Citations for
1RALB
RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1.
Biondini M, Duclos G, Meyer-Schaller N, Silberzan P, Camonis J, Parrini MC.
Sci Rep 5:11759. doi: 10.1038/srep11759. 2015
2KRAS, RALA, RALB
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
Tecleab A, Zhang X, Sebti SM.
J Biol Chem 289(45):31296-309. doi: 10.1074/jbc.M114.565796. Epub 2014 Sep 10. 2014
3RALA, RALB
Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression.
Guin S, Ru Y, Wynes MW, Mishra R, Lu X, Owens C, Barn AE, Vasu VT, Hirsch FR, Kern JA, Theodorescu D.
J Thorac Oncol 8(12):1492-501. doi: 10.1097/JTO.0000000000000007. 2013
4BECN1, EXOC8, RALB
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA.
Nat Cell Biol 15(10):1220-30. doi: 10.1038/ncb2847. Epub 2013 Sep 22. 2013
5RALA, RALB, RGL2
The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
Popovic M, Jakobi AJ, Rensen-de Leeuw M, Rehmann H.
J Struct Biol 183(3):312-9. doi: 10.1016/j.jsb.2013.07.009. Epub 2013 Jul 24. 2013
6RALA, RALB
Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.
Peschard P, McCarthy A, Leblanc-Dominguez V, Yeo M, Guichard S, Stamp G, Marshall CJ.
Curr Biol 22(21):2063-8. doi: 10.1016/j.cub.2012.09.013. Epub 2012 Oct 11. 2012
7PRKCA, RALB
Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.
Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ.
J Biol Chem 287(18):14827-36. doi: 10.1074/jbc.M112.344986. Epub 2012 Mar 5. 2012
8EXOC8, RALB
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
Bodemann BO, Orvedahl A, Cheng T, Ram RR, Ou YH, Formstecher E, Maiti M, Hazelett CC, Wauson EM, Balakireva M, Camonis JH, Yeaman C, Levine B, White MA.
Cell 144(2):253-67. 2011
9RALA, RALB
RalA and RalB differentially regulate development of epithelial tight junctions.
Hazelett CC, Sheff D, Yeaman C.
Mol Biol Cell 22(24):4787-800. doi: 10.1091/mbc.E11-07-0657. Epub 2011 Oct 19. 2011
10RALA, RALB
Ral activation promotes melanomagenesis.
Zipfel PA, Brady DC, Kashatus DF, Ancrile BD, Tyler DS, Counter CM.
Oncogene 29(34):4859-64. Epub 2010 Jun 21.PMID: 20562921 2010
11RALA, RALB
Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.
Kidd AR 3rd, Snider JL, Martin TD, Graboski SF, Der CJ, Cox AD.
Int J Radiat Oncol Biol Phys 78(1):205-12. Epub 2010 Jul 7.PMID: 20619549 2010
12RALA, RALB
Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.
Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D.
Biochemistry 48(10):2192-206.PMID: 19166349 2009
13RALA, RALB
Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.
Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J.
EMBO J 27(18):2375-87. Epub 2008 Aug 28.PMID: 18756269 2008
14RALA, RALB, RREB1
Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector.
Oxford G, Smith SC, Hampton G, Theodorescu D.
Oncogene 26(50):7143-52. Epub 2007 May 14.PMID: 17496927 2007
15RALA, RALB
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM.
Mol Cell Biol 27(22):8003-14. Epub 2007 Sep 17.PMID: 17875936 2007
16RALB
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M Jr, Yeaman C, Camonis JH, Zhao Y, White MA.
Cell 127(1):157-70. 2006
17RALA, RALB, RGL2
Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.
Post GR, Swiderski C, Waldrop BA, Salty L, Glembotski CC, Wolthuis RM, Mochizuki N.
J Biol Chem 277(18):15286-92. Epub 2002 Feb 14. 2002
18RALA, RALB, EXOC1, EXOC6B
The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.
Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ.
J Biol Chem 276(32):29792-7. Epub 2001 Jun 13. 2001
19RALB
Chromosomal localization and cDNA sequence of human ralB, a GTB binding protein.
Hsieh CL, et al.
Somat Cell Mol Genet 16 : 407-410. 1990