| 1 | RCAN1
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| RCAN1-mediated calcineurin inhibition as a target for cancer therapy
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| Lao M, Zhang X, Yang H, Bai X, Liang T.
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| Mol Med. Jun 18;28(1):69. doi: 10.1186/s10020-022-00492-7. 2022
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| 2 | RCAN1
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| Overexpression of RCAN1, a Gene on Human Chromosome 21, Alters Cell Redox and Mitochondrial Function in Enamel Cells
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| Li Y, Costiniti V, Souza Bomfim GH, Neginskaya M, Son GY, Rothermel B, Pavlov E, Lacruz RS.
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| Cells. Nov 11;11(22):3576. doi: 10.3390/cells11223576. 2022
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| 3 | RCAN1
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| RCAN1 in cardiovascular diseases: molecular mechanisms and a potential therapeutic target
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| Wang S, Wang Y, Qiu K, Zhu J, Wu Y.
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| Mol Med. Dec 2;26(1):118. doi: 10.1186/s10020-020-00249-0. 2020
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| 4 | RCAN1
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| RCAN1 Regulates Bidirectional Synaptic Plasticity
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| Dudilot A, Trillaud-Doppia E, Boehm J.
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| Curr Biol. 0 Apr 6;30(7):1167-1176.e2. doi: 10.1016/j.cub.2020.01.041. Epub 2020 Feb 20. 2020
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| 5 | RCAN1
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| Neurogenesis impairment: An early developmental defect in Down syndrome
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| Stagni F, Giacomini A, Emili M, Guidi S, Bartesaghi R.
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| Free Radic Biol Med. Jan;114:15-32. doi: 10.1016/j.freeradbiomed.2017.07.026. Epub 2017 Jul 27. 2018
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| 6 | RCAN1
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| The effect of RCAN1 on the biological behaviors of small cell lung cancer.
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| Ma N, Shen W, Pang H, Zhang N, Shi H, Wang J, Zhang H.
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| Tumour Biol. un;39(6):1010428317700405. doi: 10.1177/1010428317700405. 2017
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| 7 | RCAN1
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| The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth
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| Chen X, Hu Y, Wang S, Sun X.
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| Oncotarget Feb 14;8(7):12003-12012. doi: 10.18632/oncotarget.14479. 2017
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| 8 | FLNA, RCAN1
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| Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia.
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| Li Y, Wang J, Zhou Y, Li D, Xiong ZQ.
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| J Neurosci. Jan 14;35(2):610-20. doi: 10.1523/JNEUROSCI.1003-14.2015. 2015
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| 9 | PRKACA, RCAN1
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| PKA regulates calcineurin function through the phosphorylation of RCAN1: identification of a novel phosphorylation site
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| Kim SS, Lee EH, Lee K, Jo SH, Seo SR.
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| Biochem Biophys Res Commun. Apr 17;459(4):604-9. doi: 10.1016/j.bbrc.2015.02.155. Epub 2015 Mar 7. 2015
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| 10 | RCAN1
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| Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.
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| Wu Y, Ly PT, Song W.
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| Mol Neurobiol. Dec;50(3):1085-97. doi: 10.1007/s12035-014-8704-y. Epub 2014 Apr 22. 2014
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| 11 | RCAN1
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| Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
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| Shaw JL, Chang KT.
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| PLoS Genet 9(9):e1003792. doi: 10.1371/journal.pgen.1003792. Epub 2013 Sep 26.
2013
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| 12 | RCAN1
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| Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras.
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| Lee JC, Shin J, Baek KH.
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| Biochem Biophys Res Commun 440(1):50-5. doi: 10.1016/j.bbrc.2013.09.033. Epub 2013 Sep 13.
2013
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| 13 | RCAN1
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| Upregulation of RCAN1 causes Down syndrome-like immune dysfunction
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| Martin KR, Layton D, Seach N, Corlett A, Barallobre MJ, Arbonés ML, Boyd RL, Scott B, Pritchard MA.
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| J Med Genet. Jul;50(7):444-54. doi: 10.1136/jmedgenet-2013-101522. Epub 2013 May 3. 2013
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| 14 | RCAN1
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| The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.
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| Lee JW, Kang HS, Lee JY, Lee EJ, Rhim H, Yoon JH, Seo SR, Chung KC
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| Biochem Biophys Res Commun. 420(2):404-10 2012
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| 15 | PRKACA, RCAN1
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| Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).
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| Kim SS, Oh Y, Chung KC, Seo SR.
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| Biochem Biophys Res Commun 418(4):657-61. doi: 10.1016/j.bbrc.2012.01.071. Epub 2012 Jan 24.
2012
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| 16 | NEDD8, RCAN1
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| Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin.
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| Noh EH, Hwang HS, Hwang HS, Min B, Im E, Chung KC.
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| PLoS One 7(10):e48315. doi: 10.1371/journal.pone.0048315. Epub 2012 Oct 31.
2012
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| 17 | RCAN1, STAT2
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| The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.
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| Lee JW, Kang HS, Lee JY, Lee EJ, Rhim H, Yoon JH, Seo SR, Chung KC.
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| Biochem Biophys Res Commun 420(2):404-10. doi: 10.1016/j.bbrc.2012.03.007. Epub 2012 Mar 9.
2012
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| 18 | RCAN1
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| Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells.
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| Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo AM, Davies KJ.
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| J Biol Chem 287(17):14088-98. doi: 10.1074/jbc.M111.305342. Epub 2012 Mar 2.
2012
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| 19 | RCAN1
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| Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.
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| Martin KR, Corlett A, Dubach D, Mustafa T, Coleman HA, Parkington HC, Merson TD, Bourne JA, Porta S, Arbonés ML, Finkelstein DI, Pritchard MA.
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| Hum Mol Genet 21(13):3025-41. doi: 10.1093/hmg/dds134. Epub 2012 Apr 17.
2012
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| 20 | RCAN1
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| Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.
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| Sun X, Wu Y, Chen B, Zhang Z, Zhou W, Tong Y, Yuan J, Xia K, Gronemeyer H, Flavell RA, Song W.
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| J Biol Chem 286(11):9049-62. Epub 2011 Jan 7.
2011
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| 21 | CREB1, RCAN1
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| The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway.
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| Kim SS, Seo SR.
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| J Biol Chem 286(43):37841-8. doi: 10.1074/jbc.M111.232165. Epub 2011 Sep 2.
2011
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| 22 | DYRK1A, RCAN1
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| Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.
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| Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH.
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| J Biol Chem. 286(46):40401-12. 2011
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| 23 | RCAN1
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| Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells.
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| Lee MY, Garvey SM, Baras AS, Lemmon JA, Gomez MF, Schoppee Bortz PD, Daum G, LeBoeuf RC, Wamhoff BR.
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| Hum Mol Genet 19(3):468-79. Epub 2009 Nov 19.
2010
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| 24 | RCAN1
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| RCAN1-4 knockdown attenuates cell growth through the inhibition of Ras signaling.
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| Lee HJ, Kim YS, Sato Y, Cho YJ.
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| FEBS Lett 583(15):2557-64. Epub 2009 Jul 18.
2009
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| 25 | RCAN1
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| Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
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| Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S.
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| Nature 459(7250):1126-30. Epub 2009 May 20.
2009
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| 26 | RCAN1, TOLLIP
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| Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling.
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| Lee JY, Lee HJ, Lee EJ, Jang SH, Kim H, Yoon JH, Chung KC.
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| Biochim Biophys Acta 1790(12):1673-80. Epub 2009 Aug 27. 2009
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| 27 | DYRK1A, RCAN1, TRI21
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| Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.
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| Rachidi M, Lopes C.
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| Eur J Paediatr Neurol 12(3):168-82. Epub 2007 Oct 22. Review. 2008
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| 28 | RCAN1
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| DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.
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| Keating DJ, Dubach D, Zanin MP, Yu Y, Martin K, Zhao YF, Chen C, Porta S, Arbons ML, Mittaz L, Pritchard MA.
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| Hum Mol Genet 17(7):1020-30. Epub 2008 Jan 7. 2008
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| 29 | CREB1, RCAN1
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| CREB activates proteasomal degradation of DSCR1/RCAN1.
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| Seo SR, Chung KC.
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| FEBS Lett 582(13):1889-93. Epub 2008 May 15.
2008
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| 30 | RCAN1, TEAD4
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| Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells.
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| Liu X, Zhao D, Qin L, Li J, Zeng H.
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| J Biol Chem 283(49):34159-67. Epub 2008 Oct 7.
2008
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| 31 | RCAN1
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| Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.
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| Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F.
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| Cancer Cell 13(5):420-31. 2008
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| 32 | MAP3K14, RCAN1
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| NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1.
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| Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC.
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| J Biol Chem 283(6):3392-400. Epub 2007 Dec 4.
2008
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| 33 | RCAN1
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| Regulation of vascular function by RCAN1 (ADAPT78).
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| Riper DV, Jayakumar L, Latchana N, Bhoiwala D, Mitchell AN, Valenti JW, Crawford DR.
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| Arch Biochem Biophys 472(1):43-50. Epub 2008 Feb 9.PMID: 18294449 2008
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| 34 | RCAN1
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| Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.
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| Asada S, Ikeda A, Nagao R, Hama H, Sudo T, Fukamizu A, Kasuya Y, Kishi T.
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| Int J Mol Med. 22(1):95-104. 2008
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| 35 | RCAN1
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| RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.
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| Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbones ML, Marti E.
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| Hum Mol Genet 16(9):1039-50. Epub 2007 Mar 6. 2007
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| 36 | RCAN1, NFATC1
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| Down Syndrome Critical Region-1 Is a Transcriptional Target of Nuclear Factor of Activated T Cells-c1 within the Endocardium during Heart Development.
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| Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP.
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| J Biol Chem 282(42):30673-9. Epub 2007 Aug 10. 2007
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| 37 | RCAN1
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| Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
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| Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X.
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| FASEB J 21(12):3023-8. Epub 2007 Jun 26. No abstract available.
2007
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| 38 | RCAN1
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| Brain expression of the calcineurin inhibitor RCAN1 (Adapt78).
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| Mitchell AN, Jayakumar L, Koleilat I, Qian J, Sheehan C, Bhoiwala D, Hushmendy SF, Heuring JM, Crawford DR.
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| Arch Biochem Biophys 467(2):185-92. Epub 2007 Sep 7.PMID: 17910944 2007
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| 39 | RCAN1, DYRK1A, NFATC1, NFATC2, NFATC3, NFATC4, TRI21
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| NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
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| Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.
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| Nature 441(7093):595-600. Epub 2006 Mar 22. 2006
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| 40 | RCAN1, DYRK1A, NFAT, TRI21
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| Down's syndrome: critical genes in a critical region.
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| Epstein CJ.
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| Nature 441(7093):582-3. No abstract available. 2006
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| 41 | RCAN1, RCAN2
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| Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.
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| Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.
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| Mol Cancer Res 4(11):811-20.
2006
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| 42 | RCAN1
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| DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes?
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| Kluetzman KS, Perez AV, Crawford DR.
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| Biochem Biophys Res Commun 337(2):595-601. Epub 2005 Sep 22. 2005
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| 43 | RCAN1
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| Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease.
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| Harris CD, Ermak G, Davies KJ.
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| Cell Mol Life Sci 62(21):2477-86. Review. 2005
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| 44 | RCAN1, VEGFA
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| Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells.
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| Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP.
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| Blood 104(1):149-58. Epub 2004 Mar 11. 2004
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| 45 | RCAN1
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| A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript.
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| Silveira HC, Sommer CA, Soares-Costa A, Henrique-Silva F.
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| Braz J Med Biol Res. 37(6):785-9. 2004
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| 46 | RCAN1
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| Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.
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| Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M.
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| Biochem J 374(Pt 2):567-75. 2003
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| 47 | RCAN1
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| The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress.
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| Ermak G, Harris CD, Davies KJ.
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| FASEB J 16(8):814-24. 2002
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| 48 | RCAN1
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| Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
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| Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS.
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| J Biol Chem. 277(33):30401-7. 2002
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| 49 | RCAN1
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| DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.
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| Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, de la Luna S.
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| Hum Mol Genet 9(11):1681-90. 2000
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| 50 | RCAN1, RCAN2
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| A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
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| Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS.
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| J Biol Chem 275(12):8719-25. 2000
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| 51 | RCAN1
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| DSCR1, which is highly expressed in brain and heart, interacts with calcineurin.
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| Fuentes JJ, Genesca L, Kingsbury T, Cunningham KW, Arbones ML, Pirez M, Estivill X, de la Luna S.
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| Cytogenet Cell Genet 86:15 1999
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| 52 | DYRK1A, RCAN1
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| Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene.
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| Fuentes JJ, Pritchard MA, Estivill X.
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| Genomics 44(3):358-61. 1997
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| 53 | TTC3, RCAN1, DYRK1A, KCNJ6
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| Cosmid contig and transcriptional map of three regions of human chromosome 21q22: identification of 37 novel transcripts by direct selection.
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| Guimera J, Pucharcos C, Domenech A, Casas C, Solans A, Gallardo T, Ashley J, Lovett M, Estivill X, Pritchard M.
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| Genomics 45(1):59-67. 1997
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| 54 | RCAN1, ERG, SIM2
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| A 1.6-Mb P1-based physical map of the Down syndrome region on chromosome21.
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| Ohira M, et al.
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| Genomics 33 : 65-74. 1996
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| 55 | RCAN1
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| A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart.
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| Fuentes JJ, Pritchard MA, Planas AM, Bosch A, Ferrer I, Estivill X.
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| Hum Mol Genet 4(10):1935-44. 1995
|