1 | RAD18
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| Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
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| Yang Y, Poe JC, Yang L, Fedoriw A, Desai S, Magnuson T, Li Z, Fedoriw Y, Araki K, Gao Y, Tateishi S, Sarantopoulos S, Vaziri C.
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| Nucleic Acids Res ucleic Acids Res. 2016 Feb 15. pii: gkw072. [Epub ahead of print]
2016
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2 | BRCA2, FANCD2, RAD18
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| Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.
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| Tripathi K, Mani C, Clark DW, Palle K.
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| Oncotarget ncotarget. 2016 Feb 8. doi: 10.18632/oncotarget.7247. [Epub ahead of print]
2016
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3 | RAD18, USP7
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| USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
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| Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F, Vaziri C, Stewart GS.
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| Oncogene 35(8):965-76. doi: 10.1038/onc.2015.149. Epub 2015 May 11.
2016
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4 | NBN, POLH, RAD18
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| Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis.
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| Saito Y, Komatsu K.
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| Biomolecules 5(3):1990-2002. doi: 10.3390/biom5031990. Review.
2015
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5 | RAD18
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| RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.
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| Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
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| PLoS One 10(2):e0117845. doi: 10.1371/journal.pone.0117845. eCollection 2015.
2015
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6 | RAD18, RNF8
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| Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.
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| Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K.
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| Oncogene 34(33):4403-11. doi: 10.1038/onc.2014.371. Epub 2014 Nov 24.
2015
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7 | PCNA, RAD18, SIVA1
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| SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.
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| Han J, Liu T, Huen MS, Hu L, Chen Z, Huang J.
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| J Cell Biol 205(6):811-27. doi: 10.1083/jcb.201311007.
2014
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8 | PCNA, POLH, RAD18
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| A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks.
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| Durando M, Tateishi S, Vaziri C.
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| Nucleic Acids Res 41(5):3079-93. doi: 10.1093/nar/gkt016. Epub 2013 Jan 23.
2013
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9 | RAD18
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| Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
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| Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann W, Oh S, Hendrickson EA, Vaziri C.
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| Nucleic Acids Res 41(4):2296-312. doi: 10.1093/nar/gks1325. Epub 2013 Jan 7.
2013
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10 | RAD18
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| RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
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| Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J.
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| DNA Repair (Amst). 11(2):131-8. 2012
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11 | MAPK8, RAD18
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| c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks.
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| Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C.
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| Mol Biol Cell 23(10):1943-54. doi: 10.1091/mbc.E11-10-0829. Epub 2012 Mar 28.
2012
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12 | RAD18
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| Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells.
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| Yoon JH, Prakash S, Prakash L.
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| Proc Natl Acad Sci U S A 109(20):7799-804. doi: 10.1073/pnas.1204105109. Epub 2012 Apr 30.
2012
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13 | FANCD2, FANCI, RAD18
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| The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI.
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| Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM.
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| Blood 117(19):5078-87. Epub 2011 Feb 25.
2011
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14 | RAD18
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| Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
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| Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM.
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| PLoS One 6(8):e23155. Epub 2011 Aug 17.
2011
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15 | RAD18, UBE2B
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| Meiotic functions of RAD18.
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| Inagaki A, Sleddens-Linkels E, Wassenaar E, Ooms M, van Cappellen WA, Hoeijmakers JH, Seibler J, Vogt TF, Shin MK, Grootegoed JA, Baarends WM.
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| J Cell Sci 124(Pt 16):2837-50.
2011
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16 | RAD18
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| Symmetry and asymmetry of the RING-RING dimer of Rad18.
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| Huang A, Hibbert RG, de Jong RN, Das D, Sixma TK, Boelens R.
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| J Mol Biol 410(3):424-35. Epub 2011 Apr 27.
2011
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17 | RAD18
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| Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
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| Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM.
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| PLoS One. 6(8):e23155. 2011
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18 | NBN, RAD18
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| NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
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| Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K.
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| Mol Cell. 43(5):788-97. 2011
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19 | DCLRE1A, PCNA, RAD18
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| RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.
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| Yang K, Moldovan GL, D'Andrea AD.
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| J Biol Chem 285(25):19085-91. Epub 2010 Apr 12.PMID: 20385554 2010
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20 | CDC7, POLH, RAD18
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| Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.
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| Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri C.
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| J Cell Biol 191(5):953-66. Epub 2010 Nov 22.
2010
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21 | RAD18
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| RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.
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| Geng L, Huntoon CJ, Karnitz LM.
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| J Cell Biol 191(2):249-57. Epub 2010 Oct 11.
2010
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22 | RAD18
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| RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
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| Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J.
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| Nat Cell Biol 11(5):592-603. Epub 2009 Apr 26.
2009
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23 | RAD18, TP53BP1
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| RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.
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| Watanabe K, Iwabuchi K, Sun J, Tsuji Y, Tani T, Tokunaga K, Date T, Hashimoto M, Yamaizumi M, Tateishi S.
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| Nucleic Acids Res 37(7):2176-93. Epub 2009 Feb 19.
2009
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24 | RAD18, WRNIP1
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| Physical and functional interaction between WRNIP1 and RAD18.
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| Yoshimura A, Seki M, Kanamori M, Tateishi S, Tsurimoto T, Tada S, Enomoto T.
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| Genes Genet Syst 84(2):171-8.
2009
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25 | HLTF, UBE2V2, UBE2A, UBE2B, RAD18, UBE2N
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| Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
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| Unk I, Hajdś I, F‡tyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L.
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| Proc Natl Acad Sci U S A 105(10):3768-73. Epub 2008 Mar 3. 2008
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26 | RAD18, UBE2B
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| Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.
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| Tsuji Y, Watanabe K, Araki K, Shinohara M, Yamagata Y, Tsurimoto T, Hanaoka F, Yamamura K, Yamaizumi M, Tateishi S.
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| Genes Cells 13(4):343-54. 2008
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27 | RAD18
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| RAD18 signals DNA polymerase IOTA to stalled replication forks in cells entering S-phase with DNA damage.
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| Kakar S, Watson NB, McGregor WG.
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| Adv Exp Med Biol 614:137-43. 2008
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28 | RAD18
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| The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer.
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| Kanzaki H, Ouchida M, Hanafusa H, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.
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| J Cancer Res Clin Oncol 134(2):211-7. Epub 2007 Jul 12. 2008
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29 | RAD18
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| Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.
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| Kanzaki H, Ouchida M, Hanafusa H, Sakai A, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.
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| Oncol Rep 18(5):1171-5. 2007
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30 | RAD18
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| Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.
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| Shiomi N, Mori M, Tsuji H, Imai T, Inoue H, Tateishi S, Yamaizumi M, Shiomi T.
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| Nucleic Acids Res 35(2):e9. Epub 2006 Dec 7. 2007
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31 | RAD18
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| Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest.
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| Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C.
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| Mol Cell Biol. 26(9):3527-40. 2006
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32 | RAD18
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| Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination.
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| Miyase S, Tateishi S, Watanabe K, Tomita K, Suzuki K, Inoue H, Yamaizumi M.
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| J Biol Chem 280(1):515-24. Epub 2004 Oct 27. 2005
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33 | UBE2A, UBE2B, RAD18, ZMYM2
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| ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.
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| Kunapuli P, Somerville R, Still IH, Cowell JK.
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| Oncogene 22(22):3417-23. 2003
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34 | RAD18
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| Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.
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| Tateishi S, Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M.
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| Proc Natl Acad Sci U S A 97(14):7927-32. 2000
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35 | RAD18
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| The human RAD18 gene product interacts with HHR6A and HHR6B.
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| Xin H, Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z.
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| Nucleic Acids Res 28(14):2847-54. 2000
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