1 | RC3H1, RC3H2
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| Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA
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| Zhou M, Lu W, Li B, Yuan X, Liu M, Han J, Liu X, Li A.
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| Int J Biol Sci. Jul 13;17(11):2884-2898. doi: 10.7150/ijbs.59891 2021
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2 | NUFIP2, RC3H1, RC3H2
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| Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
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| Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V.
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| Nat Commun. Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1. 2018
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3 | RC3H1, RC3H2
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| New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
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| Zhang Q, Fan L, Hou F, Dong A, Wang YX, Tong Y.
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| Sci Rep. Oct 22;5:15660. doi: 10.1038/srep15660. 2015
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4 | RC3H2
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| Structure of human Roquin-2 and its complex with constitutive-decay element RNA
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| Sakurai S, Ohto U, Shimizu T.
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| . Acta Crystallogr F Struct Biol Commun. Aug;71(Pt 8):1048-54. doi: 10.1107/S2053230X15011887. Epub 2015 Jul 29. 2015
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5 | MAP3K5, RC3H2
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| Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.
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| Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A, Ichijo H.
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| Sci Signal 7(309):ra8. doi: 10.1126/scisignal.2004822.
2014
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6 | RC3H1, RC3H2
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| Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
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| Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V.
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| Immunity 38(4):655-68. doi: 10.1016/j.immuni.2012.12.004. Epub 2013 Apr 11.
2013
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7 | RC3H1, RC3H2
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| Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
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| Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, Fitch J, Botelho NK, Chang PP, Hu X, Hogan JJ, Maña P, Bernal D, Korner H, Yu D, Goodnow CC, Cook MC, Vinuesa CG.
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| Immunity 38(4):669-80. doi: 10.1016/j.immuni.2013.01.011. Epub 2013 Apr 11.
2013
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8 | RC3H2, OR1K1
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| A human gene coding for a membrane-associated nucleic acid-binding protein.
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| Siess DC, Vedder CT, Merkens LS, Tanaka T, Freed AC, McCoy SL, Heinrich MC, Deffebach ME, Bennett RM, Hefeneider SH.
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| J Biol Chem 275(43):33655-62. 2000
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