| 1 | PTPN6, RAP1B
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| The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
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| Kumar S, Xu J, Kumar RS, Lakshmikanthan S, Kapur R, Kofron M, Chrzanowska-Wodnicka M, Filippi MD.
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| J Exp Med 211(9):1741-58. doi: 10.1084/jem.20131706. Epub 2014 Aug 4.
2014
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| 2 | CD40, PTPN6
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| SHP-1 plays a crucial role in CD40 signaling reciprocity.
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| Khan TH, Srivastava N, Srivastava A, Sareen A, Mathur RK, Chande AG, Musti KV, Roy S, Mukhopadhyaya R, Saha B.
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| J Immunol 193(7):3644-53. doi: 10.4049/jimmunol.1400620. Epub 2014 Sep 3.
2014
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| 3 | IL4, PTPN6
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| Shp1 regulates T cell homeostasis by limiting IL-4 signals.
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| Johnson DJ, Pao LI, Dhanji S, Murakami K, Ohashi PS, Neel BG.
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| J Exp Med 210(7):1419-31.
2013
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| 4 | PTPN6
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| SHP-1 phosphatase is a critical regulator in preventing natural killer cell self-killing.
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| Mahmood S, Kanwar N, Tran J, Zhang ML, Kung SK.
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| PLoS One 7(8):e44244. doi: 10.1371/journal.pone.0044244. Epub 2012 Aug 31.
2012
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| 5 | PTPN6
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| The protein tyrosine phosphatase SHP-1 regulates phagolysosome biogenesis.
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| Gómez CP, Tiemi Shio M, Duplay P, Olivier M, Descoteaux A.
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| J Immunol 189(5):2203-10. doi: 10.4049/jimmunol.1103021. Epub 2012 Jul 23.
2012
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| 6 | PTPN6
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| Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
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| Kaneko T, Saito Y, Kotani T, Okazawa H, Iwamura H, Sato-Hashimoto M, Kanazawa Y, Takahashi S, Hiromura K, Kusakari S, Kaneko Y, Murata Y, Ohnishi H, Nojima Y, Takagishi K, Matozaki T.
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| J Immunol 188(11):5397-407. doi: 10.4049/jimmunol.1103210. Epub 2012 Apr 25.
2012
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| 7 | PTPN6
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| Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.
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| Kumagai C, Kalman B, Middleton FA, Vyshkina T, Massa PT.
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| J Neuroimmunol 246(1-2):51-7. doi: 10.1016/j.jneuroim.2012.03.003. Epub 2012 Mar 27.
2012
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| 8 | PTPN11, PTPN6, SIGLEC12
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| SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
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| Mitra N, Banda K, Altheide TK, Schaffer L, Johnson-Pais TL, Beuten J, Leach RJ, Angata T, Varki N, Varki A.
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| J Biol Chem 286(26):23003-11. Epub 2011 May 9. 2011
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| 9 | PTPN6, SH3BP2
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| Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells.
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| Chihara K, Nakashima K, Takeuchi K, Sada K.
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| Genes Cells 16(12):1133-45. doi: 10.1111/j.1365-2443.2011.01557.x. Epub 2011 Nov 13.
2011
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| 10 | PTPN6
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| Inhibition of the protein tyrosine phosphatase SHP-1 increases glucose uptake in skeletal muscle cells by augmenting insulin receptor signaling and GLUT4 expression.
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| Bergeron S, Dubois MJ, Bellmann K, Schwab M, Larochelle N, Nalbantoglu J, Marette A.
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| Endocrinology 152(12):4581-8. doi: 10.1210/en.2011-1268. Epub 2011 Sep 27.
2011
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| 11 | PTPN6
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| Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses.
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| Nesterovitch AB, Gyorfy Z, Hoffman MD, Moore EC, Elbuluk N, Tryniszewska B, Rauch TA, Simon M, Kang S, Fisher GJ, Mikecz K, Tharp MD, Glant TT.
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| Am J Pathol 178(4):1434-41. doi: 10.1016/j.ajpath.2010.12.035. Epub 2011 Mar 4.
2011
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| 12 | PTPN6
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| The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
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| Ramachandran IR, Song W, Lapteva N, Seethammagari M, Slawin KM, Spencer DM, Levitt JM.
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| J Immunol 186(7):3934-45. doi: 10.4049/jimmunol.1001675. Epub 2011 Feb 25.
2011
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| 13 | PTPN6
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| SHP-1 in cell-cycle regulation.
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| López-Ruiz P, Rodriguez-Ubreva J, Cariaga AE, Cortes MA, Colás B.
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| Anticancer Agents Med Chem 11(1):89-98. Review.
2011
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| 14 | PTPN6
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| SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.
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| Simoneau M, Coulombe G, Vandal G, Vézina A, Rivard N.
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| Cell Signal 23(1):269-79. doi: 10.1016/j.cellsig.2010.09.011. Epub 2010 Sep 16.
2011
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| 15 | PKNOX1, PTPN6
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| Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.
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| Oriente F, Iovino S, Cabaro S, Cassese A, Longobardi E, Miele C, Ungaro P, Formisano P, Blasi F, Beguinot F.
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| Diabetes 60(1):138-47. doi: 10.2337/db10-0860. Epub 2010 Sep 23.
2011
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| 16 | PTPN6
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| The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system.
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| Lodeiro M, Alén BO, Mosteiro CS, Beiroa D, Nogueiras R, Theodoropoulou M, Pardo M, Gallego R, Pazos Y, Casanueva FF, Camińa JP.
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| Mol Biol Cell 22(21):4182-91. doi: 10.1091/mbc.E11-04-0373. Epub 2011 Sep 7.
2011
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| 17 | PLCB3, PTPN6, STAT5B
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| Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.
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| Yasudo H, Ando T, Xiao W, Kawakami Y, Kawakami T.
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| PLoS One 6(9):e24995. doi: 10.1371/journal.pone.0024995. Epub 2011 Sep 20.
2011
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| 18 | PTPN6
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| The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress.
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| Jang MK, Kim SH, Lee KY, Kim TB, Moon KA, Park CS, Bae YJ, Zhu Z, Moon HB, Cho YS.
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| Biochem Biophys Res Commun 393(1):137-43. Epub 2010 Feb 1.
2010
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| 19 | NFAT5, PLCG1, PTPN6
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| Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP.
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| Zhou X, Gallazzini M, Burg MB, Ferraris JD.
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| Proc Natl Acad Sci U S A 107(15):7072-7. Epub 2010 Mar 29.PMID: 20351292 2010
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| 20 | LYN, PLCB3, PTPN6, STAT5B
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| Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.
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| Xiao W, Ando T, Wang HY, Kawakami Y, Kawakami T.
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| Blood 116(26):6003-13. doi: 10.1182/blood-2010-05-283937. Epub 2010 Sep 21.
2010
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| 21 | GAB2, LYN, PTPN6, TNFRSF11A
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| The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.
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| Kim HJ, Zhang K, Zhang L, Ross FP, Teitelbaum SL, Faccio R.
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| Proc Natl Acad Sci U S A 106(7):2325-30. Epub 2009 Jan 26.
2009
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| 22 | IL10, PTPN6
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| IL-10 suppresses CD2-mediated T cell activation via SHP-1.
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| Taylor A, Verhagen J, Akkoç T, Wenig R, Flory E, Blaser K, Akdis M, Akdis CA.
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| Mol Immunol 46(4):622-9. Epub 2008 Oct 25.
2009
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| 23 | PTPN6, SIGLEC9
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| Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.
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| Rashmi R, Bode BP, Panesar N, King SB, Rudloff JR, Gartner MR, Koenig JM.
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| Pediatr Res 66(3):266-71. doi: 10.1203/PDR.0b013e3181b1bc19.
2009
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| 24 | PTPN6
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| SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
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| Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT.
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| Lab Invest 88(3):243-55. Epub 2008 Jan 21.
2008
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| 25 | PTPN6, TIMP1
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| TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation.
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| Kim YS, Seo DW, Kong SK, Lee JH, Lee ES, Stetler-Stevenson M, Stetler-Stevenson WG.
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| Cancer Lett 269(1):37-45. Epub 2008 May 23.
2008
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| 26 | PTPN6
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| Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
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| An H, Hou J, Zhou J, Zhao W, Xu H, Zheng Y, Yu Y, Liu S, Cao X.
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| Nat Immunol 9(5):542-50. Epub 2008 Apr 6.PMID: 18391954 2008
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| 27 | PTPN6
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| Identification of a novel lipid raft-targeting motif in Src homology 2-containing phosphatase 1.
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| Sankarshanan M, Ma Z, Iype T, Lorenz U.
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| J Immunol 179(1):483-90.
2007
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| 28 | PTPN6
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| Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
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| Seo DW, Li H, Qu CK, Oh J, Kim YS, Diaz T, Wei B, Han JW, Stetler-Stevenson WG.
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| J Biol Chem 281(6):3711-21. Epub 2005 Dec 2. 2006
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| 29 | PTPN6
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| The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
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| Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A.
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| Nat Med 12(5):549-56. Epub 2006 Apr 16. 2006
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| 30 | HDAC1, STAT3, PTPN6, DNMT1
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| STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
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| Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA.
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| Proc Natl Acad Sci U S A 102(19):6948-53. Epub 2005 May 3. 2005
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| 31 | PTPN6, TFG
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| Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein.
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| Roccato E, Miranda C, Raho G, Pagliardini S, Pierotti MA, Greco A.
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| J Biol Chem 280(5):3382-9. Epub 2004 Nov 22.
2005
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| 32 | INPP5D, PTPN11, PTPN6
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| Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils.
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| Daigle I, Yousefi S, Colonna M, Green DR, Simon HU.
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| Nat Med 8(1):61-7. 2002
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| 33 | PTPN6
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| Molecular mechanisms underlying SHP-1 gene expression.
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| Tsui HW, Hasselblatt K, Martin A, Mok SC, Tsui FW.
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| Eur J Biochem 269(12):3057-64. 2002
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| 34 | PTPN6
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| Identification of polymorphisms in the human SHP1 gene.
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| Cao H, Hegele RA.
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| J Hum Genet 47(8):445-7. 2002
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| 35 | SIGLEC10, PTPN6
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| Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.
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| Kitzig F, Martinez-Barriocanal A, Lopez-Botet M, Sayos J.
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| Biochem Biophys Res Commun 296(2):355-62. 2002
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| 36 | PTPN6
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| Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
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| Oka T, Ouchida M, Koyama M, Ogama Y, Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, Kondo E, Takahashi K, Tsuchiyama J, Tanimoto M, Shimizu K, Akagi T.
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| Cancer Res 62(22):6390-4. 2002
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| 37 | LAIR1, PTPN6
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| Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells.
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| Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ.
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| J Immunol 166(3):1763-70. 2001
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| 38 | PTPN6
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| A functional nuclear localization sequence in the C-terminal domain of SHP-1.
|
| Craggs G, Kellie S.
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| J Biol Chem 276(26):23719-25. 2001
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| 39 | PTPN6
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| RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia
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| Beghini A, Ripamonti CB, Peterlongo P, Roversi G, Cairoli R, Morra E, Larizza L.
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| Hum Mol Genet 9(15):2297-304. 2000
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| 40 | LAIR1, PTPN6
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| Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.
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| Xu Mj, Zhao R, Zhao ZJ.
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| J Biol Chem 275(23):17440-6. 2000
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| 41 | PTPN11, PTPN6
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| SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome).
|
| Tidow N, et al.
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| Exp Hematol 27(6):1038-45. 1999
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| 42 | PTPN6
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| An intragenic deletion in the human PTPN6 gene affects transcriptional activity.
|
| Nehls M, et al.
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| Hum Genet 95 : 713-715. 1995
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| 43 | PTPN6
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| Human protein tyrosine phosphatase 1C (PTPN6) gene structure : alternate promoter usage and exon skipping generate mutliple transcripts.
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| Banville D, et al.
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| Genomics 27 : 165-173. 1995
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| 44 | CSF2RB, PTPN6
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| Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.
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| Yi T, Mui AL, Krystal G, Ihle JN.
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| Mol Cell Biol 13(12):7577-86. 1993
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| 45 | KIT, PTPN6
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| Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.
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| Yi T, Ihle JN.
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| Mol Cell Biol 13(6):3350-8. 1993
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| 46 | PTPN6
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| Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
|
| Plutzky J, et al.
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| Genomics 13 : 869-872. 1992
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| 47 | PTPN6
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| Isolation of a novel SRC homology 2 (SH2) containing tyrosine phosphatase.
|
| Plutzky J, et al.
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| Proc Natl Acad Sci U S A 89 : 1123-1127. 1992
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| 48 | PTPN6
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| Protein tyrosine phosphatase containing SH2 domains : characterization, preferential expression in hemopoietic cells, and localization to human chromosome 12p12-p13.
|
| Yi T, et al.
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| Mol Cell Biol 12 : 836-846. 1992
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| 49 | PTPN6
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| A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein tyrosine kinases.
|
| Shen SH, et al.
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| Nature 352 : 736-739. 1991
|