| 1 | DAB1, RELN
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| Optogenetic control of the Dab1 signaling pathway.
|
| Wang L, Cooper JA.
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| Sci Rep 7:43760. doi: 10.1038/srep43760.
2017
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| 2 | DAB1, LRP8, RELN, VLDLR
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| Nonneuronal roles for the reelin signaling pathway.
|
| Khialeeva E, Carpenter EM.
|
| Dev Dyn 246(4):217-226. doi: 10.1002/dvdy.24462. Epub 2016 Nov 17. Review.
2017
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| 3 | ITSN1, RELN
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| Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.
|
| Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock HH, Maritzen T, Haucke V.
|
| Proc Natl Acad Sci U S A 114(21):5533-5538. doi: 10.1073/pnas.1704447114. Epub 2017 May 8.
2017
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| 4 | CDH2, RELN
|
| Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development.
|
| Matsunaga Y, Noda M, Murakawa H, Hayashi K, Nagasaka A, Inoue S, Miyata T, Miura T, Kubo KI, Nakajima K.
|
| Proc Natl Acad Sci U S A 114(8):2048-2053. doi: 10.1073/pnas.1615215114. Epub 2017 Feb 7.
2017
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| 5 | RELN, SOCS6, SOCS7
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| Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
|
| Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, Thomas T, Voss AK.
|
| Cereb Cortex 27(1):576-588. doi: 10.1093/cercor/bhv253.
2017
|
| 6 | DAB1, PAFAH1B1, RELN
|
| How does Reelin signaling regulate the neuronal cytoskeleton during migration?
|
| Chai X, Frotscher M.
|
| Neurogenesis (Austin) 3(1):e1242455. doi: 10.1080/23262133.2016.1242455. eCollection 2016. Review.
2016
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| 7 | ETL7, RELN
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| Heterozygous Reelin Mutations Cause Autosomal-Dominant Lateral Temporal Epilepsy.
|
| Dazzo E, Fanciulli M, Serioli E, Minervini G, Pulitano P, Binelli S, Di Bonaventura C, Luisi C, Pasini E, Striano S, Striano P, Coppola G, Chiavegato A, Radovic S, Spadotto A, Uzzau S, La Neve A, Giallonardo AT, Mecarelli O, Tosatto SC, Ottman R, Michelucci R, Nobile C.
|
| Am J Hum Genet 96(6):992-1000. doi: 10.1016/j.ajhg.2015.04.020.
2015
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| 8 | RELN
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| RELN rare variants in myoclonus-dystonia.
|
| Groen JL, Ritz K, Jalalzadeh H, van der Salm SM, Jongejan A, Mook OR, Haagmans MA, Zwinderman AH, Motazacker MM, Hennekam RC, Baas F, Tijssen MA.
|
| Mov Disord 30(3):415-9. doi: 10.1002/mds.26070. Epub 2015 Feb 4.
2015
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| 9 | DAB1, RELN
|
| Human Neural Cells Transiently Express Reelin during Olfactory Placode Development.
|
| Antal MC, Samama B, Ghandour MS, Boehm N.
|
| PLoS One 10(8):e0135710. doi: 10.1371/journal.pone.0135710. eCollection 2015.
2015
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| 10 | RELN
|
| RELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls.
|
| Camacho J, Ejaz E, Ariza J, Noctor SC, Martínez-Cerdeńo V.
|
| Neurosci Lett 579:163-7. doi: 10.1016/j.neulet.2014.07.031. Epub 2014 Jul 25.
2014
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| 11 | RELN
|
| Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway.
|
| Lee GH, Chhangawala Z, von Daake S, Savas JN, Yates JR 3rd, Comoletti D, D'Arcangelo G.
|
| J Biol Chem 289(29):20307-17. doi: 10.1074/jbc.M114.576249. Epub 2014 May 29.
2014
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| 12 | RELN
|
| Expression and regulation of reelin and its receptors in the enteric nervous system.
|
| Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Förster E, Wedel T.
|
| Mol Cell Neurosci 61:23-33. doi: 10.1016/j.mcn.2014.05.001. Epub 2014 May 17.
2014
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| 13 | DAB1, RELN
|
| Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
|
| Diaz-Mendoza MJ, Lorda-Diez CI, Montero JA, Garcia-Porrero JA, Hurle JM.
|
| J Cell Physiol 229(10):1397-404. doi: 10.1002/jcp.24576.
2014
|
| 14 | DAB1, RELN
|
| Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics.
|
| Vázquez-Carretero MD, García-Miranda P, Calonge ML, Peral MJ, Ilundain AA.
|
| Biol Cell 106(3):83-96. doi: 10.1111/boc.201300078. Epub 2014 Jan 17.
2014
|
| 15 | DAB1, RELN
|
| Novel Disabled-1-expressing neurons identified in adult brain and spinal cord.
|
| Abadesco AD, Cilluffo M, Yvone GM, Carpenter EM, Howell BW, Phelps PE.
|
| Eur J Neurosci ur J Neurosci. 2013 Nov 19. doi: 10.1111/ejn.12416. [Epub ahead of print] 2013
|
| 16 | DAB1, RELN
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| Dab1 is required for synaptic plasticity and associative learning.
|
| Trotter J, Lee GH, Kazdoba TM, Crowell B, Domogauer J, Mahoney HM, Franco SJ, Müller U, Weeber EJ, D'Arcangelo G.
|
| J Neurosci 33(39):15652-68. doi: 10.1523/JNEUROSCI.2010-13.2013. 2013
|
| 17 | DAB1, LRP8, RELN, SH3KBP1, VLDLR
|
| Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.
|
| Fuchigami T, Sato Y, Tomita Y, Takano T, Miyauchi SY, Tsuchiya Y, Saito T, Kubo K, Nakajima K, Fukuda M, Hattori M, Hisanaga S.
|
| Genes Cells 18(5):410-24. doi: 10.1111/gtc.12045. Epub 2013 Mar 19. 2013
|
| 18 | RELN, VAMP7
|
| Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission.
|
| Bal M, Leitz J, Reese AL, Ramirez DM, Durakoglugil M, Herz J, Monteggia LM, Kavalali ET.
|
| Neuron 80(4):934-46. doi: 10.1016/j.neuron.2013.08.024. Epub 2013 Nov 7.
2013
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| 19 | EPHB1, EPHB2, RELN
|
| Reelin induces EphB activation.
|
| Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH.
|
| Cell Res 23(4):473-90. doi: 10.1038/cr.2013.7. Epub 2013 Jan 15.
2013
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| 20 | RELN
|
| Reelin promotes microtubule dynamics in processes of developing neurons.
|
| Meseke M, Cavus E, Förster E.
|
| Histochem Cell Biol 139(2):283-97. doi: 10.1007/s00418-012-1025-1. Epub 2012 Sep 19.
2013
|
| 21 | ARHGEF6, RELN
|
| Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons.
|
| Meseke M, Rosenberger G, Förster E.
|
| Eur J Neurosci 37(9):1404-12. doi: 10.1111/ejn.12153.
2013
|
| 22 | DAB1, RELN, VEGFA
|
| VEGF activates NR2B phosphorylation through Dab1 pathway.
|
| Howell KR, Hoda MN, Pillai A.
|
| Neurosci Lett 552:30-4. doi: 10.1016/j.neulet.2013.07.032. Epub 2013 Jul 31.
2013
|
| 23 | LRP8, RELN
|
| Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.
|
| Hellwig S, Hack I, Zucker B, Brunne B, Junghans D.
|
| PLoS One 7(11):e50646. doi: 10.1371/journal.pone.0050646. Epub 2012 Nov 29.
2012
|
| 24 | ADAMTS4, RELN
|
| A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner.
|
| Hisanaga A, Morishita S, Suzuki K, Sasaki K, Koie M, Kohno T, Hattori M.
|
| FEBS Lett 586(19):3349-53. doi: 10.1016/j.febslet.2012.07.017. Epub 2012 Jul 20.
2012
|
| 25 | DAB1, RELN
|
| Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
|
| Keilani S, Healey D, Sugaya K.
|
| Can J Physiol Pharmacol 90(3):361-9. doi: 10.1139/y2012-001. Epub 2012 Mar 6. 2012
|
| 26 | ATXN7, RELN
|
| Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.
|
| McCullough SD, Xu X, Dent SY, Bekiranov S, Roeder RG, Grant PA.
|
| Proc Natl Acad Sci U S A 109(52):21319-24. doi: 10.1073/pnas.1218331110. Epub 2012 Dec 10.
2012
|
| 27 | RELN
|
| Reelin is required for class-specific retinogeniculate targeting.
|
| Su J, Haner CV, Imbery TE, Brooks JM, Morhardt DR, Gorse K, Guido W, Fox MA.
|
| J Neurosci 31(2):575-86.
2011
|
| 28 | EFNB1, EFNB2, EFNB3, RELN
|
| Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
|
| Sentürk A, Pfennig S, Weiss A, Burk K, Acker-Palmer A.
|
| Nature. 472(7343):356-60. 2011
|
| 29 | CDH2, RELN, TERF2IP
|
| Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.
|
| Jossin Y, Cooper JA.
|
| Nat Neurosci. 14(6):697-703. 2011
|
| 30 | DAB1, RELN
|
| Dab1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages.
|
| Martín-López E, Blanchart A, De Carlos JA, López-Mascaraque L.
|
| PLoS One 6(10):e26673. doi: 10.1371/journal.pone.0026673. Epub 2011 Oct 25. 2011
|
| 31 | RELN
|
| Genetic variants in the RELN gene are associated with otosclerosis in multiple European populations.
|
| Schrauwen I, Ealy M, Fransen E, Vanderstraeten K, Thys M, Meyer NC, Cosgarea M, Huber A, Mazzoli M, Pfister M, Smith RJ, Van Camp G.
|
| Hum Genet 127(2):155-62. Epub 2009 Oct 22.PMID: 19847460 2010
|
| 32 | RELN
|
| Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression.
|
| Maloku E, Covelo IR, Hanbauer I, Guidotti A, Kadriu B, Hu Q, Davis JM, Costa E.
|
| Proc Natl Acad Sci U S A 107(9):4407-11. Epub 2010 Feb 11.PMID: 20150511 2010
|
| 33 | GRIK2, RELN
|
| Linkage and candidate gene studies of autism spectrum disorders in European populations.
|
| Holt R, Barnby G, Maestrini E, Bacchelli E, Brocklebank D, Sousa I, Mulder EJ, Kantojärvi K, Järvelä I, Klauck SM, Poustka F, Bailey AJ, Monaco AP.
|
| Eur J Hum Genet ur J Hum Genet. 2010 May 5. [Epub ahead of print]PMID: 20442744 2010
|
| 34 | LRP8, RELN
|
| Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.
|
| Duit S, Mayer H, Blake SM, Schneider WJ, Nimpf J.
|
| J Biol Chem 285(7):4896-908. doi: 10.1074/jbc.M109.025973. Epub 2009 Nov 30.
2010
|
| 35 | RELN, STK25
|
| Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.
|
| Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW.
|
| Cell 143(5):826-36. doi: 10.1016/j.cell.2010.10.029.
2010
|
| 36 | RELN, SLC26A5
|
| A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.
|
| Schrauwen I, Ealy M, Huentelman MJ, Thys M, Homer N, Vanderstraeten K, Fransen E, Corneveaux JJ, Craig DW, Claustres M, Cremers CW, Dhooge I, Van de Heyning P, Vincent R, Offeciers E, Smith RJ, Van Camp G.
|
| Am J Hum Genet 84(3):328-38. Epub 2009 Feb 19.
2009
|
| 37 | RELN
|
| The N-terminal fragment of Reelin is generated after endocytosis and released through the pathway regulated by Rab11.
|
| Hibi T, Hattori M.
|
| FEBS Lett 583(8):1299-303. Epub 2009 Mar 20.
2009
|
| 38 | CASK, GPR34, GPR82, MICPCH, RELN, TBR1
|
| An X-linked microcephaly syndrome caused by disruptions of CASK implicates the CASK-TBR1-RELN pathway in human brain development.
|
| Bailey KA, Aldinger KA.
|
| Clin Genet 75(5):424-5. No abstract available. 2009
|
| 39 | LRP8, RELN
|
| Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.
|
| Hibi T, Mizutani M, Baba A, Hattori M.
|
| Neurosci Res 63(4):251-8. doi: 10.1016/j.neures.2008.12.009. Epub 2009 Jan 9.
2009
|
| 40 | RELN
|
| The RELN locus in Alzheimer's disease.
|
| Seripa D, Matera MG, Franceschi M, Daniele A, Bizzarro A, Rinaldi M, Panza F, Fazio VM, Gravina C, D'Onofrio G, Solfrizzi V, Masullo C, Pilotto A.
|
| J Alzheimers Dis 14(3):335-44.
2008
|
| 41 | FABP7, NOTCH1, RELN
|
| Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1.
|
| Keilani S, Sugaya K.
|
| BMC Dev Biol 8:69.
2008
|
| 42 | GRM8, RELN
|
| The association analysis of RELN and GRM8 genes with autistic spectrum disorder in Chinese Han population.
|
| Li H, Li Y, Shao J, Li R, Qin Y, Xie C, Zhao Z.
|
| Am J Med Genet B Neuropsychiatr Genet 147B(2):194-200.
2008
|
| 43 | RELN, LIS2
|
| The role of RELN in lissencephaly and neuropsychiatric disease.
|
| Chang BS, Duzcan F, Kim S, Cinbis M, Aggarwal A, Apse KA, Ozdel O, Atmaca M, Zencir S, Bagci H, Walsh CA.
|
| Am J Med Genet B Neuropsychiatr Genet 144(1):58-63. 2007
|
| 44 | RELN
|
| Association of Reelin gene polymorphisms with autism.
|
| Serajee FJ, Zhong H, Mahbubul Huq AH.
|
| Genomics 87(1):75-83. Epub 2005 Nov 28. 2006
|
| 45 | RELN
|
| Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report.
|
| Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, Thiagalingam S, Tsuang MT.
|
| Am J Med Genet B Neuropsychiatr Genet 134(1):60-6. 2005
|
| 46 | RELN
|
| Reelin promoter hypermethylation in schizophrenia.
|
| Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, Costa E.
|
| Proc Natl Acad Sci U S A 102(26):9341-6. Epub 2005 Jun 16. 2005
|
| 47 | RELN
|
| Population-based and family-based association study of 5'UTR polymorphism of the reelin gene and schizophrenia.
|
| Goldberger C, Gourion D, Leroy S, Schurhoff F, Bourdel MC, Leboyer M, Krebs MO.
|
| Am J Med Genet B Neuropsychiatr Genet 137(1):51-5. 2005
|
| 48 | RELN
|
| Analysis of the RELN gene as a genetic risk factor for autism.
|
| Skaar DA, Shao Y, Haines JL, Stenger JE, Jaworski J, Martin ER, DeLong GR, Moore JH, McCauley JL, Sutcliffe JS, Ashley-Koch AE, Cuccaro ML, Folstein SE, Gilbert JR, Pericak-Vance MA.
|
| Mol Psychiatry 10(6):563-71. 2005
|
| 49 | GAD1, DNMT1, RELN
|
| DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.
|
| Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E.
|
| Proc Natl Acad Sci U S A 101(1):348-53. Epub 2003 Dec 18. 2004
|
| 50 | RELN, PAFAH1B1
|
| Interaction of reelin signaling and Lis1 in brain development.
|
| Assadi AH, Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S, Quattrocchi CC, Antalffy BA, Sheldon M, Armstrong DD, Wynshaw-Boris A, Herz J, D'Arcangelo G, Clark GD.
|
| Nat Genet 35(3):270-6. Epub 2003 Oct 26. 2003
|
| 51 | MDS, ARX, DCX, PAFAH1B1, RELN, YWHAE
|
| Lissencephaly and the molecular basis of neuronal migration.
|
| Kato M, Dobyns WB.
|
| Hum Mol Genet 12 Spec No 1:R89-96. Review. 2003
|
| 52 | CASK, CASKIN1, CASKP, RELN
|
| CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.
|
| Wang Q, Lu J, Yang C, Wang X, Cheng L, Hu G, Sun Y, Zhang X, Wu M, Liu Z.
|
| Cancer Lett 179(1):71-7. 2002
|
| 53 | RELN
|
| Reelin is a serine protease of the extracellular matrix.
|
| Quattrocchi CC, Wannenes F, Persico AM, Ciafre SA, D'Arcangelo G, Farace MG, Keller F.
|
| J Biol Chem 277(1):303-9. Epub 2001 Oct 31. Erratum in: J Biol Chem 2002 Mar 29;277(13):11616. 2002
|
| 54 | RELN
|
| Secreted Reelin molecules form homodimers.
|
| Kubo K, Mikoshiba K, Nakajima K.
|
| Neurosci Res 43(4):381-8. 2002
|
| 55 | DNAJC2, KMT2E, LRRC17, ORC5, PSMC2, RELN, S100A11P, SRPK2
|
| Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
|
| Kratz CP, Emerling BM, Donovan S, Laig-Webster M, Taylor BR, Thompson P, Jensen S, Banerjee A, Bonifas J, Makalowski W, Green ED, Le Beau MM, Shannon KM.
|
| Genomics 77(3):171-80. 2001
|
| 56 | RELN, CRAC1
|
| The reelin pathway modulates the structure and function of retinal synaptic circuitry.
|
| Rice DS, Nusinowitz S, Azimi AM, Martinez A, Soriano E, Curran T.
|
| Neuron 31(6):929-41. 2001
|
| 57 | RELN
|
| Three novel repetitive units of reelin.
|
| Ichihara H, Jingami H, Toh H.
|
| Brain Res Mol Brain Res 97(2):190-3. 2001
|
| 58 | reln
|
| Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder.
|
| Persico AM, D'Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, Wassink TH, Schneider C, Melmed R, Trillo S, Montecchi F, Palermo M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Conciatori M, Marino R, Quattrocchi CC, Baldi A, Zelante L, Gasparini P, Keller F; Collaborative Linkage Study of Autism.
|
| Mol Psychiatry 6(2):150-9.
2001
|
| 59 | RELN
|
| Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells.
|
| Smalheiser NR, Costa E, Guidotti A, Impagnatiello F, Auta J, Lacor P, Kriho V, Pappas GD.
|
| Proc Natl Acad Sci U S A 97(3):1281-6. 2000
|
| 60 | RELN
|
| The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex.
|
| Mallamaci A, Mercurio S, Muzio L, Cecchi C, Pardini CL, Gruss P, Boncinelli E.
|
| J Neurosci 20(3):1109-18. 2000
|
| 61 | RELN
|
| Reelin controls position of autonomic neurons in the spinal cord.
|
| Yip JW, Yip YP, Nakajima K, Capriotti C.
|
| Proc Natl Acad Sci U S A 97(15):8612-6. 2000
|
| 62 | LIS2, RELN
|
| Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.
|
| Hong SE, Shugart YY, Huang DT, Shahwan SA, Grant PE, Hourihane JO, Martin ND, Walsh CA.
|
| Nat Genet 26(1):93-6. No abstract available. 2000
|
| 63 | RELN
|
| Reelin is a ligand for lipoprotein receptors.
|
| D'Arcangelo G, Homayouni R, Keshvara L, Rice DS, Sheldon M, Curran T.
|
| Neuron 24(2):471-9.
1999
|
| 64 | RELN
|
| Proteins of the CNR family are multiple receptors for Reelin.
|
| Senzaki K, Ogawa M, Yagi T.
|
| Cell. 99(6):635-47. 1999
|
| 65 | ACTL6B, AGFG2, CUX1, EPO, GIGYF1, GNB2, IRS3L, LRCH4, PCOLCE, RELN, SH2B2, TFR2
|
| Large-scale sequencing of two regions in human chromosome 7q22 : analysis of 650kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.
|
| Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A.
|
| Genome Res 8 : 1060-1073. 1998
|
| 66 | RELN
|
| The human reelin gene : isolation, sequencing, and mapping on chromosome 7.
|
| DeSilva U, et al.
|
| Genome Res 7 : 157-164. 1997
|
| 67 | RELN
|
| Comparative mapping of the reeler gene on human chromosome 7q22, rat chromosome 4q11.2, and mouse chromosome 5 A3-B1.
|
| Matsuda Y, et al.
|
| Mamm Genome 7 : 468-469. 1996
|