| 1 | NECTIN2, PVR, TIGIT
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| Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.
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| Samanta D, Guo H, Rubinstein R, Ramagopal UA, Almo SC.
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| Mol Immunol 81:151-159. doi: 10.1016/j.molimm.2016.12.003.
2017
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| 2 | CD226, CD96, PVR, TIGIT
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| Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.
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| Lenac Rovis T, Kucan Brlic P, Kaynan N, Juranic Lisnic V, Brizic I, Jordan S, Tomic A, Kvestak D, Babic M, Tsukerman P, Colonna M, Koszinowski U, Messerle M, Mandelboim O, Krmpotic A, Jonjic S.
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| J Exp Med 213(9):1835-50. doi: 10.1084/jem.20151899.
2016
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| 3 | ARRB2, INPP5D, PVR, TIGIT
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| T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling.
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| Li M, Xia P, Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li P, Yang X, Fan Z.
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| J Biol Chem 289(25):17647-57. doi: 10.1074/jbc.M114.572420.
2014
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| 4 | PVR, TIGIT
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| TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk.
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| Bi J, Zheng X, Chen Y, Wei H, Sun R, Tian Z.
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| Hepatology 60(4):1389-98. doi: 10.1002/hep.27245.
2014
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| 5 | NECTIN2, PVR, TIGIT
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| Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR.
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| Stanietsky N, Rovis TL, Glasner A, Seidel E, Tsukerman P, Yamin R, Enk J, Jonjic S, Mandelboim O.
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| Eur J Immunol 43(8):2138-50. doi: 10.1002/eji.201243072.
2013
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| 6 | INPP5D, PVR, TIGIT
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| Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.
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| Liu S, Zhang H, Li M, Hu D, Li C, Ge B, Jin B, Fan Z.
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| Cell Death Differ 20(3):456-64. doi: 10.1038/cdd.2012.141.
2013
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| 7 | CD226, PVR, TIGIT
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| The TIGIT/CD226 Axis Regulates Human T Cell Function.
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| Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA.
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| J Immunol Immunol. 2012 Mar 16. [Epub ahead of print]
2012
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| 8 | PVR, TIGIT
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| Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.
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| Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.
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| Proc Natl Acad Sci U S A 109(14):5399-404. doi: 10.1073/pnas.1120606109.
2012
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| 9 | PVR
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| CD155 on human vascular endothelial cells attenuates the acquisition of effector functions in CD8 T cells.
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| Escalante NK, von Rossum A, Lee M, Choy JC.
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| Arterioscler Thromb Vasc Biol 31(5):1177-84. Epub 2011 Feb 17.
2011
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| 10 | CD226, PVR
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| DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases.
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| Chan CJ, Andrews DM, McLaughlin NM, Yagita H, Gilfillan S, Colonna M, Smyth MJ.
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| J Immunol 184(2):902-11. Epub 2009 Dec 11.
2010
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| 11 | PVR
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| Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma.
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| Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Satoh N, Ogita H, Takai Y, Hayashi Y.
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| Cancer Sci 101(5):1326-30. Epub 2010 Feb 11.
2010
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| 12 | CD96, PVR
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| CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains.
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| Meyer D, Seth S, Albrecht J, Maier MK, du Pasquier L, Ravens I, Dreyer L, Burger R, Gramatzki M, Schwinzer R, Kremmer E, Foerster R, Bernhardt G.
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| J Biol Chem 284(4):2235-44. Epub 2008 Dec 4.
2009
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| 13 | NECTIN2, NECTIN3, PVR, TIGIT
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| The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
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| Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O.
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| Proc Natl Acad Sci U S A 106(42):17858-63. Epub 2009 Oct 7.PMID: 19815499 2009
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| 14 | PVR
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| The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells.
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| Kono T, Imai Y, Yasuda S, Ohmori K, Fukui H, Ichikawa K, Tomita S, Imura J, Kuroda Y, Ueda Y, Fujimori T.
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| Int J Cancer 122(2):317-24.
2008
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| 15 | PVR
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| Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.
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| Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG.
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| Proc Natl Acad Sci U S A 105(47):18284-9. Epub 2008 Nov 14.
2008
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| 16 | CD226, PVR
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| Expression and possible role of PVR/CD155/Necl-5 in osteoclastogenesis.
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| Kakehi S, Nakahama K, Morita I.
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| Mol Cell Biochem 301(1-2):209-17. Epub 2007 Feb 8. 2007
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| 17 | NECTIN2, PVR
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| Linkage disequilibrium analysis of two genes mapping on OFC3: PVR and PVRL2.
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| Pezzetti F, Palmieri A, Martinelli M, Scapoli L, Arlotti M, Baciliero U, Padula E, Carinci P, Caramelli E, Carinci F.
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| Eur J Hum Genet 15(9):992-4. Epub 2007 May 30.PMID: 17534374 2007
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| 18 | NECTIN1, NECTIN2, PVR
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| Genetic evidence for the role of loci at 19q13 in cleft lip and palate.
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| Warrington A, Vieira AR, Christensen K, Orioli IM, Castilla EE, Romitti PA, Murray JC.
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| J Med Genet 43(6):e26.PMID: 16740910 2006
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| 19 | PVR
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| Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
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| Tomasec P, Wang EC, Davison AJ, Vojtesek B, Armstrong M, Griffin C, McSharry BP, Morris RJ, Llewellyn-Lacey S, Rickards C, Nomoto A, Sinzger C, Wilkinson GW.
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| Nat Immunol 6(2):181-8. Epub 2005 Jan 9.
2005
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| 20 | NECTIN3, PVR
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| Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.
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| Fujito T, Ikeda W, Kakunaga S, Minami Y, Kajita M, Sakamoto Y, Monden M, Takai Y.
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| J Cell Biol 171(1):165-73.PMID: 16216929 2005
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| 21 | CD226, NECTIN2, PVR
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| Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
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| Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A.
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| Int Immunol 16(4):533-8. 2004
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| 22 | PVR
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| Identification of secreted CD155 isoforms.
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| Baury B, Masson D, McDermott BM Jr, Jarry A, Blottiere HM, Blanchardie P, Laboisse CL, Lustenberger P, Racaniello VR, Denis MG.
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| Biochem Biophys Res Commun 309(1):175-82. 2003
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| 23 | NECTIN3, PVR
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| Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.
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| Mueller S, Wimmer E.
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| J Biol Chem 278(33):31251-60. Epub 2003 May 19.PMID: 12759359 2003
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| 24 | PVR
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| Identification of a nuclear respiratory factor-1 binding site within the core promoter of the human polio virus receptor/CD155 gene.
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| Solecki D, Bernhardt G, Lipp M, Wimmer E.
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| J Biol Chem 275(17):12453-62. 2000
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| 25 | PVR
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| The poliovirus sensitivity (PVS) gene is on chromosome 19q12-q13.2.
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| Siddique T, et al.
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| Genomics 3 : 156-160. 1988
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| 26 | CXB3S, E11S, PVR
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| Echovirus 6, 11, 19; coxsackievirus B3 sensitivities and poliovirus I, II, III sensitivities are on chromosome 19 respectively on 19pter-q133 and 19q131-133.
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| Couillin P, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 599. 1987
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| 27 | DM1, D19S7, BCAM, MSK37, PVR
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| Further mapping of markers around the centromere of human chromosome 19.
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| Brook JD, et al.
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| Genomics 1 : 320-328. 1987
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| 28 | PVR
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| Human chromosome 19 carries a poliovirus receptor gene.
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| Miller DA, et al.
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| Cell 1 : 167. 1974
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