Citations for
1GIT2, PXN, RUSC2
EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
Duan B, Cui J, Sun S, Zheng J, Zhang Y, Ye B, Chen Y, Deng W, Du J, Zhu Y, Chen Y, Gu L.
Cancer Lett 379(1):70-83. doi: 10.1016/j.canlet.2016.05.027. 2016
2PTK2, PXN, RACGAP1, RHOA
RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088. 2015
3PXN
Paxillin is an intrinsic negative regulator of platelet activation in mice.
Sakata A, Ohmori T, Nishimura S, Suzuki H, Madoiwa S, Mimuro J, Kario K, Sakata Y.
Thromb J 12(1):1. doi: 10.1186/1477-9560-12-1. 2014
4NRP2, PXN
Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.
German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A.
J Cell Sci 127(Pt 8):1672-83. doi: 10.1242/jcs.132316. Epub 2014 Feb 12. 2014
5PTK2B, PTPN12, PXN
Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12.
Rhee I, Davidson D, Souza CM, Vacher J, Veillette A.
Mol Cell Biol 33(12):2458-69. doi: 10.1128/MCB.00197-13. Epub 2013 Apr 15. 2013
6PXN, SLK
SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration.
Quizi JL, Baron K, Al-Zahrani KN, O'Reilly P, Sriram RK, Conway J, Laurin AA, Sabourin LA.
Oncogene 32(39):4656-63. doi: 10.1038/onc.2012.488. Epub 2012 Nov 5. 2013
7PXN
Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer.
Kawada I, Hasina R, Lennon FE, Bindokas VP, Usatyuk P, Tan YH, Krishnaswamy S, Arif Q, Carey G, Hseu RD, Robinson M, Tretiakova M, Brand TM, Iida M, Ferguson MK, Wheeler DL, Husain AN, Natarajan V, Vokes EE, Singleton PA, Salgia R.
Cancer Biol Ther 14(7):679-91. doi: 10.4161/cbt.25091. Epub 2013 May 31. 2013
8PXN
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC.
PLoS One 8(8):e69378. doi: 10.1371/journal.pone.0069378. eCollection 2013. 2013
9PXN
Paxillin controls directional cell motility in response to physical cues.
Sero JE, German AE, Mammoto A, Ingber DE.
Cell Adh Migr 6(6):502-8. doi: 10.4161/cam.21672. Epub 2012 Oct 17. 2012
10PXN
Paxillin controls directional cell motility in response to physical cues.
Sero JE, German AE, Mammoto A, Ingber DE.
Cell Adh Migr 6(6):502-8. doi: 10.4161/cam.21672. Epub 2012 Oct 17. 2012
11PXN
Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension.
Veith C, Marsh LM, Wygrecka M, Rutschmann K, Seeger W, Weissmann N, Kwapiszewska G.
Am J Pathol 181(5):1621-33. doi: 10.1016/j.ajpath.2012.07.026. Epub 2012 Sep 6. 2012
12MAPK14, PXN
Paxillin phosphorylation by JNK and p38 is required for NFAT activation.
Lee YC, Chang AY, Lin-Feng MH, Tsou WI, Chiang IH, Lai MZ.
Eur J Immunol 42(8):2165-75. doi: 10.1002/eji.201142192. 2012
13MAPK8, PXN
Paxillin is the target of c-Jun N-terminal kinase in Schwann cells and regulates migration.
Miyamoto Y, Torii T, Yamamori N, Eguchi T, Nagao M, Nakamura K, Tanoue A, Yamauchi J.
Cell Signal 24(11):2061-9. doi: 10.1016/j.cellsig.2012.06.013. Epub 2012 Jun 30. 2012
14PXN
Identification of paxillin domains interacting with β-catenin.
Dubrovskyi O, Tian X, Poroyko V, Yakubov B, Birukova AA, Birukov KG.
FEBS Lett 586(16):2294-9. doi: 10.1016/j.febslet.2012.06.016. Epub 2012 Jun 20. 2012
15PXN, TGFB1I1
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA.
Deakin NO, Ballestrem C, Turner CE.
PLoS One 7(5):e37990. doi: 10.1371/journal.pone.0037990. Epub 2012 May 22. 2012
16KCNA10, ODF2, PXN
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.
Carlisle FA, Steel KP, Lewis MA.
Gene Expr Patterns 12(5-6):172-9. doi: 10.1016/j.gep.2012.03.001. Epub 2012 Mar 16. 2012
17PXN
Role of paxillin in the early phase of orientation of the vascular endothelial cells exposed to cyclic stretching.
Huang W, Sakamoto N, Miyazawa R, Sato M.
Biochem Biophys Res Commun 418(4):708-13. doi: 10.1016/j.bbrc.2012.01.083. Epub 2012 Jan 24. 2012
18GPLD1, PXN
Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells.
Pribic J, Brazill D.
Cell Signal 24(8):1531-40. doi: 10.1016/j.cellsig.2012.03.015. Epub 2012 Mar 28. 2012
19GIT1, PRKD3, PXN
GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity.
Huck B, Kemkemer R, Franz-Wachtel M, Macek B, Hausser A, Olayioye MA.
J Biol Chem 287(41):34604-13. doi: 10.1074/jbc.M112.374652. Epub 2012 Aug 13. 2012
20PXN
Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation.
Robertson LK, Ostergaard HL.
J Immunol 187(11):5824-33. doi: 10.4049/jimmunol.1003690. Epub 2011 Oct 31. 2011
21PXN
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.
Wade R, Brimer N, Lyons C, Vande Pol S.
J Biol Chem 286(44):37932-44. doi: 10.1074/jbc.M111.294504. Epub 2011 Sep 7. 2011
22LPXN, PXN
LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
Tanaka T, Moriwaki K, Murata S, Miyasaka M.
Cancer Sci 101(2):363-8. Epub 2009 Oct 12. 2010
23PXN, RPS27
Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth.
Dai Y, Pierson SE, Dudney WC, Stack BC Jr.
Int J Cancer 126(3):611-9. 2010
24PTPRT, PXN
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, Wang Z.
Proc Natl Acad Sci U S A 107(6):2592-7. Epub 2010 Jan 21.PMID: 20133777 2010
25CYTH2, PXN
Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.
Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A.
J Biol Chem 285(31):24270-81. Epub 2010 Jun 4. 2010
26GIT2, PXN
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration.
Yu JA, Deakin NO, Turner CE.
Cell Adh Migr 4(3):342-7. 2010
27PXN
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation.
Dong JM, Lau LS, Ng YW, Lim L, Manser E.
Biochem J 418(1):173-84. Erratum in: Biochem J. 2009 Mar 15;418(3):717. 2009
28PXN
Fibronectin promotes tyrosine phosphorylation of paxillin and cell invasiveness in the gastric cancer cell line AGS.
Li D, Ding J, Wang X, Wang C, Wu T.
Tumori 95(6):769-79. 2009
29IL8, PXN
Cell migration to the chemokine CXCL8: paxillin is activated and regulates adhesion and cell motility.
Cohen-Hillel E, Mintz R, Meshel T, Garty BZ, Ben-Baruch A.
Cell Mol Life Sci 66(5):884-99. 2009
30PXN
Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF.
Birukova AA, Cokic I, Moldobaeva N, Birukov KG.
Am J Respir Cell Mol Biol 40(1):99-107. Epub 2008 Jul 29. 2009
31PXN, GIT1
GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs.
Zhang ZM, Simmerman JA, Guibao CD, Zheng JJ.
J Biol Chem 283(27):18685-93. Epub 2008 Apr 30. 2008
32PXN
Paxillin localisation in osteocytes--is it determined by the direction of loading?
Vatsa A, Semeins CM, Smit TH, Klein-Nulend J.
Biochem Biophys Res Commun 377(4):1019-24. Epub 2008 Jan 8. 2008
33PXN
JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.
Huang Z, Yan DP, Ge BX.
Cell Signal 20(11):2002-12. Epub 2008 Jul 31. 2008
34PXN, LPXN
Leupaxin negatively regulates B cell receptor signaling.
Chew V, Lam KP.
J Biol Chem 282(37):27181-91. Epub 2007 Jul 19. 2007
35RACK1, PXN
RACK1 regulates Src activity and modulates paxillin dynamics during cell migration.
Doan AT, Huttenlocher A.
Exp Cell Res 313(12):2667-79. Epub 2007 May 18. 2007
36PXN, CMT4J
Periaxin mutation in Japanese patients with Charcot-Marie-Tooth disease.
Otagiri T, Sugai K, Kijima K, Arai H, Sawaishi Y, Shimohata M, Hayasaka K.
J Hum Genet 51(7):625-8. Epub 2006 Jun 13. 2006
37PTPN12, PXN
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.
Jamieson JS, Tumbarello DA, Halle M, Brown MC, Tremblay ML, Turner CE.
J Cell Sci 118(Pt 24):5835-47. Epub 2005 Nov 29. 2005
38PXN
JNK phosphorylates paxillin and regulates cell migration.
Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K.
Nature 424(6945):219-23. 2003
39NF2, PXN, SCHIP1
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.
Fernandez-Valle C, Tang Y, Ricard J, Rodenas-Ruano A, Taylor A, Hackler E, Biggerstaff J, Iacovelli J.
Nat Genet 31(4):354-62. 2002
40NUDT16L1, PXN, SDC4
Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.
Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, Neveu W, Goetinck PF.
J Biol Chem 277(14):12270-4. Epub 2002 Jan 22. 2002
41PXN
Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.
Herreros L, Rodriguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabanas C, Sanchez-Madrid F, Longo N, Turner CE, Sanchez-Mateos P.
J Biol Chem 275(34):26436-40. 2000
42PXN
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
Salgia R, et al.
J Biol Chem 270 : 5039-5047. 1995