Citations for
1FAM118B, RELA, YAP1
Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes
Takadera M, Satomi K, Szulzewsky F, Cimino PJ, Holland EC, Yamamoto T, Ichimura K, Ozawa T.
Acta Neuropathol Commun. Nov 23;8(1):203. doi: 10.1186/s40478-020-01080-8. 2020
2MACC1, RELA, TNF
Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1
Kobelt D, Zhang C, Clayton-Lucey IA, Glauben R, Voss C, Siegmund B, Stein U.
Front Immunol. May 27;11:980. doi: 10.3389/fimmu.2020.00980. 2020
3RELA, RNF182
The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation
Cao Y, Sun Y, Chang H, Sun X, Yang S.
FEBS Lett. Nov;593(22):3210-3219. doi: 10.1002/1873-3468.13583. Epub 2019 Sep 3 2019
4EP300, GTF2B, GTF2H1, RELA, TAF9B
Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors.
Lecoq L, Raiola L, Chabot PR, Cyr N, Arseneault G, Legault P, Omichinski JG.
Nucleic Acids Res. May 19;45(9):5564-5576. doi: 10.1093/nar/gkx146 2017
5ECSIT, NFKB1, RELA
Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
Mi Wi S, Park J, Shim JH, Chun E, Lee KY.
Mol Biol Cell 26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29. 2015
6KPNB1, RELA
KPNβ1 promotes palmitate-induced insulin resistance via NF-κB signaling in hepatocytes.
Wang S, Zhao Y, Xia N, Zhang W, Tang Z, Wang C, Zhu X, Cui S.
J Physiol Biochem 71(4):763-72. doi: 10.1007/s13105-015-0440-x. 2015
7RELA, RMDN3
PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway
Brobeil A, Kämmerer F, Tag C, Steger K, Gattenlöhner S, Wimmer M.
Biomolecules. Apr 16;5(2):485-504. doi: 10.3390/biom5020485 2015
8C11orf95, RELA
C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.
Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li Y, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksford J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL, Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ.
Nature 506(7489):451-5. doi: 10.1038/nature13109. Epub 2014 Feb 19. 2014
9CDK6, RELA
Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.
Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.
Mol Cell 53(2):193-208. doi: 10.1016/j.molcel.2013.12.002. Epub 2014 Jan 2. Erratum in: Mol Cell. 2014 Feb 20;53(4):682. 2014
10BEX2, RELA
Bex2 controls proliferation of human glioblastoma cells through NF-κB signaling pathway.
Meng Q, Zhi T, Chao Y, Nie E, Xu X, Shi Q, Hua L, Wang L, Zhan W, Wang Y, Zhou X, Yu R.
J Mol Neurosci 53(2):262-70. doi: 10.1007/s12031-013-0215-1. Epub 2014 Jan 4. 2014
11PPIA, RELA
Cyclophilin A (CypA) interacts with NF-κB subunit, p65/RelA, and contributes to NF-κB activation signaling.
Sun S, Guo M, Zhang JB, Ha A, Yokoyama KK, Chiu RH.
PLoS One 9(8):e96211. doi: 10.1371/journal.pone.0096211. eCollection 2014. 2014
12PHF20, RELA
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Zhang T, Park KA, Li Y, Byun HS, Jeon J, Lee Y, Hong JH, Kim JM, Huang SM, Choi SW, Kim SH, Sohn KC, Ro H, Lee JH, Lu T, Stark GR, Shen HM, Liu ZG, Park J, Hur GM.
Nat Commun 4:2062. doi: 10.1038/ncomms3062. 2013
13ACTN4, RELA
Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.
Oncotarget 4(2):362-72. 2013
14ADAMTS5, RELA
Transcriptional induction of ADAMTS5 protein by nuclear factor-κB (NF-κB) family member RelA/p65 in chondrocytes during osteoarthritis development.
Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.
J Biol Chem 288(40):28620-9. doi: 10.1074/jbc.M113.452169. Epub 2013 Aug 20. 2013
15LIMK1, RELA, SSH1
Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.
Leonard A, Marando C, Rahman A, Fazal F.
Am J Physiol Lung Cell Mol Physiol 305(9):L651-64. doi: 10.1152/ajplung.00071.2013. Epub 2013 Sep 13. 2013
16ING4, RELA
Inhibitor of growth 4 induces NFκB/p65 ubiquitin-dependent degradation.
Hou Y, Zhang Z, Xu Q, Wang H, Xu Y, Chen K.
Oncogene ncogene. 2013 Apr 29. doi: 10.1038/onc.2013.135. [Epub ahead of print] 2013
17PRMT5, RELA
PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.
Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang DB, Ghosh G, Stark GR, Lu T.
Proc Natl Acad Sci U S A 110(33):13516-21. doi: 10.1073/pnas.1311784110. Epub 2013 Jul 31. 2013
18ACTN4, RELA
Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.
Oncotarget 4(2):362-72. 2013
19FGF10, RELA, SP3
Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression.
Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince LS.
J Biol Chem 288(21):15318-25. doi: 10.1074/jbc.M112.447318. Epub 2013 Apr 4. 2013
20RELA, ZMYND8
Fusion of ZMYND8 and RELA genes in acute erythroid leukemia.
Panagopoulos I, Micci F, Thorsen J, Haugom L, Buechner J, Kerndrup G, Tierens A, Zeller B, Heim S.
PLoS One 8(5):e63663. doi: 10.1371/journal.pone.0063663. Print 2013. 2013
21IPO8, KPNA2, KPNB1, RELA, XPO7
KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus.
Liang P, Zhang H, Wang G, Li S, Cong S, Luo Y, Zhang B.
Traffic 14(11):1132-43. doi: 10.1111/tra.12097. 2013
22NOS2, RELA, STAT1
Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.
Burke SJ, Updegraff BL, Bellich RM, Goff MR, Lu D, Minkin SC Jr, Karlstad MD, Collier JJ.
Mol Endocrinol 27(10):1724-42. doi: 10.1210/me.2013-1159. Epub 2013 Sep 6. 2013
23EIF4H, RELA
Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.
Fiume G, Rossi A, de Laurentiis A, Falcone C, Pisano A, Vecchio E, Pontoriero M, Scala I, Scialdone A, Masci FF, Mimmi S, Palmieri C, Scala G, Quinto I.
PLoS One 8(6):e66087. doi: 10.1371/journal.pone.0066087. Print 2013. 2013
24HES6, NFKB1, RELA
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S.
Mol Cell Biol. Jul;33(14):2797-808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20. 2013
25KLF11, RELA
Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.
Fan Y, Guo Y, Zhang J, Subramaniam M, Song CZ, Urrutia R, Chen YE.
Arterioscler Thromb Vasc Biol 32(12):2981-8. doi: 10.1161/ATVBAHA.112.300349. Epub 2012 Oct 4. 2012
26COL1A1, RELA
The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
Beauchef G, Bigot N, Kypriotou M, Renard E, Porée B, Widom R, Dompmartin-Blanchere A, Oddos T, Maquart FX, Demoor M, Boumediene K, Galera P.
J Biol Chem 287(5):3462-78. doi: 10.1074/jbc.M111.286443. Epub 2011 Dec 2. 2012
27RELA
Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression.
Wier EM, Neighoff J, Sun X, Fu K, Wan F.
J Biol Chem 287(51):43019-29. doi: 10.1074/jbc.M112.388694. Epub 2012 Oct 31. 2012
28PTK2B, RELA
Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2.
Bijli KM, Fazal F, Rahman A.
Am J Respir Cell Mol Biol 47(5):660-8. doi: 10.1165/rcmb.2012-0047OC. Epub 2012 Jul 27. 2012
29RELA
Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells.
George LE, Lokhandwala MF, Asghar M.
Am J Physiol Renal Physiol 302(11):F1440-6. doi: 10.1152/ajprenal.00006.2012. Epub 2012 Mar 7. 2012
30ERG, RELA
The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
Dryden NH, Sperone A, Martin-Almedina S, Hannah RL, Birdsey GM, Khan ST, Layhadi JA, Mason JC, Haskard DO, Göttgens B, Randi AM.
J Biol Chem 287(15):12331-42. doi: 10.1074/jbc.M112.346791. Epub 2012 Feb 15. 2012
31RELA
Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1.
Liu Y, Mayo MW, Nagji AS, Smith PW, Ramsey CS, Li D, Jones DR.
Oncogene 31(9):1143-54. doi: 10.1038/onc.2011.308. Epub 2011 Jul 18. 2012
32MCL1, NAA10, RELA
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Xu H, Jiang B, Meng L, Ren T, Zeng Y, Wu J, Qu L, Shou C.
Carcinogenesis 33(6):1193-202. doi: 10.1093/carcin/bgs144. Epub 2012 Apr 10. 2012
33PIAS3, RELA
NF-κB repression by PIAS3 mediated RelA SUMOylation.
Liu Y, Bridges R, Wortham A, Kulesz-Martin M.
PLoS One 7(5):e37636. doi: 10.1371/journal.pone.0037636. Epub 2012 May 23. 2012
34GSK3A, GSK3B, RELA
GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.
Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.
J Biol Chem 287(35):29227-36. doi: 10.1074/jbc.M112.372086. Epub 2012 Jul 3. 2012
35GH1, IGF1, RELA
Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2.
Wu S, Morrison A, Sun H, De Luca F.
J Biol Chem 286(28):24726-34. Epub 2011 May 18. 2011
36IKBKG, RELA, TRAF7
TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.
Zotti T, Uva A, Ferravante A, Vessichelli M, Scudiero I, Ceccarelli M, Vito P, Stilo R.
J Biol Chem 286(26):22924-33. Epub 2011 Apr 25. 2011
37RELA
The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration.
Msaki A, Sánchez AM, Koh LF, Barré B, Rocha S, Perkins ND, Johnson RF.
Mol Biol Cell 22(17):3032-40. Epub 2011 Jul 7. 2011
38RELA
NF-κB p65 represses β-catenin-activated transcription of cyclin D1.
Hwang I, Choi YS, Jeon MY, Jeong S.
Biochem Biophys Res Commun 403(1):79-84. Epub 2010 Nov 4. 2010
39COMMD1, RELA
Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination.
Thoms HC, Loveridge CJ, Simpson J, Clipson A, Reinhardt K, Dunlop MG, Stark LA.
Cancer Res 70(1):139-49. 2010
40KAT2A, RELA
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E.
Genes Dev 23(7):849-61. 2009
41RELA, SIRT6
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF.
Cell 136(1):62-74. 2009
42BRD4, CDK9, RELA
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA.
Huang B, Yang XD, Zhou MM, Ozato K, Chen LF.
Mol Cell Biol 29(5):1375-87. Epub 2008 Dec 22. 2009
43BECN1, RELA
p65/RelA modulates BECN1 transcription and autophagy.
Copetti T, Bertoli C, Dalla E, Demarchi F, Schneider C.
Mol Cell Biol 29(10):2594-608. Epub 2009 Mar 16. 2009
44RELA
RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair.
Wang J, Jacob NK, Ladner KJ, Beg A, Perko JD, Tanner SM, Liyanarachchi S, Fishel R, Guttridge DC.
EMBO Rep 10(11):1272-8. Epub 2009 Sep 25. 2009
45MED17, RELA
Two modes of transcriptional activation at native promoters by NF-kappaB p65.
van Essen D, Engist B, Natoli G, Saccani S.
PLoS Biol 7(3):e73.PMID: 19338389 2009
46REL, RELA
Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene.
Liu Z, Ma Z, Terada LS, Garrard WT.
J Immunol 183(6):3819-30. Epub 2009 Aug 26. 2009
47COMMD1, RELA
HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1.
Lian M, Zheng X.
J Biol Chem 284(27):17998-8006. Epub 2009 May 11. 2009
48AKIP1, RELA
AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
Gao N, Asamitsu K, Hibi Y, Ueno T, Okamoto T.
J Biol Chem 283(12):7834-43. Epub 2008 Jan 4. 2008
49RELA
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C.
Blood 111(9):4681-9. Epub 2008 Jan 28. 2008
50RELA
RelA/NF-kappaB transcription factor associates with alpha-actinin-4.
Babakov VN, Petukhova OA, Turoverova LV, Kropacheva IV, Tentler DG, Bolshakova AV, Podolskaya EP, Magnusson KE, Pinaev GP.
Exp Cell Res 314(5):1030-8. Epub 2007 Dec 8. 2008
51RELA
RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.
Cianfrocca R, Muscolini M, Marzano V, Annibaldi A, Marinari B, Levrero M, Costanzo A, Tuosto L.
Cell Death Differ 15(2):354-63. Epub 2007 Nov 23. 2008
52IER3, RELA
IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.
Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Fölsch UR, Schreiber S, Schäfer H.
Biochim Biophys Acta 1783(5):941-52. Epub 2007 Dec 23.PMID: 18191642 2008
53PDLIM2, RELA
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.
Tanaka T, Grusby MJ, Kaisho T.
Nat Immunol 8(6):584-91. Epub 2007 Apr 29. 2007
54NKX3-2, RELA
Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability.
Park M, Yong Y, Choi SW, Kim JH, Lee JE, Kim DW.
Nat Cell Biol 9(3):287-98. Epub 2007 Feb 18.PMID: 17310243 2007
55PSMD10, RELA
Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export.
Chen Y, Li HH, Fu J, Wang XF, Ren YB, Dong LW, Tang SH, Liu SQ, Wu MC, Wang HY.
Cell Res 17(12):1020-9.PMID: 18040287 2007
56NFKB2, RELA
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".
Tucker E, O'Donnell K, Fuchsberger M, Hilton AA, Metcalf D, Greig K, Sims NA, Quinn JM, Alexander WS, Hilton DJ, Kile BT, Tarlinton DM, Starr R.
J Immunol 179(11):7514-22. 2007
57CALM2, RELA
Gene expression profiling of human placentas from preeclamptic and normotensive pregnancies.
Hansson SR, Chen Y, Brodszki J, Chen M, Hernandez-Andrade E, Inman JM, Kozhich OA, Larsson I, Mars‡l K, Medstrand P, Xiang CC, Brownstein MJ.
Mol Hum Reprod 12(3):169-79. Epub 2006 Mar 23. 2006
58NFKBIB, RELA
RelA/p65 regulation of IkappaBbeta.
Hertlein E, Wang J, Ladner KJ, Bakkar N, Guttridge DC.
Mol Cell Biol 25(12):4956-68.PMID: 15923614 2005
59PIAS3, RELA
PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit.
Jang HD, Yoon K, Shin YJ, Kim J, Lee SY.
J Biol Chem 279(23):24873-80. Epub 2004 Mar 26. 2004
60IRAK1BP1, RELA
Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL.
Kwon HJ, Breese EH, Vig-Varga E, Luo Y, Lee Y, Goebl MG, Harrington MA.
Mol Cell Biol 24(21):9317-26.PMID: 15485901 2004
61RNF25, RELA
RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.
Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T.
J Biol Chem 278(29):26879-87. Epub 2003 May 13. 2003
62REL, RELA, CALM1
Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin.
Antonsson A, Hughes K, Edin S, Grundstršm T.
Mol Cell Biol 23(4):1418-27. 2003
63MTPN, RELA
Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy.
Gupta S, Sen S.
Biochim Biophys Acta 1589(3):247-60. 2002
64PCNXL3, MALAT1, RELA, TFEB, SCYL1
Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints.
van Asseldonk M, Schepens M, de Bruijn D, Janssen B, Merkx G, Geurts van Kessel A.
Genomics 66(1):35-42. 2000
65CAPN1, FAU, KAT5, MAP3K11, MEN1, PABYL, PLCB3, PYGM, RELA, SEA, SF1, SIPA1
A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.
Sawicki M, Arnold E, Ebrahimi S, Duell T, Jin S, Wood T, Chakrabarti R, Peters J, Wan Y, Samara G, Weier HU, Udar N, Passaro E Jr, Srivatsan ES.
Genomics 42(3):405-12. 1997
66RELA, RELB
The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kB is located on chromosome 11q12.
Deloukas P, et al.
Genomics 19 : 592-594. 1994
67RELA
Genomic organization of the gene encoding the p65 subunit of NF-khi B : multiple variants of the p65 protein may be generated by alternative splicing.
Deloukas P, et al.
Hum Mol Genet 2 : 1895-1900. 1993
68REL, NFKB1, NFKB2, RELA
Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappaBp50, NF-kappaBp65, and lyt-10 by fluorescence in situ hybridization.
Mathew S, et al.
Oncogene 8 : 191-193. 1993