Citations for
1FAT4, RET
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling
Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H.
Dev Cell. Mar 25;48(6):780-792.e4. doi: 10.1016/j.devcel.2019.02.004. Epub 2019 Mar 7. 2019
2RET
Exome sequencing reveals mutant genes with low penetrance involved in MEN2A-associated tumorigenesis.
Cai J, Li L, Ye L, Jiang X, Shen L, Gao Z, Fang W, Huang F, Su T, Zhou Y, Wang W, Ning G.
Endocr Relat Cancer 22(1):23-33. doi: 10.1530/ERC-14-0225. Epub 2014 Nov 17. 2015
3ATF4, RET
A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.
Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF.
J Biol Chem 290(18):11749-61. doi: 10.1074/jbc.M114.619833. Epub 2015 Mar 20. 2015
4KIF5B, RET
KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer.
Qian Y, Chai S, Liang Z, Wang Y, Zhou Y, Xu X, Zhang C, Zhang M, Si J, Huang F, Huang Z, Hong W, Wang K.
Mol Cancer 13:176. doi: 10.1186/1476-4598-13-176. 2014
5CBLC, PDLIM7, RET
Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A.
Kales SC, Nau MM, Merchant AS, Lipkowitz S.
PLoS One 9(1):e87116. doi: 10.1371/journal.pone.0087116. eCollection 2014. 2014
6MEN2A, RET
The association between Hirschsprung's disease and multiple endocrine neoplasia type 2a: a systematic review.
Coyle D, Friedmacher F, Puri P.
Pediatr Surg Int 30(8):751-6. doi: 10.1007/s00383-014-3538-2. Epub 2014 Jun 28. 2014
7RET
The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function.
Fonseca-Pereira D, Arroz-Madeira S, Rodrigues-Campos M, Barbosa IA, Domingues RG, Bento T, Almeida AR, Ribeiro H, Potocnik AJ, Enomoto H, Veiga-Fernandes H.
Nature 514(7520):98-101. doi: 10.1038/nature13498. Epub 2014 Jul 27. 2014
8RET
Expression variability and function of the RET gene in adult peripheral blood mononuclear cells.
Rusmini M, Griseri P, Matera I, Pontarini E, Ravazzolo R, Mavilio D, Ceccherini I.
J Cell Physiol 229(12):2027-37. doi: 10.1002/jcp.24660. 2014
9RET
Tissue specific somatic mutations and aganglionosis in Hirschsprung's disease.
Moore SW, Zaahl MG.
J Pediatr Surg 49(2):258-61; discussion 261. doi: 10.1016/j.jpedsurg.2013.11.035. Epub 2013 Nov 15. 2014
10RET
Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer.
Spanheimer PM, Park JM, Askeland RW, Kulak MV, Woodfield GW, De Andrade JP, Cyr AR, Sugg SL, Thomas A, Weigel RJ.
Clin Cancer Res 20(8):2115-25. doi: 10.1158/1078-0432.CCR-13-2221. Epub 2014 Feb 13. 2014
11HOXB5, RET
HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.
Zhu JJ, Kam MK, Garcia-Barceló MM, Tam PK, Lui VC.
Int J Biochem Cell Biol 51:142-9. doi: 10.1016/j.biocel.2014.04.013. Epub 2014 Apr 29. 2014
12FGFR1OP, RET
Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.
Bossi D, Carlomagno F, Pallavicini I, Pruneri G, Trubia M, Raviele PR, Marinelli A, Anaganti S, Cox MC, Viale G, Santoro M, Di Fiore PP, Minucci S.
Mol Oncol 8(2):221-31. doi: 10.1016/j.molonc.2013.11.004. Epub 2013 Nov 19. 2014
13RET
RET is a potential tumor suppressor gene in colorectal cancer.
Luo Y, Tsuchiya KD, Il Park D, Fausel R, Kanngurn S, Welcsh P, Dzieciatkowski S, Wang J, Grady WM.
Oncogene 32(16):2037-47. doi: 10.1038/onc.2012.225. Epub 2012 Jul 2. 2013
14RET, TOP1, TOP2A
DNA topoisomerases participate in fragility of the oncogene RET.
Dillon LW, Pierce LC, Lehman CE, Nikiforov YE, Wang YH.
PLoS One 8(9):e75741. doi: 10.1371/journal.pone.0075741. eCollection 2013. 2013
15ECM1, RET
Stromal protein Ecm1 regulates ureteric bud patterning and branching.
Paroly SS, Wang F, Spraggon L, Merregaert J, Batourina E, Tycko B, Schmidt-Ott KM, Grimmond S, Little M, Mendelsohn C.
PLoS One 8(12):e84155. doi: 10.1371/journal.pone.0084155. eCollection 2013. 2013
16KIF5B, RET
KIF5B-RET fusions in lung adenocarcinoma.
Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R, Ogiwara H, Oike T, Enari M, Schetter AJ, Okayama H, Haugen A, Skaug V, Chiku S, Yamanaka I, Arai Y, Watanabe S, Sekine I, Ogawa S, Harris CC, Tsuda H, Yoshida T, Yokota J, Shibata T.
Nat Med 18(3):375-7. doi: 10.1038/nm.2644. 2012
17RET
Alternative splicing results in RET isoforms with distinct trafficking properties.
Richardson DS, Rodrigues DM, Hyndman BD, Crupi MJ, Nicolescu AC, Mulligan LM.
Mol Biol Cell 23(19):3838-50. doi: 10.1091/mbc.E12-02-0114. Epub 2012 Aug 8. 2012
18RET
GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization.
Yosef N, Ubogu EE.
Microvasc Res 83(3):298-310. doi: 10.1016/j.mvr.2012.01.005. Epub 2012 Feb 2. 2012
19GDNF, RET
RET and GDNF mutations are rare in fetuses with renal agenesis or other severe kidney development defects.
Jeanpierre C, Macé G, Parisot M, Morinière V, Pawtowsky A, Benabou M, Martinovic J, Amiel J, Attié-Bitach T, Delezoide AL, Loget P, Blanchet P, Gaillard D, Gonzales M, Carpentier W, Nitschke P, Tores F, Heidet L, Antignac C, Salomon R; Société Française de Foetopathologie.
J Med Genet 48(7):497-504. Epub 2011 Apr 13. 2011
20RET
RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons.
Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P.
J Biol Chem 286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub 2011 Feb 28. 2011
21HOXB5, NKX2-1, RET
HOXB5 cooperates with NKX2-1 in the transcription of human RET.
Zhu J, Garcia-Barcelo MM, Tam PK, Lui VC.
PLoS One 6(6):e20815. doi: 10.1371/journal.pone.0020815. Epub 2011 Jun 3. 2011
22HSCR1, RET
Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease.
Miao X, Leon TY, Ngan ES, So MT, Yuan ZW, Lui VC, Chen Y, Wong KK, Tam PK, Garcia-Barceló M.
Hum Mol Genet 19(8):1461-7. Epub 2010 Jan 20. 2010
23RET
Targeting RET Receptor Tyrosine Kinase Activation in Cancer.
Phay JE, Shah MH.
Clin Cancer Res lin Cancer Res. 2010 Oct 7. [Epub ahead of print]PMID: 20930041 2010
24RAP1GAP, RET
Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.
Jiao L, Zhang Y, Hu C, Wang YG, Huang A, He C.
Cell Res ell Res. 2010 Sep 28. [Epub ahead of print]PMID: 20877310 2010
25MEN2A, MEN2B, RET
Multiple endocrine neoplasia type 2.
Wohllk N, Schweizer H, Erlic Z, Schmid KW, Walz MK, Raue F, Neumann HP.
Best Pract Res Clin Endocrinol Metab 24(3):371-87.PMID: 20833330 2010
26RET
Acidification of the Golgi apparatus is indispensable for maturation but not for cell surface delivery of Ret.
Hirata Y, Shimokawa N, Oh-Hashi K, Yu ZX, Kiuchi K.
J Neurochem Neurochem. 2010 Aug 25. doi: 10.1111/j.1471-4159.2010.06966.x. [Epub ahead of print]PMID: 20796177 2010
27RET
Medullary thyroid cancer: a promising model for targeted therapy.
Torino F, Paragliola RM, Barnabei A, Corsello SM.
Curr Mol Med 10(7):608-25.PMID: 20712590 2010
28ITGB1, RET
RET-Mediated Cell Adhesion and Migration Require Multiple Integrin Subunits.
Cockburn JG, Richardson DS, Gujral TS, Mulligan LM.
J Clin Endocrinol Metab Clin Endocrinol Metab. 2010 Aug 11. [Epub ahead of print]PMID: 20702524 2010
29RET
Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret.
Honma Y, Kawano M, Kohsaka S, Ogawa M.
Development 137(14):2319-28. Epub 2010 Jun 9.PMID: 20534675 2010
30NR4A2, RET
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain.
Galleguillos D, Fuentealba JA, Gómez LM, Saver M, Gómez A, Nash K, Burger C, Gysling K, Andrés ME.
J Neurochem 114(4):1158-67. Epub 2010 Jun 1.PMID: 20533997 2010
31FKBP4, RET
The RET51/FKBP52 complex and its involvement in Parkinson disease.
Fusco D, Vargiolu M, Vidone M, Mariani E, Pennisi LF, Bonora E, Capellari S, Dirnberger D, Baumeister R, Martinelli P, Romeo G.
Hum Mol Genet 19(14):2804-16. Epub 2010 May 4.PMID: 20442138 2010
32CCDC6, RET
DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.
Gandhi M, Dillon LW, Pramanik S, Nikiforov YE, Wang YH.
Oncogene 29(15):2272-80. Epub 2010 Jan 25.PMID: 20101222 2010
33HSCR, HSCR1, RET, TRI21
Interaction between a chromosome 10 RET enhancer and chromosome 21 in the Down syndrome-Hirschsprung disease association.
Arnold S, Pelet A, Amiel J, Borrego S, Hofstra R, Tam P, Ceccherini I, Lyonnet S, Sherman S, Chakravarti A.
Hum Mutat 30(5):771-5. 2009
34BBS4, BBS5, BBS7, RET
Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease.
de Pontual L, Zaghloul NA, Thomas S, Davis EE, McGaughey DM, Dollfus H, Baumann C, Bessling SL, Babarit C, Pelet A, Gascue C, Beales P, Munnich A, Lyonnet S, Etchevers H, Attie-Bitach T, Badano JL, McCallion AS, Katsanis N, Amiel J.
Proc Natl Acad Sci U S A 106(33):13921-6. Epub 2009 Jul 31. 2009
35RET
Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals.
Mijatovic J, Piltonen M, Alberton P, Männistö PT, Saarma M, Piepponen TP.
Neurobiol Aging eurobiol Aging. 2009 Sep 18. [Epub ahead of print]PMID: 19767128 2009
36CCDC6, RET
Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins.
Richardson DS, Gujral TS, Peng S, Asa SL, Mulligan LM.
Cancer Res 69(11):4861-9.PMID: 19487296 2009
37GDNF, RADP, RET
Renal aplasia in humans is associated with RET mutations.
Skinner MA, Safford SD, Reeves JG, Jackson ME, Freemerman AJ.
Am J Hum Genet 82(2):344-51. Epub 2008 Jan 31. 2008
38MEN2A, MTC1, RET
Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene.
Peppa M, Boutati E, Kamakari S, Pikounis V, Peros G, Panayiotides IG, Economopoulos T, Raptis SA, Hadjidakis D.
Eur J Endocrinol 159(6):767-71. Epub 2008 Sep 19. Review. 2008
39CBLC, CD2AP, RET
CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.
Tsui CC, Pierchala BA.
J Neurosci 28(35):8789-800. doi: 10.1523/JNEUROSCI.2738-08.2008. 2008
40RET, HSCR1
Epistatic interactions with a common hypomorphic RET allele in syndromic Hirschsprung disease.
de Pontual L, Pelet A, Clement-Ziza M, Trochet D, Antonarakis SE, Attie-Bitach T, Beales PL, Blouin JL, Dastot-Le Moal F, Dollfus H, Goossens M, Katsanis N, Touraine R, Feingold J, Munnich A, Lyonnet S, Amiel J.
Hum Mutat 28(8):790-6. 2007
41SH2B1, RET
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.
Donatello S, Fiorino A, Degl'Innocenti D, Alberti L, Miranda C, Gorla L, Bongarzone I, Rizzetti MG, Pierotti MA, Borrello MG.
Oncogene 26(45):6546-59. Epub 2007 Apr 30. 2007
42RET, GFRA1, GFRA2, GFRA3
Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age.
Quartu M, Serra MP, Boi M, Ferretti MT, Lai ML, Del Fiacco M.
Brain Res 1173:36-52. Epub 2007 Aug 9. 2007
43HOOK3, RET
HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma.
Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, Koenig RJ, Nikiforov YE.
Endocr Relat Cancer 14(2):445-52. 2007
44RET
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system.
Kramer ER, Aron L, Ramakers GM, Seitz S, Zhuang X, Beyer K, Smidt MP, Klein R.
PLoS Biol 5(3):e39.PMID: 17298183 2007
45CCHS3, PHOX2B, RET
Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus.
de Pontual L, Pelet A, Trochet D, Jaubert F, Espinosa-Parrilla Y, Munnich A, Brunet JF, Goridis C, Feingold J, Lyonnet S, Amiel J.
J Med Genet 43(5):419-23. Epub 2006 Jan 27. 2006
46HSCR1, RET
A common variant located in the 3'UTR of the RET gene is associated with protection from Hirschsprung disease.
Griseri P, Lantieri F, Puppo F, Bachetti T, Di Duca M, Ravazzolo R, Ceccherini I.
Hum Mutat [Epub ahead of print] 2006
47RET, HSCR1
Mutations and polymorphisms of Hirschsprung disease candidate genes in Thai patients.
Sangkhathat S, Kusafuka T, Chengkriwate P, Patrapinyokul S, Sangthong B, Fukuzawa M.
J Hum Genet [Epub ahead of print] 2006
48HSCR1, RET
Allele dosage-dependent penetrance of RET proto-oncogene in an Israeli-Arab inbred family segregating Hirschsprung disease.
Basel-Vanagaite L, Pelet A, Steiner Z, Munnich A, Rozenbach Y, Shohat M, Lyonnet S.
Eur J Hum Genet [Epub ahead of print] 2006
49RET, MBD2, MBD4
RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.
Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A.
Biochem Biophys Res Commun 351(1):85-92. Epub 2006 Oct 10. 2006
50RET, MEN2B
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.
Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA.
Cancer Res 66(20):10179-87. 2006
51NKX2-1, RET
TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease.
Garcia-Barcelo M, Ganster RW, Lui VC, Leon TY, So MT, Lau AM, Fu M, Sham MH, Knight J, Zannini MS, Sham PC, Tam PK.
Hum Mol Genet 14(2):191-204. Epub 2004 Nov 17. 2005
52RET
A common haplotype at the 5' end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression.
Griseri P, Bachetti T, Puppo F, Lantieri F, Ravazzolo R, Devoto M, Ceccherini I.
Hum Mutat 25(2):189-95. 2005
53RET, CSGALNACT2, RASGEF1A
A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk.
Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A.
Nature 434(7035):857-63. 2005
54HSCR1, RET
Identifying candidate Hirschsprung disease-associated RET variants.
Burzynski GM, Nolte IM, Bronda A, Bos KK, Osinga J, Plaza Menacho I, Twigt B, Maas S, Brooks AS, Verheij JB, Buys CH, Hofstra RM.
Am J Hum Genet 76(5):850-8. Epub 2005 Mar 9. 2005
55MTC1, RET
Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg.
Dvorakova S, Vaclavikova E, Duskova J, Vlcek P, Ryska A, Bendlova B.
J Endocrinol Invest 28(10):905-9. 2005
56DOK6, RET
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J.
J Biol Chem 279(40):42072-81. Epub 2004 Jul 30. 2004
57RET
Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease.
Nishikawa M, Murakumo Y, Imai T, Kawai K, Nagaya M, Funahashi H, Nakao A, Takahashi M.
Eur J Hum Genet 11(5):364-8. 2003
58GDNF, GFRA1, NCAM1, RET
The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.
Paratcha G, Ledda F, Ibanez CF.
Cell 113(7):867-79. 2003
59EDNRB, GDNF, GFRA1, RET, SOX10
Hirschsprung disease is linked to defects in neural crest stem cell function.
Iwashita T, Kruger GM, Pardal R, Kiel MJ, Morrison SJ.
Science 301(5635):972-6. 2003
60RET
Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET.
Kjaer S, Ibanez CF.
Hum Mol Genet 12(17):2133-44. Epub 2003 Jul 15. 2003
61HSCR1, RET
Single nucleotide polymorphic alleles in the 5' region of the RET proto-oncogene define a risk haplotype in Hirschsprung's disease.
Sancandi M, Griseri P, Pesce B, Patrone G, Puppo F, Lerone M, Martucciello G, Romeo G, Ravazzolo R, Devoto M, Ceccherini I.
J Med Genet 40(9):714-8. No abstract available. 2003
62CCHS1, RET, CCHS3, PHOX2B
Molecular analysis of congenital central hypoventilation syndrome.
Sasaki A, Kanai M, Kijima K, Akaba K, Hashimoto M, Hasegawa H, Otaki S, Koizumi T, Kusuda S, Ogawa Y, Tuchiya K, Yamamoto W, Nakamura T, Hayasaka K.
Hum Genet 114(1):22-6. Epub 2003 Oct 18. 2003
63RET
Allelic loss of DNA locus of the RET proto-oncogene in small cell lung cancer.
Futami H, Egawa S, Takasaki K, Tsukada T, Shiraishi M, Yamaguchi K.
Cancer Lett 195(1):59-65. 2003
64GDNF, RET, GFRA1
Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET.
Kjaer S, Ibanez CF.
J Biol Chem 278(48):47898-904. Epub 2003 Sep 26. 2003
65RET, MTC1
A novel germ-line point mutation in RET exon 8 (Gly(533)Cys) in a large kindred with familial medullary thyroid carcinoma.
Da Silva AM, Maciel RM, Da Silva MR, Toledo SR, De Carvalho MB, Cerutti JM.
J Clin Endocrinol Metab 88(11):5438-43. 2003
66RET
Association between c135G/A genotype and RET proto-oncogene germline mutations and phenotype of Hirschsprung's disease.
Fitze G, Cramer J, Ziegler A, Schierz M, Schreiber M, Kuhlisch E, Roesner D, Schackert HK.
Lancet 359(9313):1200-5. 2002
67RET, MEN2A, MEN2B
Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.
Sanso GE, Domene HM, Garcia R, Pusiol E, de M, Roque M, Ring A, Perinetti H, Elsner B, Iorcansky S, Barontini M.
Cancer 94(2):323-30. 2002
68FPTC, TCO, RET, MEN2A
Familial thyroid cancer.
Alsanea O, Clark OH.
Curr Opin Oncol 13(1):44-51. Review. 2001
69HSCR1, RET
Mutational analysis of RET/GDNF/NTN genes in children with total colonic aganglionosis with small bowel involvement.
Inoue K, Shimotake T, Iwai N.
Am J Med Genet 93(4):278-84. 2000
70GDNF, RET
The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease.
Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P.
EMBO J 19(15):4056-4063. 2000
71HSCR1, RET
Familial form of hirschsprung disease: nucleotide sequence studies reveal point mutations in the RET proto-oncogene in two of six families but not in other candidate genes.
Munnes M, Fanaei S, Schmitz B, Muiznieks I, Holschneider AM, Doerfler W.
Am J Med Genet 94(1):19-27. 2000
72HSCR1, HSCR8, HSCRM, RET
A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.
Bolk S, Pelet A, Hofstra RM, Angrist M, Salomon R, Croaker D, Buys CH, Lyonnet S, Chakravarti A.
Proc Natl Acad Sci U S A 97(1):268-73. 2000
73RADP, RET
Genetic evidence for a novel gene(s) involved in urogenital development on 10q26.
Ogata T, Muroya K, Sasagawa I, Kosho T, Wakui K, Sakazume S, Ito K, Matsuo N, Ohashi H, Nagai T.
Kidney Int 58(6):2281-90. 2000
74MEN2B, RET
Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation.
Miyauchi A, et al.
Jpn J Cancer Res 90(1):1-5. 1999
75ERC1, PTC5, RET
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.
Nakata T, et al.
Genes Chromosomes Cancer 25(2):97-103. 1999
76RET
Mechanism of Ret activation by a mutation at aspartic acid 631 identified in sporadic pheochromocytoma.
Asai N, et al.
Biochem Biophys Res Commun 255(3):587-90. 1999
77MTC1, RET
A novel 9-base pair duplication in RET exon 8 in familial medullary thyroid carcinoma.
Pigny P, et al.
J Clin Endocrinol Metab 84(5):1700-4. 1999
78RET, MEN2B, MTC1
Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.
Iwashita T, et al.
Oncogene 18(26):3919-22 1999
79HSCR1, RET
Specific polymorphisms in the RET proto-oncogene are over-represented in patients with Hirschsprung disease and may represent loci modifying phenotypic expression.
Borrego S, et al.
J Med Genet 36(10):771-4 1999
80HSCR1, RET
Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site.
Geneste O, et al.
Hum Mol Genet 8(11):1989-99 1999
81MECP2, RET
Molecular approaches to the Rett syndrome gene.
Schanen NC.
J Child Neurol 14(12):806-14. Review. 1999
82CCHS1, RET
Mutations of the RET-GDNF signaling pathway in Ondine's curse.
Amiel J, Salomon R, AttiŽ T, Pelet A, Trang H, Mokhtari M, Gaultier C, Munnich A, Lyonnet S
Am J Hum Genet 62 : 715-717. 1998
83MTC1, RET
Novel point mutations and allele loss at the RET locus in sporadic medullary thyroid carcinomas.
Uchino S, et al.
Jpn J Cancer Res 89 : 411-418. 1998
84MTC1, RET
Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.
Oriola J, et al.
Am J Med Genet 78 : 271-273. 1998
85EDNRB, HSCR1, HSCR2, RET
Phenotypic variation in a family with mutations in two Hirschsprung-related genes (RET and endothelin receptor B).
Svensson PJ, et al.
Hum Genet 103 : 145-148. 1998
86RET
Expression of the RET proto-oncogene in human embryos.
AttiŽ-Bitach T, et al.
Am J Med Genet 80 : 481-486. 1998
87MEN2A, RET
Germ line mutation analysis in families with multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma.
Karga HJ, Karayianni MK, Linos DA, Tseleni SC, Karaiskos KD, Papapetrou PD.
Eur J Endocrinol 139 : 410-415. 1998
88MTC1, RET
Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma.
Eng C, et al.
J Clin Endocrinol Metab 83 : 4310-4313. 1998
89MEN2A, MEN2B, MTC1, RET
Prevalence and parental origin of De novo RET mutations in multiple endocrine neoplasia type 2A and familial medullary thyroid carcinoma.
Schuffenecker I, et al.
Am J Hum Genet 60 : 233-237. 1997
90HSCR1, MEN2A, MEN2B, RET
Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and Hirschsprung disease.
Eng C, et al.
Hum Mutat 9 : 97-109. 1997
91MTC2, RET
A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A.
Hšppner W, et al.
Hum Mol Genet 6 : 587-590. 1997
92HSCR1, RET
Frequency of RET mutations in long- and short-segment Hirschsprung disease.
Seri M, et al.
Hum Mutat 9 : 243-249. 1997
93MEN2A, RET
A Cys634Gly substitution of the RET proto-oncogene in a family with recurrence of multiple endocrine neoplasia type 2A and cutaneous lichen amyloidosis.
Seri M, et al.
Clin Genet 51 : 86-90. 1997
94MTC1, RET
Mutation of RET codon 768 is associated with the FMTC phenotype.
Boccia LM, et al.
Clin Genet 51 : 81-85. 1997
95MTC1, RET
Identification of a novel somatic mutation in the RET proto-oncogene in a patient with sporadic medullary thyroid carcinoma.
Matias-Guiu X, et al.
Hum Mutat 9 : 476. 1997
96PTC3, PCM1, RET
Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.
Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA.
Genomics 42(2):252-9. 1997
97MTC1, RET
Molecular analysis of the RET proto-oncogene in patients with sporadic medullary thyroid carcinoma: a novel point mutation in the extracellular cysteine-rich domain.
Bugalho MJ, Frade JP, Santos JR, Limbert E, Sobrinho L.
Eur J Endocrinol 136(4):423-6. 1997
98CCDC6, HSCR1, MTC1, PTC1, RET
Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting.
Peretz H, Luboshitsky R, Baron E, Biton A, Gershoni R, Usher S, Grynberg E, Yakobson E, Graff E, Lapidot M.
Hum Mutat 10(2):155-9. 1997
99MTC2, RET
A novel somatic mutation in the RET proto-oncogene in familial medullary thyroid carcinoma with a germline codon 768 mutation.
Miyauchi A, Egawa S, Futami H, Kuma K, Obara T, Yamaguchi K.
Jpn J Cancer Res 88(6):527-31. 1997
100HSCR1, MEN2A, MTC1, RET
Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.
Ito S, Iwashita T, Asai N, Murakami H, Iwata Y, Sobue G, Takahashi M.
Cancer Res 57(14):2870-2. 1997
101MEN2B, RET
Germline mutation of RET codon 883 in two cases of de novo MEN 2B.
Smith DP, Houghton C, Ponder BA.
Oncogene 15(10):1213-7. 1997
102MEN2A, MEN2B, MTC1, RET
Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC : two novel mutations and one De novo mutation for MEN2A.
Landsvater RM, et al.
Hum Genet 97 : 11-14. 1996
103RET
No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma.
Hofstra RMW, et al.
Hum Genet 97 : 362-364. 1996
104MEN2A, MTC1, RET
Detection of RET mutations in multiple endocrine neoplasia type 2a and familial medullary thyroid carcinoma by denaturing gradient gel electrophoresis.
Peacock ML, et al.
Hum Mutat 7 : 100-104. 1996
105RET, MTC1
Germline and somatic mutations in an oncogene : RET mutations in inherited medullary thyroid carcinoma.
Marsh DJ, et al.
Cancer Res 56 : 1241-1243. 1996
106RET, MEN2A, MEN2B
A mutation in the RET proto-oncogene in Hirschsprung's disease affects the tyrosine kinase activity associated with multiple endocrine neoplasia type 2A and 2B.
Cosma MP, et al.
Biochem J 314 : 397-400. 1996
107HSCR1, RET
Molecular heterogeneity of RET loss of function in Hirschsprung's disease.
Carlomagno F, et al.
EMBO J 15 : 2717-2725. 1996
108GDNF, RET
GDNF signalling through the Ret receptor tyrosine kinase.
Durbec P, et al.
Nature 381 : 789-793. 1996
109GDNF, RET
Functional receptor for GDNF encoded by the c-ret proto-oncogene.
Trupp M, et al.
Nature 381 : 785-789. 1996
110RET
Exclusion of linkage between RET and neuronal intestinal dysplasia type B.
Barone V, et al.
Am J Med Genet 62 : 195-198. 1996
111CCHS1, RET
Congenital central hypoventilation syndrome : mutation analysis of the receptor tyrosine kinase ret.
Bolk S, Angrist M, Schwartz S, Silvestri JM, Weese-Mayer DE, Chakravarti A.
Am J Med Genet 63 : 603-609. 1996
112PTCH1, RET
RET proto-oncogene point mutations in sporadic neuroendocrine tumors.
Komminoth P, et al.
J Clin Endocrinol Metab 81 : 2041-2046. 1996
113GFRA1, GFRA2, RET
Characterization of a multicomponent receptor for GDNF.
Treanor JJS, et al.
Nature 382 : 80-83. 1996
114RET, HSCR1, MEN2A
C618R mutation in exon 10 of the RET proto-oncogene in a kindred with multiple endocrine neoplasia type 2A and Hirschsprung's disease.
Caron P, et al.
J Clin Endocrinol Metab 81 : 2731-2733. 1996
115RET, MEN2A, MEN2B
Role of the RET proto-oncogene in sporadic hyperparathyroidism and in hyperparathyroidism of multiple endocrine neoplasia type 2.
Pausova Z, et al.
J Clin Endocrinol Metab 81 : 2711-2718. 1996
116HSCR1, RET
Mechanism of Ret dysfunction by Hirschsprung mutations affecting its extracelllar domain.
Iwashita T, et al.
Hum Mol Genet 5 : 1577-1580. 1996
117GDNF, HSCR1, RET
Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient.
Angrist M, et al.
Nat Genet 14 : 341-344. 1996
118GDNF, HSCR1, RET
Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease.
Salomon R, et al.
Nat Genet 14 : 345-347. 1996
119PCM1,RET
Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer.
Fugazzola L, et al.
Oncogene 13 : 1093-1097. 1996
120MTC1, RET
A novel deletion in the RET proto-oncogene found in sporadic medullary thyroid carcinoma.
Alemi M, et al.
Anticancer Res 16 : 2619-2622. 1996
121MEN2A, MEN2B, RET
Somatic mutations of the RET proto-oncogene are not required for tumor development in multiple endocrine neoplasia type 2 (MEN 2) gene carriers.
Landsvater RM, et al.
Cancer Res 56 : 4853-4855. 1996
122HSCR1, RET
Prevalence and parental origin of de novo RET mutations in Hirschsprung's disease.
Yin L, et al.
Eur J Hum Genet 4 : 356-358. 1996
123MTC1, RET
Relevance of RET proto-oncogene mutations in sporadic medullary thyroid carcinoma.
Wohllk N, et al.
J Clin Endocrinol Metab 81 : 3740-3745. 1996
124MEN2A, RET
Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma.
Eng C, et al.
Genes Chromosomes Cancer 12 : 209-212. 1995
125RET, MTC1
A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.
Eng C, et al.
Oncogene 10 : 509-513. 1995
126RET
The physical map of the human RET proto-oncogene.
Pasini B, et al.
Oncogene 11 : 1737-1743. 1995
127RET
Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites : a novel C-terminus for RET.
Myers SM, et al.
Oncogene 11 : 2039-2045. 1995
128CCDC6, PTC1, PTC3, RET
Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma.
Smanik PA, et al.
Hum Mol Genet 4 : 2313-2318. 1995
129MTC1, RET, VHL
Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.
Eng C, et al.
J Med Genet 32 : 934-937. 1995
130RET, MEN2A, MEN2B, MTC1
Genotype-phenotype correlation in multiple endocrine neoplasia type 2 : report of the international RET mutation consortium.
Mulligan LM, et al.
J Int Med 238 : 343-346. 1995
131MEN2B, RET
Detection of a germline mutation at codon 918 of the RET proto-oncogene in French MEN 2B families.
Rossel M, et al.
Hum Genet 95 : 403-406. 1995
132RET, HSCR1
Loss of function effect of RET mutations causing Hirschsprung disease.
Pasini B, et al.
Nat Genet 10 : 35-40. 1995
133HSCR1, RET
Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease.
Angrist M, et al.
Hum Mol Genet 4 : 821-830. 1995
134RET, MTC1
RET mutations in exons 13 and 14 of FMTC patients.
Bolino A, et al.
Oncogene 10 : 2415-2419. 1995
135HSCR1, RET
Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease.
AttiŽ T, et al.
Hum Mol Genet 4 : 1381-1386. 1995
136RET, MEN2A
Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A).
Takiguchi-Shirahama S, et al.
Hum Genet 95 : 187-190. 1995
137MEN2A, MEN2B, MTC1, RET
Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.
Mulligan LM, et al.
Nat Genet 6 : 70-74. 1994
138RET, HSCR1
Mutations of the RET proto-oncogene in Hirschsprung's disease.
Edery P, et al.
Nature 367 : 378-380. 1994
139HSCR1, RET
Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease.
Romeo G, et al.
Nature 367 : 377-378. 1994
140RET, MTC1, MEN2B
A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.
Hofstra RMW, et al.
Nature 367 : 375-376. 1994
141RET
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor ret.
Schuchardt A, et al.
Nature 367 : 380-383. 1994
142MEN2B, RET
Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.
Eng C, et al.
Hum Mol Genet 3 : 237-241. 1994
143RET, MEN2B
Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.
Carlson KM, et al.
Proc Natl Acad Sci U S A 91 : 1579-1583. 1994
144PRKAR1A, RET, PTC2
A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma.
Sozzi G, et al.
Genes Chromosomes Cancer 9 : 244-250. 1994
145MEN2A, RET
A De novo mutation of the RET proto-oncogene in a patient with MEN2A.
Mulligan LM, et al.
Hum Mol Genet 3 : 1007-1008. 1994
146RET, MEN2A
Identification of the Cys634-Tyr mutation of the RET proto-onogene in a pedigree with multiple endocrine neoplasia type 2A and localized cutaneous lichen amyloidosis.
Ceccherini I, et al.
J Endocrinol Invest 17 : 201-204. 1994
147PTC3, RET
Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.
Bongarzone I, et al.
Cancer Res 54 : 2979-2985. 1994
148PTC3, RET
Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma.
Santoro M, et al.
Oncogene 9 : 509-516. 1994
149RET, HSCR1
A 7 bp deletion of the RET proto-oncogene in familial Hirschsprung's disease.
Attie T, et al.
Hum Mol Genet 3 : 1439-1440. 1994
150RET, PTC3
The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2.
Minoletti F, et al.
Genes Chromosomes Cancer 11 : 51-57. 1994
151CCDC6, PTC1, RET
Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo.
Grieco M, et al.
Oncogene 9 : 2531-2535. 1994
152RET, HSCR1
Des mutations du proto-oncogne RET dans la maladie de Hirschsprung.
Lyonnet S, et al.
C R Acad Sci III 317 : 358-362. 1994
153RET, MEN2A, MTC1
A rapid screening method for the detection of mutations in the RET proto-oncogene in multiple endocrine neoplasia type 2A and familial medullary thyroid arcinoma families.
Marsh DJ, et al.
Genomics 23 : 477-479. 1994
154MTC1, RET
RET proto-oncogene mutations in inherited and sporadic medullary thyroid cancer. (abstr)
Blaugrund JE, et al.
Hum Mol Genet 3 : 1895-1897. 1994
155MEN2A, RET
Haplotype analysis of MEN 2 mutations.
Gardner E, et al.
Hum Mol Genet 3 : 1771-1774. 1994
156RET
A novel polymorphism in the coding sequence of the human RET proto-oncogene.
Edery P, et al.
Hum Genet 94 : 579-580. 1994
157RET, MTC1, MEN2A
RET proto-oncogene mutations in French MEN 2A and FMTC families.
Schuffenecker I, et al.
Hum Mol Genet 3 : 1939-1943. 1994
158MEN2A, MEN2B, RET
Germ line mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2A and type 2B.
Maruyama S, et al.
Jpn J Cancer Res 85 : 879-882. 1994
159RET
Identification of a polymorphism in exon 11 of the RET proto-oncogene.
Bugalho MJM, et al.
Hum Mol Genet 3 : 2263. 1994
160MEN2A, HSCR1, MTC1, RET
Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene.
Mulligan LM, et al.
Hum Mol Genet 3 : 2163-2167. 1994
161RET, HSCR1
De-novo mutations of the RET proto-oncogene in Hirschsprung's disease.
Pelet A, et al.
Lancet 344 : 1769-1770. 1994
162MEN2A, RET
Frequent RET protooncogene mutations in multiple endocrine neoplasia type 2A.
Quadro L, et al.
J Clin Endocrinol Metab 79 : 590-594. 1994
163HSCR1, RET
Close linkage with the RET proto-oncogene and boundaries of deletion mutations in autosomal dominant Hirschsprung disease.
Luo Y, et al.
Hum Mol Genet 2 : 1803-1808. 1993
164MEN2A, RET
Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.
Mulligan LM, et al.
Nature 363 : 458-460. 1993
165CCDC6, MEN2A, MTC1, RET
Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
Donis-Keller H, et al.
Hum Mol Genet 2 : 851-856. 1993
166RET
Structural analysis of the human ret proto-oncogene using exon trapping.
Kwok JBJ, et al.
Oncogene 8 : 2575-2582. 1993
167MEN2A, RET
Genomic and yeast artificial chromosome long-range physical maps linking six loci in 10q11.2 and spanning the multiple endocrine neoplasia type 2A (MEN2A) region.
Brooks-Wilson AR, et al.
Genomics 17 : 611-617. 1993
168RET, MEN2A
Detection of mutations in the RET proto-oncogene in MEN 2A, FMTC, and sporadic MTC families based on analysis of the genomic structure of RET.
Chi D, et al.
Am J Hum Genet 53 : 169. 1993
169RET, MEN2A
Identification and characterization of mutations in the RET proto-oncogene associated with MEN 2A.
Goodfellow PJ, et al.
Am J Hum Genet 53 : 167. 1993
170PTC1, RET
Detection of the PTC/retTPC oncogene in human thyroid cancers.
Jhiang SM, et al.
Oncogene 7 : 1331-1337. 1992
171RET
A highly informative dinucleotide repeat polymorphism at the ret proto-oncogene locus within human chromosome 10q11.2.
Chi D, et al.
Am J Hum Genet 51 : A184. 1992
172RET
A new polymorphism in the ret protooncogene (RET).
Mulligan LM, et al.
Nucleic Acids Res 19 : 5795. 1991
173ITGB1, RET
Characterization of the FNRB locus with YAC clones and identification of new highly informative flanking markers for predictive testing in multiple endocrine neoplasia type 2 (MEN2).
Lairmore TC, et al.
Am J Hum Genet 49S : 348. 1991
174RET
A TaqI RFLP in the human ret proto-oncogene.
Tahira T, et al.
Nucleic Acids Res 18 : 7472. 1990
175CCDC6, MEN2A, PTC1, RET
The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).
Donghi R, et al.
Oncogene 4 : 521-523. 1989
176RET
Human ret proto-oncogene mapped to chromosome 10q11.2.
Ishizaka Y, et al.
Oncogene 4 : 1519-1521. 1989
177RET
Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.
Takahashi M, et al.
Oncogene 3 : 571-578. 1988
178RET, RFP5RET
Developmentally regulated expression of a human Finger -containing gene encoded by the 5' half of the ret transforming gene.
Takahashi M, et al.
Mol Cell Biol 8 : 1853-1856. 1988