| 1 | LCK, PTPRC
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| Membrane-cytoskeleton interactions in cholesterol-dependent domain formation.
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| Byrum JN, Rodgers W.
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| Essays Biochem 57:177-87. doi: 10.1042/bse0570177. Review.
2015
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| 2 | INPP5D, PTPRC, SLAMF7
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| Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.
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| Guo H, Cruz-Munoz ME, Wu N, Robbins M, Veillette A.
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| Mol Cell Biol 35(1):41-51. doi: 10.1128/MCB.01107-14. Epub 2014 Oct 13.
2015
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| 3 | PTPRC
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| Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation.
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| Germena G, Volmering S, Sohlbach C, Zarbock A.
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| J Immunol 194(2):728-38. doi: 10.4049/jimmunol.1401646. Epub 2014 Dec 10.
2015
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| 4 | LCK, PTPRC
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| Phosphatase CD45 both positively and negatively regulates T cell receptor phosphorylation in reconstituted membrane protein clusters.
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| Furlan G, Minowa T, Hanagata N, Kataoka-Hamai C, Kaizuka Y.
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| J Biol Chem 289(41):28514-25. doi: 10.1074/jbc.M114.574319. Epub 2014 Aug 15.
2014
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| 5 | LCK, LGALS1, PTPRC
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| GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.
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| Novák J, Kriston-Pál É, Czibula Á, Deák M, Kovács L, Monostori É, Fajka-Boja R.
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| Mol Immunol 57(2):302-9. doi: 10.1016/j.molimm.2013.10.010. Epub 2013 Nov 12.
2014
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| 6 | PTPRC
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| Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.
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| Saunders AE, Shim YA, Johnson P.
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| J Immunol 193(6):2831-42. doi: 10.4049/jimmunol.1302681. Epub 2014 Aug 11.
2014
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| 7 | PTPRC, SLC39A10
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| Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength
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| Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin BH, Irié T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, Fukada T.
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| Proc Natl Acad Sci U S A. Aug 12;111(32):11786-91. doi: 10.1073/pnas.1323557111. Epub 2014 Jul 29. 2014
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| 8 | PTPRC, PTPRJ
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| The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor.
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| Cordoba SP, Choudhuri K, Zhang H, Bridge M, Basat AB, Dustin ML, van der Merwe PA.
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| Blood 121(21):4295-302. doi: 10.1182/blood-2012-07-442251. Epub 2013 Apr 11.
2013
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| 9 | PTPRC
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| Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
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| Caignard G, Leiva-Torres GA, Leney-Greene M, Charbonneau B, Dumaine A, Fodil-Cornu N, Pyzik M, Cingolani P, Schwartzentruber J, Dupaul-Chicoine J, Guo H, Saleh M, Veillette A, Lathrop M, Blanchette M, Majewski J, Pearson A, Vidal SM.
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| PLoS Pathog 9(9):e1003637. doi: 10.1371/journal.ppat.1003637. Epub 2013 Sep 12.
2013
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| 10 | PTPRC
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| A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation.
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| St-Pierre J, Ostergaard HL.
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| PLoS One 8(7):e71531. doi: 10.1371/journal.pone.0071531. Print 2013.
2013
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| 11 | PTPRC
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| The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.
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| Zikherman J, Parameswaran R, Hermiston M, Weiss A.
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| J Immunol 190(6):2527-35. doi: 10.4049/jimmunol.1202928. Epub 2013 Feb 8.
2013
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| 12 | PTPRC, SCIDNK
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| Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia.
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| Porcu M, Kleppe M, Gianfelici V, Geerdens E, De Keersmaecker K, Tartaglia M, Foŕ R, Soulier J, Cauwelier B, Uyttebroeck A, Macintyre E, Vandenberghe P, Asnafi V, Cools J.
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| Blood 119(19):4476-9. Epub 2012 Mar 21. 2012
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| 13 | PTPRC
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| CD45-deficient severe combined immunodeficiency caused by uniparental disomy.
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| Roberts JL, Buckley RH, Luo B, Pei J, Lapidus A, Peri S, Wei Q, Shin J, Parrott RE, Dunbrack RL Jr, Testa JR, Zhong XP, Wiest DL.
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| Proc Natl Acad Sci U S A 109(26):10456-61. doi: 10.1073/pnas.1202249109. Epub 2012 Jun 11.
2012
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| 14 | PTPRC
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| PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy.
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| Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM; BRAGGSS.
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| Arthritis Rheum rthritis Rheum. 2010 Mar 22. [Epub ahead of print]PMID: 20309874 2010
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| 15 | GRB2, PLD2, PTPRC
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| PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.
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| Henkels KM, Short S, Peng HJ, Di Fulvio M, Gomez-Cambronero J.
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| Biochem Biophys Res Commun 389(2):224-8. Epub 2009 Aug 26.PMID: 19715678 2009
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| 16 | DOK1, PTPRC
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| CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.
|
| Wu L, Bijian K, Shen SH.
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| Mol Immunol 46(11-12):2167-77. Epub 2009 May 28. Erratum in: Mol Immunol. 2010 Jan;47(4):41. Shen, Shi-Shiang [corrected to Shen, Shi-Hsiang 2009
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| 17 | PTPRC
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| Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.
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| Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A.
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| Science 321(5889):686-91. Epub 2008 Jul 10.PMID: 18669861 2008
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| 18 | PTPRC
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| The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells.
|
| Kirchberger S, Majdic O, Blüml S, Schrauf C, Leitner J, Gerner C, Paster W, Gundacker N, Sibilia M, Stöckl J.
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| Blood 112(4):1240-8. Epub 2008 May 29.PMID: 18511809 2008
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| 19 | HNRNPLL, PTPRC
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| Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.
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| Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A.
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| Science 321(5889):686-91. doi: 10.1126/science.1157610. Epub 2008 Jul 10.
2008
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| 20 | PTPRC, SCIDNK
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| Disease associations and altered immune function in CD45 138G variant carriers.
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| Boxall S, Stanton T, Hirai K, Ward V, Yasui T, Tahara H, Tamori A, Nishiguchi S, Shiomi S, Ishiko O, Inaba M, Nishizawa Y, Dawes R, Bodmer W, Beverley PC, Tchilian EZ.
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| Hum Mol Genet 13(20):2377-84. Epub 2004 Aug 27. 2004
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| 21 | PRF1, PTPRC
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| Novel perforin mutation in a patient with hemophagocytic lymphohistiocytosis and CD45 abnormal splicing.
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| McCormick J, Flower DR, Strobel S, Wallace DL, Beverley PC, Tchilian EZ.
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| Am J Med Genet 117A(3):255-60. 2003
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| 22 | PTPRC
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| A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule.
|
| Jacobsen M, Hoffmann S, Cepok S, Stei S, Ziegler A, Sommer N, Hemmer B.
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| Immunogenetics 54(3):158-63. Epub 2002 Apr 27. 2002
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| 23 | PTPRC
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| Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms.
|
| Xu Z, Weiss A.
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| Nat Immunol 3(8):764-71. Epub 2002 Jul 22.PMID: 12134145 2002
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| 24 | PTPRC
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| CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
|
| Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM.
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| Nature 409(6818):349-54. 2001
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| 25 | PTPRC
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| A deletion in the gene encoding the CD45 antigen in a patient with SCID.
|
| Tchilian EZ, Wallace DL, Wells RS, Flower DR, Morgan G, Beverley PC.
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| J Immunol 166(2):1308-13. 2001
|
| 26 | PTPRC
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| Structural and functional analysis of the human CD45 gene (PTPRC) upstream region: evidence for a functional promoter within the first intron of the gene.
|
| Timon M, Beverley PC.
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| Immunology 102(2):180-9. 2001
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| 27 | PTPRC
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| The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
|
| Tchilian EZ, Wallace DL, Imami N, Liao HX, Burton C, Gotch F, Martinson J, Haynes BF, Beverley PC.
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| J Immunol 166(10):6144-8. 2001
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| 28 | PTPRC
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| Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease.
|
| Kung C, Pingel JT, Heikinheimo M, Klemola T, Varkila K, Yoo LI, Vuopala K, Poyhonen M, Uhari M, Rogers M, Speck SH, Chatila T, Thomas ML.
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| Nat Med 6(3):343-5. 2000
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| 29 | PTPRC
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| A point mutation in PTPRC is associated with the development of multiple sclerosis.
|
| Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, Wonigeit K, Lindert RB, Kantarci O, Schaefer-Klein J, Schipper HI, Oertel WH, Heidenreich F, Weinshenker BG, Sommer N, Hemmer B.
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| Nat Genet 26(4):495-9. 2000
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| 30 | PTPRC
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| Protein tyrosine phosphatase receptor type C polypeptide (PTPRC) on human chromosome band 1q31-->q32 localizes with marker D1S413(1) on a 610-kb yeast artificial chromosome.
|
| Goff LK, van Soest S, Timon M, Tchilian E, Beverley PC.
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| Cytogenet Cell Genet 87(3-4):223-224. 1999
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| 31 | PTPRC
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| A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.
|
| Zanke B, et al.
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| Leukemia 8 : 236-244. 1994
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| 32 | REN, PTPRC, LAMC1, APOA2, SPTA1
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| Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q.
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| Seldin MF, Morse HC, LeBoeuf RC, Steinberg AD.
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| Genomics 2(1):48-56. 1988
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| 33 | ITGAL, PTPRC, ITGB2
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| Chromosomal assignments of genes coding for human leucocyte common antigen, T-200, and lymphocyte function-associated antigen 1, LFA-1 beta subunit.
|
| Akao Y, et al.
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| Somat Cell Mol Genet 13 : 273-278. 1987
|