| 1 | PTPN2
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| PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis.
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| Spalinger MR, Kasper S, Chassard C, Raselli T, Frey-Wagner I, Gottier C, Lang S, Atrott K, Vavricka SR, Mair F, Becher B, Lacroix C, Fried M, Rogler G, Scharl M.
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| Mucosal Immunol 8(4):918-29. doi: 10.1038/mi.2014.122. Epub 2014 Dec 10.
2015
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| 2 | PTPN1, PTPN2
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| Differential regulation of FGFR3 by PTPN1 and PTPN2.
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| St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
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| Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17.
2015
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| 3 | FGFR3, PTPN1, PTPN2
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| Differential regulation of FGFR3 by PTPN1 and PTPN2.
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| St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
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| Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17.
2015
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| 4 | GJA1, PTPN2
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| TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication.
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| Li H, Spagnol G, Naslavsky N, Caplan S, Sorgen PL.
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| J Cell Sci 127(Pt 15):3269-79. doi: 10.1242/jcs.145193. Epub 2014 May 20.
2014
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| 5 | PTPN2
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| PTPN2 attenuates T-cell lymphopenia-induced proliferation.
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| Wiede F, La Gruta NL, Tiganis T.
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| Nat Commun 5:3073. doi: 10.1038/ncomms4073.
2014
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| 6 | PTPN2, STAT3, UBL4A
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| GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.
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| Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, Su F, Cai C, Jin Z, Li Z, Gong X, Zhai Y, Wang D, Jia B, Qiu Y, Tomita Y, Sung JJ, Yu J, Irwin DM, Yang X, Fu X, Chin YE, Chang Z.
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| Mol Cell 53(5):752-65. doi: 10.1016/j.molcel.2014.01.020. Epub 2014 Feb 13.
2014
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| 7 | EGFR, PTPN2, STAT3
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| TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
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| Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O'Toole SA, Daly RJ, Sutherland RL, Mitchell CA, McLean CA, Tiganis T.
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| Mol Cell Biol 33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19.
2013
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| 8 | PTPN2
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| Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function.
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| Penrose HM, Marchelletta RR, Krishnan M, McCole DF.
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| J Biol Chem 288(45):32651-62. doi: 10.1074/jbc.M113.475962. Epub 2013 Sep 10.
2013
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| 9 | PTPN2
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| Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway.
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| Muppirala M, Gupta V, Swarup G.
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| Biochim Biophys Acta 1833(5):1125-32. doi: 10.1016/j.bbamcr.2013.01.004. Epub 2013 Jan 15. Review.
2013
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| 10 | PTPN2
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| The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl.
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| Mitra A, Sasikumar K, Parthasaradhi BV, Radha V.
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| Biochim Biophys Acta 1832(1):275-84. doi: 10.1016/j.bbadis.2012.10.014. Epub 2012 Oct 31.
2013
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| 11 | PTPN2
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| Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
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| McCole DF.
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| Ann N Y Acad Sci 1257:108-14. doi: 10.1111/j.1749-6632.2012.06522.x.
2012
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| 12 | PTPN2
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| The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
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| Scharl M, Rogler G.
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| Ann N Y Acad Sci 1257:93-102. doi: 10.1111/j.1749-6632.2012.06578.x.
2012
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| 13 | JAK1, PTPN2
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| PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.
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| Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, Knoops L, Constantinescu S, Sigaux F, Meijerink JP, Vandenberghe P, Tartaglia M, Foa R, Macintyre E, Haferlach T, Cools J.
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| Blood 117(26):7090-8. Epub 2011 May 6.
2011
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| 14 | PTPN2
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| PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.
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| Morgan AR, Han DY, Huebner C, Lam WJ, Fraser AG, Ferguson LR.
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| Tissue Antigens issue Antigens. 2010 Apr 13. [Epub ahead of print]PMID: 20403149 2010
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| 15 | IFIH1, PTPN2
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| MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
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| Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL.
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| Hum Mol Genet 19(1):135-46. Epub .PMID: 19825843 2010
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| 16 | PTPN2
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| Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
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| Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J.
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| Nat Genet 42(6):530-5. Epub 2010 May 16.PMID: 20473312 2010
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| 17 | PTPN2
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| Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2.
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| Scharl M, Paul G, Weber A, Jung BC, Docherty MJ, Hausmann M, Rogler G, Barrett KE, McCole DF.
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| Gastroenterology 137(6):2030-2040.e5. Epub 2009 Oct 8.PMID: 19818778 2009
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| 18 | PTPN2
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| PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
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| Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.
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| Diabetes 58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 2009
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| 19 | CLEC16A, CTLA4, IFIH1, IL2RA, INS, MODY10, PTPN2, PTPN22
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| The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
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| Ounissi-Benkalha H, Polychronakos C.
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| Trends Mol Med 14(6):268-75. Epub 2008 May 14. 2008
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| 20 | PTPN2, TUBB6
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| A syndromic form of autosomal recessive congenital microcephaly (Jawad syndrome) maps to chromosome 18p11.22-q11.2.
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| Hassan MJ, Chishti MS, Jamal SM, Tariq M, Ahmad W.
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| Hum Genet 123(1):77-82. Epub 2007 Dec 11.PMID: 1807175 2008
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| 21 | PTPN2
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| The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling.
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| Mattila E, Auvinen K, Salmi M, Ivaska J.
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| J Cell Sci 121(Pt 21):3570-80. Epub 2008 Oct 7.PMID: 18840653 2008
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| 22 | PTPN2
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| Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER.
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| Gupta V, Swarup G.
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| J Cell Sci 119(Pt 9):1703-14. Epub 2006 Apr 4. 2006
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| 23 | PTPN2
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| Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism.
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| Dupuis M, De Jesus Ibarra-Sanchez M, Tremblay ML, Duplay P.
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| J Immunol 171(2):726-32. 2003
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| 24 | PTPN2
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| Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.
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| Pasquali C, Curchod ML, WŠlchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Van Huijsduijnen RH.
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| Mol Endocrinol 17(11):2228-39. Epub 2003 Aug 7. 2003
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| 25 | STAT1, PTPN2
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| Identification of a nuclear Stat1 protein tyrosine phosphatase.
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| ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K.
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| Mol Cell Biol 22(16):5662-8. 2002
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| 26 | PTPN2, PTPN2P1, PTPN2P2
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| Isolation and mapping of human T-cell protein tyrosine phosphatase sequences : localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes.
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| Johnson CV, et al.
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| Genomics 16 : 619-629. 1993
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| 27 | PTPN2
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| Assignment of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18.
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| Sakaguchi AY, et al.
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| Genomics 12 : 151-154. 1992
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| 28 | PTPN2
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| Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase.
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| Gebbink MFBG, et al.
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| FEBS Lett 290 : 123-130. 1991
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