Citations for
1BLM, BRCA1, RAD50
Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.
Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden J.
PLoS One 9(8):e103819. doi: 10.1371/journal.pone.0103819. eCollection 2014. 2014
2NCL, RAD50
Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.
Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB.
Proc Natl Acad Sci U S A 110(42):16874-9. doi: 10.1073/pnas.1306160110. Epub 2013 Sep 30. 2013
3RAD50
Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.
J Biol Chem 287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25. 2012
4RAD50
Misregulation of Rad50 expression in melanoma cells.
Avaritt NL, Owings R, Reynolds M, Larson SK, Byrum S, Hiatt KM, Smoller BR, Tackett AJ, Cheung WL.
J Cutan Pathol 39(7):680-4. doi: 10.1111/j.1600-0560.2012.01915.x. 2012
5MRE11A, RAD50
ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease.
Majka J, Alford B, Ausio J, Finn RM, McMurray CT.
J Biol Chem 287(4):2328-41. doi: 10.1074/jbc.M111.307041. Epub 2011 Nov 18. 2012
6MRE11A, RAD50
The Mre11:Rad50 structure shows an ATP-dependent molecular clamp in DNA double-strand break repair.
Lammens K, Bemeleit DJ, Möckel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermüller C, Söding J, Strässer K, Hopfner KP.
Cell 145(1):54-66. 2011
7BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17. 2011
8RAD50
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.
Hohl M, Kwon Y, Galván SM, Xue X, Tous C, Aguilera A, Sung P, Petrini JH.
Nat Struct Mol Biol 18(10):1124-31. doi: 10.1038/nsmb.2116. 2011
9RAD50
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.
J Biol Chem 286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14. 2011
10RAD50
Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.
Kavitha CV, Choudhary B, Raghavan SC, Muniyappa K.
Biochem Biophys Res Commun 399(4):575-80. doi: 10.1016/j.bbrc.2010.07.117. Epub 2010 Aug 2. 2010
11ATM, MRE11, RAD50, TP53BP1
53BP1 promotes ATM activity through direct interactions with the MRN complex.
Lee JH, Goodarzi AA, Jeggo PA, Paull TT.
EMBO J 29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10. 2010
12NBN, RAD50
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering.
van der Linden E, Sanchez H, Kinoshita E, Kanaar R, Wyman C.
Nucleic Acids Res 37(5):1580-8. Epub 2009 Jan 16. 2009
13NBSLD, RAD50
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T.
Am J Hum Genet 84(5):605-16. Epub 2009 Apr 30. 2009
14RAD50
The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers.
Gao J, Zhang H, Arbman G, Sun XF.
Dis Markers 24(2):127-34. 2008
15MRE11A, TERF1, RAD50, NBS1
MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.
Wu Y, Xiao S, Zhu XD.
Nat Struct Mol Biol 14(9):832-40. Epub 2007 Aug 12. 2007
16MRE11A, MRE11B, RAD50
The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
Lee AY, Liu E, Wu X.
J Biol Chem 282(44):32243-55. Epub 2007 Aug 22. 2007
17ATM, RAD50, NBN
Active role for nibrin in the kinetics of atm activation.
Cerosaletti K, Wright J, Concannon P.
Mol Cell Biol 26(5):1691-9. 2006
18ATR, SMC1A, RAD50, NBN
Rad50 depletion impacts upon ATR-dependent DNA damage responses.
Zhong H, Bryson A, Eckersdorff M, Ferguson DO.
Hum Mol Genet 14(18):2685-93. Epub 2005 Aug 8. 2005
19STAT6, GATA3, KIF3A, IL4, IL13, RAD50
Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.
Lee DU, Rao A.
Proc Natl Acad Sci U S A 101(45):16010-5. Epub 2004 Oct 26. 2004
20BLM, MRE11A, NBS1, RAD50, WRN, NBN
Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
Franchitto A, Pichierri P.
Hum Mol Genet 11(20):2447-53. 2002
21RAD50
DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP.
de Jager M, Wyman C, van Gent DC, Kanaar R.
Nucleic Acids Res 30(20):4425-31. 2002
22RAD50
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
Huang J, Dynan WS.
Nucleic Acids Res 30(3):667-74. 2002
23RAD50
Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.
Matsutani N, Yokozaki H, Tahara E, Tahara H, Kuniyasu H, Kitadai Y, Haruma K, Chayama K, Tahara E, Yasui W.
Pathobiology 69(4):219-24. 2001
24MRE11A, RAD50, TERF2
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Zhu XD, Kuster B, Mann M, Petrini JH, Lange Td.
Nat Genet 25(3):347-52. 2000
25RAD50
Molecular cloning and characterization of splice variants of human RAD50 gene.
Kim KK, et al.
Gene 235(1-2):59-67 1999
26BRCA1, FAS, RAD50
Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.
Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH.
Science. 285(5428):747-50. 1999
27RAD50
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR 3rd, Hays L, Morgan WF, Petrini JH.
Cell 93(3):477-86. 1998
28AFF4, ARAP3, CCNL1, FACLL, IL5, IRF1, KIF3A, P4HA2, PDLIM4, RAD50, SEPTIN8, SHROOM1
Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region.
Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM.
Genome Res 7 : 495-512. 1997