| 1 | RAB8A
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| Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
|
| Ouchi K, Yoshie S, Miyake M, Hazama A.
|
| Biosci Biotechnol Biochem 84(2):247-255. doi: 10.1080/09168451.2019.1677143. Epub 2019 Oct 10.
2020
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| 2 | OCRL, RAB8A
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| Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.
|
| Wall AA, Condon ND, Luo L, Stow JL.
|
| Philos Trans R Soc Lond B Biol Sci 374(1765):20180151. doi: 10.1098/rstb.2018.0151.
2019
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| 3 | BAG6, RAB8A
|
| Cytoplasmic control of Rab family small GTPases through BAG6.
|
| Takahashi T, Minami S, Tsuchiya Y, Tajima K, Sakai N, Suga K, Hisanaga SI, Ohbayashi N, Fukuda M, Kawahara H.
|
| EMBO Rep 20(4). pii: e46794. doi: 10.15252/embr.201846794. Epub 2019 Feb 25.
2019
|
| 4 | LRRK2, RAB8A
|
| The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
|
| Rivero-Ríos P, Romo-Lozano M, Madero-Pérez J, Thomas AP, Biosa A, Greggio E, Hilfiker S.
|
| J Biol Chem 294(13):4738-4758. doi: 10.1074/jbc.RA118.005008. Epub 2019 Feb 1.
2019
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| 5 | LRRK2, RAB10, RAB29, RAB8A
|
| LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
|
| Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T.
|
| Proc Natl Acad Sci U S A 115(39):E9115-E9124. doi: 10.1073/pnas.1812196115. Epub 2018 Sep 12.
2018
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| 6 | LRRK2, RAB8A
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| LRRK2 mediated Rab8a phosphorylation promotes lipid storage.
|
| Yu M, Arshad M, Wang W, Zhao D, Xu L, Zhou L.
|
| Lipids Health Dis 17(1):34. doi: 10.1186/s12944-018-0684-x.
2018
|
| 7 | LRRK2, RAB8A
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| Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
|
| Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.
|
| Mol Neurodegener 13(1):3. doi: 10.1186/s13024-018-0235-y.
2018
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| 8 | RAB8A
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| Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
|
| Chen Q, Rong P, Xu D, Zhu S, Chen L, Xie B, Du Q, Quan C, Sheng Y, Zhao TJ, Li P, Wang HY, Chen S.
|
| Diabetes 66(9):2387-2399. doi: 10.2337/db17-0077. Epub 2017 Jul 10.
2017
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| 9 | ARHGAP26, RAB8A
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| Endocytic turnover of Rab8 controls cell polarization.
|
| Vidal-Quadras M, Holst MR, Francis MK, Larsson E, Hachimi M, Yau WL, Peränen J, Martín-Belmonte F, Lundmark R.
|
| J Cell Sci 130(6):1147-1157. doi: 10.1242/jcs.195420. Epub 2017 Jan 30.
2017
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| 10 | LRRK2, RAB8A, TMEM230
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| The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.
|
| Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D.
|
| Hum Mol Genet 26(4):729-741. doi: 10.1093/hmg/ddw413.
2017
|
| 11 | RAB8A
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| A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes.
|
| Madugula V, Lu L.
|
| J Cell Sci 129(20):3922-3934. Epub 2016 Sep 15.
2016
|
| 12 | EHBP1L1, RAB8A
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| EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
|
| Nakajo A, Yoshimura S, Togawa H, Kunii M, Iwano T, Izumi A, Noguchi Y, Watanabe A, Goto A, Sato T, Harada A.
|
| J Cell Biol 212(3):297-306. doi: 10.1083/jcb.201508086.
2016
|
| 13 | RAB8A
|
| The Rab GTPase Rab8 as a shared regulator of ciliogenesis and immune synapse assembly: From a conserved pathway to diverse cellular structures.
|
| Patrussi L, Baldari CT.
|
| Small GTPases 7(1):16-20. doi: 10.1080/21541248.2015.1111852. Epub 2015 Nov 20.
2016
|
| 14 | RAB8A, WLS
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| Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.
|
| Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N.
|
| Development 142(12):2147-62. doi: 10.1242/dev.121046. Epub 2015 May 26.
2015
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| 15 | IFT20, RAB8A, VAMP3
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| The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse.
|
| Finetti F, Patrussi L, Galgano D, Cassioli C, Perinetti G, Pazour GJ, Baldari CT.
|
| J Cell Sci 128(14):2541-52. doi: 10.1242/jcs.171652. Epub 2015 Jun 1.
2015
|
| 16 | DZIP1, GSK3B, RAB8A
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| GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
|
| Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, Zhang C.
|
| PLoS Biol 13(4):e1002129. doi: 10.1371/journal.pbio.1002129. eCollection 2015 Apr.
2015
|
| 17 | MICALL1, RAB13, RAB35, RAB36, RAB8A
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| Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth.
|
| Kobayashi H, Etoh K, Ohbayashi N, Fukuda M.
|
| Biol Open 3(9):803-14. doi: 10.1242/bio.20148771.
2014
|
| 18 | RAB8A
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| RAB8A a new biomarker for endometrial cancer?
|
| Bie Y, Zhang Z.
|
| World J Surg Oncol 12:371. doi: 10.1186/1477-7819-12-371.
2014
|
| 19 | CIDEC, RAB8A, TBC1D4
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| Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
|
| Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P.
|
| Dev Cell 30(4):378-93. doi: 10.1016/j.devcel.2014.07.005.
2014
|
| 20 | RAB8A, SNCA
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| α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
|
| Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M.
|
| Neurobiol Dis 70:149-61. doi: 10.1016/j.nbd.2014.06.018. Epub 2014 Jun 28.
2014
|
| 21 | MYO5A, RAB8A
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| Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.
|
| Sun Y, Chiu TT, Foley KP, Bilan PJ, Klip A.
|
| Mol Biol Cell 25(7):1159-70. doi: 10.1091/mbc.E13-08-0493. Epub 2014 Jan 29.
2014
|
| 22 | RAB8A, RAB8B
|
| Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
|
| Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A.
|
| J Cell Sci 127(Pt 2):422-31. doi: 10.1242/jcs.136903. Epub 2013 Nov 8.
2014
|
| 23 | CEP290, KIAA0586, RAB8A
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| The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.
|
| Kobayashi T, Kim S, Lin YC, Inoue T, Dynlacht BD.
|
| J Cell Biol 204(2):215-29. doi: 10.1083/jcb.201304153. Epub 2014 Jan 13.
2014
|
| 24 | CEP290, RAB8A, SSX2IP
|
| The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
|
| Klinger M, Wang W, Kuhns S, Bärenz F, Dräger-Meurer S, Pereira G, Gruss OJ.
|
| Mol Biol Cell 25(4):495-507. doi: 10.1091/mbc.E13-09-0526.
2014
|
| 25 | EXOC6, RAB8A, STK38L
|
| NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.
|
| Chiba S, Amagai Y, Homma Y, Fukuda M, Mizuno K.
|
| EMBO J 32(6):874-85. doi: 10.1038/emboj.2013.32. Epub 2013 Feb 22. 2013
|
| 26 | RAB8A, SYTL1, SYTL4
|
| Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.
|
| Hampson A, O'Connor A, Smolenski A.
|
| J Thromb Haemost 11(1):161-8. doi: 10.1111/jth.12068.
2013
|
| 27 | RAB11A, RAB11B, RAB3A, RAB3IL1, RAB8A, RAB8B
|
| GRAB is a binding partner for the Rab11a and Rab11b GTPases.
|
| Horgan CP, Hanscom SR, McCaffrey MW.
|
| Biochem Biophys Res Commun 441(1):214-9. doi: 10.1016/j.bbrc.2013.10.043.
2013
|
| 28 | ARF6, RAB8A, SYTL1, TBC1D10A
|
| EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
|
| Hokanson DE, Bretscher AP.
|
| Mol Biol Cell 23(4):701-15. doi: 10.1091/mbc.E11-06-0521. Epub 2012 Jan 4. 2012
|
| 29 | OPTN, RAB8A, TBC1D17
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| Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17.
|
| Vaibhava V, Nagabhushana A, Chalasani ML, Sudhakar C, Kumari A, Swarup G.
|
| J Cell Sci 125(Pt 21):5026-39. doi: 10.1242/jcs.102327. Epub 2012 Aug 1.
2012
|
| 30 | EXOC6, RAB11A, RAB8A
|
| A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.
|
| Feng S, Knödler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peränen J, Guo W.
|
| J Biol Chem 287(19):15602-9. doi: 10.1074/jbc.M111.333245. Epub 2012 Mar 19. 2012
|
| 31 | OCRL, RAB8A
|
| OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome.
|
| Luo N, West CC, Murga-Zamalloa CA, Sun L, Anderson RM, Wells CD, Weinreb RN, Travers JB, Khanna H, Sun Y.
|
| Hum Mol Genet 21(15):3333-44. doi: 10.1093/hmg/dds163. Epub 2012 Apr 27.
2012
|
| 32 | ARF4, ASAP1, RAB11A, RAB3IP, RAB8A
|
| The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.
|
| Wang J, Morita Y, Mazelova J, Deretic D.
|
| EMBO J 31(20):4057-71. doi: 10.1038/emboj.2012.253. Epub 2012 Sep 14.
2012
|
| 33 | CEP164, RAB3IP, RAB8A
|
| Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis.
|
| Schmidt KN, Kuhns S, Neuner A, Hub B, Zentgraf H, Pereira G.
|
| J Cell Biol 199(7):1083-101. doi: 10.1083/jcb.201202126. Epub 2012 Dec 17.
2012
|
| 34 | RAB11A, RAB8A, RAB8B, TRAPPC2
|
| Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.
|
| Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.
|
| Proc Natl Acad Sci U S A 108(7):2759-64. Epub 2011 Jan 27.
2011
|
| 35 | CEP290, PEBP1, RAB8A
|
| Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies.
|
| Murga-Zamalloa CA, Ghosh AK, Patil SB, Reed NA, Chan LS, Davuluri S, Peränen J, Hurd TW, Rachel RA, Khanna H.
|
| J Biol Chem 286(32):28276-86. Epub 2011 Jun 17.
2011
|
| 36 | MICAL3, RAB6A, RAB6B, RAB8A
|
| Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
|
| Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A.
|
| Curr Biol 21(11):967-74. Epub 2011 May 19. 2011
|
| 37 | RAB11A, RAB8A
|
| Coordination of Rab8 and Rab11 in primary ciliogenesis.
|
| Knödler A, Feng S, Zhang J, Zhang X, Das A, Peränen J, Guo W.
|
| Proc Natl Acad Sci U S A 107(14):6346-51. Epub 2010 Mar 22. 2010
|
| 38 | RAB8A, RPGR
|
| Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
|
| Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H.
|
| Hum Mol Genet 19(18):3591-8. Epub 2010 Jul 14.PMID: 20631154 2010
|
| 39 | RAB13, RAB14, RAB8A
|
| Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
|
| Sun Y, Bilan PJ, Liu Z, Klip A.
|
| Proc Natl Acad Sci U S A 107(46):19909-14. Epub 2010 Nov 1.
2010
|
| 40 | AHI1, JBTS3, KMT2A, RAB8A
|
| Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking.
|
| Hsiao YC, Tong ZJ, Westfall JE, Ault JG, Page-McCaw PS, Ferland RJ.
|
| Hum Mol Genet 18(20):3926-41. Epub 2009 Jul 22. 2009
|
| 41 | MICALL2, RAB13, RAB8A
|
| The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
|
| Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T.
|
| Mol Biol Cell 19(3):971-83. Epub 2007 Dec 19.
2008
|
| 42 | RAB8A
|
| The Rab8 GTPase regulates apical protein localization in intestinal cells.
|
| Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A.
|
| Nature 448(7151):366-9. Epub 2007 Jun 27. 2007
|
| 43 | RAB8A, EHD1, EHD3
|
| Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.
|
| Roland JT, Kenworthy AK, Peranen J, Caplan S, Goldenring JR.
|
| Mol Biol Cell 18(8):2828-37. Epub 2007 May 16. 2007
|
| 44 | RAB3IP, RAB8A
|
| Purification and functional properties of a Rab8-specific GEF (Rabin3) in action remodeling and polarized transport.
|
| Hattula K, Peränen J.
|
| Methods Enzymol 403:284-95.
2005
|
| 45 | RAB3IP, RAB8A, RAB8B
|
| A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.
|
| Hattula K, Furuhjelm J, Arffman A, Peränen J.
|
| Mol Biol Cell 13(9):3268-80.
2002
|
| 46 | RAB1A, RAB4A, RAB5B, RAB7A, RAB8A, RAB13
|
| Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.
|
| Bao S, et al.
|
| Horm Metab Res 30(11):656-62. 1998
|
| 47 | RAB8A, MTENC1
|
| Identification of a mutation in the mitochondrial tRNACys gene associated with mitochondrial encephalopathy.
|
| Manfredi G, et al.
|
| Hum Mutat 7 : 158-163. 1996
|
| 48 | RAB8A, MMEL1
|
| Physical mapping of a cluster of RAB genes at human chromosome 19p13.1-13.2.
|
| Nimmo E, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 2022. 1991
|
| 49 | RAB8A
|
| The MEL gene : a new member of the RAB/YPT class of RAS-related genes.
|
| Nimmo ER, et al.
|
| Oncogene 6 : 1347-1351. 1991
|
| 50 | RAB8A
|
| Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping.
|
| Nimmo E, et al.
|
| Hum Genet 81 : 382-384. 1989
|
| 51 | RAB8A
|
| Localization of the c-MEL gene to 19(cen-p13.2).
|
| Nimmo E, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1053. 1989
|
| 52 | RAB8A
|
| A cDNA probe for the oncogene c-Mel (pC7-1) recognises a polymorphism with NcoI.
|
| Nimmo ER, et al.
|
| Nucleic Acids Res 15 : 3940. 1987
|
| 53 | RAB8A
|
| Chromosomal assignment of c-MEL, a human transforming oncogene, to chromosome 19 (p13.2-q13.2).
|
| Spurr NK, et al.
|
| Somat Cell Mol Genet 12 : 637-640. 1986
|