Citations for
1PTPN1, RNF213
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
Nat Cell Biol 18(7):803-13. doi: 10.1038/ncb3376. 2016
2PTPN1, PTPN2
Differential regulation of FGFR3 by PTPN1 and PTPN2.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17. 2015
3FGFR3, PTPN1, PTPN2
Differential regulation of FGFR3 by PTPN1 and PTPN2.
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF.
Proteomics 15(2-3):419-33. doi: 10.1002/pmic.201400259. Epub 2014 Dec 17. 2015
4NCK1, PTPN1
Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.
Li H, Dusseault J, Larose L.
Cell Commun Signal 12:71. doi: 10.1186/s12964-014-0071-9. 2014
5CHRM3, PTPN1
Type 3 muscarinic acetylcholine receptor stimulation is a determinant of endothelial barrier function and adherens junctions integrity: role of protein-tyrosine phosphatase 1B.
Jiao ZY, Wu J, Liu C, Wen B, Zhao WZ, Du XL.
BMB Rep 47(10):552-7. 2014
6GAB1, PTPN1
Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina.
Rajala A, Dilly AK, Rajala RV.
Cell Commun Signal 11(1):20. doi: 10.1186/1478-811X-11-20. 2013
7EIF2AK3, EIF2S1, PTPN1
Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.
Bettaieb A, Matsuo K, Matsuo I, Wang S, Melhem R, Koromilas AE, Haj FG.
PLoS One 7(4):e34412. Epub 2012 Apr 3. 2012
8PTPN1
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M.
PLoS One 7(2):e32700. Epub 2012 Feb 28. 2012
9IRS2, PTPN1
Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
Murillo-Cuesta S, Camarero G, González-Rodríguez A, De La Rosa LR, Burks DJ, Avendańo C, Valverde AM, Varela-Nieto I.
Mol Med 18:260-9. doi: 10.2119/molmed.2011.00328. 2012
10PTPN1
Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma.
Zheng LY, Zhou DX, Lu J, Zhang WJ, Zou DJ.
Biochem Biophys Res Commun 420(3):680-4. doi: 10.1016/j.bbrc.2012.03.066. Epub 2012 Mar 17. 2012
11PTPN1, SNCA
Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction.
Choi HS, Liew H, Jang A, Kim YM, Lashuel H, Suh YH.
Biochem Biophys Res Commun 424(3):597-603. doi: 10.1016/j.bbrc.2012.06.159. Epub 2012 Jul 7. 2012
12PTPN1, PTPRJ
Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B.
Mori J, Wang YJ, Ellison S, Heising S, Neel BG, Tremblay ML, Watson SP, Senis YA.
Arterioscler Thromb Vasc Biol 32(12):2956-65. doi: 10.1161/ATVBAHA.112.300447. Epub 2012 Oct 11. 2012
13PTPN1
Endoplasmic reticulum stress and the on site function of resident PTP1B.
Popov D.
Biochem Biophys Res Commun 422(4):535-8. doi: 10.1016/j.bbrc.2012.05.048. Epub 2012 May 15. Review. 2012
14IFNAR1, PTPN1
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY.
Proc Natl Acad Sci U S A 109(47):19226-31. doi: 10.1073/pnas.1211491109. Epub 2012 Nov 5. 2012
15PTPN1, SCLY
Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice.
Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ.
Mol Cell Biol 32(20):4141-54. Epub 2012 Aug 13. 2012
16POMC, PTPN1
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.
Am J Physiol Endocrinol Metab 300(6):E1002-11. Epub 2011 Mar 15. 2011
17PTPN1
Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors.
Sangwan V, Abella J, Lai A, Bertos N, Stuible M, Tremblay ML, Park M.
J Biol Chem 286(52):45000-13. Epub 2011 Nov 1. 2011
18PTPN1
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
Agouni A, Mody N, Owen C, Czopek A, Zimmer D, Bentires-Alj M, Bence KK, Delibegović M.
Biochem J 438(2):369-78. 2011
19PTPN1
Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B.
Matsuo K, Bettaieb A, Nagata N, Matsuo I, Keilhack H, Haj FG.
PLoS One 6(1):e16446. 2011
20PTPN1
Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.
Alvira D, Naughton R, Bhatt L, Tedesco S, Landry WD, Cotter TG.
J Biol Chem 286(37):32313-23. Epub 2011 Jul 27. 2011
21NCK1, PTPN1
Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
Wu CL, Buszard B, Teng CH, Chen WL, Warr CG, Tiganis T, Meng TC.
Biochem J 439(1):151-9. doi: 10.1042/BJ20110799. 2011
22GRB14, PTPN1
Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.
Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV.
Mol Cell Biol 31(19):3975-87. doi: 10.1128/MCB.05659-11. 2011
23CSF3R, PRDX4, PTPN1
Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.
Palande K, Roovers O, Gits J, Verwijmeren C, Iuchi Y, Fujii J, Neel BG, Karisch R, Tavernier J, Touw IP.
J Cell Sci 124(Pt 21):3695-705. doi: 10.1242/jcs.089656. 2011
24PTPN1
Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells.
Parvaneh L, Meshkani R, Bakhtiyari S, Mohammadtaghvaie N, Gorganifiruzjaee S, Taheripak G, Golestani A, Foruzandeh M, Larijani B, Taghikhani M.
Biochem Biophys Res Commun 396(2):467-71. Epub 2010 Apr 24. 2010
25PTPN1
Modulation of hypothalamic PTP1B in the TNF-alpha-induced insulin and leptin resistance.
Picardi PK, Caricilli AM, de Abreu LL, Carvalheira JB, Velloso LA, Saad MJ.
FEBS Lett 584(14):3179-84. Epub 2010 Jun 2. 2010
26PTPN1, STAM2
PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.
Stuible M, Abella JV, Feldhammer M, Nossov M, Sangwan V, Blagoev B, Park M, Tremblay ML.
J Biol Chem 285(31):23899-907. Epub 2010 May 26. 2010
27EPHA3, PTPN1
PTP1B regulates Eph receptor function and trafficking.
Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M.
J Cell Biol 191(6):1189-203. Epub 2010 Dec 6. 2010
28PTPN1
Microtubule and cell contact dependency of ER-bound PTP1B localization in growth cones.
Fuentes F, Arregui CO.
Mol Biol Cell 20(6):1878-89. Epub 2009 Jan 21. 2009
29CDH22, HNF4A, PREX1, PTPN1, SLC2A10
Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Rich SS, Bowden DW, Mychaleckyj JC.
Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.
Genomics 92(4):226-34. Epub 2008 Aug 9. 2008
30PTPN1, STAT6
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Lu X, Malumbres R, Shields B, Jiang X, Sarosiek KA, Natkunam Y, Tiganis T, Lossos IS.
Blood 112(10):4098-108. Epub 2008 Aug 20. 2008
31PTPN1
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Julien SG, Dube N, Read M, Penney J, Paquet M, Han Y, Kennedy BP, Muller WJ, Tremblay ML.
Nat Genet 39(3):338-46. Epub 2007 Jan 28. 2007
32PTPN1, TRPV6
Identification of tyrosines in the putative regulatory site of the Ca2+ channel TRPV6.
Sternfeld L, Anderie I, Schmid A, Al-Shaldi H, Krause E, Magg T, Schreiner D, Hofer HW, Schulz I.
Cell Calcium 42(1):91-102. Epub 2006 Dec 29. 2007
33PTPN1
Neuronal PTP1B regulates body weight, adiposity and leptin action.
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB.
Nat Med 12(8):917-24. Epub 2006 Jul 16. 2006
34PTPN1, CAV1
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.
Lee H, Xie L, Luo Y, Lee SY, Lawrence DS, Wang XB, Sotgia F, Lisanti MP, Zhang ZY.
Biochemistry 45(1):234-40. 2006
35PTPN1
Human polynucleotide phosphorylase (hPNPase old-35): an RNA degradation enzyme with pleiotrophic biological effects.
Sarkar D, Fisher PB.
Cell Cycle 5(10):1080-4. Epub 2006 May 15. Review.PMID: 16687933 2006
36PTPN1
Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
Olivier M, Hsiung CA, Chuang LM, Ho LT, Ting CT, Bustos VI, Lee TM, De Witte A, Chen YD, Olshen R, Rodriguez B, Wen CC, Cox DR.
Hum Mol Genet 13(17):1885-92. Epub 2004 Jun 30. 2004
37GRK4, PTPN1, HSD3B1
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Speirs HJ, Katyk K, Kumar NN, Benjafield AV, Wang WY, Morris BJ.
J Hypertens 22(5):931-6. 2004
38PTPN1
Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor.
Dadke S, Kusari A, Kusari J.
Mol Cell Biochem 221(1-2):147-54.PMID: 11506178 2001
39PTPN1
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.
Brown-Shimer S, et al.
Proc Natl Acad Sci U S A 87 : 5148-5152. 1990
40PTPN1
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
Charbonneau H, Tonks NK, Kumar S, Diltz CD, Harrylock M, Cool DE, Krebs EG, Fischer EH, Walsh KA.
Proc Natl Acad Sci U S A 86 : 5252-5256. 1989