| 1 | BLM, BRCA1, RAD50
|
| Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.
|
| Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden J.
|
| PLoS One 9(8):e103819. doi: 10.1371/journal.pone.0103819. eCollection 2014.
2014
|
| 2 | NCL, RAD50
|
| Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
|
| Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB.
|
| Proc Natl Acad Sci U S A 110(42):16874-9. doi: 10.1073/pnas.1306160110. Epub 2013 Sep 30.
2013
|
| 3 | RAD50
|
| Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
|
| He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.
|
| J Biol Chem 287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25.
2012
|
| 4 | RAD50
|
| Misregulation of Rad50 expression in melanoma cells.
|
| Avaritt NL, Owings R, Reynolds M, Larson SK, Byrum S, Hiatt KM, Smoller BR, Tackett AJ, Cheung WL.
|
| J Cutan Pathol 39(7):680-4. doi: 10.1111/j.1600-0560.2012.01915.x.
2012
|
| 5 | MRE11A, RAD50
|
| ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.
|
| Majka J, Alford B, Ausio J, Finn RM, McMurray CT.
|
| J Biol Chem 287(4):2328-41. doi: 10.1074/jbc.M111.307041. Epub 2011 Nov 18.
2012
|
| 6 | MRE11A, RAD50
|
| The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
|
| Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
|
| Cell 145(1):54-66.
2011
|
| 7 | BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
|
| Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
|
| Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
|
| Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17.
2011
|
| 8 | RAD50
|
| The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.
|
| Hohl M, Kwon Y, Galván SM, Xue X, Tous C, Aguilera A, Sung P, Petrini JH.
|
| Nat Struct Mol Biol 18(10):1124-31. doi: 10.1038/nsmb.2116.
2011
|
| 9 | RAD50
|
| ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
|
| Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.
|
| J Biol Chem 286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14.
2011
|
| 10 | RAD50
|
| Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.
|
| Kavitha CV, Choudhary B, Raghavan SC, Muniyappa K.
|
| Biochem Biophys Res Commun 399(4):575-80. doi: 10.1016/j.bbrc.2010.07.117. Epub 2010 Aug 2.
2010
|
| 11 | ATM, MRE11, RAD50, TP53BP1
|
| 53BP1 promotes ATM activity through direct interactions with the MRN complex.
|
| Lee JH, Goodarzi AA, Jeggo PA, Paull TT.
|
| EMBO J 29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10.
2010
|
| 12 | NBN, RAD50
|
| RAD50 and NBS1 form a stable complex functional in DNA binding and tethering.
|
| van der Linden E, Sanchez H, Kinoshita E, Kanaar R, Wyman C.
|
| Nucleic Acids Res 37(5):1580-8. Epub 2009 Jan 16.
2009
|
| 13 | NBSLD, RAD50
|
| Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
|
| Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T.
|
| Am J Hum Genet 84(5):605-16. Epub 2009 Apr 30.
2009
|
| 14 | RAD50
|
| The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers.
|
| Gao J, Zhang H, Arbman G, Sun XF.
|
| Dis Markers 24(2):127-34.
2008
|
| 15 | MRE11A, TERF1, RAD50, NBS1
|
| MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
|
| Wu Y, Xiao S, Zhu XD.
|
| Nat Struct Mol Biol 14(9):832-40. Epub 2007 Aug 12. 2007
|
| 16 | MRE11A, MRE11B, RAD50
|
| The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
|
| Lee AY, Liu E, Wu X.
|
| J Biol Chem 282(44):32243-55. Epub 2007 Aug 22.
2007
|
| 17 | ATM, RAD50, NBN
|
| Active role for nibrin in the kinetics of atm activation.
|
| Cerosaletti K, Wright J, Concannon P.
|
| Mol Cell Biol 26(5):1691-9. 2006
|
| 18 | ATR, SMC1A, RAD50, NBN
|
| Rad50 depletion impacts upon ATR-dependent DNA damage responses.
|
| Zhong H, Bryson A, Eckersdorff M, Ferguson DO.
|
| Hum Mol Genet 14(18):2685-93. Epub 2005 Aug 8. 2005
|
| 19 | STAT6, GATA3, KIF3A, IL4, IL13, RAD50
|
| Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.
|
| Lee DU, Rao A.
|
| Proc Natl Acad Sci U S A 101(45):16010-5. Epub 2004 Oct 26. 2004
|
| 20 | BLM, MRE11A, NBS1, RAD50, WRN, NBN
|
| Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
|
| Franchitto A, Pichierri P.
|
| Hum Mol Genet 11(20):2447-53. 2002
|
| 21 | RAD50
|
| DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.
|
| de Jager M, Wyman C, van Gent DC, Kanaar R.
|
| Nucleic Acids Res 30(20):4425-31. 2002
|
| 22 | RAD50
|
| Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
|
| Huang J, Dynan WS.
|
| Nucleic Acids Res 30(3):667-74. 2002
|
| 23 | RAD50
|
| Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.
|
| Matsutani N, Yokozaki H, Tahara E, Tahara H, Kuniyasu H, Kitadai Y, Haruma K, Chayama K, Tahara E, Yasui W.
|
| Pathobiology 69(4):219-24. 2001
|
| 24 | MRE11A, RAD50, TERF2
|
| Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
|
| Zhu XD, Kuster B, Mann M, Petrini JH, Lange Td.
|
| Nat Genet 25(3):347-52. 2000
|
| 25 | RAD50
|
| Molecular cloning and characterization of splice variants of human RAD50 gene.
|
| Kim KK, et al.
|
| Gene 235(1-2):59-67 1999
|
| 26 | BRCA1, FAS, RAD50
|
| Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
|
| Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH.
|
| Science. 285(5428):747-50. 1999
|
| 27 | RAD50
|
| The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
|
| Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH.
|
| Cell 93(3):477-86.
1998
|
| 28 | AFF4, ARAP3, CCNL1, FACLL, IL5, IRF1, KIF3A, P4HA2, PDLIM4, RAD50, SEPTIN8, SHROOM1
|
| Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region.
|
| Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM.
|
| Genome Res 7 : 495-512. 1997
|