Citations for
1RAD18
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
Yang Y, Poe JC, Yang L, Fedoriw A, Desai S, Magnuson T, Li Z, Fedoriw Y, Araki K, Gao Y, Tateishi S, Sarantopoulos S, Vaziri C.
Nucleic Acids Res ucleic Acids Res. 2016 Feb 15. pii: gkw072. [Epub ahead of print] 2016
2BRCA2, FANCD2, RAD18
Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery.
Tripathi K, Mani C, Clark DW, Palle K.
Oncotarget ncotarget. 2016 Feb 8. doi: 10.18632/oncotarget.7247. [Epub ahead of print] 2016
3RAD18, USP7
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F, Vaziri C, Stewart GS.
Oncogene 35(8):965-76. doi: 10.1038/onc.2015.149. Epub 2015 May 11. 2016
4NBN, POLH, RAD18
Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis.
Saito Y, Komatsu K.
Biomolecules 5(3):1990-2002. doi: 10.3390/biom5031990. Review. 2015
5RAD18
RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure.
Sasatani M, Xu Y, Kawai H, Cao L, Tateishi S, Shimura T, Li J, Iizuka D, Noda A, Hamasaki K, Kusunoki Y, Kamiya K.
PLoS One 10(2):e0117845. doi: 10.1371/journal.pone.0117845. eCollection 2015. 2015
6RAD18, RNF8
Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining.
Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K.
Oncogene 34(33):4403-11. doi: 10.1038/onc.2014.371. Epub 2014 Nov 24. 2015
7PCNA, RAD18, SIVA1
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.
Han J, Liu T, Huen MS, Hu L, Chen Z, Huang J.
J Cell Biol 205(6):811-27. doi: 10.1083/jcb.201311007. 2014
8PCNA, POLH, RAD18
A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks.
Durando M, Tateishi S, Vaziri C.
Nucleic Acids Res 41(5):3079-93. doi: 10.1093/nar/gkt016. Epub 2013 Jan 23. 2013
9RAD18
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Yang Y, Durando M, Smith-Roe SL, Sproul C, Greenwalt AM, Kaufmann W, Oh S, Hendrickson EA, Vaziri C.
Nucleic Acids Res 41(4):2296-312. doi: 10.1093/nar/gks1325. Epub 2013 Jan 7. 2013
10RAD18
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J.
DNA Repair (Amst). 11(2):131-8. 2012
11MAPK8, RAD18
c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks.
Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C.
Mol Biol Cell 23(10):1943-54. doi: 10.1091/mbc.E11-10-0829. Epub 2012 Mar 28. 2012
12RAD18
Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells.
Yoon JH, Prakash S, Prakash L.
Proc Natl Acad Sci U S A 109(20):7799-804. doi: 10.1073/pnas.1204105109. Epub 2012 Apr 30. 2012
13FANCD2, FANCI, RAD18
The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI.
Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM.
Blood 117(19):5078-87. Epub 2011 Feb 25. 2011
14RAD18
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM.
PLoS One 6(8):e23155. Epub 2011 Aug 17. 2011
15RAD18, UBE2B
Meiotic functions of RAD18.
Inagaki A, Sleddens-Linkels E, Wassenaar E, Ooms M, van Cappellen WA, Hoeijmakers JH, Seibler J, Vogt TF, Shin MK, Grootegoed JA, Baarends WM.
J Cell Sci 124(Pt 16):2837-50. 2011
16RAD18
Symmetry and asymmetry of the RING-RING dimer of Rad18.
Huang A, Hibbert RG, de Jong RN, Das D, Sixma TK, Boelens R.
J Mol Biol 410(3):424-35. Epub 2011 Apr 27. 2011
17RAD18
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM.
PLoS One. 6(8):e23155. 2011
18NBN, RAD18
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K.
Mol Cell. 43(5):788-97. 2011
19DCLRE1A, PCNA, RAD18
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.
Yang K, Moldovan GL, D'Andrea AD.
J Biol Chem 285(25):19085-91. Epub 2010 Apr 12.PMID: 20385554 2010
20CDC7, POLH, RAD18
Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.
Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri C.
J Cell Biol 191(5):953-66. Epub 2010 Nov 22. 2010
21RAD18
RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network.
Geng L, Huntoon CJ, Karnitz LM.
J Cell Biol 191(2):249-57. Epub 2010 Oct 11. 2010
22RAD18
RAD18 transmits DNA damage signalling to elicit homologous recombination repair.
Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J.
Nat Cell Biol 11(5):592-603. Epub 2009 Apr 26. 2009
23RAD18, TP53BP1
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.
Watanabe K, Iwabuchi K, Sun J, Tsuji Y, Tani T, Tokunaga K, Date T, Hashimoto M, Yamaizumi M, Tateishi S.
Nucleic Acids Res 37(7):2176-93. Epub 2009 Feb 19. 2009
24RAD18, WRNIP1
Physical and functional interaction between WRNIP1 and RAD18.
Yoshimura A, Seki M, Kanamori M, Tateishi S, Tsurimoto T, Tada S, Enomoto T.
Genes Genet Syst 84(2):171-8. 2009
25HLTF, UBE2V2, UBE2A, UBE2B, RAD18, UBE2N
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
Unk I, Hajdś I, F‡tyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L.
Proc Natl Acad Sci U S A 105(10):3768-73. Epub 2008 Mar 3. 2008
26RAD18, UBE2B
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.
Tsuji Y, Watanabe K, Araki K, Shinohara M, Yamagata Y, Tsurimoto T, Hanaoka F, Yamamura K, Yamaizumi M, Tateishi S.
Genes Cells 13(4):343-54. 2008
27RAD18
RAD18 signals DNA polymerase IOTA to stalled replication forks in cells entering S-phase with DNA damage.
Kakar S, Watson NB, McGregor WG.
Adv Exp Med Biol 614:137-43. 2008
28RAD18
The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer.
Kanzaki H, Ouchida M, Hanafusa H, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.
J Cancer Res Clin Oncol 134(2):211-7. Epub 2007 Jul 12. 2008
29RAD18
Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.
Kanzaki H, Ouchida M, Hanafusa H, Sakai A, Yamamoto H, Suzuki H, Yano M, Aoe M, Imai K, Date H, Nakachi K, Shimizu K.
Oncol Rep 18(5):1171-5. 2007
30RAD18
Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination.
Shiomi N, Mori M, Tsuji H, Imai T, Inoue H, Tateishi S, Yamaizumi M, Shiomi T.
Nucleic Acids Res 35(2):e9. Epub 2006 Dec 7. 2007
31RAD18
Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest.
Bi X, Barkley LR, Slater DM, Tateishi S, Yamaizumi M, Ohmori H, Vaziri C.
Mol Cell Biol. 26(9):3527-40. 2006
32RAD18
Differential regulation of Rad18 through Rad6-dependent mono- and polyubiquitination.
Miyase S, Tateishi S, Watanabe K, Tomita K, Suzuki K, Inoue H, Yamaizumi M.
J Biol Chem 280(1):515-24. Epub 2004 Oct 27. 2005
33UBE2A, UBE2B, RAD18, ZMYM2
ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.
Kunapuli P, Somerville R, Still IH, Cowell JK.
Oncogene 22(22):3417-23. 2003
34RAD18
Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.
Tateishi S, Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M.
Proc Natl Acad Sci U S A 97(14):7927-32. 2000
35RAD18
The human RAD18 gene product interacts with HHR6A and HHR6B.
Xin H, Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z.
Nucleic Acids Res 28(14):2847-54. 2000