Citations for
1RHO
The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants.
Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, Xie H, Zhao C.
J Biol Chem Biol Chem. 2017 Aug 30. pii: jbc.M117.784017. doi: 10.1074/jbc.M117.784017. [Epub ahead of print] 2017
2RHO
Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.
Wang X, Mu Y, Sun M, Han J.
J Mol Cell Biol 9(2):104-116. doi: 10.1093/jmcb/mjw041. 2017
3ARF4, GBF1, RHO
The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking.
Wang J, Fresquez T, Kandachar V, Deretic D.
J Cell Sci. Dec 1;130(23):3975-3987. doi: 10.1242/jcs.205492. Epub 2017 Oct 12 2017
4CSNB6, RHO
Structural role of the T94I rhodopsin mutation in congenital stationary night blindness.
Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan EC, Standfuss J.
EMBO Rep 17(10):1431-1440. Epub 2016 Jul 25. 2016
5RHO
Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution.
Fernández-Sampedro MA, Invergo BM, Ramon E, Bertranpetit J, Garriga P.
Sci Rep 6:21570. doi: 10.1038/srep21570. 2016
6PRCD, RHO
Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.
Spencer WJ, Pearring JN, Salinas RY, Loiselle DR, Skiba NP, Arshavsky VY.
Biochemistry Sep 13;55(36):5028-37. doi: 10.1021/acs.biochem.6b00489. Epub 2016 Aug 30 2016
7GUCY1A3, RHO
Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.
Pearring JN, Spencer WJ, Lieu EC, Arshavsky VY.
Elife 4. pii: e12058. doi: 10.7554/eLife.12058. 2015
8RHO
Haplotypes of RHO polymorphisms and susceptibility to age-related macular degeneration.
Tang K, Wang W, Wang Q, Wang L, Bai H, Jiang Y, Huang Y.
Int J Clin Exp Pathol 8(3):3174-9. eCollection 2015. 2015
9RHO
Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs.
Murray AR, Vuong L, Brobst D, Fliesler SJ, Peachey NS, Gorbatyuk MS, Naash MI, Al-Ubaidi MR.
Hum Mol Genet 24(10):2709-23. doi: 10.1093/hmg/ddv031. Epub 2015 Jan 30. 2015
10RER1, RHO
Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking.
Yamasaki A, Hara T, Maejima I, Sato M, Sato K, Sato K.
Sci Rep 4:5973. doi: 10.1038/srep05973. 2014
11RHO, RP4
The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death.
Hollingsworth TJ, Gross AK.
J Biol Chem 288(40):29047-55. doi: 10.1074/jbc.M113.495184. Epub 2013 Aug 12. 2013
12RHO, RP4
Rhodopsin p.N78I dominant mutation causing sectorial retinitis pigmentosa in a pedigree with intrafamilial clinical heterogeneity.
Rivera-De la Parra D, Cabral-Macias J, Matias-Florentino M, Rodriguez-Ruiz G, Robredo V, Zenteno JC.
Gene 519(1):173-6. doi: 10.1016/j.gene.2013.01.048. Epub 2013 Feb 9. 2013
13RHO, SAG
Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.
Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV.
Cell Signal. Dec;25(12):2613-24. doi: 10.1016/j.cellsig.2013.08.022. Epub 2013 Sep 3. 2013
14GNAT1, GNB1, PDE6G, RGS9, RHO, SLC24A1
Selection of Phototransduction Genes in Homo sapiens
Christopher M, Scheetz TE, Mullins RF, Abràmoff MD
Invest Ophthalmol Vis Sci. Aug 13;54(8):5489-96. doi: 10.1167/iovs.12-11454. 2013
15KAT5, NRL, RHO
Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development.
Kim JW, Jang SM, Kim CH, An JH, Choi KH.
Mol Cell Biol 32(9):1720-32. doi: 10.1128/MCB.06440-11. Epub 2012 Feb 21. 2012
16CSNB6, RHO
Structural, energetic, and mechanical perturbations in rhodopsin mutant that causes congenital stationary night blindness.
Kawamura S, Colozo AT, Ge L, Müller DJ, Park PS.
J Biol Chem 287(26):21826-35. doi: 10.1074/jbc.M112.340182. Epub 2012 May 1. 2012
17RHO
Molecular mechanisms of disease for mutations at Gly-90 in rhodopsin.
Toledo D, Ramon E, Aguilà M, Cordomí A, Pérez JJ, Mendes HF, Cheetham ME, Garriga P.
J Biol Chem. 286(46):39993-40001 2011
18RHO
Severe retinal degeneration caused by a novel rhodopsin mutation.
Liu H, Wang M, Xia CH, Du X, Flannery JG, Ridge KD, Beutler B, Gong X.
Invest Ophthalmol Vis Sci. 51(2):1059-65. 2010
19ABCA4, ARMS2, CFH, FBLN5, PRPF31, PRPF31, RHO, RPGR, USH2A
Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait.
Wright AF, Chakarova CF, Abd El-Aziz MM, Bhattacharya SS.
Nat Rev Genet. 11(4):273-284. 2010
20ARRP1, RHO, RP4
Mutation spectrum and frequency of the RHO gene in 248 Chinese families with retinitis pigmentosa.
Li S, Xiao X, Wang P, Guo X, Zhang Q.
Biochem Biophys Res Commun 401(1):42-7. Epub 2010 Sep 9. 2010
21RHO
Engineered zinc finger nuclease-mediated homologous recombination of the human rhodopsin gene.
Greenwald DL, Cashman SM, Kumar-Singh R.
Invest Ophthalmol Vis Sci. 51(12):6374-80. 2010
22ASAP1, RHO
Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4.
Mazelova J, Astuto-Gribble L, Inoue H, Tam BM, Schonteich E, Prekeris R, Moritz OL, Randazzo PA, Deretic D.
EMBO J 28(3):183-92. Epub 2009 Jan 15. 2009
23RHO
A dual role for EDEM1 in the processing of rod opsin.
Kosmaoglou M, Kanuga N, Aguilà M, Garriga P, Cheetham ME.
J Cell Sci. 122(Pt 24):4465-72. 2009
24RHO, RP4
Retinal laminar architecture in human retinitis pigmentosa caused by rhodopsin gene mutations.
Aleman TS, Cideciyan AV, Sumaroka A, Windsor EA, Herrera W, White DA, Kaushal S, Naidu A, Roman AJ, Schwartz SB, Stone EM, Jacobson SG.
Invest Ophthalmol Vis Sci 49(4):1580-90. 2008
25CSNB6, RHO
Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB.
Zeitz C, Gross AK, Leifert D, Kloeckener-Gruissem B, McAlear SD, Lemke J, Neidhardt J, Berger W.
Invest Ophthalmol Vis Sci 49(9):4105-14. Epub 2008 May 16. 2008
26RHO, RP4
Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa.
Mendes HF, Cheetham ME.
Hum Mol Genet 17(19):3043-54. Epub 2008 Jul 17. 2008
27IMPDH1, RHO
IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA.
Mortimer SE, Xu D, McGrew D, Hamaguchi N, Lim HC, Bowne SJ, Daiger SP, Hedstrom L.
J Biol Chem 283(52):36354-60. Epub 2008 Oct 30. 2008
28RHO
Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease.
White, D. A., Hauswirth, W. W., Kaushal, S., Lewin, A. S.
Invest. Ophthal. Vis. Sci. 48: 1942-1951 2007
29ARRP1, RHO, RP4
Retinitis pigmentosa associated with rhodopsin mutations: Correlation between phenotypic variability and molecular effects.
Iannaccone A, Man D, Waseem N, Jennings BJ, Ganapathiraju M, Gallaher K, Reese E, Bhattacharya SS, Klein-Seetharaman J.
Vision Res 46(27):4556-67. Epub 2006 Oct 2. 2006
30RP4, RHO
Rhodopsin maturation defects induce photoreceptor death by apoptosis: a fly model for RhodopsinPro23His human retinitis pigmentosa.
Galy A, Roux MJ, Sahel JA, Leveillard T, Giangrande A.
Hum Mol Genet 14(17):2547-57. Epub 2005 Jul 27. 2005
31PRPF31, RHO, RP11
Mutations in PRPF31 inhibit pre-mRNA splicing of rhodopsin gene and cause apoptosis of retinal cells.
Yuan L, Kawada M, Havlioglu N, Tang H, Wu JY.
J Neurosci 25(3):748-57. 2005
32RHO, SAG
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes.
Chuang JZ, Vega C, Jun W, Sung CH.
J Clin Invest 114(1):131-40. 2004
33KLF15, RBP3, RHO
Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters.
Otteson DC, Liu Y, Lai H, Wang C, Gray S, Jain MK, Zack DJ.
Invest Ophthalmol Vis Sci 45(8):2522-30. 2004
34RHO
Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations.
Organisciak, D. T., Darrow, R. M., Barsalou, L., Kutty, R. K., Wiggert, B.
Invest. Ophthal. Vis. Sci. 44: 486-492 2003
35RHO
Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.
Kijas JW, Cideciyan AV, Aleman TS, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM.
Proc Natl Acad Sci U S A. 99(9):6328-33. 2002
36RHO
Crystal structure of rhodopsin: A G protein-coupled receptor.
Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M.
Science 289(5480):739-45. 2000
37RHO
Interaction between the conserved region in the C-terminal domain of GRK2 and rhodopsin is necessary for GRK2 to catalyze receptor phosphorylation.
Gan XQ, Wang JY, Yang QH, Li Z, Liu F, Pei G, Li L.
J Biol Chem. 275(12):8469-74. 2000
38RHO
The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction.
Marin EP, Krishna AG, Zvyaga TA, Isele J, Siebert F, Sakmar TP.
J Biol Chem. 275(3):1930-6. 2000
39RHO
Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.
Mendez A, Burns ME, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J.
Neuron. 28(1):153-64. 2000
40RHO
Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration.
Grimm C, Wenzel A, Hafezi F, Yu S, Redmond TM, Remé CE.
Nature Genet. 25(1):63-6. 2000
41RHO
Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1.
Chang HY, Ready DF.
Science 290(5498):1902-3. 2000
42CSNB6, RHO
A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness.
Al-Jandal N, et al.
Hum Mutat 13 : 75-81. 1999
43RHO, RP4
Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man.
Cideciyan AV, et al.
Proc Natl Acad Sci U S A 95 : 7103-7108. 1998
44RHO, RP4
Thr mutation in the rhodopsin gene associated with retinitis pigmentosa.
Capeans C, et al.
Hum Hered 48 : 237-240. 1998
45RHO, RP4
Rhodopsin C110Y mutation causes a type 2 autosomal dominant retinitis pigmentosa.
Milla E, Heon E, Grounauer PA, Piguet B, Ducrey N, Stone EM, Schorderet DF, Munier FL.
Ophthalmic Genet 19(3):131-9. 1998
46RHO
Retinopathy induced in mice by targeted disruption of the rhodopsin gene.
Humphries MM, Rancourt D, Farrar GJ, Kenna P, Hazel M, Bush RA, Sieving PA, Sheils DM, McNally N, Creighton P, Erven A, Boros A, Gulya K, Capecchi MR, Humphries P.
Nat Genet. 15(2):216-9. 1997
47RHO
Structural and enzymatic aspects of rhodopsin phosphorylation.
Ohguro H, Rudnicka-Nawrot M, Buczyłko J, Zhao X, Taylor JA, Walsh KA, Palczewski K.
J Biol Chem. 271(9):5215-24. 1996
48RHO
RER, an evolutionarily conserved sequence upstream of the rhodopsin gene, has enhancer activity.
Nie Z, Chen S, Kumar R, Zack DJ.
J Biol Chem. 271(5):2667-75. 1996
49RP4, RHO, D3S621
Autosomal dominant retinitis pigmentosa : no evidence for nonallelic genetic heterogeneity on 3q.
Kumar-Singh R, et al.
Am J Hum Genet 52 : 319-326. 1993
50RHO
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.
Benovic JL, Gomez J.
J Biol Chem. 268(26):19521-7. 1993
51RHO
Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa.
Olsson JE, Gordon JW, Pawlyk BS, Roof D, Hayes A, Molday RS, Mukai S, Cowley GS, Berson EL, Dryja TP.
Neuron. 9(5):815-30. 1992
52RHO
Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.
Khorana HG.
J Biol Chem. 267(1):1-4. 1992
53RHO, RP4
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.
Sung CH, et al.
Proc Natl Acad Sci U S A 88 : 8840-8844. 1991