| 1 | PODXL, RAP1A
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| Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.
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| Li P, Karaczyn AA, McGlauflin R, Favreau-Lessard AJ, Jachimowicz E, Vary CP, Xu K, Wojchowski DM, Sathyanarayana P.
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| Exp Hematol 50:77-83.e6. doi: 10.1016/j.exphem.2017.04.001. Epub 2017 Apr 10.
2017
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| 2 | FYB1, RAC1, RAP1A, RASSF5, UBE2I
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| Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
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| Xiong Y, Ye C, Yang N, Li M, Liu H.
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| J Immunol 199(12):4142-4154. doi: 10.4049/jimmunol.1700572. Epub 2017 Nov 10.
2017
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| 3 | RAP1A, RASIP1
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| Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
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| Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH.
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| Structure 24(12):2152-2162. doi: 10.1016/j.str.2016.10.001. Epub 2016 Nov 10.
2016
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| 4 | APBB1IP, RAP1A, RASSF5
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| Rap1 and its effector RIAM are required for lymphocyte trafficking.
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| Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.
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| Blood 126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31. 2015
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| 5 | RAP1A
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| Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.
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| Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ.
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| PLoS One 10(12):e0145689. doi: 10.1371/journal.pone.0145689. eCollection 2015.
2015
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| 6 | RAP1A
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| Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling.
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| Wu Y, Zhou J, Li Y, Zhou Y, Cui Y, Yang G, Hong Y.
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| PLoS One 10(11):e0143777. doi: 10.1371/journal.pone.0143777. eCollection 2015.
2015
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| 7 | RAP1A
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| Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
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| Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV.
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| Dev Biol 406(1):74-91. doi: 10.1016/j.ydbio.2015.06.022. Epub 2015 Jul 23.
2015
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| 8 | RAP1A
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| RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
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| Bögershausen N, Tsai IC, Pohl E, Kiper PÖ, Beleggia F, Percin EF, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart AF, Donnai D, Strom TM, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B.
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| J Clin Invest 125(9):3585-99. doi: 10.1172/JCI80102. Epub 2015 Aug 17.
2015
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| 9 | RAP1A
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| Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.
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| Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M.
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| EMBO Rep 16(5):628-37. doi: 10.15252/embr.201439846. Epub 2015 Mar 25.
2015
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| 10 | ARHGAP29, RADIL, RAP1A, RASIP1
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| Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation.
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| Post A, Pannekoek WJ, Ponsioen B, Vliem MJ, Bos JL.
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| Mol Cell Biol 35(14):2495-502. doi: 10.1128/MCB.01453-14. Epub 2015 May 11.
2015
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| 11 | CDK5, RAP1A, RAPGEF2
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| Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
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| Ye T, Ip JP, Fu AK, Ip NY.
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| Nat Commun 5:4826. doi: 10.1038/ncomms5826.
2014
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| 12 | MEX3B, RAP1A, RAP1GAP
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| The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
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| Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, Nègre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Crépieux P, Guillou F, Durand P, Perrard MH, Billaud M.
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| Development 141(10):2096-107. doi: 10.1242/dev.108514.
2014
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| 13 | APBB1IP, RAP1A
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| The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.
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| Zhang H, Chang YC, Brennan ML, Wu J.
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| J Mol Cell Biol 6(2):128-39. doi: 10.1093/jmcb/mjt044. Epub 2013 Nov 28.
2014
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| 14 | RAP1A, ZSCAN4
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| Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status.
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| Lee K, Gollahon LS.
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| Cancer Biol Ther 15(8):1094-105. doi: 10.4161/cbt.29220. Epub 2014 May 19.
2014
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| 15 | RAP1A, RASIP1
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| Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling.
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| Wilson CW, Ye W.
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| Cell Adh Migr 8(2):76-83.
2014
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| 16 | RAP1A, TLN1
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| Talin1 and Rap1 are critical for osteoclast function.
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| Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL.
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| Mol Cell Biol 33(4):830-44. doi: 10.1128/MCB.00790-12. Epub 2012 Dec 10. 2013
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| 17 | PIK3CG, RAP1A
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| PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.
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| Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.
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| PLoS One 8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.
2013
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| 18 | RAP1A, RAP2A
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| Rap1 and Rap2 antagonistically control endothelial barrier resistance.
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| Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H.
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| PLoS One 8(2):e57903. doi: 10.1371/journal.pone.0057903. Epub 2013 Feb 28.
2013
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| 19 | RAP1A
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| Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.
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| Subramanian J, Dye L, Morozov A.
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| J Neurosci 33(17):7245-52. doi: 10.1523/JNEUROSCI.5963-11.2013.
2013
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| 20 | ARHGAP29, RADIL, RAP1A, RASIP1
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| Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.
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| Post A, Pannekoek WJ, Ross SH, Verlaan I, Brouwer PM, Bos JL.
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| Proc Natl Acad Sci U S A 110(28):11427-32. doi: 10.1073/pnas.1306595110. Epub 2013 Jun 24.
2013
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| 21 | RAP1A, SDC1
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| Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.
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| Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P.
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| J Cell Sci 125(Pt 21):5188-95. doi: 10.1242/jcs.109884. Epub 2012 Aug 16.
2012
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| 22 | RAP1A
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| Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
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| Dorn A, Zoellner A, Follo M, Martin S, Weber F, Marks R, Melchinger W, Zeiser R, Fisch P, Scheele JS.
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| Cell Immunol 276(1-2):187-95. doi: 10.1016/j.cellimm.2012.05.008. Epub 2012 May 23.
2012
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| 23 | KIF14, RADIL, RAP1A
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| KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
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| Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S.
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| J Cell Biol 199(6):951-67. doi: 10.1083/jcb.201206051. Epub 2012 Dec 3.
2012
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| 24 | RADIL, RAP1A
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| Radil controls neutrophil adhesion and motility through β2-integrin activation.
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| Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.
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| Mol Biol Cell 23(24):4751-65. doi: 10.1091/mbc.E12-05-0408. Epub 2012 Oct 24.
2012
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| 25 | RAP1A
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| Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids.
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| Birukova AA, Zebda N, Fu P, Poroyko V, Cokic I, Birukov KG.
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| J Cell Physiol 226(8):2052-62. doi: 10.1002/jcp.22543.
2011
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| 26 | RAP1A, RASSF1
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| The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
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| Verma SK, Ganesan TS, Kishore U, Parker PJ.
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| Protein Cell 2(3):237-49. doi: 10.1007/s13238-011-1028-z. Epub 2011 Apr 6.
2011
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| 27 | GNB1, GNG2, RADIL, RAP1A
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| G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.
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| Ahmed SM, Daulat AM, Meunier A, Angers S.
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| J Biol Chem 285(9):6538-51. Epub 2010 Jan 4. 2010
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| 28 | RAN, RANBP2, RAP1A, RAPGEF3
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| The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.
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| Liu C, Takahashi M, Li Y, Dillon TJ, Kaech S, Stork PJ.
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| Mol Cell Biol 30(16):3956-69. Epub 2010 Jun 14.PMID: 20547757 2010
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| 29 | RAP1A
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| Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
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| Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME.
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| J Biol Chem 285(21):15777-85. Epub 2010 Mar 25.PMID: 20339002 2010
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| 30 | RAP1A
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| Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.
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| Ebisuno Y, Katagiri K, Katakai T, Ueda Y, Nemoto T, Inada H, Nabekura J, Okada T, Kannagi R, Tanaka T, Miyasaka M, Hogg N, Kinashi T.
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| Blood 115(4):804-14. Epub 2009 Nov 25.PMID: 19965628 2010
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| 31 | ITGB2, RAP1A
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| Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.
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| Li L, Kim J, Boussiotis VA.
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| Cell Immunol 266(1):7-13. Epub 2010 Sep 22.
2010
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| 32 | AFDN, RAP1A
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| Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.
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| Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata K, Takai Y.
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| Circ Res 106(11):1731-42. Epub 2010 Apr 22. 2010
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| 33 | RAP1A, TERF2IP
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| Human RAP1 inhibits non-homologous end joining at telomeres.
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| Sarthy J, Bae NS, Scrafford J, Baumann P.
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| EMBO J 28(21):3390-9. Epub 2009 Sep 17.PMID: 19763083 2009
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| 34 | RAP1A
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| Human RAP1 inhibits non-homologous end joining at telomeres.
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| Sarthy J, Bae NS, Scrafford J, Baumann P.
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| EMBO J 28(21):3390-9. Epub 2009 Sep 17.PMID: 19763083 2009
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| 35 | RAP1A
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| Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis.
|
| Dao VT, Dupuy AG, Gavet O, Caron E, de Gunzburg J.
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| J Cell Sci 122(Pt 16):2996-3004. Epub 2009 Jul 28.PMID: 19638416 2009
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| 36 | RAP1A, RAPGEF1
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| Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.
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| Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M.
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| J Immunol 181(8):5501-9.PMID: 18832707 2008
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| 37 | TIAM2, RAP1A, RAC1
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| Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.
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| Zaldua N, Gastineau M, Hoshino M, Lezoualc'h F, Zugaza JL.
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| FEBS Lett 581(30):5814-8. Epub 2007 Nov 29. 2007
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| 38 | KRIT1, RAP1A
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| KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.
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| Glading A, Han J, Stockton RA, Ginsberg MH.
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| J Cell Biol 179(2):247-54.PMID: 17954608 2007
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| 39 | RAP1A, RAP2A
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| Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion.
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| Jenei V, Deevi RK, Adams CA, Axelsson L, Hirst DG, Andersson T, Dib K.
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| J Biol Chem 281(46):35008-20. Epub 2006 Sep 8.
2006
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| 40 | RAP1A, MAP1A, RAPGEF3
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| MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
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| Gupta M, Yarwood SJ.
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| J Biol Chem 280(9):8109-16. Epub 2004 Dec 9. 2005
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| 41 | RAP1A, RASGRP3
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| Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
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| Regier DS, Higbee J, Lund KM, Sakane F, Prescott SM, Topham MK.
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| Proc Natl Acad Sci U S A 102(21):7595-600. Epub 2005 May 13. 2005
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| 42 | HRAS, RAP1A
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| Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.
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| Nomura K, Kanemura H, Satoh T, Kataoka T.
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| J Biol Chem 279(21):22664-73. Epub 2004 Mar 18. 2004
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| 43 | AFDN, RAP1A
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| The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.
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| Boettner B, Govek EE, Cross J, Van Aelst L.
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| Proc Natl Acad Sci U S A 97(16):9064-9. 2000
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| 44 | RAP1A, RAP2A
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| Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.
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| Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M.
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| Mol Cell Biol 20(16):6074-83. 2000
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| 45 | RAP1AP, RAP1A
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| Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.
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| Takai S, et al.
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| Cytogenet Cell Genet 63 : 59-61. 1993
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| 46 | RAP1A, RAP1B, RAP2A
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| Chromosome mapping of the human RAS-related RAP1A, RAP1B, RAP2 genes to chromosomes 1p12-p13, 12q14, and 13q34, respectively.
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| Rousseau-Merck MF, et al.
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| Cytogenet Cell Genet 53 : 2-4. 1990
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| 47 | RAB3A, RAB3B, RALA, RAP1A, RAP1B, RAP2A
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| Chromosome mapping of the human RAS related RAB3A and RAB3B genes to chromosomes 19p13.2 and 1p31-p32, respectively.
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| Rousseau-Merck MF, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1070. 1989
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| 48 | RAP1A
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| A ras-related gene with transformation suppressor activity.
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| Kitayama H, et al.
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| Cell 56 : 77-84. 1989
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| 49 | RAP1A, RAP1B, RAP2A
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| Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the effector region.
|
| Pizon V, et al.
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| Oncogene 3 : 201-204. 1988
|