| 1 | PTPN1, RNF213
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| PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
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| Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
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| Nat Cell Biol 18(7):803-13. doi: 10.1038/ncb3376.
2016
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| 2 | PTPN1, PTPN2
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| Differential regulation of FGFR3 by PTPN1 and PTPN2.
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| St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
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| Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17.
2015
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| 3 | FGFR3, PTPN1, PTPN2
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| Differential regulation of FGFR3 by PTPN1 and PTPN2.
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| St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
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| Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17.
2015
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| 4 | NCK1, PTPN1
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| Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.
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| Li H, Dusseault J, Larose L.
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| Cell Commun Signal 12:71. doi: 10.1186/s12964-014-0071-9.
2014
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| 5 | CHRM3, PTPN1
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| Type 3 muscarinic acetylcholine receptor stimulation is a determinant of endothelial barrier function and adherens junctions integrity: role of protein-tyrosine phosphatase 1B.
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| Jiao ZY, Wu J, Liu C, Wen B, Zhao WZ, Du XL.
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| BMB Rep 47(10):552-7. 2014
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| 6 | GAB1, PTPN1
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| Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina.
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| Rajala A, Dilly AK, Rajala RV.
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| Cell Commun Signal 11(1):20. doi: 10.1186/1478-811X-11-20.
2013
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| 7 | EIF2AK3, EIF2S1, PTPN1
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| Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.
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| Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas AE, Haj FG.
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| PLoS One 7(4):e34412. Epub 2012 Apr 3. 2012
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| 8 | PTPN1
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| Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
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| Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M.
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| PLoS One 7(2):e32700. Epub 2012 Feb 28.
2012
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| 9 | IRS2, PTPN1
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| Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
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| Murillo-Cuesta S, Camarero G, González-Rodríguez A, De La Rosa LR, Burks DJ, Avendańo C, Valverde AM, Varela-Nieto I.
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| Mol Med 18:260-9. doi: 10.2119/molmed.2011.00328.
2012
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| 10 | PTPN1
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| Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma.
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| Zheng LY, Zhou DX, Lu J, Zhang WJ, Zou DJ.
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| Biochem Biophys Res Commun 420(3):680-4. doi: 10.1016/j.bbrc.2012.03.066. Epub 2012 Mar 17.
2012
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| 11 | PTPN1, SNCA
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| Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
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| Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH.
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| Biochem Biophys Res Commun 424(3):597-603. doi: 10.1016/j.bbrc.2012.06.159. Epub 2012 Jul 7.
2012
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| 12 | PTPN1, PTPRJ
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| Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.
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| Mori J, Wang YJ, Ellison S, Heising S, Neel BG, Tremblay ML, Watson SP, Senis YA.
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| Arterioscler Thromb Vasc Biol 32(12):2956-65. doi: 10.1161/ATVBAHA.112.300447. Epub 2012 Oct 11.
2012
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| 13 | PTPN1
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| Endoplasmic reticulum stress and the on site function of resident PTP1B.
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| Popov D.
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| Biochem Biophys Res Commun 422(4):535-8. doi: 10.1016/j.bbrc.2012.05.048. Epub 2012 May 15. Review.
2012
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| 14 | IFNAR1, PTPN1
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| Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
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| Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY.
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| Proc Natl Acad Sci U S A 109(47):19226-31. doi: 10.1073/pnas.1211491109. Epub 2012 Nov 5.
2012
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| 15 | PTPN1, SCLY
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| Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice.
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| Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ.
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| Mol Cell Biol 32(20):4141-54. Epub 2012 Aug 13.
2012
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| 16 | POMC, PTPN1
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| Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
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| De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.
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| Am J Physiol Endocrinol Metab 300(6):E1002-11. Epub 2011 Mar 15.
2011
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| 17 | PTPN1
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| Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors.
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| Sangwan V, Abella J, Lai A, Bertos N, Stuible M, Tremblay ML, Park M.
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| J Biol Chem 286(52):45000-13. Epub 2011 Nov 1.
2011
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| 18 | PTPN1
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| Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
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| Agouni A, Mody N, Owen C, Czopek A, Zimmer D, Bentires-Alj M, Bence KK, Delibegović M.
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| Biochem J 438(2):369-78.
2011
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| 19 | PTPN1
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| Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B.
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| Matsuo K, Bettaieb A, Nagata N, Matsuo I, Keilhack H, Haj FG.
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| PLoS One 6(1):e16446.
2011
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| 20 | PTPN1
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| Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.
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| Alvira D, Naughton R, Bhatt L, Tedesco S, Landry WD, Cotter TG.
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| J Biol Chem 286(37):32313-23. Epub 2011 Jul 27.
2011
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| 21 | NCK1, PTPN1
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| Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
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| Wu CL, Buszard B, Teng CH, Chen WL, Warr CG, Tiganis T, Meng TC.
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| Biochem J 439(1):151-9. doi: 10.1042/BJ20110799.
2011
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| 22 | GRB14, PTPN1
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| Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.
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| Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV.
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| Mol Cell Biol 31(19):3975-87. doi: 10.1128/MCB.05659-11.
2011
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| 23 | CSF3R, PRDX4, PTPN1
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| Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.
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| Palande K, Roovers O, Gits J, Verwijmeren C, Iuchi Y, Fujii J, Neel BG, Karisch R, Tavernier J, Touw IP.
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| J Cell Sci 124(Pt 21):3695-705. doi: 10.1242/jcs.089656. 2011
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| 24 | PTPN1
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| Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells.
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| Parvaneh L, Meshkani R, Bakhtiyari S, Mohammadtaghvaie N, Gorganifiruzjaee S, Taheripak G, Golestani A, Foruzandeh M, Larijani B, Taghikhani M.
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| Biochem Biophys Res Commun 396(2):467-71. Epub 2010 Apr 24.
2010
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| 25 | PTPN1
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| Modulation of hypothalamic PTP1B in the TNF-alpha-induced insulin and leptin resistance.
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| Picardi PK, Caricilli AM, de Abreu LL, Carvalheira JB, Velloso LA, Saad MJ.
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| FEBS Lett 584(14):3179-84. Epub 2010 Jun 2. 2010
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| 26 | PTPN1, STAM2
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| PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.
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| Stuible M, Abella JV, Feldhammer M, Nossov M, Sangwan V, Blagoev B, Park M, Tremblay ML.
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| J Biol Chem 285(31):23899-907. Epub 2010 May 26.
2010
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| 27 | EPHA3, PTPN1
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| PTP1B regulates Eph receptor function and trafficking.
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| Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M.
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| J Cell Biol 191(6):1189-203. Epub 2010 Dec 6.
2010
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| 28 | PTPN1
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| Microtubule and cell contact dependency of ER-bound PTP1B localization in growth cones.
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| Fuentes F, Arregui CO.
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| Mol Biol Cell 20(6):1878-89. Epub 2009 Jan 21.
2009
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| 29 | CDH22, HNF4A, PREX1, PTPN1, SLC2A10
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| Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Rich SS, Bowden DW, Mychaleckyj JC.
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| Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.
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| Genomics 92(4):226-34. Epub 2008 Aug 9.
2008
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| 30 | PTPN1, STAT6
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| PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
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| Lu X, Malumbres R, Shields B, Jiang X, Sarosiek KA, Natkunam Y, Tiganis T, Lossos IS.
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| Blood 112(10):4098-108. Epub 2008 Aug 20.
2008
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| 31 | PTPN1
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| Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
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| Julien SG, Dube N, Read M, Penney J, Paquet M, Han Y, Kennedy BP, Muller WJ, Tremblay ML.
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| Nat Genet 39(3):338-46. Epub 2007 Jan 28. 2007
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| 32 | PTPN1, TRPV6
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| Identification of tyrosines in the putative regulatory site of the Ca2+ channel TRPV6.
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| Sternfeld L, Anderie I, Schmid A, Al-Shaldi H, Krause E, Magg T, Schreiner D, Hofer HW, Schulz I.
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| Cell Calcium 42(1):91-102. Epub 2006 Dec 29.
2007
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| 33 | PTPN1
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| Neuronal PTP1B regulates body weight, adiposity and leptin action.
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| Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.
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| Nat Med 12(8):917-24. Epub 2006 Jul 16. 2006
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| 34 | PTPN1, CAV1
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| Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.
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| Lee H, Xie L, Luo Y, Lee SY, Lawrence DS, Wang XB, Sotgia F, Lisanti MP, Zhang ZY.
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| Biochemistry 45(1):234-40. 2006
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| 35 | PTPN1
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| Human polynucleotide phosphorylase (hPNPase old-35): an RNA degradation enzyme with pleiotrophic biological effects.
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| Sarkar D, Fisher PB.
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| Cell Cycle 5(10):1080-4. Epub 2006 May 15. Review.PMID: 16687933 2006
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| 36 | PTPN1
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| Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
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| Olivier M, Hsiung CA, Chuang LM, Ho LT, Ting CT, Bustos VI, Lee TM, De Witte A, Chen YD, Olshen R, Rodriguez B, Wen CC, Cox DR.
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| Hum Mol Genet 13(17):1885-92. Epub 2004 Jun 30. 2004
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| 37 | GRK4, PTPN1, HSD3B1
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| Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
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| Speirs HJ, Katyk K, Kumar NN, Benjafield AV, Wang WY, Morris BJ.
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| J Hypertens 22(5):931-6. 2004
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| 38 | PTPN1
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| Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.
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| Dadke S, Kusari A, Kusari J.
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| Mol Cell Biochem 221(1-2):147-54.PMID: 11506178 2001
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| 39 | PTPN1
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| Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.
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| Brown-Shimer S, et al.
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| Proc Natl Acad Sci U S A 87 : 5148-5152. 1990
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| 40 | PTPN1
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| Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
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| Charbonneau H, Tonks NK, Kumar S, Diltz CD, Harrylock M, Cool DE, Krebs EG, Fischer EH, Walsh KA.
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| Proc Natl Acad Sci U S A 86 : 5252-5256. 1989
|