3, RHOA, RHOB
Structure of the Rho-specific guanine nucleotide-exchange factor Xpln.
Murayama K, Kato-Murayama M, Akasaka R, Terada T, Yokoyama S, Shirouzu M.
Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 12):1455-9. doi: 10.1107/S1744309112045265. Epub 2012 Nov 19. 2012
27PLD1, RHOA
PLD1 Negatively Regulates Dendritic Branching.
Zhu YB, Kang K, Zhang Y, Qi C, Li G, Yin DM, Wang Y.
J Neurosci 32(23):7960-9. doi: 10.1523/JNEUROSCI.5378-11.2012. 2012
28PRKD1, PRKD2, PRKD3, RHOA, RTKN
Protein kinase D regulates RhoA activity via rhotekin phosphorylation.
Pusapati GV, Eiseler T, Rykx A, Vandoninck S, Derua R, Waelkens E, Van Lint J, von Wichert G, Seufferlein T.
J Biol Chem 287(12):9473-83. doi: 10.1074/jbc.M112.339564. Epub 2012 Jan 6. 2012
29FYN, RHOA, SLIT2
Slit2 regulates the dispersal of oligodendrocyte precursor cells via Fyn/RhoA signaling.
Liu X, Lu Y, Zhang Y, Li Y, Zhou J, Yuan Y, Gao X, Su Z, He C.
J Biol Chem 287(21):17503-16. doi: 10.1074/jbc.M111.317610. Epub 2012 Mar 20. 2012
30F11R, RHOA, ROCK1
Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.
Stamatovic SM, Sladojevic N, Keep RF, Andjelkovic AV.
Mol Cell Biol 32(17):3414-27. doi: 10.1128/MCB.06678-11. Epub 2012 Jun 25. 2012
31AGAP1, AGAP2, RHOA
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.
J Biol Chem 287(21):17176-85. doi: 10.1074/jbc.M111.334458. Epub 2012 Mar 27. 2012
32GMIP, RHOA, SYTL1
Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Johnson JL, Monfregola J, Napolitano G, Kiosses WB, Catz SD.
Mol Biol Cell 23(10):1902-16. doi: 10.1091/mbc.E11-12-1001. Epub 2012 Mar 21. 2012
33CDC42, OPHN1, RAC1, RHOA
The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets.
Elvers M, Beck S, Fotinos A, Ziegler M, Gawaz M.
Cardiovasc Res 94(3):526-36. doi: 10.1093/cvr/cvs079. Epub 2012 Feb 1. 2012
34RHOA, SYNCRIP
Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis.
Xing L, Yao X, Williams KR, Bassell GJ.
Mol Biol Cell 23(8):1500-9. doi: 10.1091/mbc.E11-10-0867. Epub 2012 Feb 22. 2012
35RHOA
RHOA is a modulator of the cholesterol-lowering effects of statin.
Medina MW, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite LM, Kuang YL, Krauss RM.
PLoS Genet 8(11):e1003058. doi: 10.1371/journal.pgen.1003058. Epub 2012 Nov 15. Erratum in: PLoS Genet. 2013 Feb;9(2). doi: 10.1371/annotat 2012
36CDH1, RHOA, SMURF1
The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth.
Kannan M, Lee SJ, Schwedhelm-Domeyer N, Stegmüller J.
Development 139(19):3600-12. doi: 10.1242/dev.081786. 2012
37IQGAP1, RHOA, RHOB, RHOC
Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration.
Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB.
J Biol Chem 287(45):38367-78. doi: 10.1074/jbc.M112.377499. Epub 2012 Sep 19. 2012
38RHOA
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.
Herzog D, Loetscher P, van Hengel J, Knüsel S, Brakebusch C, Taylor V, Suter U, Relvas JB.
J Neurosci. 31(13):5120-30. 2011
39RHOA, SMURF1
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR.
FEBS Lett 585(14):2199-204. Epub 2011 Jun 23. 2011
40ARGAP18, RHOA
ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.
Maeda M, Hasegawa H, Hyodo T, Ito S, Asano E, Yuang H, Funasaka K, Shimokata K, Hasegawa Y, Hamaguchi M, Senga T.
Mol Biol Cell 22(20):3840-52. doi: 10.1091/mbc.E11-04-0364. Epub 2011 Aug 24. 2011
41ARHGEF3, RHOA
Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake.
Serbanovic-Canic J, Cvejic A, Soranzo N, Stemple DL, Ouwehand WH, Freson K.
Blood 118(18):4967-76. doi: 10.1182/blood-2011-02-337295. Epub 2011 Jun 28. 2011
42CIT, RHOA
Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis.
Bassi ZI, Verbrugghe KJ, Capalbo L, Gregory S, Montembault E, Glover DM, D'Avino PP.
J Cell Biol 195(4):595-603. doi: 10.1083/jcb.201105136. 2011
43RHOA, RHOC, ROCK2
RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.
Kanai M, Crowe MS, Zheng Y, Vande Woude GF, Fukasawa K.
Oncogene 29(45):6040-50. doi: 10.1038/onc.2010.328. Epub 2010 Aug 9. 2010
44RHOA, RHOB, RHOC
Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells.
Hutchison N, Hendry BM, Sharpe CC.
Cell Signal 21(10):1522-31. Epub 2009 May 27.PMID: 19477269 2009
45MYH9, PLEKHG6, RHOA, RHOC
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
Wu D, Asiedu M, Wei Q.
Oncogene 28(22):2219-30.PMID: 19421144 2009
46CDH1, RAC1, RHOA, RHOB
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Deplazes J, Fuchs M, Rauser S, Genth H, Lengyel E, Busch R, Luber B.
Hum Mol Genet 18(19):3632-44. Epub 2009 Jul 7.PMID: 19584084 2009
47ARHGEF10, KIF3B, RHOA
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Aoki T, Ueda S, Kataoka T, Satoh T.
BMC Cell Biol 10:56.PMID: 19635168 2009
48DIAPH1, RHOA
RhoA effector mDia1 is required for PI 3-kinase-dependent actin remodeling and spreading by thrombin in platelets.
Gao G, Chen L, Dong B, Gu H, Dong H, Pan Y, Gao Y, Chen X.
Biochem Biophys Res Commun 385(3):439-44. Epub 2009 May 24. 2009
49CYTH1, RHOA
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Förster R, Alon R, Fraemohs L, Dreck K, Weber C, Lämmermann T, Sixt M, Kolanus W.
Blood 113(23):5801-10. Epub 2009 Apr 3. 2009
50ARHGDIA, RHOA, RHOB
RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha.
Ho TT, Merajver SD, Lapière CM, Nusgens BV, Deroanne CF.
J Biol Chem 283(31):21588-98. Epub 2008 Jun 4. 2008
51PLEKHG6, PLK1, RHOA
Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle.
Asiedu M, Wu D, Matsumura F, Wei Q.
J Biol Chem 283(42):28392-400. Epub 2008 Aug 11.PMID: 18694934 2008
52CGNL1, RAC1, RHOA
Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
Guillemot L, Paschoud S, Jond L, Foglia A, Citi S.
Mol Biol Cell 19(10):4442-53. Epub 2008 Jul 23. 2008
53DIAPH1, MEMO1, RHOA
Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells.
Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A.
J Cell Biol 183(3):401-8. Epub 2008 Oct 27. 2008
54ANLN, RHOA
Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis.
Piekny AJ, Glotzer M.
Curr Biol 18(1):30-6. Epub 2007 Dec 27. 2008
55CIT, RHOA, TTC3
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, Silengo L, Di Cunto F.
J Cell Sci 120(Pt 11):1859-67. Epub 2007 May 8. 2007
56RHOA
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension.
Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS.
Exp Cell Res 313(16):3616-23. Epub 2007 Jul 10. 2007
57ECT2, PKP4, RHOA
Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.
Keil R, Wolf A, Hüttelmaier S, Hatzfeld M.
Cell Cycle 6(2):122-7. Epub 2007 Jan 19. Review. 2007
58ECT2, RHOA
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.
Nishimura Y, Yonemura S.
J Cell Sci 119(Pt 1):104-14. Epub 2005 Dec 13. 2006
59NEDD9, RHOA
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.
Dadke D, Jarnik M, Pugacheva EN, Singh MK, Golemis EA.
Mol Biol Cell 17(3):1204-17. Epub 2006 Jan 4. 2006
60MYHG, PLEKHG6, RHOA
A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis.
Wu D, Asiedu M, Adelstein RS, Wei Q.
Cell Cycle 5(11):1234-9. Epub 2006 Jun 1.PMID: 16721066 2006
61ARF1, ARPC2, ARPC3, RHOA, ARHGAP21
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
Dubois T, Paleotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P.
Nat Cell Biol 7(4):353-64. Epub 2005 Mar 27. 2005
62ECT2, RHOA
An ECT2-centralspindlin complex regulates the localization and function of RhoA.
YŸce O, Piekny A, Glotzer M.
J Cell Biol 170(4):571-82. 2005
63CDC42, RHOA
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.
Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F.
Exp Cell Res. 294(2):335-44. 2004
64CDC42, RHOA
Protein profile of tax-associated complexes.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F.
J Biol Chem. 279(1):495-508. 2004
65RHOA, RHOC
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.
Horiuchi A, Imai T, Wang C, Ohira S, Feng Y, Nikaido T, Konishi I.
Lab Invest 83(6):861-70. 2003
66MPRIP, RHOA
Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.
Surks HK, Richards CT, Mendelsohn ME.
J Biol Chem 278(51):51484-93. Epub 2003 Sep 23. 2003
67RAC1, RAP1GDS1, RHOA
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
Lanning CC, Ruiz-Velasco R, Williams CL.
J Biol Chem 278(14):12495-506. Epub 2003 Jan 27.PMID: 12551911 2003
68RHOA
RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.
Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB.
J Biol Chem. 278(35):33492-500. 2003
69RHOA
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.
Liu TS, Musch MW, Sugi K, Walsh-Reitz MM, Ropeleski MJ, Hendrickson BA, Pothoulakis C, Lamont JT, Chang EB.
Am J Physiol Cell Physiol. 284(4):C1073-82 2003
70RHOA, RHPN1, RHPN2
The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.
Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD.
J Biol Chem 277(46):43924-32. Epub 2002 Sep 06. 2002
71RHOA, CRMP1, DPYSL2
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.
Leung T, Ng Y, Cheong A, Ng CH, Tan I, Hall C, Lim L.
FEBS Lett 532(3):445-9. 2002
72ARHGEF3, RHOA
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K.
J Biol Chem 277(45):42964-72. Epub 2002 Sep 06. 2002
73RHOA, RAC1, RTN4
Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1.
Niederost B, Oertle T, Fritsche J, McKinney RA, Bandtlow CE.
J Neurosci 22(23):10368-76. 2002
74KRAS, RAC1, RAP1GDS1, RHOA
SmgGDS displays differential binding and exchange activity towards different Ras isoforms.
Vikis HG, Stewart S, Guan KL.
Oncogene 21(15):2425-32.PMID: 11948427 2002
75RHOA
Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.
Thodeti CK, Massoumi R, Bindslev L, Sjölander A.
Biochem J. 365(Pt 1):157-63. 2002
76RHOA
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.
Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ.
J Biol Chem. 276(29):27145-51. 2001
77RHOA
Determination of interaction sites of phospholipase D1 for RhoA.
Cai S, Exton JH.
Biochem J. 355(Pt 3):779-85. 2001
78RHOA
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2.
Singh US, Kunar MT, Kao YL, Baker KM.
EMBO J. 20(10):2413-23. 2001
79RHOA, RHOB, RHOC, RHOG
Motility and invasion are differentially modulated by Rho family GTPases.
Banyard J, Anand-Apte B, Symons M, Zetter BR.
Oncogene 19(4):580-91. 2000
80RHOA, RHOB, RHOC, RHOG
Rho family proteins in cell adhesion and cell migration.
Evers EE, Zondag GC, Malliri A, Price LS, ten Klooster JP, van der Kammen RA, Collard JG.
Eur J Cancer 36(10):1269-74. Review. 2000
81RHOA
The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain.
Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M.
J Biol Chem. 275(46):36116-23. 2000
82RHOA, RHOB, RHOC, RHOG
Rho-like GTPases: their role in epithelial cell-cell adhesion and invasion.
Sander EE, Collard JG.
Eur J Cancer 35(14):1905-11. Review. 1999
83RHOA
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.
Houssa B, de Widt J, Kranenburg O, Moolenaar WH, van Blitterswijk WJ.
J Biol Chem. 274(11):6820-2. 1999
84RHOA, TIAM1
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling.
Stam JC, Michiels F, van der Kammen RA, Moolenaar WH, Collard JG.
EMBO J 17(14):4066-74. 1998
85CDC42, RHOA
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.
Alberts AS, Bouquin N, Johnston LH, Treisman R.
J Biol Chem. 273(15):8616-22. 1998
86RHOA
Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains.
Gingras D, Gauthier F, Lamy S, Desrosiers RR, Béliveau R.
Biochem Biophys Res Commun. 247(3):888-93. 1998
87RHOA
Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.
Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ.
J Biol Chem. 273(5):2698-705. 1998
88RHOA, GPX1
Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids.
Kiss C, Li J, Szeles A, Gizatullin RZ, Kashuba VI, Lushnikova T, Protopopov AI, Kelve M, Kiss H, Kholodnyuk ID, Imreh S, Klein G, Zabarovsky ER.
Cytogenet Cell Genet 79 : 228-230. 1997
89RHOA
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190.
Li R, Zhang B, Zheng Y.
J Biol Chem. 272(52):32830-5. 1997
90RHOA
Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology.
Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH.
J Cell Biol. 137(7):1603-13. 1997
91RHOA, RTKN
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
Reid T, Furuyashiki T, Ishizaki T, Watanabe G, Watanabe N, Fujisawa K, Morii N, Madaule P, Narumiya S.
J Biol Chem. 271(23):13556-60. 1996
92RHOA, RHOB, RHOC, RHOD, RHOG, RAC1, RAC2, RAC3
Activation of the small GTP-binding proteins rho and rac by growth factor receptors.
Nobes CD, Hawkins P, Stephens L, Hall A.
J Cell Sci 108 ( Pt 1):225-33. 1995
93RHOA, RHOB, RHOC, RHOD, RHOG
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Ridley AJ, Hall A.
Cell 70(3):389-99. 1992
94RHOA, RHOB, RHOC
Chromosome localization of human ARH genes, a ras-related gene family.
Cannizzaro LA, et al.
Genomics 6 : 197-203. 1990