1 | RALB
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| RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1.
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| Biondini M, Duclos G, Meyer-Schaller N, Silberzan P, Camonis J, Parrini MC.
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| Sci Rep 5:11759. doi: 10.1038/srep11759.
2015
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2 | KRAS, RALA, RALB
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| Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
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| Tecleab A, Zhang X, Sebti SM.
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| J Biol Chem 289(45):31296-309. doi: 10.1074/jbc.M114.565796. Epub 2014 Sep 10.
2014
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3 | RALA, RALB
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| Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression.
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| Guin S, Ru Y, Wynes MW, Mishra R, Lu X, Owens C, Barn AE, Vasu VT, Hirsch FR, Kern JA, Theodorescu D.
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| J Thorac Oncol 8(12):1492-501. doi: 10.1097/JTO.0000000000000007.
2013
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4 | BECN1, EXOC8, RALB
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| The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
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| Simicek M, Lievens S, Laga M, Guzenko D, Aushev VN, Kalev P, Baietti MF, Strelkov SV, Gevaert K, Tavernier J, Sablina AA.
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| Nat Cell Biol 15(10):1220-30. doi: 10.1038/ncb2847. Epub 2013 Sep 22.
2013
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5 | RALA, RALB, RGL2
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| The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
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| Popovic M, Jakobi AJ, Rensen-de Leeuw M, Rehmann H.
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| J Struct Biol 183(3):312-9. doi: 10.1016/j.jsb.2013.07.009. Epub 2013 Jul 24.
2013
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6 | RALA, RALB
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| Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis.
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| Peschard P, McCarthy A, Leblanc-Dominguez V, Yeo M, Guichard S, Stamp G, Marshall CJ.
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| Curr Biol 22(21):2063-8. doi: 10.1016/j.cub.2012.09.013. Epub 2012 Oct 11.
2012
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7 | PRKCA, RALB
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| Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.
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| Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ.
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| J Biol Chem 287(18):14827-36. doi: 10.1074/jbc.M112.344986. Epub 2012 Mar 5.
2012
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8 | EXOC8, RALB
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| RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
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| Bodemann BO, Orvedahl A, Cheng T, Ram RR, Ou YH, Formstecher E, Maiti M, Hazelett CC, Wauson EM, Balakireva M, Camonis JH, Yeaman C, Levine B, White MA.
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| Cell 144(2):253-67.
2011
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9 | RALA, RALB
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| RalA and RalB differentially regulate development of epithelial tight junctions.
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| Hazelett CC, Sheff D, Yeaman C.
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| Mol Biol Cell 22(24):4787-800. doi: 10.1091/mbc.E11-07-0657. Epub 2011 Oct 19.
2011
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10 | RALA, RALB
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| Ral activation promotes melanomagenesis.
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| Zipfel PA, Brady DC, Kashatus DF, Ancrile BD, Tyler DS, Counter CM.
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| Oncogene 29(34):4859-64. Epub 2010 Jun 21.PMID: 20562921 2010
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11 | RALA, RALB
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| Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation.
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| Kidd AR 3rd, Snider JL, Martin TD, Graboski SF, Der CJ, Cox AD.
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| Int J Radiat Oncol Biol Phys 78(1):205-12. Epub 2010 Jul 7.PMID: 20619549 2010
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12 | RALA, RALB
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| Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.
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| Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D.
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| Biochemistry 48(10):2192-206.PMID: 19166349 2009
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13 | RALA, RALB
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| Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.
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| Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J.
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| EMBO J 27(18):2375-87. Epub 2008 Aug 28.PMID: 18756269 2008
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14 | RALA, RALB, RREB1
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| Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector.
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| Oxford G, Smith SC, Hampton G, Theodorescu D.
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| Oncogene 26(50):7143-52. Epub 2007 May 14.PMID: 17496927 2007
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15 | RALA, RALB
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| Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
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| Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM.
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| Mol Cell Biol 27(22):8003-14. Epub 2007 Sep 17.PMID: 17875936 2007
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16 | RALB
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| RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
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| Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M Jr, Yeaman C, Camonis JH, Zhao Y, White MA.
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| Cell 127(1):157-70. 2006
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17 | RALA, RALB, RGL2
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| Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.
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| Post GR, Swiderski C, Waldrop BA, Salty L, Glembotski CC, Wolthuis RM, Mochizuki N.
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| J Biol Chem 277(18):15286-92. Epub 2002 Feb 14.
2002
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18 | RALA, RALB, EXOC1, EXOC6B
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| The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.
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| Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ.
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| J Biol Chem 276(32):29792-7. Epub 2001 Jun 13. 2001
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19 | RALB
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| Chromosomal localization and cDNA sequence of human ralB, a GTB binding protein.
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| Hsieh CL, et al.
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| Somat Cell Mol Genet 16 : 407-410. 1990
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