| 1 | PRDM16, REST, SRCAP
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| The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
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| Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y, Fan Z.
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| EMBO J. Jul 1;39(13):e103786. doi: 10.15252/embj.2019103786. Epub 2020 May 25 2020
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| 2 | GINGF5, REST
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| REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis.
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| Bayram Y, White JJ, Elcioglu N, Cho MT, Zadeh N, Gedikbasi A, Palanduz S, Ozturk S, Cefle K, Kasapcopur O, Coban Akdemir Z, Pehlivan D, Begtrup A, Carvalho CMB, Paine IS, Mentes A, Bektas-Kayhan K, Karaca E, Jhangiani SN, Muzny DM; Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR.
|
| Am J Hum Genet 101(1):149-156. doi: 10.1016/j.ajhg.2017.06.006.
2017
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| 3 | REST, TSPYL2
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| TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation.
|
| Epping MT, Lunardi A, Nachmani D, Castillo-Martin M, Thin TH, Cordon-Cardo C, Pandolfi PP.
|
| Cell Death Differ ell Death Differ. 2015 Jan 23. doi: 10.1038/cdd.2014.226. [Epub ahead of print]
2015
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| 4 | REST
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| NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases.
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| Song Z, Zhao D, Zhao H, Yang L.
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| J Mol Neurosci Mol Neurosci. 2014 Dec 6. [Epub ahead of print]
2014
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| 5 | PDYN, REST
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| PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain.
|
| Henriksson R, Bäckman CM, Harvey BK, Kadyrova H, Bazov I, Shippenberg TS, Bakalkin G.
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| Biochim Biophys Acta 1839(11):1226-32. doi: 10.1016/j.bbagrm.2014.09.001. Epub 2014 Sep 8.
2014
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| 6 | REST
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| The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes.
|
| McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ.
|
| Elife 3:e01267. doi: 10.7554/eLife.01267.
2014
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| 7 | REST, ZFP36L2
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| An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.
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| Cargnin F, Nechiporuk T, Müllendorff K, Stumpo DJ, Blackshear PJ, Ballas N, Mandel G.
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| J Neurosci 34(50):16650-61. doi: 10.1523/JNEUROSCI.1650-14.2014.
2014
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| 8 | REST
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| REST and stress resistance in ageing and Alzheimer's disease.
|
| Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA.
|
| Nature 507(7493):448-54. doi: 10.1038/nature13163. Epub 2014 Mar 19.
2014
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| 9 | REST
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| Identification of REST-regulated genes and pathways using a REST-targeted antisense approach.
|
| Sedaghat Y, Bui HH, Mazur C, Monia BP.
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| Nucleic Acid Ther 23(6):389-400. doi: 10.1089/nat.2013.0445.
2013
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| 10 | REST
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| REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.
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| Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.
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| EMBO J 32(22):2994-3007. doi: 10.1038/emboj.2013.231. Epub 2013 Oct 22.
2013
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| 11 | REST
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| Role of NRSF/REST in the regulation of cardiac gene expression and function.
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| Kuwahara K.
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| Circ J 77(11):2682-6. Epub 2013 Oct 12. Review.
2013
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| 12 | REST
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| Expression and function of the dense-core vesicle membranes are governed by the transcription repressor REST.
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| D'Alessandro R, Meldolesi J.
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| FEBS Lett 587(13):1915-22. doi: 10.1016/j.febslet.2013.04.024. Epub 2013 May 4. Review.
2013
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| 13 | REST, SP1, SYN1
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| Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation.
|
| Paonessa F, Latifi S, Scarongella H, Cesca F, Benfenati F.
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| J Biol Chem 288(5):3227-39. doi: 10.1074/jbc.M112.399782. Epub 2012 Dec 18.
2013
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| 14 | REST
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| REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells.
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| Covey MV, Streb JW, Spektor R, Ballas N.
|
| Development 139(16):2878-90. doi: 10.1242/dev.074765. Epub 2012 Jul 12.
2012
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| 15 | MAP2K5, REST
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| REST and its downstream molecule Mek5 regulate survival of primordial germ cells.
|
| Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Schöler HR, Matsui Y.
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| Dev Biol 372(2):190-202. doi: 10.1016/j.ydbio.2012.09.013. Epub 2012 Sep 26.
2012
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| 16 | PPARG, REST, TBX20
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| Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function.
|
| Sakabe NJ, Aneas I, Shen T, Shokri L, Park SY, Bulyk ML, Evans SM, Nobrega MA.
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| Hum Mol Genet 21(10):2194-204. doi: 10.1093/hmg/dds034. Epub 2012 Feb 10.
2012
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| 17 | ATOH7, REST
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| Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.
|
| Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH.
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| Dev Biol 349(1):90-9. Epub 2010 Oct 20. 2011
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| 18 | REST, USP7
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| Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.
|
| Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, Bao S.
|
| Nat Cell Biol 13(2):142-52. Epub 2011 Jan 23.
2011
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| 19 | DYRK1A, REST
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| REST regulates DYRK1A transcription in a negative feedback loop.
|
| Lu M, Zheng L, Han B, Wang L, Wang P, Liu H, Sun X.
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| J Biol Chem 286(12):10755-63. Epub 2011 Jan 20.
2011
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| 20 | KCNQ2, REST
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| Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.
|
| Rose K, Ooi L, Dalle C, Robertson B, Wood IC, Gamper N.
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| Pain 152(4):742-54. Epub 2011 Feb 23.
2011
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| 21 | REST
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| The RE1 binding protein REST regulates oligodendrocyte differentiation.
|
| Dewald LE, Rodriguez JP, Levine JM.
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| J Neurosci 31(9):3470-83.
2011
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| 22 | REST
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| REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.
|
| Ren X, Kerppola TK.
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| Mol Cell Biol 31(10):2100-10. Epub 2011 Mar 14.
2011
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| 23 | REST, TERF2
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| Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor.
|
| Zhang P, Casaday-Potts R, Precht P, Jiang H, Liu Y, Pazin MJ, Mattson MP.
|
| Proc Natl Acad Sci U S A 108(39):16434-9. Epub 2011 Sep 8.
2011
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| 24 | HIP1, IFT57, REST
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| Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).
|
| Datta M, Bhattacharyya NP.
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| J Biol Chem 286(39):33759-69. Epub 2011 Aug 6.
2011
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| 25 | DCX, REST
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| Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development.
|
| Mandel G, Fiondella CG, Covey MV, Lu DD, Loturco JJ, Ballas N.
|
| Proc Natl Acad Sci U S A 108(40):16789-94. Epub 2011 Sep 15.
2011
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| 26 | REST
|
| Cysteine 397 plays important roles in the folding of the neuron-restricted silencer factor/RE1-silencing transcription factor.
|
| Zhang Y, Hu W, Shen J, Tong X, Yang Z, Shen Z, Lan W, Wu H, Cao C.
|
| Biochem Biophys Res Commun 414(2):309-14. Epub 2011 Sep 17.
2011
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| 27 | REST
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| The transcription factor REST is lost in aggressive breast cancer.
|
| Wagoner MP, Gunsalus KT, Schoenike B, Richardson AL, Friedl A, Roopra A.
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| PLoS Genet. 6(6):e1000979. 2010
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| 28 | REST
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| Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer.
|
| Kreisler A, Strissel PL, Strick R, Neumann SB, Schumacher U, Becker CM.
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| Oncogene 29(43):5828-38. Epub 2010 Aug 9.
2010
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| 29 | REST
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| Expression and functions of the repressor element 1 (RE-1)-silencing transcription factor (REST) in breast cancer.
|
| Lv H, Pan G, Zheng G, Wu X, Ren H, Liu Y, Wen J.
|
| J Cell Biochem 110(4):968-74.
2010
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| 30 | REST
|
| The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease.
|
| Buckley NJ, Johnson R, Zuccato C, Bithell A, Cattaneo E.
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| Neurobiol Dis 39(1):28-39. Epub 2010 Feb 17. Review.
2010
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| 31 | NEUROD2, REST, ZEB1
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| Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.
|
| Ravanpay AC, Hansen SJ, Olson JM.
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| Mol Cell Neurosci 44(2):178-89. Epub 2010 Mar 24.
2010
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| 32 | DYRK1A, REST, TRI21
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| DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.
|
| Lepagnol-Bestel AM, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, Imbeaud S, Loe-Mie Y, Benihoud K, Agier N, Salin PA, Cardona A, Khung-Savatovsky S, Kallunki P, Delabar JM, Puskas LG, Delacroix H, Aggerbeck L, Delezoide AL, Delattre O, Gorwood P, Moalic JM, Simonneau M.
|
| Hum Mol Genet 18(8):1405-1414. 2009
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| 33 | BDNF, REST
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| Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF.
|
| Hara D, Fukuchi M, Miyashita T, Tabuchi A, Takasaki I, Naruse Y, Mori N, Kondo T, Tsuda M.
|
| Biochem Biophys Res Commun 384(4):506-11. Epub 2009 May 6.
2009
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| 34 | REST
|
| MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.
|
| Yoo AS, Staahl BT, Chen L, Crabtree GR.
|
| Nature. 460(7255):642-6. 2009
|
| 35 | PHF21A, REST
|
| The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex.
|
| Klajn A, Ferrai C, Stucchi L, Prada I, Podini P, Baba T, Rocchi M, Meldolesi J, D'Alessandro R.
|
| J Neurosci 29(19):6296-307.
2009
|
| 36 | DYRK1A, REST, TRI21
|
| DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
|
| Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, Shipley J, Denyer G, Epstein CJ, Fillat C, Estivill X, Tybulewicz VL, Fisher EM, Antonarakis SE, Nizetic D.
|
| Am J Hum Genet 83(3):388-400. Epub 2008 Sep 4. 2008
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| 37 | REST
|
| REST maintains self-renewal and pluripotency of embryonic stem cells.
|
| Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S.
|
| Nature 453(7192):223-7. Epub 2008 Mar 23. 2008
|
| 38 | REST
|
| Additive effect of BDNF and REST polymorphisms is associated with improved general cognitive ability.
|
| Miyajima F, Quinn JP, Horan M, Pickles A, Ollier WE, Pendleton N, Payton A.
|
| Genes Brain Behav enes Brain Behav. 2008 Jun 2. [Epub ahead of print] 2008
|
| 39 | DCTN1, HAP1, HTT, REST, RILP
|
| Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.
|
| Shimojo M.
|
| J Biol Chem 283(50):34880-6. Epub 2008 Oct 15. 2008
|
| 40 | REST, YY1
|
| Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor.
|
| Jiang L, Yao M, Shi J, Shen P, Niu G, Fei J.
|
| J Neurosci Res 86(6):1209-16.PMID: 18092359 2008
|
| 41 | REST
|
| SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.
|
| Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.
|
| Nature. 452(7185):370-4. 2008
|
| 42 | CDYL, REST
|
| CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
|
| Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y.
|
| Mol Cell 32(5):718-26. doi: 10.1016/j.molcel.2008.10.025.
2008
|
| 43 | KDM5C, REST
|
| The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.
|
| Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y.
|
| Nature 447(7144):601-5. Epub 2007 Apr 29. 2007
|
| 44 | REST, TRPC1
|
| Regulatory role of neuron-restrictive silencing factor in expression of TRPC1.
|
| Ohba T, Watanabe H, Takahashi Y, Suzuki T, Miyoshi I, Nakayama S, Satoh E, Iino K, Sasano H, Mori Y, Kuromitsu S, Imagawa K, Saito Y, Iijima T, Ito H, Murakami M.
|
| Biochem Biophys Res Commun 351(3):764-70. Epub 2006 Nov 3.
2006
|
| 45 | DYRK1A, GMNN, TFAP4, STMN2, REST
|
| A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.
|
| Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, Kim NS, Kim YH, Kim JK, Ahn KY, Kim KK.
|
| Proc Natl Acad Sci U S A 103(35):13074-9. Epub 2006 Aug 21. 2006
|
| 46 | REST, MYC
|
| Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation.
|
| Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S.
|
| Mol Cell Biol 26(5):1666-78. 2006
|
| 47 | REST
|
| Molecular genetic analysis of the REST/NRSF gene in nervous system tumors.
|
| Blom T, Tynninen O, Puputti M, Halonen M, Paetau A, Haapasalo H, Tanner M, Nupponen NN.
|
| Acta Neuropathol 112(4):483-90. Epub 2006 Jul 6. 2006
|
| 48 | REST, SMARCA4
|
| BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression.
|
| Ooi L, Belyaev ND, Miyake K, Wood IC, Buckley NJ.
|
| J Biol Chem 281(51):38974-80. Epub 2006 Oct 4. 2006
|
| 49 | REST
|
| Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.
|
| Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R, Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K.
|
| J Mol Cell Cardiol. 41(6):1010-22. 2006
|
| 50 | REST
|
| A genetic screen for candidate tumor suppressors identifies REST.
|
| Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ.
|
| Cell 121(6):837-48. 2005
|
| 51 | YY1, REST
|
| Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2.
|
| Kang HC, Chung BM, Chae JH, Yang SI, Kim CG, Kim CG.
|
| FEBS J 272(5):1265-77. 2005
|
| 52 | REST
|
| Small CTD phosphatases function in silencing neuronal gene expression.
|
| Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN.
|
| Science. 307(5709):596-600. 2005
|
| 53 | REST
|
| The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1.
|
| Plaisance V, Niederhauser G, Azzouz F, Lenain V, Haefliger JA, Waeber G, Abderrahmani A.
|
| J Biol Chem. 280(1):401-7. 2005
|
| 54 | REST
|
| Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.
|
| Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch C, Buckley NJ, Neylon CB, Porter KE, Beech DJ, Wood IC.
|
| Mol Cell. 20(1):45-52. 2005
|
| 55 | SYP, REST, NPTXR, NRXN3
|
| Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes.
|
| Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, Gottgens B, Buckley NJ.
|
| Proc Natl Acad Sci U S A 101(28):10458-63. Epub 2004 Jul 06. 2004
|
| 56 | REST
|
| Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation.
|
| Su X, Kameoka S, Lentz S, Majumder S.
|
| Mol Cell Biol 24(18):8018-25. 2004
|
| 57 | REST, OPRM1
|
| Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene.
|
| Kim CS, Hwang CK, Choi HS, Song KY, Law PY, Wei LN, Loh HH.
|
| J Biol Chem 279(45):46464-73. Epub 2004 Aug 18. 2004
|
| 58 | HTT, REST
|
| Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
|
| Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E.
|
| Nat Genet 35(1):76-83. Epub 2003 Jul 27. 2003
|
| 59 | REST
|
| NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.
|
| Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K.
|
| EMBO J. 22(23):6310-21. 2003
|
| 60 | REST, TRI21
|
| Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study.
|
| Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P.
|
| Lancet 359(9303):310-5.
2002
|
| 61 | DNM1, REST
|
| The neuron restrictive silencer factor can act as an activator for dynamin I gene promoter activity in neuronal cells.
|
| Yoo J, Jeong MJ, Lee SS, Lee KI, Kwon BM, Kim DS, Park YM, Han MY.
|
| Biochem Biophys Res Commun 283(4):928-32. 2001
|
| 62 | OPRM1, REST
|
| Identification of a neurorestrictive suppressor element (NRSE) in the human mu-opioid receptor gene.
|
| Andria ML, Simon EJ.
|
| Brain Res Mol Brain Res 91(1-2):73-80. 2001
|
| 63 | REST, RCOR1
|
| CoREST: a functional corepressor required for regulation of neural-specific gene expression.
|
| Andres ME, et al.
|
| Proc Natl Acad Sci U S A 96(17):9873-8 1999
|
| 64 | REST
|
| NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.
|
| Chen ZF, et al.
|
| Nat Genet 20 : 136-142. 1998
|
| 65 | REST
|
| Biological activity and modular structure of RE-1-silencing transcription factor (REST), a repressor of neuronal genes.
|
| Thiel G, Lietz M, Cramer M.
|
| J Biol Chem 273 : 26891-26899. 1998
|
| 66 | REST
|
| A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter.
|
| Tapia-Ramirez J, et al.
|
| Proc Natl Acad Sci U S A 94(4):1177-82 1997
|
| 67 | REST
|
| Assignment of the REST gene to 4q12 by fluorescence in situ hybridization.
|
| Cowan JM, et al.
|
| Genomics 34 : 260-262. 1996
|
| 68 | REST
|
| REST : a mammalian silencer protein that restricts sodium channel gene expression to neurons.
|
| Chong JA, et al.
|
| Cell 80 : 949-957. 1995
|
| 69 | REST
|
| The neuron-restrictive silencer factor (NRSF) : a coordinate repressor of multiple neuron-specific genes.
|
| Schoenherr CJ, et al.
|
| Science 267 : 1360-1363. 1995
|