1 | KIF23, RACGAP1
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| Preparation of centralspindlin as an active heterotetramer of kinesin and GTPase activating protein subunits for in vitro structural and functional assays.
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| Mishima M.
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| Methods Cell Biol 137:371-385. doi: 10.1016/bs.mcb.2016.04.005.
2017
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2 | PTK2, PXN, RACGAP1, RHOA
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| RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
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| Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
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| Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088.
2015
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3 | KIF23, RACGAP1
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| CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.
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| Davies T, Kodera N, Kaminski Schierle GS, Rees E, Erdelyi M, Kaminski CF, Ando T, Mishima M.
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| PLoS Biol 13(4):e1002121. doi: 10.1371/journal.pbio.1002121.
2015
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4 | KIF23, RACGAP1
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| Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
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| Basant A, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M.
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| Dev Cell 33(2):204-15. doi: 10.1016/j.devcel.2015.03.015.
2015
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5 | PLK1, RACGAP1
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| Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis.
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| Kim H, Guo F, Brahma S, Xing Y, Burkard ME.
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| Cell Cycle 13(18):2952-61. doi: 10.4161/15384101.2014.947201.
2014
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6 | CDC42, RAC1, RACGAP1
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| Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
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| Lorès P, Vernet N, Kurosaki T, Van de Putte T, Huylebroeck D, Hikida M, Gacon G, Touré A.
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| Dev Biol 386(2):419-27. doi: 10.1016/j.ydbio.2013.12.006.
2014
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7 | RACGAP1
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| Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression.
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| Ke HL, Ke RH, Li ST, Li B, Lu HT, Wang XQ.
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| J Neurooncol 113(2):327-32. doi: 10.1007/s11060-013-1121-7.
2013
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8 | RACGAP1
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| Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.
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| White EA, Raghuraman H, Perozo E, Glotzer M.
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| J Biol Chem. Jul 5;288(27):19785-95. doi: 10.1074/jbc.M113.463695. Epub 2013 May 17. 2013
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9 | ECT2, RACGAP1
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| Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
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| Matthews HK, Delabre U, Rohn JL, Guck J, Kunda P, Baum B.
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| Dev Cell 23(2):371-83. doi: 10.1016/j.devcel.2012.06.003. 2012
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10 | RACGAP1
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| Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.
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| Lekomtsev S, Su KC, Pye VE, Blight K, Sundaramoorthy S, Takaki T, Collinson LM, Cherepanov P, Divecha N, Petronczki M.
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| Nature 492(7428):276-9. doi: 10.1038/nature11773.
2012
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11 | RACGAP1
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| The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.
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| Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema K.
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| J Cell Biol 193(1):155-69.
2011
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12 | PLK1, RACGAP1
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| Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
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| Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV.
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| PLoS Biol 7(5):e1000111. Epub 2009 May 26.
2009
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13 | KIF23, RACGAP1
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| Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase.
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| Touré A, Mzali R, Liot C, Seguin L, Morin L, Crouin C, Chen-Yang I, Tsay YG, Dorseuil O, Gacon G, Bertoglio J.
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| FEBS Lett 582(8):1182-8. Epub 2008 Jan 15. Erratum in: FEBS Lett. 2008 May 14;582(11):1635.
2008
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14 | HIF1A, RACGAP1
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| MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity.
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| Lyberopoulou A, Venieris E, Mylonis I, Chachami G, Pappas I, Simos G, Bonanou S, Georgatsou E.
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| Cell Physiol Biochem 20(6):995-1006.
2007
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15 | CEP55, RACGAP1
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| Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis.
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| Zhao WM, Seki A, Fang G.
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| Mol Biol Cell 17(9):3881-96. Epub 2006 Jun 21.
2006
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16 | ECT2, RACGAP1
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| Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
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| Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S.
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| J Cell Biol 168(2):221-32. Epub 2005 Jan 10.
2005
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17 | RACGAP1
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| MgcRacGAP is involved in the control of growth and differentiation ofhematopoietic cells.
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| Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T,Kitamura T.
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| Blood 96(6):2116-24. 2000
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18 | ATP10D, BEGAIN, CALCOCO1, CDK5RAP2, CERCAM, CIP2A, DHX36, DHX37, DPP10, DTX2, GPR124, GRAMD1A, HCN3, ISLR2, KANK2, KBTBD2, KBTBD2, KIAA1468, KIAA1522, KLHL1, KMT2C, LRCH2, MARK1, MBD5, MYH7B, NUSAP1, PDZD4, PITPNM2, PLCE1, POGK, POLR3E, PPP2R2D, RACGAP1, RCC2, SCAPER, SDK2, SEMA6D, SH3RF1, SPPL2B, STIM2, TSHZ3, UBAP2, URG4, USP28, VPS18, WDR48, WHRN, ZBTB2, ZNF530
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| Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O.
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| DNA Res 7(2):143-50. 2000
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