| 1 | CTDSPL, CTNNA1, GOLGA4, LRCH3, MAP4, PRKAR2A, RAF1
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| Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles
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| Williams EA, Shah N, Montesion M, Sharaf R, Pavlick DC, Sokol ES, Alexander BM, Venstrom JM, Elvin JA, Ross JS, Tse JY, Mochel MC.
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| Mod Pathol. Aug;33(8):1466-1474. doi: 10.1038/s41379-020-0510-7. Epub 2020 Mar 2. 2020
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| 2 | LRRFIP2, RAF1
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| Novel LRRFIP2-RAF1 fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with RAF1 fusions and the potential therapeutic implications
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| LeBlanc RE, Lefferts JA, Baker ML, Linos KD.
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| J Cutan Pathol. Dec;47(12):1181-1186. doi: 10.1111/cup.13817. Epub 2020 Sep 7 2020
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| 3 | PDE8A, RAF1
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| PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.
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| Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S.
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| Cell Signal 40:62-72. doi: 10.1016/j.cellsig.2017.08.007. Epub 2017 Aug 26.
2017
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| 4 | CMD1NN, RAF1
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| RAF1 mutations in childhood-onset dilated cardiomyopathy.
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| Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD.
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| Nat Genet 46(6):635-639. doi: 10.1038/ng.2963. Epub 2014 Apr 28.
2014
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| 5 | DIRAS3, RAF1
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| The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration.
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| Klingauf M, Beck M, Berge U, Turgay Y, Heinzer S, Horvath P, Kroschewski R.
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| Biol Cell 105(2):91-107. doi: 10.1111/boc.201200030. Epub 2012 Dec 28.
2013
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| 6 | MAP2K1, RAF1
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| MEK-1 activates C-Raf through a Ras-independent mechanism.
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| Leicht DT, Balan V, Zhu J, Kaplun A, Bronisz A, Rana A, Tzivion G.
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| Biochim Biophys Acta 1833(5):976-86. doi: 10.1016/j.bbamcr.2013.01.015. Epub 2013 Jan 27.
2013
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| 7 | CDK10, RAF1
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| Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression.
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| Yeh CW, Kao SH, Cheng YC, Hsu LS.
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| J Biol Chem 288(39):27927-39. doi: 10.1074/jbc.M112.420265. Epub 2013 Jul 31. 2013
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| 8 | PDE8A, RAF1
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| Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
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| Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, Houslay MD, Baillie GS.
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| Proc Natl Acad Sci U S A 110(16):E1533-42. doi: 10.1073/pnas.1303004110. Epub 2013 Mar 18.
2013
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| 9 | NS5, RAF1
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| Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.
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| Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T.
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| Mol Cell Biol 32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23.
2012
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| 10 | ADRBK1, PEBP1, RAF1
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| Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.
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| Deiss K, Kisker C, Lohse MJ, Lorenz K.
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| J Biol Chem 287(28):23407-17. doi: 10.1074/jbc.M112.363812. Epub 2012 May 17.
2012
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| 11 | RAF1
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| Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.
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| Leontovich AA, Zhang S, Quatraro C, Iankov I, Veroux PF, Gambino MW, Degnim A, McCubrey J, Ingle J, Galanis E, D'Assoro AB.
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| Int J Oncol 40(6):1858-64. doi: 10.3892/ijo.2012.1407. Epub 2012 Mar 19.
2012
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| 12 | DIRAS3, HRAS, RAF1
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| The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.
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| Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR.
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| J Biol Chem 287(27):23128-40. doi: 10.1074/jbc.M112.343780. Epub 2012 May 17.
2012
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| 13 | BRAF, KSR1, RAF1
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| Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
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| Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS.
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| Proc Natl Acad Sci U S A 108(15):6067-72. Epub 2011 Mar 25.
2011
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| 14 | IQGAP1, ITGB1BP2, PTK2, RAF1
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| ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
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| Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G.
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| J Cell Sci 124(Pt 20):3515-24. doi: 10.1242/jcs.091140.
2011
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| 15 | ARRB2, RAF1
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| The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.
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| Coffa S, Breitman M, Hanson SM, Callaway K, Kook S, Dalby KN, Gurevich VV.
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| PLoS One 6(12):e28723. doi: 10.1371/journal.pone.0028723. Epub 2011 Dec 12.
2011
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| 16 | RAF1
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| Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.
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| Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD.
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| FASEB J 25(11):3884-95. doi: 10.1096/fj.10-180349. Epub 2011 Aug 4.
2011
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| 17 | PEBP1, RAF1
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| RKIP downregulation induces the HBx-mediated Raf-1 mitochondrial translocation.
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| Kim SY, Park SG, Jung H, Chi SW, Yu DY, Lee SC, Bae KH.
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| J Microbiol Biotechnol 21(5):525-8.
2011
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| 18 | RAF1
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| Raf kinases in cancer-roles and therapeutic opportunities.
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| Maurer G, Tarkowski B, Baccarini M.
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| Oncogene 30(32):3477-88. doi: 10.1038/onc.2011.160. Epub 2011 May 16. Review.
2011
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| 19 | RAF1
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| c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
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| Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M.
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| Cancer Cell 19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.
2011
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| 20 | BRAF, RAF1, RAS
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| Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF.
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| Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R.
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| Cell 140(2):209-221.PMID: 20141835 2010
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| 21 | LEOPS2, NS5, RAF1
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| Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
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| Molzan M, Schumacher B, Ottmann C, Baljuls A, Polzien L, Weyand M, Thiel P, Rose R, Rose M, Kuhenne P, Kaiser M, Rapp UR, Kuhlmann J, Ottmann C.
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| Mol Cell Biol 30(19):4698-711. Epub 2010 Aug 2.
2010
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| 22 | RAF1, SOS1
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| Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations.
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| Longoni M, Moncini S, Cisternino M, Morella IM, Ferraiuolo S, Russo S, Mannarino S, Brazzelli V, Coi P, Zippel R, Venturin M, Riva P.
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| Am J Med Genet A 152A(9):2176-84 2010
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| 23 | FGFR1, RAF1, SOS1
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| Decreased expression of FGFR1, SOS1, RAF1 genes in cryptorchidism.
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| Hadziselimovic NO, de Geyter Ch, Demougin P, Oakeley EJ, Hadziselimovic F.
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| Urol Int 84(3):353-61. doi: 10.1159/000288242. Epub 2010 Apr 13.
2010
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| 24 | RAF1, STK3
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| Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
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| Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W.
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| Cancer Res 70(3):1195-203. doi: 10.1158/0008-5472.CAN-09-3147. Epub 2010 Jan 19.
2010
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| 25 | NS5, RAF1
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| Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.
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| Kobayashi T, Aoki Y, Niihori T, Cavé H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, Sakazume S, Ando T, Nakagawa N, Lapunzina P, Meneses AG, Gillessen-Kaesbach G, Wieczorek D, Kurosawa K, Mizuno S, Ohashi H, David A, Philip N, Guliyeva A, Narumi Y, Kure S, Tsuchiya S, Matsubara Y.
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| Hum Mutat 31(3):284-94. doi: 10.1002/humu.21187.
2010
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| 26 | MAP2K1, MAP2K4, MAP3K5, MAPK1, MAPK10, RAF1
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| How does arrestin assemble MAPKs into a signaling complex?
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| Song X, Coffa S, Fu H, Gurevich VV.
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| J Biol Chem 284(1):685-95. Epub 2008 Nov 10. 2009
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| 27 | RAF1
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| RAF may induce cell proliferation through hypermethylation of tumor suppressor gene promoter in gastric epithelial cells.
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| Wang X, Sun DF, Lu R, Chen ZF, Chen YX, Fang JY.
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| Cancer Sci 100(1):117-25.
2009
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| 28 | BRAF, KIAA1549, RAF1, SRGAP3
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| Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
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| Jones DT, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP.
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| Oncogene 28(20):2119-23. Epub 2009 Apr 13. 2009
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| 29 | MTOR, RAF1
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| Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1.
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| Wei Y, Tsang CK, Zheng XF.
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| EMBO J 28(15):2220-30. Epub 2009 Jul 2.PMID: 19574957 2009
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| 30 | BRAF, CFC2, CFC3, COSTS, HRAS, KRAS, LEOPS, MAP2K1, MAPK1, MTOR, NF1, NFNS, NS1, NS3, NS4, NS5, PTPN11, RAF1, SOS1
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| Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.
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| Krab LC, Goorden SM, Elgersma Y.
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| Trends Genet 24(10):498-510. Epub 2008 Sep 4. 2008
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| 31 | CFC3, CFC4, CFC5, KRAS, MAP2K1, MAP2K2, NS3, NS5, RAF1
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| Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders.
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| Nyström AM, Ekvall S, Berglund E, Björkqvist M, Braathen G, Duchen K, Enell H, Holmberg E, Holmlund U, Olsson-Engman M, Annerén G, Bondeson ML.
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| J Med Genet 45(8):500-6. Epub 2008 May 2.
2008
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| 32 | KRAS, NS1, NS3, NS4, NS5, PTPN11, RAF1, SOS1
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| PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
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| Ko JM, Kim JM, Kim GH, Yoo HW.
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| J Hum Genet 53(11-12):999-1006. Epub 2008 Nov 20.
2008
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| 33 | RAF1
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| Isoform-specific interaction of C-RAF with mitochondria.
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| Galmiche A, Fueller J, Santel A, Krohne G, Wittig I, Doye A, Rolando M, Flatau G, Lemichez E, Rapp UR.
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| J Biol Chem 283(21):14857-66. Epub 2008 Mar 20.
2008
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| 34 | RAF1, STUB1, XIAP
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| X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
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| Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K.
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| Nat Cell Biol 10(12):1447-55. Epub 2008 Nov 16. Erratum in: Nat Cell Biol. 2009 Jan;11(1):110. 2008
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| 35 | BAD, RAF1
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| C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome.
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| Fueller J, Becker M, Sienerth AR, Fischer A, Hotz C, Galmiche A.
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| Biochem Biophys Res Commun 370(4):552-6. Epub 2008 Apr 8.PMID: 18402774 2008
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| 36 | HSPA5, RAF1
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| GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
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| Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK.
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| J Cell Physiol 215(3):627-35.PMID: 18064632 2008
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| 37 | PAK6, RAF1
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| p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.
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| Wu X, Carr HS, Dan I, Ruvolo PP, Frost JA.
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| J Cell Biochem 105(1):167-75.
2008
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| 38 | EEF1A1,RAF1
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| C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
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| Lamberti A, Longo O, Marra M, Tagliaferri P, Bismuto E, Fiengo A, Viscomi C, Budillon A, Rapp UR, Wang E, Venuta S, Abbruzzese A, Arcari P, Caraglia M.
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| Cell Death Differ 14(5):952-62. Epub 2007 Mar 2. 2007
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| 39 | RAF1, NS5
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| Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
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| Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R, Kamisago M, Momma K, Katayama H, Nakagawa M, Fujiwara Y, Matsushima M, Mizuno K, Tokuyama M, Hirota H, Muneuchi J, Higashinakagawa T, Matsuoka R.
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| Nat Genet 39(8):1013-7. Epub 2007 Jul 1. 2007
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| 40 | CFC2, BRAF, RAF1, MAP2K1, MAP2K2, CFC3, CFC4
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| Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.
|
| Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA.
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| Science 311(5765):1287-90. Epub 2006 Jan 26. 2006
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| 41 | RAF1, RANBP9
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| Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts.
|
| Johnson SE, Winner DG Jr, Wang X.
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| Biochem Biophys Res Commun 340(2):409-16. Epub 2005 Dec 15. 2006
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| 42 | PEBP1, RAF1
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| Regulation of RKIP binding to the N-region of the Raf-1 kinase.
|
| Park S, Rath O, Beach S, Xiang X, Kelly SM, Luo Z, Kolch W, Yeung KC.
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| FEBS Lett 580(27):6405-12. Epub 2006 Nov 3.
2006
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| 43 | CNKSR1, RAF1
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| CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation.
|
| Ziogas A, Moelling K, Radziwill G.
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| J Biol Chem 280(25):24205-11. Epub 2005 Apr 21. 2005
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| 44 | RAF1, BRAF, ARAF
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| Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
|
| Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R; Cancer Genome Project.
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| Cell 116(6):855-67. 2004
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| 45 | BRAF, ARAF, RAF1
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| Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.
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| Fransen K, Klintenas M, Osterstrom A, Dimberg J, Monstein HJ, Soderkvist P.
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| Carcinogenesis 25(4):527-33. Epub 2003 Dec 19. 2004
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| 46 | RAF1
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| High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer.
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| Simon R, Richter J, Wagner U, Fijan A, Bruderer J, Schmid U, Ackermann D, Maurer R, Alund G, Knonagel H, Rist M, Wilber K, Anabitarte M, Hering F, Hardmeier T, Schonenberger A, Flury R, Jager P, Fehr JL, Schraml P, Moch H, Mihatsch MJ, Gasser T, Sauter G.
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| Cancer Res 61(11):4514-9. 2001
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| 47 | MKRN2, RAF1
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| Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-fingerprotein, antisense to the RAF1 proto-oncogene.
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| Gray TA, Azama K, Whitmore K, Min A, Abe S, Nicholls RD.
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| Genomics 77(3):119-26. 2001
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| 48 | RAF1
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| Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.
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| Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR, Wirth T.
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| Proc Natl Acad Sci U S A 97(9):4615-20. 2000
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| 49 | RAF1
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| Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.
|
| Rosario M, et al.
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| EMBO J 18(5):1270-1279. 1999
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| 50 | RAF1
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| Tetranucleotide repeat polymorphism in RAF1.
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| Mao L, et al.
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| Hum Mol Genet 3 : 521. 1994
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| 51 | VHL, RAF1
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| Physical mapping of chromosome 3p25-p26 by fluorescence in situ hybridisation (FISH).
|
| Phipps ME, et al.
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| Hum Genet 92 : 18-22. 1993
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| 52 | RAF1, VHL, D3S1255
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| Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.
|
| Pericak-Vance MA, et al.
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| J Med Genet 30 : 487-491. 1993
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| 53 | BCR, RAF1, ERBB2, CSF1R
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| Metaphase and interphase cytogenetics with Alu-PCR-amplified yeast artificial chromosome clones containing the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erbB-2.
|
| Lengauer C, et al.
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| Cancer Res 52 : 2590-2596. 1992
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| 54 | RAF1
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| Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol.
|
| Maslinski W, Remillard B, Tsudo M, Strom TB.
|
| J Biol Chem 267(22):15281-4.
1992
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| 55 | VHL, RAF1
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| New RFLP markers around the von Hippel-Lindau disease (VHL) locus.
|
| Lerman M, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1878. 1991
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| 56 | THRB, RARB, RAF1
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| Co-localization of the chromosome 3 genes; thyroid hormone receptor (THRB) retinoic acid receptor (RARB) and the rat oncogene (RAFI) to 3p24.2-3p25.
|
| Wood ME, et al.
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| Am J Hum Genet 47 : A266. 1990
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| 57 | RAF1, D3F15S2, D3S2
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| Long-range restriction enzyme maps of DNF15S2, D3S2, and c-raf1 loci on the short arm of human chromosome 3.
|
| Boldog F, et al.
|
| Cancer Genet Cytogenet 42 : 295-306. 1989
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| 58 | RAF1, RAF1P1
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| Two human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.
|
| Bonner T, et al.
|
| Science 223 : 71-74. 1984
|
| 59 | LEOPS2, RAF1, NS5
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| Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, Lopez Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD.
|
|
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| Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy ain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. 0
|