Citations for
1HSPD1, RAN
Heat shock protein 60 involvement in vascular smooth muscle cell proliferation.
Deniset JF, Hedley TE, Hlaváčková M, Chahine MN, Dibrov E, O'Hara K, Maddaford GG, Nelson D, Maddaford TG, Fandrich R, Kardami E, Pierce GN.
Cell Signal 47:44-51. doi: 10.1016/j.cellsig.2018.03.011. Epub 2018 Mar 26. 2018
2EMD, RAN, TMEM201
RanGTPase regulates the interaction between the inner nuclear membrane proteins, Samp1 and Emerin.
Vijayaraghavan B, Figueroa RA, Bergqvist C, Gupta AJ, Sousa P, Hallberg E.
Biochim Biophys Acta Biomembr 1860(6):1326-1334. doi: 10.1016/j.bbamem.2018.03.001. Epub 2018 Mar 3. 2018
3RAN, TPX2
Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.
Chen WS, Chen YJ, Huang YA, Hsieh BY, Chiu HC, Kao PY, Chao CY, Hwang E.
Sci Rep 7:42297. doi: 10.1038/srep42297. 2017
4RAN, VHL
Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes.
Jiang X, Zhang D, Zhang H, Huang Y, Teng M.
Sci Rep 5:9193. doi: 10.1038/srep09193. Erratum in: Sci Rep. 2015;5:11307. 2015
5RAN
Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins.
Deng L, Lu Y, Zhao X, Sun Y, Shi Y, Fan H, Liu C, Zhou J, Nie Y, Wu K, Fan D, Guo X.
Biochem Biophys Res Commun 440(2):322-9. doi: 10.1016/j.bbrc.2013.09.079. Epub 2013 Sep 25. 2013
6CLASP1, RAN
RanGTP and CLASP1 cooperate to position the mitotic spindle.
Bird SL, Heald R, Weis K.
Mol Biol Cell 24(16):2506-14. doi: 10.1091/mbc.E13-03-0150. Epub 2013 Jun 19. 2013
7MYC, RAN
RanGTPase: a candidate for Myc-mediated cancer progression.
Yuen HF, Gunasekharan VK, Chan KK, Zhang SD, Platt-Higgins A, Gately K, O'Byrne K, Fennell DA, Johnston PG, Rudland PS, El-Tanani M.
J Natl Cancer Inst 105(7):475-88. doi: 10.1093/jnci/djt028. Epub 2013 Mar 6. 2013
8RAN
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
Mastroeni D, Chouliaras L, Grover A, Liang WS, Hauns K, Rogers J, Coleman PD.
PLoS One 8(1):e53349. doi: 10.1371/journal.pone.0053349. Epub 2013 Jan 8. 2013
9RAN, TACC3
Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.
Fu W, Chen H, Wang G, Luo J, Deng Z, Xin G, Xu N, Guo X, Lei J, Jiang Q, Zhang C.
Proc Natl Acad Sci U S A 110(38):15295-300. doi: 10.1073/pnas.1312382110. Epub 2013 Sep 3. 2013
10RAN, SMOC2
Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.
Milano SK, Kwon W, Pereira R, Antonyak MA, Cerione RA.
J Biol Chem 287(30):24955-66. doi: 10.1074/jbc.M111.306514. Epub 2012 Jun 7. 2012
11NUTF2, RAN, XPO6
Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
Park SH, Park TJ, Lim IK.
Exp Cell Res 317(7):941-54. Epub 2010 Dec 31. 2011
12RAN
Essential role of the small GTPase Ran in postnatal pancreatic islet development.
Xia F, Dohi T, Martin NM, Raskett CM, Liu Q, Altieri DC.
PLoS One 6(11):e27879. doi: 10.1371/journal.pone.0027879. Epub 2011 Nov 17. 2011
13RAN
Induction of Ran GTP drives ciliogenesis.
Fan S, Whiteman EL, Hurd TW, McIntyre JC, Dishinger JF, Liu CJ, Martens JR, Verhey KJ, Sajjan U, Margolis B.
Mol Biol Cell 22(23):4539-48. doi: 10.1091/mbc.E11-03-0267. Epub 2011 Oct 12. 2011
14RAN, RANBP2, RAP1A, RAPGEF3
The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.
Liu C, Takahashi M, Li Y, Dillon TJ, Kaech S, Stork PJ.
Mol Cell Biol 30(16):3956-69. Epub 2010 Jun 14.PMID: 20547757 2010
15KIF17, RAN
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ.
Nat Cell Biol 12(7):703-10. Epub 2010 Jun 6.PMID: 20526328 2010
16RAN
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Barrès V, Ouellet V, Lafontaine J, Tonin PN, Provencher DM, Mes-Masson AM.
Mol Cancer 9:272.PMID: 20942967 2010
17RAN
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Ly TK, Wang J, Pereira R, Rojas KS, Peng X, Feng Q, Cerione RA, Wilson KF.
J Biol Chem 285(8):5815-26. Epub 2009 Dec 22.PMID: 20028979 2010
18RAN, RCC1
Structure of RCC1 chromatin factor bound to the nucleosome core particle.
Makde RD, England JR, Yennawar HP, Tan S.
Nature 467(7315):562-6. Epub 2010 Aug 25. 2010
19RAN, RCBTB2, ZHX2
Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors.
Legartova S, Harnicarova-Horakova A, Bartova E, Hajek R, Pour L, Kozubek S.
Neoplasma 57(5):482-7. doi: 10.4149/neo_2010_05_482 2010
20RAN, RANBP1
RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.
Rensen WM, Roscioli E, Tedeschi A, Mangiacasale R, Ciciarello M, Di Gioia SA, Lavia P.
Oncogene 28(15):1748-58. Epub 2009 Mar 9.PMID: 19270727 2009
21RAN
ISWI is a RanGTP-dependent MAP required for chromosome segregation.
Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E.
J Cell Biol 187(6):813-29.PMID: 20008562 2009
22RAN
Dynamic localisation of Ran GTPase during the cell cycle.
Hutchins JR, Moore WJ, Clarke PR.
BMC Cell Biol 10:66.PMID: 19765287 2009
23MAD2L2, RAN
The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.
Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, van den Hurk WH, de Bruijn DR, Brugmans L, van Kessel AG.
PLoS One 4(9):e7020. doi: 10.1371/journal.pone.0007020. 2009
24AR, RAN
ARA24/Ran enhances the androgen-dependent NH2- and COOH-terminal interaction of the androgen receptor.
Harada N, Ohmori Y, Yamaji R, Higashimura Y, Okamoto K, Isohashi F, Nakano Y, Inui H.
Biochem Biophys Res Commun 373(3):373-7. Epub 2008 Jun 17. 2008
25RAN
Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells.
Torosantucci L, De Luca M, Guarguaglini G, Lavia P, Degrassi F.
Mol Biol Cell 19(5):1873-82. Epub 2008 Feb 20.PMID: 18287525 2008
26CAPG, NUTF2, RAN
A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
Van Impe K, Hubert T, De Corte V, Vanloo B, Boucherie C, Vandekerckhove J, Gettemans J.
Traffic 9(5):695-707. Epub 2008 Feb 7.PMID: 18266911 2008
27RAN, NUP153
Molecular characterization of the Ran-binding zinc finger domain of Nup153.
Higa MM, Alam SL, Sundquist WI, Ullman KS.
J Biol Chem 282(23):17090-100. Epub 2007 Apr 10. 2007
28RANGRF, RAN
Identification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction.
Oki M, Ma L, Wang Y, Hatanaka A, Miyazato C, Tatebayashi K, Nishitani H, Uchida H, Nishimoto T.
Gene 400(1-2):114-21. Epub 2007 Jun 27. 2007
29RAN
Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.
Silverman-Gavrila RV, Wilde A.
Mol Biol Cell 17(4):2069-80. Epub 2006 Feb 15. 2006
30RAN, RANBP1, RANGAP1
Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.
Takeda E, Hieda M, Katahira J, Yoneda Y.
Cell Struct Funct 30(2):69-80. 2005
31RAN, RANBP1, RANGAP1
Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.
Takeda E, Hieda M, Katahira J, Yoneda Y.
Cell Struct Funct 30(2):69-80.PMID: 16428860 2005
32NUTF2, RAN
Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.
Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS.
J Mol Biol 344(2):303-10. 2004
33RAN, RANBP1, RANGAP1
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?
Seewald MJ, Kraemer A, Farkasovsky M, Körner C, Wittinghofer A, Vetter IR.
Mol Cell Biol 23(22):8124-36.PMID: 14585972 2003
34RAN
Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts.
Kalab P, Weis K, Heald R.
Science 295(5564):2452-6. 2002
35RAN
The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form.
Nilsson J, Weis K, Kjems J.
J Mol Biol 318(2):583-93. 2002
36RAN
GTP-binding proteins G(salpha), G(ialpha), and Ran identified in mitochondria of human placenta.
Kuyznierewicz I, Thomson M.
Cell Biol Int 26(1):99-108. 2002
37RAN, SBMA
The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.
Hsiao PW, Lin DL, Nakao R, Chang C.
J Biol Chem 274(29):20229-34. 1999
38RCC1, RAN
Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.
Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW.
Nature 400(6740):178-81. 1999
39RCC1, RAN, RANBP9
A new role of ran GTPase.
Nishimoto T.
Biochem Biophys Res Commun 262(3):571-4. Review. 1999
40BSN, GNL1, HFEC@, MOG, QMR1, RAN, TRAM2, TRIM15, TRIM27, TRNAS2, TRNAS3, TUBB, UBD
A transcription map of the major histocompatibility complex (MHC) class I region.
Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM.
Genomics 36(1):70-85. 1996
41RAN
Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.
Ren M, Drivas G, D'Eustachio P, Rush MG.
J Cell Biol 120(2):313-23. 1993
42RAC1, RAN, RHOQ
Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.
Drivas GT, et al.
Mol Cell Biol 10 : 1793-1798. 1990