Citations for
1KIF23, RACGAP1
Preparation of centralspindlin as an active heterotetramer of kinesin and GTPase activating protein subunits for in vitro structural and functional assays.
Mishima M.
Methods Cell Biol 137:371-385. doi: 10.1016/bs.mcb.2016.04.005. 2017
2PTK2, PXN, RACGAP1, RHOA
RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088. 2015
3KIF23, RACGAP1
CYK4 promotes antiparallel microtubule bundling by optimizing MKLP1 neck conformation.
Davies T, Kodera N, Kaminski Schierle GS, Rees E, Erdelyi M, Kaminski CF, Ando T, Mishima M.
PLoS Biol 13(4):e1002121. doi: 10.1371/journal.pbio.1002121. 2015
4KIF23, RACGAP1
Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane.
Basant A, Lekomtsev S, Tse YC, Zhang D, Longhini KM, Petronczki M, Glotzer M.
Dev Cell 33(2):204-15. doi: 10.1016/j.devcel.2015.03.015. 2015
5PLK1, RACGAP1
Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis.
Kim H, Guo F, Brahma S, Xing Y, Burkard ME.
Cell Cycle 13(18):2952-61. doi: 10.4161/15384101.2014.947201. 2014
6CDC42, RAC1, RACGAP1
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
Lorès P, Vernet N, Kurosaki T, Van de Putte T, Huylebroeck D, Hikida M, Gacon G, Touré A.
Dev Biol 386(2):419-27. doi: 10.1016/j.ydbio.2013.12.006. 2014
7RACGAP1
Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression.
Ke HL, Ke RH, Li ST, Li B, Lu HT, Wang XQ.
J Neurooncol 113(2):327-32. doi: 10.1007/s11060-013-1121-7. 2013
8RACGAP1
Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit.
White EA, Raghuraman H, Perozo E, Glotzer M.
J Biol Chem. Jul 5;288(27):19785-95. doi: 10.1074/jbc.M113.463695. Epub 2013 May 17. 2013
9ECT2, RACGAP1
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
Matthews HK, Delabre U, Rohn JL, Guck J, Kunda P, Baum B.
Dev Cell 23(2):371-83. doi: 10.1016/j.devcel.2012.06.003. 2012
10RACGAP1
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.
Lekomtsev S, Su KC, Pye VE, Blight K, Sundaramoorthy S, Takaki T, Collinson LM, Cherepanov P, Divecha N, Petronczki M.
Nature 492(7428):276-9. doi: 10.1038/nature11773. 2012
11RACGAP1
The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.
Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema K.
J Cell Biol 193(1):155-69. 2011
12PLK1, RACGAP1
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV.
PLoS Biol 7(5):e1000111. Epub 2009 May 26. 2009
13KIF23, RACGAP1
Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase.
Touré A, Mzali R, Liot C, Seguin L, Morin L, Crouin C, Chen-Yang I, Tsay YG, Dorseuil O, Gacon G, Bertoglio J.
FEBS Lett 582(8):1182-8. Epub 2008 Jan 15. Erratum in: FEBS Lett. 2008 May 14;582(11):1635. 2008
14HIF1A, RACGAP1
MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity.
Lyberopoulou A, Venieris E, Mylonis I, Chachami G, Pappas I, Simos G, Bonanou S, Georgatsou E.
Cell Physiol Biochem 20(6):995-1006. 2007
15CEP55, RACGAP1
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis.
Zhao WM, Seki A, Fang G.
Mol Biol Cell 17(9):3881-96. Epub 2006 Jun 21. 2006
16ECT2, RACGAP1
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S.
J Cell Biol 168(2):221-32. Epub 2005 Jan 10. 2005
17RACGAP1
MgcRacGAP is involved in the control of growth and differentiation ofhematopoietic cells.
Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T,Kitamura T.
Blood 96(6):2116-24. 2000
18ATP10D, BEGAIN, CALCOCO1, CDK5RAP2, CERCAM, CIP2A, DHX36, DHX37, DPP10, DTX2, GPR124, GRAMD1A, HCN3, ISLR2, KANK2, KBTBD2, KBTBD2, KIAA1468, KIAA1522, KLHL1, KMT2C, LRCH2, MARK1, MBD5, MYH7B, NUSAP1, PDZD4, PITPNM2, PLCE1, POGK, POLR3E, PPP2R2D, RACGAP1, RCC2, SCAPER, SDK2, SEMA6D, SH3RF1, SPPL2B, STIM2, TSHZ3, UBAP2, URG4, USP28, VPS18, WDR48, WHRN, ZBTB2, ZNF530
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O.
DNA Res 7(2):143-50. 2000