Citations for
1PTPN2
PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis.
Spalinger MR, Kasper S, Chassard C, Raselli T, Frey-Wagner I, Gottier C, Lang S, Atrott K, Vavricka SR, Mair F, Becher B, Lacroix C, Fried M, Rogler G, Scharl M.
Mucosal Immunol 8(4):918-29. doi: 10.1038/mi.2014.122. Epub 2014 Dec 10. 2015
2PTPN1, PTPN2
Differential regulation of FGFR3 by PTPN1 and PTPN2.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17. 2015
3FGFR3, PTPN1, PTPN2
Differential regulation of FGFR3 by PTPN1 and PTPN2.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17. 2015
4GJA1, PTPN2
TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication.
Li H, Spagnol G, Naslavsky N, Caplan S, Sorgen PL.
J Cell Sci 127(Pt 15):3269-79. doi: 10.1242/jcs.145193. Epub 2014 May 20. 2014
5PTPN2
PTPN2 attenuates T-cell lymphopenia-induced proliferation.
Wiede F, La Gruta NL, Tiganis T.
Nat Commun 5:3073. doi: 10.1038/ncomms4073. 2014
6PTPN2, STAT3, UBL4A
GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.
Wang Y, Ning H, Ren F, Zhang Y, Rong Y, Wang Y, Su F, Cai C, Jin Z, Li Z, Gong X, Zhai Y, Wang D, Jia B, Qiu Y, Tomita Y, Sung JJ, Yu J, Irwin DM, Yang X, Fu X, Chin YE, Chang Z.
Mol Cell 53(5):752-65. doi: 10.1016/j.molcel.2014.01.020. Epub 2014 Feb 13. 2014
7EGFR, PTPN2, STAT3
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O'Toole SA, Daly RJ, Sutherland RL, Mitchell CA, McLean CA, Tiganis T.
Mol Cell Biol 33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19. 2013
8PTPN2
Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function.
Penrose HM, Marchelletta RR, Krishnan M, McCole DF.
J Biol Chem 288(45):32651-62. doi: 10.1074/jbc.M113.475962. Epub 2013 Sep 10. 2013
9PTPN2
Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway.
Muppirala M, Gupta V, Swarup G.
Biochim Biophys Acta 1833(5):1125-32. doi: 10.1016/j.bbamcr.2013.01.004. Epub 2013 Jan 15. Review. 2013
10PTPN2
The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl.
Mitra A, Sasikumar K, Parthasaradhi BV, Radha V.
Biochim Biophys Acta 1832(1):275-84. doi: 10.1016/j.bbadis.2012.10.014. Epub 2012 Oct 31. 2013
11PTPN2
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
McCole DF.
Ann N Y Acad Sci 1257:108-14. doi: 10.1111/j.1749-6632.2012.06522.x. 2012
12PTPN2
The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
Scharl M, Rogler G.
Ann N Y Acad Sci 1257:93-102. doi: 10.1111/j.1749-6632.2012.06578.x. 2012
13JAK1, PTPN2
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.
Kleppe M, Soulier J, Asnafi V, Mentens N, Hornakova T, Knoops L, Constantinescu S, Sigaux F, Meijerink JP, Vandenberghe P, Tartaglia M, Foa R, Macintyre E, Haferlach T, Cools J.
Blood 117(26):7090-8. Epub 2011 May 6. 2011
14PTPN2
PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.
Morgan AR, Han DY, Huebner C, Lam WJ, Fraser AG, Ferguson LR.
Tissue Antigens issue Antigens. 2010 Apr 13. [Epub ahead of print]PMID: 20403149 2010
15IFIH1, PTPN2
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL.
Hum Mol Genet 19(1):135-46. Epub .PMID: 19825843 2010
16PTPN2
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, Van Roosbroeck K, Ferrando AA, Langerak AW, Meijerink JP, Sigaux F, Haferlach T, Wlodarska I, Vandenberghe P, Soulier J, Cools J.
Nat Genet 42(6):530-5. Epub 2010 May 16.PMID: 20473312 2010
17PTPN2
Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2.
Scharl M, Paul G, Weber A, Jung BC, Docherty MJ, Hausmann M, Rogler G, Barrett KE, McCole DF.
Gastroenterology 137(6):2030-2040.e5. Epub 2009 Oct 8.PMID: 19818778 2009
18PTPN2
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA, Bugliani M, Marchetti P, Eizirik DL.
Diabetes 58(6):1283-91. Epub 2009 Mar 31.PMID: 19336676 2009
19CLEC16A, CTLA4, IFIH1, IL2RA, INS, MODY10, PTPN2, PTPN22
The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
Ounissi-Benkalha H, Polychronakos C.
Trends Mol Med 14(6):268-75. Epub 2008 May 14. 2008
20PTPN2, TUBB6
A syndromic form of autosomal recessive congenital microcephaly (Jawad syndrome) maps to chromosome 18p11.22-q11.2.
Hassan MJ, Chishti MS, Jamal SM, Tariq M, Ahmad W.
Hum Genet 123(1):77-82. Epub 2007 Dec 11.PMID: 1807175 2008
21PTPN2
The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling.
Mattila E, Auvinen K, Salmi M, Ivaska J.
J Cell Sci 121(Pt 21):3570-80. Epub 2008 Oct 7.PMID: 18840653 2008
22PTPN2
Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER.
Gupta V, Swarup G.
J Cell Sci 119(Pt 9):1703-14. Epub 2006 Apr 4. 2006
23PTPN2
Gr-1+ myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism.
Dupuis M, De Jesus Ibarra-Sanchez M, Tremblay ML, Duplay P.
J Immunol 171(2):726-32. 2003
24PTPN2
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.
Pasquali C, Curchod ML, WŠlchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Van Huijsduijnen RH.
Mol Endocrinol 17(11):2228-39. Epub 2003 Aug 7. 2003
25STAT1, PTPN2
Identification of a nuclear Stat1 protein tyrosine phosphatase.
ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, Zhu W, Tremblay M, David M, Shuai K.
Mol Cell Biol 22(16):5662-8. 2002
26PTPN2, PTPN2P1, PTPN2P2
Isolation and mapping of human T-cell protein tyrosine phosphatase sequences : localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes.
Johnson CV, et al.
Genomics 16 : 619-629. 1993
27PTPN2
Assignment of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18.
Sakaguchi AY, et al.
Genomics 12 : 151-154. 1992
28PTPN2
Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase.
Gebbink MFBG, et al.
FEBS Lett 290 : 123-130. 1991