Citations for
1PTK2B, PTPN12, PXN
Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12.
Rhee I, Davidson D, Souza CM, Vacher J, Veillette A.
Mol Cell Biol 33(12):2458-69. doi: 10.1128/MCB.00197-13. Epub 2013 Apr 15. 2013
2PTPN12
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.
Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.
Oncogene ncogene. 2013 Feb 25. doi: 10.1038/onc.2013.24. [Epub ahead of print] 2013
3PTPN12, SKAP2
Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
Ayoub E, Hall A, Scott AM, Chagnon MJ, Miquel G, Hallé M, Noda M, Bikfalvi A, Tremblay ML.
J Biol Chem 288(36):25739-48. doi: 10.1074/jbc.M113.501007. Epub 2013 Jul 29. 2013
4PTK2B, PTPN12
Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
Eleniste PP, Du L, Shivanna M, Bruzzaniti A.
Int J Biochem Cell Biol 44(5):790-800. doi: 10.1016/j.biocel.2012.01.022. Epub 2012 Feb 8. 2012
5PTPN12
The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.
Souza CM, Davidson D, Rhee I, Gratton JP, Davis EC, Veillette A.
J Biol Chem 287(51):43180-90. doi: 10.1074/jbc.M112.387456. Epub 2012 Oct 26. 2012
6PTPN12
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.
Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF.
Cell 144(5):703-18. doi: 10.1016/j.cell.2011.02.003. 2011
7PTK2B, PTPN12
The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
Davidson D, Shi X, Zhong MC, Rhee I, Veillette A.
Immunity 33(2):167-80. doi: 10.1016/j.immuni.2010.08.001. 2010
8PTPN12
Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro.
Chellaiah MA, Schaller MD.
J Cell Physiol 220(2):382-93. doi: 10.1002/jcp.21777. 2009
9LCK, PTPN12
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Arimura Y, Vang T, Tautz L, Williams S, Mustelin T.
Mol Immunol 45(11):3074-84. doi: 10.1016/j.molimm.2008.03.019. Epub 2008 May 5. 2008
10CASP3, PTPN12
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.
Halle M, Liu YC, Hardy S, Theberge JF, Blanchetot C, Bourdeau A, Meng TC, Tremblay ML.
Mol Cell Biol 27(3):1172-90. Epub 2006 Nov 27. 2007
11PT2KB, LPXN, PTPN12
Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.
Sahu SN, Nunez S, Bai G, Gupta A.
Am J Physiol Cell Physiol 292(6):C2288-96. Epub 2007 Feb 28. 2007
12PTPN12
Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.
Hallé M, Liu YC, Hardy S, Théberge JF, Blanchetot C, Bourdeau A, Meng TC, Tremblay ML.
Mol Cell Biol 27(3):1172-90. Epub 2006 Nov 27. 2007
13PTPN12, PXN
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.
Jamieson JS, Tumbarello DA, Halle M, Brown MC, Tremblay ML, Turner CE.
J Cell Sci 118(Pt 24):5835-47. Epub 2005 Nov 29. 2005
14WAS, PTPN12
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA.
J Exp Med 199(1):99-112. 2004
15PTPN12
Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells.
Takekawa M, et al.
FEBS Lett 339 : 222-228. 1994
16PTPN12
Cloning, and expression of PTP-PEST.
Yang Q, et al.
J Biol Chem 268 : 6622-6628. 1993
17PTPN12
Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase.
Takekawa M, et al.
Biochem Biophys Res Commun 189 : 1223-1230. 1992