| 1 | GMEB1, KPNA2, RAG1, SF3A2
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| A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions.
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| 2 | CDC34, KPNA1, RAG1
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| Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.
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| Simkus C, Makiya M, Jones JM.
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| Mol Immunol 46(7):1319-25. Epub 2008 Dec 31.
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| 3 | RAG1
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| Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.
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| 4 | RAG1, RAG2
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| Mechanisms controlling expression of the RAG locus during lymphocyte development.
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| Kuo TC, Schlissel MS.
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| Curr Opin Immunol 21(2):173-8. Epub 2009 Apr 7. Review.PMID: 19359154 2009
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| 5 | CCHIG, RAG1, RAG2
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| An immunodeficiency disease with RAG mutations and granulomas.
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| Schuetz C, Huck K, Gudowius S, Megahed M, Feyen O, Hubner B, Schneider DT, Manfras B, Pannicke U, Willemze R, Knüchel R, Göbel U, Schulz A, Borkhardt A, Friedrich W, Schwarz K, Niehues T.
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| N Engl J Med 358(19):2030-8.PMID: 18463379 2008
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| 6 | IL6, RAG1, RAG2
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| IL-6 contributes to the expression of RAGs in human mature B cells.
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| Hillion S, Dueymes M, Youinou P, Jamin C.
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| J Immunol 179(10):6790-8.
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| 7 | RAG1, RAG2
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| RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
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| Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA.
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| Nature 450(7172):1106-10. Epub 2007 Nov 21.PMID: 18033247 2007
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| 8 | RAG1, RAG2, SCIDO
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| Biochemical and folding defects in a RAG1 variant associated with Omenn syndrome.
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| Simkus C, Anand P, Bhattacharyya A, Jones JM.
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| J Immunol 179(12):8332-40.PMID: 18056378 2007
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| 9 | CHUK, RAG1, RAG2
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| A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.
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| Verkoczy L, Ait-Azzouzene D, Skog P, Martensson A, Lang J, Duong B, Nemazee D.
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| Immunity 22(4):519-31. 2005
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| 10 | RAG1, RAG2
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| A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
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| Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP.
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| J Biol Chem 280(31):28701-10. Epub 2005 Jun 17. 2005
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| 11 | RAG1, RAG2
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| A short peptide at the C terminus is responsible for the nuclear localization of RAG2.
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| Corneo B, Benmerah A, Villartay JP.
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| Eur J Immunol 32(7):2068-73. 2002
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| 12 | RAG1, RAG2
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| The RAG proteins in V(D)J recombination: more than just a nuclease.
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| Sadofsky MJ.
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| Nucleic Acids Res 29(7):1399-409. 2001
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| 13 | RAG1, RAG2
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| RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood.
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| Girschick HJ, Grammer AC, Nanki T, Mayo M, Lipsky PE.
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| J Immunol 166(1):377-86. 2001
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| 14 | RAG1, RAG2
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| Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex.
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| Fugmann SD, Schatz DG.
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| Mol Cell 8(4):899-910. 2001
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| 15 | RAG1, SCIDO
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| N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains
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| Santagata S, Gomez CA, Sobacchi C, Bozzi F, Abinun M, Pasic S, Cortes P, Vezzoni P, Villa A.
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| Proc Natl Acad Sci U S A 97(26):14572-7. 2000
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| 16 | RAG1, RAG2, SCIDO
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| The genetic and biochemical basis of Omenn syndrome.
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| Santagata S, Villa A, Sobacchi C, Cortes P, Vezzoni P.
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| Immunol Rev 178:64-74. Review. 2000
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| 17 | RAG1, RAG2
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| Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.
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| Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA.
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| Genes Dev 13(23):3070-80. 1999
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| 18 | RAG1, RAG2
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| Rejoining of DNA by the RAG1 and RAG2 proteins.
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| Melek M, et al.
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| Science 280 : 301-303. 1998
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| 19 | RAG1, RAG2, SCIDO
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| Partial V(D)J recombination activity leads to Omenn syndrome.
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| Villa A, et al.
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| Cell 93 : 885-896. 1998
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| 20 | RAG1, RAG2
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| Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system.
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| Agrawal A, et al.
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| Nature 394 : 744-751. 1998
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| 21 | RAG1, RAG2
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| DNA transposition by the RAG1 and RAG2 proteins : a possible source of oncogenic translocations.
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| Hiom K, Melek M, Gellert M.
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| Cell 94 : 463-470. 1998
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| 22 | RAG1
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| Cloning and characterization of the human recombination activating gene 1 (RAG1) and RAG2 promoter regions.
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| Zarrin AA, Fong I, Malkin L, Marsden PA, Berinstein NL.
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| J Immunol 159(9):4382-94. 1997
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| 23 | RAG1, RAG2, SCIDO
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| Oligoclonal expansion of CD45RO+ T lymphocytes in Omenn syndrome.
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| Harville TO, et al.
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| J Clin Immunol 17 : 322-332. 1997
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| 24 | RAG1
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| Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors.
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| Tagoh H, et al.
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| Biochem Biophys Res Commun 221 : 744-749. 1996
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| 25 | RAG1, RAG2
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| RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.
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| Difilippantonio MJ, et al.
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| Cell 87 : 253-262. 1996
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| 26 | RAG1
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| The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
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| Cell 87 : 263-276. 1996
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| 27 | RAG1
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| Mutational analysis of RAG-1 in lymphoid malignancies.
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| Nomdedu J, et al.
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| Leukemia 10 : 1715-1718. 1996
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| 28 | RAG1
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| Chromatin structure and transcriptional regulation of human RAG-1 gene.
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| Blood 88 : 3785-3791. 1996
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| 29 | RAG1, RAG2
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| The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination.
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| Van Gent DC, et al.
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| Cell 85 : 107-113. 1996
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| 30 | RAG1, RAG2
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| RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation.
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| Lynch S, Kelleher D, McManus R, O'Farrelly C.
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| Eur J Immunol 25(5):1143-7.PMID: 7774617 1995
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| 31 | RAG1
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| Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13.
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| Schwarz K, et al.
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| Hum Genet 93 : 215-217. 1994
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| 32 | RAG1, RAG2
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| Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11.
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| Huppi K, et al.
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| Immunogenetics 37 : 288-291. 1993
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| 33 | RAG1
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| Human recombination activating gene-1 in leukemia/lymphoma cells : expression depends on stage of lymphoid differentiation defined by phenotype and genotype.
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| Yoneda N, et al.
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| Blood 82 : 207-216. 1993
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| 34 | RAG1
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| Assignment of the human recombination activating gene 1 (RAG1) to the 14q21.3-q22.2 region.
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| Blanquet V, et al.
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| Genomics 13 : 488-489. 1992
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| 35 | RAG1, RAG2
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| Sequence and chromosome assignment to 11p13-p12 of human RAG genes.
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| Ichihara Y, et al.
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| Immunol Lett 33 : 277-284. 1992
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| 36 | RAG1, RAG2
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| Human RAG2, like RAG1, is on chromosome 11 band p13 and therefore not linked to ataxia telangiectasia complementation groups.
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| Sherrington PD, et al.
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| Genes Chromosomes Cancer 5 : 404-406. 1992
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| 37 | RAG1, RAG2
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| Expression of human recombination activating genes (RAG-1 and RAG-2) in Hodgkin's disease.
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| Knecht H, et al.
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| Blood 80 : 2867-2872. 1992
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| 38 | RAG1, RAG2
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| The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and 2p in mice.
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| Oettinger MA, et al.
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| Immunogenetics 35 : 97-101. 1992
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| 39 | RAG1, RAG2
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| A simple technique for generating probes for RNA in situ hybridization : an adjunct to genome mapping exemplified by the RAG-1/RAG-2 gene cluster.
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| 40 | RAG1, RAG2
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| RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.
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| Oettinger MA, et al.
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| 41 | RAG1
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| The V(D)J recombination activating gene, RAG-1.
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