Citations for
1PODXL, RAP1A
Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.
Li P, Karaczyn AA, McGlauflin R, Favreau-Lessard AJ, Jachimowicz E, Vary CP, Xu K, Wojchowski DM, Sathyanarayana P.
Exp Hematol 50:77-83.e6. doi: 10.1016/j.exphem.2017.04.001. Epub 2017 Apr 10. 2017
2FYB1, RAC1, RAP1A, RASSF5, UBE2I
Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
Xiong Y, Ye C, Yang N, Li M, Liu H.
J Immunol 199(12):4142-4154. doi: 10.4049/jimmunol.1700572. Epub 2017 Nov 10. 2017
3RAP1A, RASIP1
Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins.
Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH.
Structure 24(12):2152-2162. doi: 10.1016/j.str.2016.10.001. Epub 2016 Nov 10. 2016
4APBB1IP, RAP1A, RASSF5
Rap1 and its effector RIAM are required for lymphocyte trafficking.
Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.
Blood 126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31. 2015
5RAP1A
Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.
Chrzanowska-Wodnicka M, White GC 2nd, Quilliam LA, Whitehead KJ.
PLoS One 10(12):e0145689. doi: 10.1371/journal.pone.0145689. eCollection 2015. 2015
6RAP1A
Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling.
Wu Y, Zhou J, Li Y, Zhou Y, Cui Y, Yang G, Hong Y.
PLoS One 10(11):e0143777. doi: 10.1371/journal.pone.0143777. eCollection 2015. 2015
7RAP1A
Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV.
Dev Biol 406(1):74-91. doi: 10.1016/j.ydbio.2015.06.022. Epub 2015 Jul 23. 2015
8RAP1A
RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
Bögershausen N, Tsai IC, Pohl E, Kiper PÖ, Beleggia F, Percin EF, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart AF, Donnai D, Strom TM, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B.
J Clin Invest 125(9):3585-99. doi: 10.1172/JCI80102. Epub 2015 Aug 17. 2015
9RAP1A
Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.
Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang DX, Chrzanowska-Wodnicka M.
EMBO Rep 16(5):628-37. doi: 10.15252/embr.201439846. Epub 2015 Mar 25. 2015
10ARHGAP29, RADIL, RAP1A, RASIP1
Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation.
Post A, Pannekoek WJ, Ponsioen B, Vliem MJ, Bos JL.
Mol Cell Biol 35(14):2495-502. doi: 10.1128/MCB.01453-14. Epub 2015 May 11. 2015
11CDK5, RAP1A, RAPGEF2
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
Ye T, Ip JP, Fu AK, Ip NY.
Nat Commun 5:4826. doi: 10.1038/ncomms5826. 2014
12MEX3B, RAP1A, RAP1GAP
The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, Nègre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Crépieux P, Guillou F, Durand P, Perrard MH, Billaud M.
Development 141(10):2096-107. doi: 10.1242/dev.108514. 2014
13APBB1IP, RAP1A
The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.
Zhang H, Chang YC, Brennan ML, Wu J.
J Mol Cell Biol 6(2):128-39. doi: 10.1093/jmcb/mjt044. Epub 2013 Nov 28. 2014
14RAP1A, ZSCAN4
Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status.
Lee K, Gollahon LS.
Cancer Biol Ther 15(8):1094-105. doi: 10.4161/cbt.29220. Epub 2014 May 19. 2014
15RAP1A, RASIP1
Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling.
Wilson CW, Ye W.
Cell Adh Migr 8(2):76-83. 2014
16RAP1A, TLN1
Talin1 and Rap1 are critical for osteoclast function.
Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL.
Mol Cell Biol 33(4):830-44. doi: 10.1128/MCB.00790-12. Epub 2012 Dec 10. 2013
17PIK3CG, RAP1A
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.
Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.
PLoS One 8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2. 2013
18RAP1A, RAP2A
Rap1 and Rap2 antagonistically control endothelial barrier resistance.
Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H.
PLoS One 8(2):e57903. doi: 10.1371/journal.pone.0057903. Epub 2013 Feb 28. 2013
19RAP1A
Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.
Subramanian J, Dye L, Morozov A.
J Neurosci 33(17):7245-52. doi: 10.1523/JNEUROSCI.5963-11.2013. 2013
20ARHGAP29, RADIL, RAP1A, RASIP1
Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.
Post A, Pannekoek WJ, Ross SH, Verlaan I, Brouwer PM, Bos JL.
Proc Natl Acad Sci U S A 110(28):11427-32. doi: 10.1073/pnas.1306595110. Epub 2013 Jun 24. 2013
21RAP1A, SDC1
Syndecan-1 controls cell migration by activating Rap1 to regulate focal adhesion disassembly.
Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P.
J Cell Sci 125(Pt 21):5188-95. doi: 10.1242/jcs.109884. Epub 2012 Aug 16. 2012
22RAP1A
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
Dorn A, Zoellner A, Follo M, Martin S, Weber F, Marks R, Melchinger W, Zeiser R, Fisch P, Scheele JS.
Cell Immunol 276(1-2):187-95. doi: 10.1016/j.cellimm.2012.05.008. Epub 2012 May 23. 2012
23KIF14, RADIL, RAP1A
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.
Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S.
J Cell Biol 199(6):951-67. doi: 10.1083/jcb.201206051. Epub 2012 Dec 3. 2012
24RADIL, RAP1A
Radil controls neutrophil adhesion and motility through β2-integrin activation.
Liu L, Aerbajinai W, Ahmed SM, Rodgers GP, Angers S, Parent CA.
Mol Biol Cell 23(24):4751-65. doi: 10.1091/mbc.E12-05-0408. Epub 2012 Oct 24. 2012
25RAP1A
Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids.
Birukova AA, Zebda N, Fu P, Poroyko V, Cokic I, Birukov KG.
J Cell Physiol 226(8):2052-62. doi: 10.1002/jcp.22543. 2011
26RAP1A, RASSF1
The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
Verma SK, Ganesan TS, Kishore U, Parker PJ.
Protein Cell 2(3):237-49. doi: 10.1007/s13238-011-1028-z. Epub 2011 Apr 6. 2011
27GNB1, GNG2, RADIL, RAP1A
G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.
Ahmed SM, Daulat AM, Meunier A, Angers S.
J Biol Chem 285(9):6538-51. Epub 2010 Jan 4. 2010
28RAN, RANBP2, RAP1A, RAPGEF3
The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.
Liu C, Takahashi M, Li Y, Dillon TJ, Kaech S, Stork PJ.
Mol Cell Biol 30(16):3956-69. Epub 2010 Jun 14.PMID: 20547757 2010
29RAP1A
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME.
J Biol Chem 285(21):15777-85. Epub 2010 Mar 25.PMID: 20339002 2010
30RAP1A
Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.
Ebisuno Y, Katagiri K, Katakai T, Ueda Y, Nemoto T, Inada H, Nabekura J, Okada T, Kannagi R, Tanaka T, Miyasaka M, Hogg N, Kinashi T.
Blood 115(4):804-14. Epub 2009 Nov 25.PMID: 19965628 2010
31ITGB2, RAP1A
Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.
Li L, Kim J, Boussiotis VA.
Cell Immunol 266(1):7-13. Epub 2010 Sep 22. 2010
32AFDN, RAP1A
Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.
Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata K, Takai Y.
Circ Res 106(11):1731-42. Epub 2010 Apr 22. 2010
33RAP1A, TERF2IP
Human RAP1 inhibits non-homologous end joining at telomeres.
Sarthy J, Bae NS, Scrafford J, Baumann P.
EMBO J 28(21):3390-9. Epub 2009 Sep 17.PMID: 19763083 2009
34RAP1A
Human RAP1 inhibits non-homologous end joining at telomeres.
Sarthy J, Bae NS, Scrafford J, Baumann P.
EMBO J 28(21):3390-9. Epub 2009 Sep 17.PMID: 19763083 2009
35RAP1A
Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis.
Dao VT, Dupuy AG, Gavet O, Caron E, de Gunzburg J.
J Cell Sci 122(Pt 16):2996-3004. Epub 2009 Jul 28.PMID: 19638416 2009
36RAP1A, RAPGEF1
Rap1 activation is required for Fc gamma receptor-dependent phagocytosis.
Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M.
J Immunol 181(8):5501-9.PMID: 18832707 2008
37TIAM2, RAP1A, RAC1
Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.
Zaldua N, Gastineau M, Hoshino M, Lezoualc'h F, Zugaza JL.
FEBS Lett 581(30):5814-8. Epub 2007 Nov 29. 2007
38KRIT1, RAP1A
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.
Glading A, Han J, Stockton RA, Ginsberg MH.
J Cell Biol 179(2):247-54.PMID: 17954608 2007
39RAP1A, RAP2A
Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion.
Jenei V, Deevi RK, Adams CA, Axelsson L, Hirst DG, Andersson T, Dib K.
J Biol Chem 281(46):35008-20. Epub 2006 Sep 8. 2006
40RAP1A, MAP1A, RAPGEF3
MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion.
Gupta M, Yarwood SJ.
J Biol Chem 280(9):8109-16. Epub 2004 Dec 9. 2005
41RAP1A, RASGRP3
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
Regier DS, Higbee J, Lund KM, Sakane F, Prescott SM, Topham MK.
Proc Natl Acad Sci U S A 102(21):7595-600. Epub 2005 May 13. 2005
42HRAS, RAP1A
Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.
Nomura K, Kanemura H, Satoh T, Kataoka T.
J Biol Chem 279(21):22664-73. Epub 2004 Mar 18. 2004
43AFDN, RAP1A
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.
Boettner B, Govek EE, Cross J, Van Aelst L.
Proc Natl Acad Sci U S A 97(16):9064-9. 2000
44RAP1A, RAP2A
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.
Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M.
Mol Cell Biol 20(16):6074-83. 2000
45RAP1AP, RAP1A
Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.
Takai S, et al.
Cytogenet Cell Genet 63 : 59-61. 1993
46RAP1A, RAP1B, RAP2A
Chromosome mapping of the human RAS-related RAP1A, RAP1B, RAP2 genes to chromosomes 1p12-p13, 12q14, and 13q34, respectively.
Rousseau-Merck MF, et al.
Cytogenet Cell Genet 53 : 2-4. 1990
47RAB3A, RAB3B, RALA, RAP1A, RAP1B, RAP2A
Chromosome mapping of the human RAS related RAB3A and RAB3B genes to chromosomes 19p13.2 and 1p31-p32, respectively.
Rousseau-Merck MF, et al.
(HGM10) Cytogenet Cell Genet 51 : 1070. 1989
48RAP1A
A ras-related gene with transformation suppressor activity.
Kitayama H, et al.
Cell 56 : 77-84. 1989
49RAP1A, RAP1B, RAP2A
Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the effector region.
Pizon V, et al.
Oncogene 3 : 201-204. 1988